\n\n500 IU powder and solvent for injection , solution
C1 inhibitor ( human )<\/p>\n\n\n\n
Cinryze contains the human protein called “C1 inhibitor” as the active substance.
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C1 inhibitor is a naturally occurring protein that is normally found in the blood. If you have a low amount of C1 inhibitors in your blood or if the C1 inhibitor does not work normally, this can lead to swelling attacks (called angioedema ). Symptoms may include abdominal pain and swelling of:<\/p>\n\n\n\n
In adults and children, Cinryze can increase the amount of C1 inhibitors in the blood and either prevent (before medical or dental procedures) the swelling attacks from occurring or stop the swelling attacks once they have started.<\/p>\n\n\n\n
In adults, adolescents and children (6 years of age and older), Cinryze may increase the amount of C1 inhibitors in the blood and regularly prevent the onset of swelling attacks.
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Cinryze should not be used in children under 6 years of age for routine prevention of angioedema attacks.<\/p>\n\n\n\n
Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine. There is only limited information on the safety of Cinryze use during pregnancy and lactation. Your doctor will discuss with you the risks and benefits of taking this medicine.<\/p>\n\n\n\n
Cinryze has less influence on the ability to drive and use machines.<\/p>\n\n\n\n
This medicine contains 11.5 mg sodium (the main ingredient in table salt\/table salt) per vial. This corresponds to 0.5% of the maximum recommended daily sodium intake for adults.
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Treatment will be initiated and supervised by a physician experienced in the management of patients with hereditary angioedema (HAE).
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A doctor or nurse can prepare and inject Cinryze for you. If your doctor thinks you can inject the medicine yourself, a doctor or nurse will instruct you or a family member on how to prepare and inject Cinryze. The doctor will regularly agree with you or a relative \/ carer on how preparations and administration are going .
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The recommended dose of Cinryze for adults, adolescents, children, the elderly or patients suffering from kidney or liver problems is as follows:
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Use in adults and adolescents (12 years and older)<\/strong><\/em> Treatment of swelling attacks<\/strong> Routine prevention of swelling attacks<\/strong> Prevention of swelling attacks before surgery<\/strong> Use for children<\/em><\/strong><\/p>\n\n\n\n Preparation and method of administration<\/strong> Cinryze is usually injected into a vein ( intravenously ) by your doctor or nurse. You or your carer can also give Cinryze as an injection , but only after getting enough exercise. If you inject Cinryze yourself, always do as your doctor advised. Consult a doctor if you are unsure. If your doctor thinks you may be suitable for such treatment at home, you will receive detailed instructions from him \/ her. You must keep a diary to document each treatment you take \/ receive at home and bring the diary to all your visits to the doctor. Your \/ your caregiver’s injection technique will be checked regularly to ensure continued appropriate handling. If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n Like all medicines, this medicine can cause side effects , although not everybody gets them. This may include allergic reactions. Tell your doctor immediately<\/strong> if you get any of the following symptoms after taking this medicine. Although the symptoms are rare, they can be severe. Sudden wheezing, difficulty breathing, swelling of eyelids, face or lips, rash or itching(especially if the rash or itching affects the whole body). Very common side effect are<\/strong> (can occur in more than 1 in 10): headache, nausea. Common side effects are<\/strong> (may affect up to 1 in 10): hypersensitivity, dizziness, vomiting, rashes, itching or redness , rash or pain at the injection site, fever. Less common side effects are<\/strong> (may affect up to 1 in 100): high blood sugar, blood clots, pain in the veins, hot flush, cough, abdominal pain, diarrhea, flaky skin, joint swelling and joint pain, muscle pain, and chest discomfort. Side effects in children and adolescents are expected to be similar to those in adults. Reporting of side effects<\/em><\/p>\n\n\n\n If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly to the Medical Products Agency, www.lakemedelsverket.se. By reporting side effects, you can help increase drug safety information. <\/p>\n\n\n\n Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton and vials after EXP.