{"id":6685,"date":"2021-01-12T10:26:43","date_gmt":"2021-01-12T10:26:43","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6685"},"modified":"2021-06-11T13:25:37","modified_gmt":"2021-06-11T13:25:37","slug":"champix","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/champix\/","title":{"rendered":"Champix &#8211; Varenicline uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n0.5 mg and 1 mg&nbsp;film-coated tablets&nbsp;<br>varenicline<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What CHAMPIX is and what it is used for<\/h2>\n\n\n\n<p>CHAMPIX contains the active substance varenicline.&nbsp;CHAMPIX is a medicine used by adults to quit smoking.<br><\/p>\n\n\n\n<p>CHAMPIX can help relieve cravings and other symptoms that may occur when trying to quit smoking.<br><\/p>\n\n\n\n<p>CHAMPIX can also reduce the pleasure of cigarettes if you smoke during treatment.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using CHAMPIX<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use CHAMPIX<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to varenicline or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking CHAMPIX.<br><\/p>\n\n\n\n<p>There have been cases of depression, suicidal ideation, suicidal behavior, and suicide attempts in patients taking CHAMPIX.&nbsp;If you are taking CHAMPIX and develop anxiety, depression, changes in your behavior that worry you or your loved ones, or if you experience suicidal thoughts or behavior, stop taking CHAMPIX and contact your doctor immediately for an assessment of treatment.<br><\/p>\n\n\n\n<p><em>The effects of smoking cessation<\/em><\/p>\n\n\n\n<p>The changes that occur in your body when you stop smoking, regardless of whether you are treated with CHAMPIX or not, can affect the effectiveness of other medicines.&nbsp;In some cases, therefore, a&nbsp;dose&nbsp;may&nbsp;need to be adjusted.&nbsp;For more information, see below under &#8220;Other medicines and CHAMPIX&#8221;.&nbsp;<br><\/p>\n\n\n\n<p>Some people who have tried to quit smoking, with or without treatment, have experienced an increased degree of mental symptoms such as changes in mindset or behavior, depression or anxiety, and may lead to worsening of mental illness.&nbsp;If you have previously had a mental illness, discuss this with your doctor.<br><\/p>\n\n\n\n<p><em>Heart symptoms<\/em><\/p>\n\n\n\n<p>New or worsening symptoms from the heart or blood vessels (cardiovascular) have been reported mainly in patients who already have cardiovascular disease.&nbsp;Tell your doctor if your symptoms change during treatment with CHAMPIX.&nbsp;Seek&nbsp;emergencymedical attention immediately if you experience symptoms of a heart attack or&nbsp;stroke&nbsp;.<br><\/p>\n\n\n\n<p><em>Cramps<\/em><\/p>\n\n\n\n<p>Tell your doctor if you have had seizures or are suffering from&nbsp;epilepsy&nbsp;before starting your treatment with CHAMPIX.&nbsp;Some patients have reported seizures during treatment with CHAMPIX.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><em>Hypersensitivity&nbsp;s<\/em><\/p>\n\n\n\n<p>Stop taking CHAMPIX and contact your doctor immediately if you get any of the following signs and symptoms that may indicate a severe allergic reaction: swelling of the face, lips, tongue, palate, throat, or body and\/or difficulty breathing and wheezing.<br><\/p>\n\n\n\n<p><em>Skin reactions<\/em><\/p>\n\n\n\n<p>Potential life-threatening rash (&nbsp;Stevens-Johnson syndrome&nbsp;and multiforme erythema) has been reported with the use of CHAMPIX.&nbsp;If you get a rash or if your skin starts to flake or if you get blisters, stop taking CHAMPIX and seek&nbsp;emergencymedical help&nbsp;immediately&nbsp;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>CHAMPIX is not recommended for the treatment of children or adolescents under 18 years of age as no effect has been demonstrated.