{"id":6683,"date":"2021-01-12T10:25:26","date_gmt":"2021-01-12T10:25:26","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6683"},"modified":"2021-06-11T13:34:32","modified_gmt":"2021-06-11T13:34:32","slug":"cetrotide","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/cetrotide\/","title":{"rendered":"Cetrotide &#8211; Cetrorelix uses, dose and side effects"},"content":{"rendered":"\n<p> 0.25 mg&nbsp;powder and solvent for&nbsp;injection, solution&nbsp;<br>cetrorelix<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Cetrotide is and what it is used for<\/h2>\n\n\n\n<p><strong>What Cetrotide is<\/strong><\/p>\n\n\n\n<p>Cetrotide contains a medicine called cetrorelix.&nbsp;This medicine prevents the body from secreting an egg from the ovaries (ovulation) during the menstrual cycle.&nbsp;Cetrotide belongs to a group of medicines called anti-gonadotropin-releasing&nbsp;hormones.<br><\/p>\n\n\n\n<p><strong>What Cetrotide is used for<\/strong><\/p>\n\n\n\n<p>Cetrotide is one of the drugs used in assisted reproduction techniques to help you get pregnant.&nbsp;This prevents the eggs from being released immediately.&nbsp;This is because if the eggs are released prematurely (premature ovulation), the doctor may not be able to remove them.<br><\/p>\n\n\n\n<p><strong>How Cetrotide works<\/strong><\/p>\n\n\n\n<p>Cetrotide blocks a natural&nbsp;hormone&nbsp;in the body called LHRH (&nbsp;luteinizing hormone-releasing hormone&nbsp;).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>LHRH controls another&nbsp;hormone&nbsp;called&nbsp;LH&nbsp;(&nbsp;luteinizing hormone&nbsp;).<\/li><li>LH&nbsp;stimulates ovulation during the menstrual cycle.<\/li><\/ul>\n\n\n\n<p>This means that Cetrotide stops the chain of events that leads to an egg being released from your ovaries.&nbsp;When your eggs are ready to be taken out, you will receive another medicine that loosens the eggs (ovulation induction).<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Cetrotide<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Cetrotide<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to cetrorelix or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are allergic to medicines similar to Cetrotide (any other peptide hormone)<\/li><li>if you are pregnant or breastfeeding<\/li><li>if you have severe kidney disease.<\/li><\/ul>\n\n\n\n<p>Do not use Cetrotide if any of the above apply to you.&nbsp;If you are not sure, talk to your doctor before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>Allergy&nbsp;is<\/strong><\/p>\n\n\n\n<p>Tell your doctor before using Cetrotide if you have an ongoing&nbsp;allergic reaction&nbsp;or have previously had allergic reactions.<br><\/p>\n\n\n\n<p><strong>Ovarian hyperstimulation syndrome (OHSS)<\/strong><\/p>\n\n\n\n<p>Cetrotide is used with other medicines that stimulate the ovaries to develop more eggs that can be released.&nbsp;While or after receiving these medicines, you may develop OHSS.&nbsp;This happens when the follicles develop too much and become large cysts.&nbsp;Possible signs of this that you should pay attention to and what to do if this happens to see section 4 &#8221;&nbsp;<em>Possible&nbsp;side effects&nbsp;are<\/em>&nbsp;.&#8221;<br><\/p>\n\n\n\n<p><strong>Use of Cetrotide for more than one cycle<\/strong><\/p>\n\n\n\n<p>Experience with the use of Cetrotide for more than one cycle is limited.&nbsp;Your doctor will carefully review the benefits and risks for you if you need to take Cetrotide for more than one cycle.<br><\/p>\n\n\n\n<p><strong>Liver disease<\/strong><\/p>\n\n\n\n<p>Tell your doctor before using Cetrotide if you have liver disease.&nbsp;Cetrotide has not been studied in patients with liver disease.<br><\/p>\n\n\n\n<p><strong>Kidney disease<\/strong><\/p>\n\n\n\n<p>Tell your doctor before using Cetrotide if you have kidney disease.&nbsp;Cetrotide has not been studied in patients with kidney disease.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Cetrotide is not intended for use by children or adolescents.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Cetrotide<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Do not use Cetrotide if you are pregnant, think you may be pregnant, or are breast-feeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Cetrotide is not expected to affect your ability to drive and use machines.