<\/p>\n\n\n\n Do not store above 25 \u00b0 C. Do not freeze. Store in the original package. Sensitive to light. When the Cinryze solution is ready, it should be used immediately. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n The active substance is a C1 inhibitor made from plasma from human donors. Each vial of powder contains 500 IU C1 inhibitors. After reconstitution , one vial contains 500 IU C1 inhibitor ( human ) per 5 ml, corresponding to a concentration of 100 IU \/ ml. Two vials of reconstituted Cinryze contain 1,000 IU C1 inhibitor ( human ) per 10 ml, corresponding to a concentration of 100 IU \/ ml. The total protein content of the reconstituted solution is 15 \u00b1 5 mg\/ml. An international unit (IU) corresponds to the amount of C1 inhibitors present in 1 ml of normal human plasma . The other ingredients are sodium chloride, sucrose, sodium citrate, L- valine , L-alanine, L-threonine. (See section 2). Liquid: water for injection.<\/p>\n\n\n\n Powder and solvent for solution for injection.<\/p>\n\n\n\n Cinryze is a white powder enclosed in a vial .<\/p>\n\n\n\n When the powder is dissolved in the water for injection , the solution is clear and colorless to bluish. Each package contains:<\/em> 2 vials of Cinryze 500 IU powder for injection solution 2 vials of water for injections (5 ml each)<\/p>\n\n\n\n 2 transfer units with filters<\/p>\n\n\n\n 2 disposable syringes of 10 ml<\/p>\n\n\n\n 2 sets for venipuncture<\/p>\n\n\n\n 2 protective pads Use only a silicone-free syringe (included in the package) to administer the product.<\/p>\n\n\n\n Marketing Authorisation Holder<\/strong> Shire Services BVBA<\/p>\n\n\n\n Rue Montoyer 47<\/p>\n\n\n\n 1000 Brussels<\/p>\n\n\n\n Belgium<\/p>\n\n\n\n medinfoEMEA@shire.com<\/p>\n\n\n\n Tel: +800 66838470 Manufacturer<\/strong> Takeda Manufacturing Austria AG<\/p>\n\n\n\n Industriestrasse 67<\/p>\n\n\n\n 1221 Vienna<\/p>\n\n\n\n Austria Baxter AG<\/p>\n\n\n\n Industriestrasse 67<\/p>\n\n\n\n 1221 Vienna<\/p>\n\n\n\n Austria Shire International Licensing BV<\/p>\n\n\n\n Strawinskylaan 481<\/p>\n\n\n\n 1077 XX Amsterdam<\/p>\n\n\n\n Netherlands Cinryze contains the human protein called “C1 inhibitor” as the active substance.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[7326,7328,7329,7330,7331,7334,7333,2215,2212,7327,7332],"class_list":["post-6765","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-c1-inhibitor","tag-c1-inhibitor-injection","tag-c1-inhibitor-side-effects","tag-c1-inhibitor-uses","tag-cinryze","tag-cinryze-injection","tag-cinryze-side-effects","tag-injection","tag-medicine","tag-what-is-c1-inhibitor","tag-what-is-cinryze"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6765","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6765"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6765\/revisions"}],"predecessor-version":[{"id":11482,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6765\/revisions\/11482"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6765"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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<\/li><\/ul>\n\n\n\nTreatment of angioedema attacks<\/strong><\/td> Prevention of angioedema attacks before surgery<\/strong><\/td> Routine prevention of angioedema attacks<\/strong><\/td><\/tr> 2 to 11 years,> 25 kg:<\/em>A dose of 1,000 IU (two vials) of Cinryze should be injected at the first sign of a swelling attack.
Another injection on1,000 IU can be given if your symptoms do not improve after 60 minutes.
2 to 11 years, 10\u201325 kg:<\/em>A dose of 500 IU (one vial) of Cinryze should be injected at the first sign of a swelling attack.
An additional 500 IU injection may be given if your symptoms have not improved after 60 minutes.<\/td>2 to 11 years,> 25 kg:<\/em>A dose of 1,000 IU (two vials) of Cinryze should be injected up to 24 hours before a medical, dental or surgical procedure.
2 to 11 years, 10\u201325 kg:<\/em> A dose of 500 IU (one vial ) of Cinryze should be injected up to 24 hours before a medical, dental or surgical procedure.<\/td>6 to 11 years:<\/em>A dose of 500 IU (one vial) of Cinryze should be injected at 3 or 4 day intervals for routine prevention of swelling attacks.
Your doctor may need to adjust the dosing interval depending on how you respond to treatment with Cinryze.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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<\/p>\n\n\n\n4. Possible side effects<\/h2>\n\n\n\n
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<\/p>\n\n\n\n5. How to store Cinryze<\/h2>\n\n\n\n
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<\/p>\n\n\n\n6. Contents of the packaging and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
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<\/p>\n\n\n\nWhat the medicine looks like and contents of the pack<\/h2>\n\n\n\n
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