{"id":6879,"date":"2021-02-01T08:06:54","date_gmt":"2021-02-01T08:06:54","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6879"},"modified":"2021-06-07T07:14:31","modified_gmt":"2021-06-07T07:14:31","slug":"cleviprex","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/cleviprex\/","title":{"rendered":"Cleviprex &#8211; Clevidipine uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n0.5 mg \/ mL&nbsp;injection&nbsp;,&nbsp;emulsion&nbsp;<br>Clevidipine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Cleviprex is and what it is used for<\/h2>\n\n\n\n<p>Cleviprex contains the active substance clevidipine.<br><\/p>\n\n\n\n<p>Clevidipine is a calcium channel blocker.&nbsp;Calcium channel blockers are medications that lower&nbsp;blood pressure.<br><\/p>\n\n\n\n<p>Cleviprex is used to lower&nbsp;blood pressure&nbsp;in adult patients before, during, or immediately after surgery.<br><\/p>\n\n\n\n<p>Clevidipine contained in Cleviprex may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor if you have any further questions and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Cleviprex<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Cleviprex<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to clevidipine, soybeans, soybean oil, soy products, peanuts, eggs, or egg products, or to any of the other ingredients of Cleviprex<\/li><li>if you have extremely high levels of fat in your blood, including&nbsp;acute inflammation&nbsp;of the pancreas or kidney problems<\/li><li>if you have a kidney disease that causes loss of&nbsp;protein&nbsp;in the urine<\/li><\/ul>\n\n\n\n<p>Talk to your doctor if you are unsure.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before using Cleviprex:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have heart disease which means that the aortic valve of the heart does not open completely<\/li><li>if you have an abnormally large heart caused by narrowing blood vessels (&nbsp;hypertrophic&nbsp;obstructive&nbsp;cardiomyopathy&nbsp;)<\/li><li>if you have a heart disease that involves a narrowed valve (mitral valve stenosis)<\/li><li>if you have a tear in the main artery of the body (aortic dissection)<\/li><li>if you have a&nbsp;tumor&nbsp;on the gland on top of the kidney (adrenal gland) that causes high&nbsp;blood pressure&nbsp;(&nbsp;pheochromocytoma&nbsp;)<\/li><li>if you have had a heart attack<\/li><li>if you have a condition that means that your heart rate cannot increase to compensate for reduced&nbsp;blood pressure, such as<ul><li>disturbances in the electrical system of the heart<\/li><li>you have a pacemaker<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Cleviprex<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>It is especially important that you tell your doctor if you have been taking any blood pressure-lowering medication.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>You must tell your doctor about:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you are pregnant or think you may be pregnant<\/li><li>you are planning to get pregnant<\/li><li>you breastfeed<\/li><\/ul>\n\n\n\n<p>There are no&nbsp;adequate&nbsp;data from the use of Cleviprex in pregnant women.&nbsp;Cleviprex should not be used during pregnancy unless clearly necessary.&nbsp;Your doctor will decide if this treatment is right for you.<br><\/p>\n\n\n\n<p>It is not known if Cleviprex is excreted in human milk.&nbsp;If you are breast-feeding, your doctor will decide if you should use Cleviprex.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Cleviprex is used to lower&nbsp;blood pressure.&nbsp;It allows you to feel dizzy, which can affect your ability to drive and use machines.<br><\/p>\n\n\n\n<p>You must not drive or use machines until the effect of Cleviprex has subsided.&nbsp;If you are not sure, talk to your doctor before leaving the hospital.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;Talk to your doctor if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cleviprex contains soybean oil<\/h2>\n\n\n\n<p>Do not use this product if you are allergic to peanuts or soy.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per&nbsp;vial, ie&nbsp;essentially &#8216;&nbsp;sodium-free&#8217;.&nbsp;the product is virtually free of&nbsp;sodium.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Cleviprex<\/h2>\n\n\n\n<p>Cleviprex is for&nbsp;infusion&nbsp;(drip) into a vein.&nbsp;This is done by a doctor.<br><\/p>\n\n\n\n<p>Your treatment with Cleviprex will be monitored by a doctor as&nbsp;an infusion&nbsp;of Cleviprex is given at the hospital.&nbsp;Your doctor will decide how much Cleviprex you are taking and will prepare your medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will check your&nbsp;blood pressure&nbsp;throughout the treatment<\/li><li>Before starting&nbsp;an infusion&nbsp;, your doctor will tell you how to&nbsp;recognize any&nbsp;signs of an&nbsp;allergic reaction<\/li><li>The&nbsp;dose&nbsp;and duration of the&nbsp;infusion&nbsp;depend on the type of treatment you are undergoing<\/li><\/ul>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>An&nbsp;infusion&nbsp;of Cleviprex should be started at 4 ml per hour (2 mg per hour) and increased every 90 seconds after the patient has shown tolerance.&nbsp;At each increase, the&nbsp;dose&nbsp;should be&nbsp;doubled (ie from 4 to 8, from 8 to 16, from 16 to 32 and from 32 to 64 ml per hour (from 2 to 4, from 4 to 8, from 8 to 16, from 16). to 32 mg per hour)).