{"id":6661,"date":"2021-01-11T13:35:19","date_gmt":"2021-01-11T13:35:19","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6661"},"modified":"2021-06-11T14:20:18","modified_gmt":"2021-06-11T14:20:18","slug":"certican","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/certican\/","title":{"rendered":"Certican &#8211; Everolimus uses, dose and side effects"},"content":{"rendered":"\n<p> Dispersible tablet 0.1 m <\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Certican is and what it is used for<\/h2>\n\n\n\n<p>The active substance in Certican is called everolimus.<br><\/p>\n\n\n\n<p>Everolimus belongs to a group of medicines called immunosuppressive medicines.&nbsp;It is used in adults to prevent the body&#8217;s immune system from rejecting a transplanted kidney, liver, or a transplanted heart.&nbsp;Certican is used with medicines containing ciclosporin in kidney or heart transplants, tacrolimus in liver transplants, and&nbsp;corticosteroids.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Certican<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Certican<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to everolimus or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are allergic (hypersensitive) to sirolimus.<\/li><\/ul>\n\n\n\n<p><strong>If any of the above applies to you, tell your doctor and do not take Certican.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>Talk to a doctor before taking Certican:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines that inhibit the immune system, such as Certican, can reduce the body&#8217;s ability to fight&nbsp;infection.&nbsp;You should therefore consult your doctor or transplant center if you get a fever, general malaise, cough, or severe burning when you urinate, which persists for several days.&nbsp;Talk to your doctor or transplant center immediately if you feel confused, have impaired speech, memory loss, headaches, visual disturbances, or seizures, as this may be a sign of a rare but very serious condition called&nbsp;progressive&nbsp;multifocal leukoencephalopathy (PML).<\/li><li>If you have recently undergone major surgery or if you still have unhealed surgical wounds, Certican may increase the risk of wound healing problems.<\/li><li>Drugs that inhibit the immune system, such as Certican, may increase the risk of developing cancer, especially in the skin and lymphoid system.&nbsp;Therefore, limit your exposure to sunlight and UV (ultraviolet) light by wearing protective clothing and frequently using sunscreen with a high sun protection factor.<\/li><li>Your doctor will closely monitor your kidney function, blood fat and blood sugar levels as well as the amount of&nbsp;protein&nbsp;in your urine.<\/li><li>If you have liver problems or have previously had a disease that may have affected the liver, tell your doctor, as it may be necessary to adjust the Certicand dose accordingly.<\/li><li>If you experience breathing symptoms (such as coughing, difficulty breathing, and wheezing), please tell your doctor.&nbsp;Your doctor may decide if and how you need to continue with Certican, and\/or if you need to be treated with other medicines to improve this condition.<\/li><li>Certican can reduce sperm production and thus affect the ability of men to have children.&nbsp;This effect generally disappears after the end of treatment.&nbsp;Male patients who want to have children should discuss treatment with their doctor.<\/li><\/ul>\n\n\n\n<p><strong>Elderly (65 years and older)<\/strong><\/p>\n\n\n\n<p>The experience of Certican in the elderly is limited.<br><\/p>\n\n\n\n<p><strong>Children and adolescents (under 18 years)<\/strong><\/p>\n\n\n\n<p>Certican should not be used in children and adolescents for kidney, heart, or liver transplantation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Certican<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.<br><\/p>\n\n\n\n<p>Some medicines may affect the effect of Certican.&nbsp;It is very important that you tell your doctor if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other immunosuppressive drugs, in addition to cyclosporine, tacrolimus, and&nbsp;corticosteroid&nbsp;s<\/li><li>antibiotics, eg rifampicin, rifabutin, clarithromycin, erythromycin, or telithromycin<\/li><li>HIV&nbsp;medicines, such as ritonavir, efavirenz, nevirapine, nelfinavir, indinavir, or amprenavir<\/li><li>medicines used to treat fungal infections, such as voriconazole,&nbsp;fluconazole,&nbsp;ketoconazole,&nbsp;or itraconazole<\/li><li>drugs used to treat&nbsp;epilepsy, such as&nbsp;phenytoin, phenobarbital, or carbamazepine<\/li><li>medicines used to treat high&nbsp;blood pressure&nbsp;or heart problems, such as verapamil, nicardipine, or&nbsp;diltiazem<\/li><li>dronedarone, a drug that regulates heart rhythm<\/li><li>drugs used to lower blood cholesterol levels, such as atorvastatin, pravastatin, or fibrates.