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and CHAMPIX<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>As a result of quitting smoking with or without CHAMPIX, in some cases, the&nbsp;dose ofone of the other medicines may need to be adjusted.&nbsp;Examples are theophylline (a medicine used for breathing difficulties),&nbsp;warfarin&nbsp;(a medicine to reduce the risk of blood clots), and&nbsp;insulin&nbsp;(a medicine for&nbsp;diabetes&nbsp;).&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<p>If you have severe kidney disease, you should avoid taking cimetidine (a medicine used to treat stomach problems) at the same time as CHAMPIX as this may cause high blood levels of CHAMPIX.<br><\/p>\n\n\n\n<p><em>Use of CHAMPIX with other smoking cessation treatments<\/em><\/p>\n\n\n\n<p>Talk to your doctor before using CHAMPIX in combination with other smoking cessation treatments.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">CHAMPIX with food, drink and alcohol<\/h2>\n\n\n\n<p>There have been some reports of increased alcohol intoxication in patients taking CHAMPIX.&nbsp;However, it is not known whether CHAMPIX actually increases the poisoning effect of alcohol.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p>You should not take CHAMPIX if you are pregnant.&nbsp;Talk to your doctor if you are planning to have a baby.<br><\/p>\n\n\n\n<p>Although not studied, CHAMPIX may pass into breast milk.&nbsp;You should consult your doctor or pharmacist before taking CHAMPIX.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>CHAMPIX may be associated with dizziness, drowsiness and transient loss of consciousness.&nbsp;You should not drive, use advanced machines, or engage in any other potentially hazardous activities until you know if this medicine affects your ability to perform these activities.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">CHAMPIX contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie it is essentially &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use CHAMPIX<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>It is easier for you to quit smoking if you are motivated.&nbsp;Doctors and pharmacists can give you advice and support as well as information brochures, which can help you succeed in quitting smoking.<br><\/p>\n\n\n\n<p>Before starting treatment with CHAMPIX, you should usually decide on a day during the second week of treatment (between Day 8 and Day 14) when you want to stop smoking.&nbsp;If you do not want or can set a goal end date within 2 weeks, you can choose your own goal end date within 5 weeks after starting treatment.&nbsp;Write this date on the package as a reminder.<br><\/p>\n\n\n\n<p>CHAMPIX is a white tablet (0.5 mg) and a light blue tablet (1 mg).&nbsp;You start with the white tablet and then usually switch to the light blue tablet.<\/p>\n\n\n\n<p>See the table below for the usual dosing instructions that you should follow from Day 1.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><td><strong>Week 1<\/strong><\/td><td><strong>Dose<\/strong><\/td><\/tr><\/thead><tbody><tr><td>Day 1-3<\/td><td>From Day 1 to Day 3, take a white CHAMPIX 0.5 mg film-coated tablet once a day.<\/td><\/tr><tr><td>Day 4-7<\/td><td>From Day 4 to Day 7, take a white CHAMPIX 0.5 mg film-coated tablet twice a day, morning and evening, at approximately the same time each day.<\/td><\/tr><tr><td><strong>Week 2<\/strong><\/td><\/tr><tr><td>Day 8-14<\/td><td>From Day 8 to Day 14, take a light blue CHAMPIX 1 mg film-coated tablet twice a day, morning and evening, at approximately the same time each day.<\/td><\/tr><tr><td><strong>Week 3-12<\/strong><\/td><\/tr><tr><td>Day 15- end of treatment<\/td><td>From Day 15 until the end of treatment, you should take a light blue CHAMPIX 1 mg film-coated tablet twice a day, morning and evening, at approximately the same time each day.