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Cetrotide<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Consult a doctor if you are unsure.<br><\/p>\n\n\n\n<p><strong>How to use this medicine<\/strong><\/p>\n\n\n\n<p>This medicine is for injection only under the skin of the abdomen (&nbsp;subcutaneously&nbsp;).&nbsp;Choose different parts of the stomach every day to reduce skin irritation.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor must monitor your first&nbsp;injection.&nbsp;Your doctor or nurse will show you how to prepare and inject the medicine.<\/li><li>You can take the following&nbsp;injections&nbsp;yourself if your doctor has informed you about the symptoms that may indicate an&nbsp;allergic reaction&nbsp;and about its possible serious or life-threatening consequences that require immediate treatment (see section 4&nbsp;<em>&#8220;Possible side effects&#8221;<\/em>&nbsp;).<\/li><li>Read carefully and follow the instructions&nbsp;<em>&#8220;How to mix and inject Cetrotide&#8221;<\/em>&nbsp;at the end of this information.<\/li><li>You start by using another medicine on day 1 of your treatment cycle.&nbsp;You will then start using Cetrotide a few days later.&nbsp;(See the next section&nbsp;<em>&#8220;How much to use&#8221;<\/em>&nbsp;.)<\/li><\/ul>\n\n\n\n<p><strong>How much to use<\/strong><\/p>\n\n\n\n<p>Inject the contents of 1&nbsp;vial&nbsp;(0.25 mg Cetrotide) once a day.&nbsp;It is best to use the medicine at the same time each day with 24 hours between each&nbsp;dose.<br><\/p>\n\n\n\n<p>You can choose to inject every morning&nbsp;<strong>or<\/strong>&nbsp;every evening.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you inject every morning: Start your&nbsp;injections&nbsp;on day 5 or day 6 of the treatment cycle.&nbsp;Based on how your ovaries react, your doctor may decide to start another day.&nbsp;Your doctor will inform you of the exact date and time.&nbsp;You should use this medicine until the morning your eggs are taken (ovulation induction).<\/li><\/ul>\n\n\n\n<p>OR<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you inject every night: Start your&nbsp;injections&nbsp;on day 5 of the treatment cycle.&nbsp;Based on how your ovaries react, your doctor may decide to start another day.&nbsp;Your doctor will inform you of the exact date and time.&nbsp;You should use this medicine until the evening before your eggs are taken out (ovulation induction).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Cetrotide than you should&nbsp;<\/h2>\n\n\n\n<p>Adverse effects are not expected if you accidentally inject too much of this medicine.&nbsp;The effect of the drug will be longer.&nbsp;Usually, no special measures are required.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Cetrotide<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you forget to take a&nbsp;dose, inject it as soon as you remember and contact your doctor.<\/li><li>Do not inject a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/li><\/ul>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Allergic reactions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Feeling of heat and&nbsp;redness&nbsp;of the skin,&nbsp;itching&nbsp;(often in the groin or armpits), redness, itching, raised rash (hives), runny nose, rapid or uneven&nbsp;pulse, swelling of the tongue and throat, sneezing, wheezing, or severe difficulty breathing, or dizziness.&nbsp;You may have had a severe, life-threatening&nbsp;allergic reaction&nbsp;to the medicine.&nbsp;This is less common (affects up to 1 in 100 women).<\/li><\/ul>\n\n\n\n<p>If you experience any of the&nbsp;side effects&nbsp;mentioned above, stop using Cetrotide and contact your doctor immediately.&nbsp;<br><\/p>\n\n\n\n<p><strong>Ovarian hyperstimulation syndrome (OHSS)<\/strong><\/p>\n\n\n\n<p>This may be due to the other medicines you use to stimulate the ovaries.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Abdominal pain along with nausea or vomiting may be symptoms of OHSS.&nbsp;This may indicate that the ovaries have overreacted to the treatment and that large ovarian cysts have formed.&nbsp;This is common (may affect up to 1 in 10 women).<\/li><li>OHSS can become serious with clearly enlarged ovaries, decreased urine flow, weight gain, difficulty breathing, or fluid in the abdomen or chest cavity.