<br><\/li><li>medicines used to treat acute seizures or as sedatives before or during surgery or other medical procedures, such as midazolam<\/li><li>octreotide, a drug used to treat&nbsp;acromegaly, a rare hormonal disorder most commonly found in middle-aged adults<\/li><li>imatinib, a drug that inhibits the growth of tumor cells<\/li><li>St. John&#8217;s wort&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;), a natural remedy for the treatment of depression<\/li><li>If you need to be vaccinated, consult your doctor first.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Certican with food and drink<\/h2>\n\n\n\n<p>Food intake can affect how much of Certican is absorbed from the gut.&nbsp;To keep the same levels of Certican in your body, you should always take Certican in the same way.&nbsp;Therefore, take Certican either always with food or always on an empty stomach.<br><\/p>\n\n\n\n<p>Do not take Certican with grapefruit juice or grapefruit.&nbsp;Grapefruit and grapefruit juice affect the effects of Certican in the body.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant, do not take Certican, unless your doctor thinks it is absolutely necessary.<\/p>\n\n\n\n<p>If you are a woman and you may become pregnant, you should use an effective contraceptive during treatment with Certican and 8 weeks after stopping treatment.<br><\/p>\n\n\n\n<p>If you think you may be pregnant, ask your doctor or&nbsp;pharmacist&nbsp;for advice before taking Certican.<br><\/p>\n\n\n\n<p>You should not breast-feed while taking Certican.&nbsp;It is not known if Certican is transferred to breast milk.<br><\/p>\n\n\n\n<p>Certican can affect male&nbsp;fertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>No studies on the effects of Certican on the ability to drive and use machines have been performed.&nbsp;You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Certican contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Certican<\/h2>\n\n\n\n<p>Your doctor will decide exactly what&nbsp;dose&nbsp;of Certican to take and when to take it.<\/p>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual starting dose is 1.5 mg per day for kidney and heart transplants and 2.0 mg per day for liver transplants.<\/li><li>The starting dose is usually divided into 2 doses, one in the morning and one in the evening.<\/li><\/ul>\n\n\n\n<p><strong>How to take Certican<\/strong><\/p>\n\n\n\n<p>Certican may only be taken by mouth.<br><\/p>\n\n\n\n<p>You should take the first&nbsp;dose&nbsp;of this medicine as early as possible after a kidney and heart transplant and approximately four weeks after a liver transplant.<br><\/p>\n\n\n\n<p>You should take the tablets together with ciclosporin microemulsion for kidney and heart transplants and with tacrolimus for liver transplants.<\/p>\n\n\n\n<p>Do not switch from Certican dispersible tablets to Certican tablets without talking to your doctor first.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Place Certican dispersible tablets in about 25 ml of water in a plastic cup.<\/li><li>The maximum amount of Certican that can be suspended (dispersed) in 25 ml of water is 1.5 mg.<\/li><li>Wait for about 2 minutes for the tablets to disintegrate and shake gently before drinking the liquid.<\/li><li>Afterward, immediately rinse the cup with another 25 ml of water and drink completely.<\/li><\/ul>\n\n\n\n<p><strong>Checks during treatment with Certican<\/strong><\/p>\n\n\n\n<p>Your doctor may need to adjust your&nbsp;dose&nbsp;based on how much Certican is in your blood and depending on how you respond to treatment.&nbsp;Your doctor will take regular blood tests to measure the blood levels of everolimus and ciclosporin.&nbsp;Your doctor will also carefully monitor your kidney function, blood fat, and sugar levels as well as the amount of&nbsp;protein&nbsp;in your urine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Certican<\/h2>\n\n\n\n<p>If you forget to take the Certicand dose, take it as soon as you remember and then continue taking the&nbsp;doses&nbsp;at the usual times.&nbsp;Ask your doctor for advice.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for forgotten tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Certican<\/h2>\n\n\n\n<p>Do not stop taking this medicine unless your doctor tells you to.