<br><\/p>\n\n\n\n<p>Cleviprex reduces&nbsp;blood pressure&nbsp;for most patients at&nbsp;doses&nbsp;up to 32 ml per hour (16 mg per hour).<br><\/p>\n\n\n\n<p>Some patients may need a&nbsp;dose of&nbsp;up to 64 ml per hour (32 mg per hour).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you ingest more Cleviprex than you should<\/h2>\n\n\n\n<p>These&nbsp;doses&nbsp;are carefully monitored by your doctor;&nbsp;an overdose is very unlikely.&nbsp;If you take more Cleviprex than you should, the infusion dose is reduced or the&nbsp;infusion&nbsp;stopped.<br><\/p>\n\n\n\n<p>An overdose of Cleviprex may make you feel dizzy and your heart may start beating faster.<br><\/p>\n\n\n\n<p>If you are concerned that you may have taken too much Cleviprex, talk to your doctor or another medical professional immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Cleviprex<\/h2>\n\n\n\n<p>Because treatment with Cleviprex is given and supervised by a doctor, this is highly unlikely.&nbsp;If you are worried about missing a&nbsp;dose, talk to your doctor immediately.<br><\/p>\n\n\n\n<p><strong>While you are receiving Cleviprex<\/strong><\/p>\n\n\n\n<p>If you develop severe allergic reactions, e.g.&nbsp;swelling of the face and\/or throat or fever, tell your doctor immediately.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;The side effects&nbsp;are usually mild and do not last very long.<br><\/p>\n\n\n\n<p>Cleviprex can cause&nbsp;atrial fibrillation&nbsp;(irregular heartbeat), chest discomfort or&nbsp;hypoxia&nbsp;(lower levels of oxygen in the blood, which can make you feel dizzy).&nbsp;If this happens to you, talk to your doctor or another healthcare professional immediately so that they can decide whether to continue treatment with Cleviprex.<br><\/p>\n\n\n\n<p>Common: can affect up to 1 in 10 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>tachycardia&nbsp;(rapid heartbeat)<\/li><li>hypotension&nbsp;(low&nbsp;blood pressure&nbsp;)<\/li><li>polyuria&nbsp;(production of large amounts of urine)<\/li><li>edema&nbsp;(swelling) at the injection site<\/li><li>redness&nbsp;(skin turns red)<\/li><li>feeling of warmth<\/li><li>acute&nbsp;kidney injury (kidney damage)<\/li><\/ul>\n\n\n\n<p>Uncommon: affects up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>atrial flutter&nbsp;(abnormal heart rhythm)<\/li><li>heart failure<\/li><li>slow heartbeat<\/li><li>AV block&nbsp;(heartbeat is felt)<\/li><li>constipation<\/li><li>pulmonary stasis (congestion in the lungs)<\/li><li>headache<\/li><li>dizziness<\/li><li>nausea<\/li><li>vomiting<\/li><li>allergic reaction<\/li><\/ul>\n\n\n\n<p>Rare: can affect up to 1 in 1,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ileus&nbsp;(blocked intestinal passage)<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Cleviprex<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Store and transport cold (2 \u00b0 C &#8211; 8 \u00b0 C).&nbsp;Do not freeze<br><\/p>\n\n\n\n<p>Once the rubber stopper has been punctured, any unused product should be discarded after 12 hours.<br><\/p>\n\n\n\n<p>Keep the vial in the outer carton.&nbsp;Sensitive to light.<br><\/p>\n\n\n\n<p>Emulsion&nbsp;one should be milky white.<br><\/p>\n\n\n\n<p>The doctor will check the&nbsp;emulsion&nbsp;and discard it if it contains particles or is discolored.<br><\/p>\n\n\n\n<p>Do not throw medicines down the drain or in the household rubbish.&nbsp;The healthcare professional who administers Cleviprex is responsible for disposing of any unused product or waste material in accordance with local regulations.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is clevidipine&nbsp;<br>1 ml&nbsp;solution for injection,&nbsp;the emulsion&nbsp;contains 0.5 mg clevidipine.&nbsp;<br>A&nbsp;vial&nbsp;of 50 ml&nbsp;emulsion&nbsp;contains 25 mg clevidipine&nbsp;<br>A&nbsp;vial&nbsp;of 100 ml&nbsp;emulsion,&nbsp;contains 50 mg clevidipine<\/li><li>The other ingredients are refined soybean oil,&nbsp;glycerol, egg phospholipids, oleic acid, disodium edetate, water for injections, and sodium hydroxide (for&nbsp;adjustment)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Cleviprex is a milky white&nbsp;emulsion&nbsp;in&nbsp;a&nbsp;glass&nbsp;vial<\/p>\n\n\n\n<p>Each pack contains 10 vials of 50 ml or 100 ml.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Chiesi Farmaceutici SpA<\/p>\n\n\n\n<p>via Palermo 26 \/ A<\/p>\n\n\n\n<p>43122 Parma<\/p>\n\n\n\n<p>Italy<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>H\u00e4lsa Pharma GmbH<\/p>\n\n\n\n<p>Hafenweg 18-20&nbsp;<br>48155 M\u00fcnster,&nbsp;<\/p>\n\n\n\n<p>Germany<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Clevidipine is a calcium channel blocker. Calcium channel blockers are medications that lower blood pressure.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[7017,7020,7019,7021,7024,7023,2215,7018,7022],"class_list":["post-6879","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-clevidipine","tag-clevidipine-injection","tag-clevidipine-side-effects","tag-cleviprex","tag-cleviprex-injection","tag-cleviprex-side-effects","tag-injection","tag-what-is-clevidipine","tag-what-is-cleviprex"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6879"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6879\/revisions"}],"predecessor-version":[{"id":11379,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6879\/revisions\/11379"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6879"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}