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>If you have managed to quit smoking after 12 weeks of treatment, your doctor may recommend additional 12-week treatment with CHAMPIX 1 mg film-coated tablets twice a day to help you stop smoking again.<br><\/p>\n\n\n\n<p>If you cannot or do not want to stop smoking immediately, you should reduce your smoking during the first 12 weeks of treatment and stop smoking completely when the treatment period is over.&nbsp;You should then continue to take CHAMPIX 1 mg film-coated tablets twice a day for a further 12 weeks, giving a total treatment duration of 24 weeks.<br><\/p>\n\n\n\n<p>Should you experience&nbsp;side effects&nbsp;that you can not tolerate, your doctor may decide to reduce the&nbsp;dose&nbsp;to 0.5 mg twice a day temporarily or permanently.<br><\/p>\n\n\n\n<p>If you have kidney problems, talk to your doctor before taking CHAMPIX.&nbsp;You may need a lower&nbsp;dose.<br><\/p>\n\n\n\n<p>CHAMPIX is for&nbsp;oral&nbsp;use.<\/p>\n\n\n\n<p>The tablets should be swallowed whole with water and can be taken with or without food.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more CHAMPIX than you should&nbsp;<\/h2>\n\n\n\n<p>If you have accidentally taken more CHAMPIX than your doctor prescribed, talk to a doctor immediately or contact your nearest hospital emergency department.&nbsp;Bring the box of tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use CHAMPIX<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.&nbsp;It is important that you take CHAMPIX regularly at the same time each day.&nbsp;If you forget to take a&nbsp;dose, take it as soon as you remember.&nbsp;If the next&nbsp;dose is&nbsp;to be taken within 3-4 hours, skip the tablet you missed.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using CHAMPIX<\/h2>\n\n\n\n<p>In&nbsp;clinical trials&nbsp;, it has been shown that your chances of succeeding in smoking increase if you take all&nbsp;doses&nbsp;of the drug at the right time and for as long as stated above.&nbsp;It is therefore important to continue taking CHAMPIX according to the instructions in the table above unless your doctor asks you to stop treatment.<br><\/p>\n\n\n\n<p>During smoking cessation, the risk of resuming smoking is increased for a period immediately following the end of treatment.&nbsp;You may temporarily experience increased irritation, smoking, depression, and\/or sleep disturbances when you stop taking CHAMPIX.&nbsp;Your doctor may decide to gradually lower your dose of CHAMPIX at the end of treatment.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>Quitting smoking with or without treatment can cause various symptoms.&nbsp;These may include mood swings (such as feeling depressed, irritated, frustrated, or anxious), insomnia, difficulty concentrating, decreased heart rate, and increased appetite or weight gain.<br><\/p>\n\n\n\n<p>You must be aware that severe neuropsychiatric symptoms, such as anxiety, depression, or behavioral changes, can develop when you try to quit smoking, whether you are treated with CHAMPIX or not.&nbsp;Contact your doctor or pharmacist if you experience such symptoms.<br><\/p>\n\n\n\n<p>Serious&nbsp;side effects&nbsp;categorized as uncommon or rare have occurred in people who have tried to quit smoking CHAMPIX: seizures,&nbsp;strokes&nbsp;, heart attack, suicidal ideation, loss of contact with reality and inability to think clearly (&nbsp;psychosis&nbsp;), altered thinking or behavior (such as aggression and abnormal behavior).&nbsp;There have also been reports of severe skin reactions, including erythema multiforme (a type of rash) and&nbsp;Stevens-Johnson syndrome&nbsp;(a serious disease with blistering of the skin, mouth, around the eyes or genitals) and severe allergic reactions including&nbsp;angioedema(swelling of the face, mouth or throat).