&nbsp;This is less common (affects up to 1 in 100 women).<\/li><\/ul>\n\n\n\n<p>If you get any of the&nbsp;side effects&nbsp;listed above, contact your doctor immediately.<br><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 women):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Mild and short-term skin irritation may occur at the injection site, e.g.&nbsp;redness,&nbsp;itching,&nbsp;or swelling.<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 women):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Feeling sick (nausea)<\/li><li>Headache.<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Cetrotide<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label on the carton, vial, and prefilled syringe after \u201cEXP\u201d and \u201cEXP\u201d, respectively.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Store in a refrigerator (2&nbsp;<sup>\u00b0<\/sup>&nbsp;C &#8211; 8&nbsp;<sup>\u00b0<\/sup>&nbsp;C).&nbsp;Do not freeze or place next to the freezer compartment or a cooling lamp.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Sensitive to light.<br><\/p>\n\n\n\n<p>Unopened medicine can be stored in the original package at room temperature (at a maximum of 30 \u00b0 C) for up to 3 months.<br><\/p>\n\n\n\n<p>The solution for injection should be used immediately after&nbsp;reconstitution.<br><\/p>\n\n\n\n<p>Do not use this medicine if you notice that the white powder in the bottle has changed its appearance.&nbsp;Do not use the reconstituted liquid in the vial if it is no longer clear and colorless or if it contains particles.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is cetrorelix.&nbsp;Each&nbsp;vial&nbsp;contains 0.25 mg cetrorelix (as acetate).<\/li><li>Other ingredients are:- In powder: mannitol- In the liquid: water for injections<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Cetrotide is a powder and solvent for&nbsp;solution&nbsp;for&nbsp;injection.&nbsp;The white powder is supplied in a&nbsp;glass&nbsp;vial&nbsp;with a rubber stopper.&nbsp;The liquid is a clear and colorless solution in a pre-filled&nbsp;syringe.<br><\/p>\n\n\n\n<p>The powder vial contains 0.25 mg of cetrorelix and the pre-filled syringe contains 1 ml of liquid.<br><\/p>\n\n\n\n<p>The medicine is available in packs of 1&nbsp;vial&nbsp;and 1 pre-filled&nbsp;syringe&nbsp;or 7 vials and 7 pre-filled syringes (not all pack sizes may be marketed).<br><\/p>\n\n\n\n<p>The pack for each&nbsp;vial&nbsp;also contains:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a&nbsp;<strong>yellow-marked<\/strong>&nbsp;needle &#8211; to inject the sterile water into the vial and to pull the reconstituted medicine out of the vial<\/li><li>a&nbsp;<strong>gray-marked<\/strong>&nbsp;needle &#8211; to inject the drug into the stomach<\/li><li>two&nbsp;compresses&nbsp;moistened with alcohol for cleaning<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Merck Europe BV, Gustav Mahlerplein 102, 1082 MA Amsterdam, The Netherlands<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Merck Healthcare KGaA, Frankfurter Stra\u00dfe 250, D-64293 Darmstadt, Germany<br><\/p>\n\n\n\n<p>Further information on this medicine is available on the European Medicines Agency web site: http:\/\/www.ema.europa.eu<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cetrotide contains a medicine called cetrorelix. This medicine prevents the body from secreting an egg from the ovaries (ovulation) during the menstrual cycle. Cetrotide belongs to a group of medicines called anti-gonadotropin-releasing hormones.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[7363,7366,7365,7367,7370,7369,2216,2212,7364,7368],"class_list":["post-6683","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-cetrorelix","tag-cetrorelix-injection","tag-cetrorelix-side-effects","tag-cetrotide","tag-cetrotide-injection","tag-cetrotide-side-effects","tag-injections","tag-medicine","tag-what-is-cetrorelix","tag-what-is-cetrotide"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6683"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6683\/revisions"}],"predecessor-version":[{"id":11491,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6683\/revisions\/11491"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}