&nbsp;You will need to take this medicine for as long as you need immunosuppression to prevent rejection of the transplanted kidney, heart, or liver.&nbsp;If you stop taking Certican, you will have an increased risk of your body rejecting the transplanted organ.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Because Certican is taken with other medicines, it is not always certain that the&nbsp;side effects&nbsp;are due to Certican.&nbsp;They can also be caused by the other drugs.<br><\/p>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;need immediate medical attention<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection&nbsp;is<\/li><li>inflammation&nbsp;of the lungs<\/li><li>allergic reactions<\/li><li>fever and bruising in the form of red spots on the skin, with or without unexplained fatigue, confusion, yellowing of the skin or eyes, decreased urine output (thrombotic microangiopathy,&nbsp;hemolytic uremic syndrome&nbsp;).<\/li><\/ul>\n\n\n\n<p>If you develop any of the following symptoms, stop taking Certican and&nbsp;<strong>contact a doctor immediately:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>persistent or worsening lung or respiratory symptoms such as cough, difficulty breathing, or wheezing<\/li><li>fever, malaise, chest or abdominal pain, chills, burning when you urinate<\/li><li>swelling of the face, lips, tongue, or throat<\/li><li>difficulty swallowing<\/li><li>bruising or bleeding for no apparent reason<\/li><li>hives<\/li><li>pain, abnormal heat, swelling or oozing from the surgical wound.<\/li><\/ul>\n\n\n\n<p><strong>Other reported&nbsp;side effects&nbsp;are as follows:<\/strong><br><\/p>\n\n\n\n<p><strong>Very common&nbsp;<\/strong><em>(may affect more than 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection&nbsp;(viral, bacterial, and fungal infections)<\/li><li>lower respiratory tract infections, such as lung infections such as&nbsp;pneumonia<\/li><li>upper respiratory tract infections, such as&nbsp;inflammation&nbsp;of the throat and common cold<\/li><li>urinary tract infections<\/li><li>anemia&nbsp;(decreased number of&nbsp;red blood cells&nbsp;)<\/li><li>low levels of&nbsp;white blood cells, which can lead to a higher risk of infection<\/li><li>decreased levels of&nbsp;platelets, which can lead to bleeding and bruising of the skin<\/li><li>high-fat content (&nbsp;lipids,&nbsp;cholesterol,&nbsp;and&nbsp;triglycerides&nbsp;) in the blood<\/li><li>the onset of&nbsp;diabetes&nbsp;(high blood sugar)<\/li><li>decreased potassium levels in the blood<\/li><li>anxiety<\/li><li>difficulty sleeping<\/li><li>headache<\/li><li>fluid accumulation in the sac around the heart, which in severe symptoms can reduce the heart&#8217;s ability to pump blood if it becomes severe<\/li><li>high&nbsp;blood pressure<\/li><li>venous thrombosis&nbsp;(blockage of the large vein due to blood clot)<\/li><li>fluid accumulation in the lungs and chest cavity, which in severe symptoms can make you short of breath<\/li><li>cough<\/li><li>shortness of breath<\/li><li>diarrhea<\/li><li>nausea<\/li><li>vomiting<\/li><li>abdominal pain<\/li><li>general pain<\/li><li>fever<\/li><li>fluid accumulation in&nbsp;tissue&nbsp;are<\/li><li>abnormal wound healing.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;<\/strong><em>(may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood poisoning<\/li><li>wound infections<\/li><li>cancer and benign&nbsp;tumor&nbsp;er<\/li><li>skin cancer<\/li><li>renal damage with low&nbsp;platelet&nbsp;levels&nbsp;and low levels of&nbsp;red blood cells&nbsp;with or without&nbsp;redness&nbsp;(&nbsp;thrombocytopenia&nbsp;purpura \/ hemolytic uremic syndrome)<\/li><li>degradation of&nbsp;red blood cells<\/li><li>low levels of&nbsp;red blood cells&nbsp;and&nbsp;platelets<\/li><li>fast heart rate<\/li><li>nosebleeds<\/li><li>decreased number of&nbsp;blood cells&nbsp;(symptoms of this may include weakness, bruising and frequent&nbsp;infections&nbsp;)<\/li><li>a blood clot in the kidney blood vessel which can lead to graft loss, usually within 30 days after the kidney transplant<\/li><li>bleeding condition<\/li><li>a cyst&nbsp;containing lymph fluid<\/li><li>pain in the mouth or throat<\/li><li>inflammation&nbsp;of the pancreas<\/li><li>cold sores<\/li><li>acne<\/li><li>hives&nbsp;(&nbsp;urticaria&nbsp;) and other allergic symptoms such as swelling of the face or throat (&nbsp;angioedema&nbsp;)<\/li><li>rash<\/li><li>joint pain<\/li><li>muscle aches<\/li><li>protein&nbsp;in the urine<\/li><li>kidney effects<\/li><li>impotence<\/li><li>hernia&nbsp;at the surgical site<\/li><li>abnormal liver values<\/li><li>menstrual disorders (such as lack of or abundant menstruation).