<br><\/p>\n\n\n\n<p>Very common&nbsp;side effects&nbsp;, which may affect more than 1 in 10 people:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;of the nose and throat, abnormal dreams, difficulty sleeping, headache<\/li><li>Nausea<\/li><\/ul>\n\n\n\n<p>Common&nbsp;side effects&nbsp;, which may affect up to 1 in 10 people:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Respiratory tract infection, sinusitis<\/li><li>Weight gain, decreased appetite, increased appetite<\/li><li>Drowsiness, dizziness, altered sense of taste<\/li><li>Shortness of breath, cough<\/li><li>Heartburn, vomiting, constipation, diarrhea, bloating, abdominal pain, toothache, indigestion, gas,&nbsp;dry mouth<\/li><li>Skin rash,&nbsp;itching<\/li><li>Joint pain, muscle aches, back pain<\/li><li>Chest pain, fatigue<\/li><\/ul>\n\n\n\n<p>Uncommon&nbsp;side effects&nbsp;, which may affect up to 1 in 100 people:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fungal infection, viral infection<\/li><li>Panic disorder, difficulty thinking, restlessness, mood swings, depression, anxiety, hallucinations, altered sex drive<\/li><li>Seizures, tremors, feeling of inertia, less sensitive to touch<\/li><li>Conjunctivitis of the eye (&nbsp;conjunctivitis&nbsp;), eye pain<\/li><li>Earrings<\/li><li>Angina, fast heartbeat, palpitations, increased heart rate<\/li><li>Increased&nbsp;blood pressure&nbsp;, hot flashes<\/li><li>Inflammation&nbsp;of the nose, sinuses or throat, stuffy nose, throat and breast, hoarseness, hay fever, throat irritation, blocked sinuses, large mucus formation from the nose which causes cough, runny nose<\/li><li>Red blood in the stool, stomach irritation, altered bowel habits, belching, cold sores, gum pain<\/li><li>Reddening of the skin,&nbsp;acne, increased sweating, night sweats<\/li><li>Muscle spasms, pain in the chest wall<\/li><li>Need to urinate abnormally often, nocturnal urination<\/li><li>Increased menstruation<\/li><li>Chest discomfort, flu-like illness, fever, weakness or general malaise<\/li><li>High blood sugar<\/li><li>Heart attack<\/li><li>Suicidal thoughts<\/li><li>Changed mindset or behavior (such as aggression)<\/li><\/ul>\n\n\n\n<p>Rare&nbsp;side effects&nbsp;that may affect up to 1 in 1,000 users:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Strong thirst<\/li><li>Feeling sick or mood swings, slow thinking<\/li><li>Stroke<\/li><li>Increased muscle tension, speech difficulties, coordination problems, impaired sense of taste, altered sleep patterns<\/li><li>Visual disturbances, discoloration of the eyes, enlarged&nbsp;pupils&nbsp;, photosensitivity, myopia, watery eyes<\/li><li>Irregular heartbeat or disturbed heartbeat<\/li><li>Sore throat, snoring<\/li><li>Bloody vomiting, abnormal stools, tongue deposits<\/li><li>Joint stiffness, pain in the ribs<\/li><li>Sugar in the urine, increased urine volume and frequency of urination<\/li><li>Vaginal discharge, altered sexual ability<\/li><li>Feeling of freezing, cysts<\/li><li>Diabetes<\/li><li>Sleepwalking<\/li><li>Lost contact with reality and inability to think clearly (&nbsp;psychosis&nbsp;)<\/li><li>Abnormal behavior<\/li><li>Severe skin reactions, including erythema multiforme (a type of skin rash) and&nbsp;Stevens-Johnson syndrome&nbsp;(a serious disease with blistering of the skin, mouth, eyes or genitals)<\/li><li>Severe allergic reactions including&nbsp;angioedema&nbsp;(swelling of the face, mouth or throat)<\/li><\/ul>\n\n\n\n<p>Has been reported (occurs in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Transient loss of consciousness<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store CHAMPIX<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Blister: Do not store above 30 \u00b0 C.<\/p>\n\n\n\n<p>Jar: No special storage instructions.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is varenicline.<\/li><li>Each 0.5 mg film-coated tablet contains 0.5 mg varenicline (as tartrate).<\/li><li>Each 1 mg film-coated tablet contains 1 mg varenicline (as tartrate).<\/li><\/ul>\n\n\n\n<p>&#8211; The other ingredients are:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\">Tablet core &#8211; CHAMPIX 0.5 mg and 1 mg film-coated tablets<\/th><\/tr><\/thead><tbody><tr><td>Microcrystalline celluloseAnhydrous calcium hydrogen phosphateCroscarmellose sodium (see section 2 \u201cCHAMPIX contains sodium\u201d)Colloidal&nbsp;anhydrous silicaMagnesium stearate<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\">Film-coating &#8211; CHAMPIX 0.5 mg film-coated tablets<\/th><\/tr><\/thead><tbody><tr><td>HypromellosTitanium dioxide (E171)Macrogol 400Triacetin<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\">Film-coating &#8211; CHAMPIX 1 mg film-coated tablets<\/th><\/tr><\/thead><tbody><tr><td>HypromellosTitanium dioxide (E171)Macrogol 400Indigo carmine aluminum lake (E132)Triacetin<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>CHAMPIX 0.5 mg film-coated tablets are white, film-coated, capsule-shaped tablets, labeled&nbsp;<em>\u201cPfizer\u201d<\/em>&nbsp;and \u201cCHX 0.5\u201d.<\/li><li>CHAMPIX 1 mg film-coated tablets are light blue, film-coated, capsule-shaped tablets, labeled&nbsp;<em>\u201cPfizer\u201d<\/em>&nbsp;and \u201cCHX 1.0\u201d.<\/li><\/ul>\n\n\n\n<p>CHAMPIX is available in the following packages:<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Escalator package containing 2 blister packs;&nbsp;1 clear blister pack of 11 CHAMPIX 0.5 mg film-coated tablets and 1 clear blister pack of 14 CHAMPIX 1 mg film-coated tablets in a foldable pocket pack.<\/li><li>Escalator package containing 2 blister packs;&nbsp;1 clear blister pack of 11 CHAMPIX 0.5 mg film-coated tablets and 14 CHAMPIX 1 mg film-coated tablets and 1 clear blister pack of 28 or 2 clear blister packs of 14 CHAMPIX 1 mg film-coated tablets in a foldable pocket pack.<\/li><li>Escalation pack in an outer carton containing 1 pack of 1 clear blister pack of 11 CHAMPIX 0.5 mg and 14 CHAMPIX 1 mg film-coated tablets and 1 clear blister pack of 28 or 2 clear blister packs of 14 CHAMPIX 1 mg film-coated tablets in a foldable 2-pack package containing 2 clear blister packs of 28 or 4 clear blister packs of 14 CHAMPIX 1 mg film-coated tablets in a foldable pocket pack.<\/li><li>Follow-up packs (for maintenance treatment) containing 2 or 4 clear blister packs of 14 or 2 clear blister packs of 28 CHAMPIX 1 mg film-coated tablets in a foldable pocket pack.<\/li><li>Follow-up packs (for maintenance treatment) containing 2 or 4 clear blister packs of 14 or 2 clear blister packs of 28 CHAMPIX 0.5 mg film-coated tablets in a foldable pocket pack.<\/li><li>Escalator package containing 2 blister packs;&nbsp;1 clear blister pack of 11 CHAMPIX 0.5 mg film-coated tablets and 1 clear blister pack of 14 CHAMPIX 1 mg film-coated tablets in a carton.<\/li><li>Follow-up packs (for maintenance treatment) containing 2, 4, 8, or 10 clear blister packs of 14 CHAMPIX 1 mg film-coated tablets in a carton.<\/li><li>Sealed white jar in HDPE plastic with childproof screw cap, in a carton containing 56 CHAMPIX 1 mg film-coated tablets.<\/li><li>Sealed white jar in HDPE plastic with childproof screw cap, in carton containing 56 CHAMPIX 0.5 mg film-coated tablets<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder:<\/strong><\/p>\n\n\n\n<p>Pfizer Europe MA EEIG<\/p>\n\n\n\n<p>Boulevard de la Plaine 17<\/p>\n\n\n\n<p>1050 Brussels<\/p>\n\n\n\n<p>Belgium<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>R-Pharm Germany GmbH<\/p>\n\n\n\n<p>Heinrich-Mack-Str.