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;<\/strong><em>(may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lymph tissue cancer (lymphoma \/ lymphoproliferative disease after transplantation)<\/li><li>low level of&nbsp;testosterone<\/li><li>inflammation&nbsp;of the lungs<\/li><li>inflammation&nbsp;of the liver<\/li><li>jaundice<\/li><li>ovarian cysts.<\/li><\/ul>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;have been reported in a small number of people, but the exact frequency is unknown:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal accumulation of&nbsp;protein&nbsp;in the lungs (symptoms of this may include persistent dry cough, fatigue, and difficulty breathing)<\/li><li>inflammation&nbsp;of the blood vessels<\/li><li>Swelling, the feeling of heaviness or tension, pain, limited mobility of body parts (this can occur anywhere in the body and is a possible sign of an abnormal accumulation of fluid in soft&nbsp;tissue&nbsp;due to a blockage in the lymphatic system, so-called lymphedema)<\/li><li>severe skin rash with swelling of the skin.<\/li><li>low level of iron in the blood.<\/li><\/ul>\n\n\n\n<p>If you have any questions about any of these&nbsp;side effects, talk to your doctor.<br><\/p>\n\n\n\n<p>In addition, there may be&nbsp;side effects&nbsp;that you are not aware of, such as abnormal laboratory values \u200b\u200bincluding tests on kidney function.&nbsp;During your treatment with Certican, your doctor may therefore take blood samples to monitor changes.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Certican<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep out of sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton after EXP.<\/li><li>The expiration date is the last day of the specified month.<\/li><li>No special temperature instructions.<\/li><li>Store the blister cards in the original packaging.&nbsp;Sensitive to light.&nbsp;Moisture sensitive.<\/li><li>Do not use any Certican packaging that is damaged or shows signs of being broken<\/li><li>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is everolimus.&nbsp;Each&nbsp;dispersible&nbsp;tablet contains 0.1 mg and 0.25 mg of everolimus, respectively<br><\/p>\n\n\n\n<p>Other excipients are:<\/p>\n\n\n\n<p>Certican 0.1 mg dispersible tablets: butylhydroxytoluene (E 321), magnesium stearate,&nbsp;lactose monohydrate&nbsp;(1 mg), hypromellose, crospovidone,&nbsp;colloidal anhydrous silica, and anhydrous&nbsp;lactose&nbsp;(72 mg).<br><\/p>\n\n\n\n<p>Certican 0.25 mg dispersible tablets: butylhydroxytoluene (E 321), magnesium stearate,&nbsp;lactose monohydrate&nbsp;(2 mg), hypromellose, crospovidone,&nbsp;colloidal anhydrous silica, and anhydrous&nbsp;lactose&nbsp;(179 mg).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Certican 0.1 mg dispersible tablets are white to yellowish, marbled, round, flat with a ground edge and 7 mm in diameter, marked \u201cI\u201d on one side and \u201cNVR\u201d on the other.<\/li><li>Certican 0.25 mg dispersible tablets are white to yellowish, marbled, round, flat with a ground edge and 9 mm in diameter, marked \u201cYES\u201d on one side and \u201cNVR\u201d on the other.<\/li><\/ul>\n\n\n\n<p>Certican dispersible tablets are supplied in packs of 50, 60, 100, and 250 dispersible tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<br><\/p>\n\n\n\n<p>Certican is also available in the form of tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder:<\/h2>\n\n\n\n<p>Novartis Sverige AB<\/p>\n\n\n\n<p>Box 1218<\/p>\n\n\n\n<p>164 28 Kista<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong>&nbsp;:<\/p>\n\n\n\n<p>Novartis Pharmac\u00e9utica SA,<\/p>\n\n\n\n<p>Ronda de Santa Maria, 158,<\/p>\n\n\n\n<p>08210 Barber\u00e0 del Vall\u00e8s, Barcelona,<\/p>\n\n\n\n<p>Spain<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active substance in Certican is called everolimus.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[7424,7426,7427,7420,7422,7423,2212,2210,7425,7421],"class_list":["post-6661","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-certican","tag-certican-side-effects","tag-certican-tablet","tag-everolimus","tag-everolimus-side-effects","tag-everolimus-tablet","tag-medicine","tag-tablet","tag-what-is-certican","tag-what-is-everolimus"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6661"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6661\/revisions"}],"predecessor-version":[{"id":11511,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6661\/revisions\/11511"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}