&nbsp;35, 89257 Illertissen<\/p>\n\n\n\n<p>Germany<br><\/p>\n\n\n\n<p>or<br><\/p>\n\n\n\n<p>Pfizer Manufacturing Deutschland GmbH<\/p>\n\n\n\n<p>Company Freiburg<\/p>\n\n\n\n<p>Mooswaldallee 1<\/p>\n\n\n\n<p>79090 Freiburg<\/p>\n\n\n\n<p>Germany<br><\/p>\n\n\n\n<p>or<br><\/p>\n\n\n\n<p>Pfizer Italia Srl<\/p>\n\n\n\n<p>Locality Marino del Tronto, 63100<\/p>\n\n\n\n<p>Ascoli Piceno (AP)<\/p>\n\n\n\n<p>Italy<br><\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicineShow larger<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Pfizer SA \/ NVTel: + 32 (0) 2 554 62 11<\/td><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel.&nbsp;+3705 2514000<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>The Pfizer of Luxembourg,Clone of BulgariaTel: +359 2 970 4333<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Pfizer SATel: + 32 (0) 2 554 62 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer, spol.&nbsp;s roTel: + 420 283 004 111<\/td><td><strong>Hungary<\/strong>Pfizer Kft.Tel .: +36 1 488 37 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Pfizer ApSTel: + 45 44 20 11 00<\/td><td><strong>Malta<\/strong>Vivian Corporation Ltd.Tel: +356 21344610<\/td><\/tr><tr><td><strong>Germany<\/strong>Pfizer Pharma GmbHTel: + 49 (0) 30 550055-10000<\/td><td><strong>The Netherlands<\/strong>Pfizer bvTel: + 31 (0) 10 406 43 01<\/td><\/tr><tr><td><strong>Eesti<\/strong>Pfizer Luxembourg SARL Eesti subsidiaryTel: + 372 666 7500<\/td><td><strong>Norway<\/strong>Pfizer ASTel: +47 67 52 61 00<\/td><\/tr><tr><td><strong>Greece<\/strong>PFIZER \u0395\u039b\u039b\u0391\u03a3 \u0391.\u0395..:\u0397\u03bb .: +30 210 67 85 800<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHTel: + 43 (0) 1 521 15-0<\/td><\/tr><tr><td><strong>Spain<\/strong>Pfizer SLTel: + 34 91 490 99 00<\/td><td><strong>Poland<\/strong>Pfizer Polska Sp.&nbsp;z ooTel .: + 48 22 335 61 00<\/td><\/tr><tr><td><strong>France<\/strong>PfizerTel: + 33 (0) 1 58 07 34 40<\/td><td><strong>Portugal<\/strong>Pfizer Lda Laboratories.Tel: +351 21 423 5500<\/td><\/tr><tr><td><strong>Croatia<\/strong>Pfizer Croatia dooTel: + 385 1 3908 777<\/td><td><strong>Romania<\/strong>Pfizer Rom\u00e2nia SRLTel: +40 (0) 21 207 28 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandTel: 1800 633 363 (tollfree)+44 (0) 1304 616161<\/td><td><strong>Slovenia<\/strong>Pfizer Luxembourg SARL, Pfizer, manufacturing and manufacturing pharmaceutical services, LjubljanaTel: + 386 (0) 1 52 11 400<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hf.Phone: + 354 540 8000<\/td><td><strong>Slovak Republic<\/strong>Pfizer Luxembourg SARL, organizerTel: + 421 2 3355 5500<\/td><\/tr><tr><td><strong>Italy<\/strong>Pfizer SrlTel: + 39 06 33 18 21<\/td><td><strong>Finland \/ Finland<\/strong>Pfizer OyPuh \/ Tel: + 358 (0) 9 43 00 40<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>PFIZER \u0395\u039b\u039b\u0391\u03a3 \u0391.\u0395.&nbsp;(CYPRUS BRANCH):\u0397\u03bb: +357 22 817690<\/td><td><\/td><\/tr><tr><td><strong>Latvia<\/strong>Pfizer Luxembourg SARL subsidiary Latvij\u0101Tel: + 371 67035775<\/td><td><strong>United Kingdom<\/strong>Pfizer LimitedTel: + 44 (0) 1304 616161<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>CHAMPIX contains the active substance varenicline. CHAMPIX is a medicine used by adults to quit smoking.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[7359,7361,7362,2212,2211,7355,7357,7358,7360,7356],"class_list":["post-6685","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-champix","tag-champix-side-effects","tag-champix-tablet","tag-medicine","tag-tablets","tag-varenicline","tag-varenicline-side-effects","tag-varenicline-tablet","tag-what-is-champix","tag-what-is-varenicline"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6685","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6685"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6685\/revisions"}],"predecessor-version":[{"id":11489,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6685\/revisions\/11489"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6685"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6685"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}