{"id":6600,"date":"2021-01-10T15:00:51","date_gmt":"2021-01-10T15:00:51","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6600"},"modified":"2021-06-14T08:07:50","modified_gmt":"2021-06-14T08:07:50","slug":"celecoxib-orion","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/celecoxib-orion\/","title":{"rendered":"Celecoxib Orion &#8211; Celecoxib uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n100 mg and 200 mg&nbsp;hard capsules&nbsp;<br>celecoxib<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Celecoxib Orion is and what it is used for<\/h2>\n\n\n\n<p>Celecoxib Orion is used in adults for symptom relief in the treatment of&nbsp;<strong>chronicrheumatoid arthritis<\/strong>&nbsp;,&nbsp;<strong>osteoarthritis<\/strong>&nbsp;and&nbsp;<strong>pelvic pondylitis<\/strong>&nbsp;(Mb. Bechterews, rheumatic back disease).&nbsp;<br><\/p>\n\n\n\n<p>Celecoxib Orion belongs to a group of medicines called non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;), and more specifically to the subgroup&nbsp;COX-2inhibitors.&nbsp;Your body produces&nbsp;prostaglandins&nbsp;that can cause pain and&nbsp;inflammationand in conditions such as&nbsp;rheumatoid arthritis&nbsp;and&nbsp;osteoarthritis&nbsp;, your body produces more of them.&nbsp;Celecoxib Orion works by reducing the production of&nbsp;prostaglandins&nbsp;and thus reducing pain and&nbsp;inflammation&nbsp;.<br><\/p>\n\n\n\n<p>You can expect the medicine to start working within a few hours after taking the first dose, but it may take several days before it takes full effect.<br><\/p>\n\n\n\n<p>Celecoxib contained in Celecoxib Orion may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Celecoxib Orion<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Celecoxib Orion<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to celecoxib or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have had an&nbsp;allergic reaction&nbsp;to a group of medicines called &#8216;sulfonamides&#8217; (eg some&nbsp;antibiotics&nbsp;used to treat&nbsp;infections&nbsp;)<\/li><li>if you&nbsp;<strong>currently<\/strong>&nbsp;have ulcers or bleeding in the stomach \/ intestines<\/li><li>if you have had&nbsp;asthma&nbsp;, nasal polyps, severe nasal congestion or an&nbsp;allergic reaction&nbsp;such as itchy skin rash, swelling of the face, lips, tongue or throat, difficulty breathing or wheezing after taking&nbsp;acetylsalicylic acid&nbsp;or any other anti-inflammatory and analgesic medicine (&nbsp;NSAID&nbsp;)<\/li><li>if you are pregnant.&nbsp;If you are likely to become pregnant during treatment, you should discuss appropriate contraceptive methods with your doctor.<\/li><li>if you are breast-feeding<\/li><li>if you have severe liver disease<\/li><li>if you have severe kidney disease<\/li><li>if you have an&nbsp;inflammatory&nbsp;bowel disease, such as ulcerative colitis or&nbsp;Crohn&#8217;s disease<\/li><li>if you have&nbsp;heart failure&nbsp;or known ischemic heart disease or disease of the blood vessels of the brain, e.g.&nbsp;if you have had a heart attack,&nbsp;stroke&nbsp;, temporary decrease in blood flow to the brain (also known as &#8220;mini-stroke&#8221;), angina or narrowing of the blood vessels to the heart or brain<\/li><li>if you have or have had problems with blood circulation (&nbsp;peripheral&nbsp;vascular disease) or if you have had surgery on the blood vessels in your legs.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Celecoxib Orion:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you&nbsp;<strong>have<\/strong>&nbsp;a history of ulcers or bleeding in the stomach or intestines (&nbsp;<strong>Do not take Celecoxib Orion<\/strong>&nbsp;if you&nbsp;<strong>currently<\/strong>&nbsp;have ulcers or bleeding in the stomach or intestines.)<\/li><li>if you are taking&nbsp;acetylsalicylic acid&nbsp;(even at low&nbsp;doses&nbsp;in order to protect your heart)<\/li><li>if you are taking medicines to reduce blood clots (eg warfarin \/ warfarin-like blood thinners or new blood thinners, eg apixaban by mouth)<\/li><li>if you are taking medicines called&nbsp;corticosteroids&nbsp;(eg prednisone)<\/li><li>if you are taking Celecoxib Orion at the same time as other&nbsp;NSAIDs&nbsp;(besides&nbsp;acetylsalicylic acid&nbsp;), such as&nbsp;ibuprofen&nbsp;or&nbsp;diclofenac&nbsp;.&nbsp;Concomitant use of these drugs should be avoided.<\/li><li>if you smoke, have&nbsp;diabetes&nbsp;, high&nbsp;blood pressure&nbsp;or high cholesterol<\/li><li>If your heart, liver, or kidneys are not working properly, your doctor may want to check you regularly<\/li><li>if you have fluid retention in your body (such as swollen ankles and feet)<\/li><li>if you are dehydrated, e.g.&nbsp;due to vomiting, diarrhea or if you are taking diuretics (to treat fluid retention in the body)<\/li><li>if you have had a severe&nbsp;allergic reaction&nbsp;or a severe skin reaction to any medicine<\/li><li>if you have an&nbsp;infection&nbsp;, or suspect you have an&nbsp;infection&nbsp;, as Celecoxib Orion may mask fever or other signs of&nbsp;infection&nbsp;and&nbsp;inflammation<\/li><li>if you are over 65, your doctor will check you regularly<\/li><li>Intake of alcohol and&nbsp;NSAIDs&nbsp;may increase the risk of gastrointestinal upset.<\/li><\/ul>\n\n\n\n<p>Like other&nbsp;NSAIDs&nbsp;(eg&nbsp;ibuprofen&nbsp;or&nbsp;diclofenac&nbsp;), this medicine may cause high&nbsp;blood pressure&nbsp;, so your doctor may ask you to have your&nbsp;blood pressure&nbsp;checked&nbsp;regularly.<br><\/p>\n\n\n\n<p>Some cases of severe hepatic reaction have been reported following the use of celecoxib, such as severe hepatitis, liver damage, liver failure (some cases fatal, or requiring liver transplantation).&nbsp;In cases where the onset of symptoms was reported, most severe liver reactions were seen within one month of starting treatment.<br><\/p>\n\n\n\n<p>Celecoxib Orion may make it harder to get pregnant.&nbsp;You should tell your doctor if you are planning to become pregnant or if you are having difficulty getting pregnant (see the section on Pregnancy, breast-feeding and&nbsp;fertility&nbsp;).<br><\/p>\n\n\n\n<p><strong>Celecoxib Orion contains&nbsp;<\/strong>lactose&nbsp;(a sugar).&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Celecoxib Orion<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dextromethorphan (used to treat cough)<\/li><li>ACE inhibitors&nbsp;,&nbsp;angiotensin&nbsp;II inhibitors,&nbsp;beta-blockers&nbsp;and diuretics (used for high&nbsp;blood pressure&nbsp;and&nbsp;heart failure&nbsp;)<\/li><li>fluconazole&nbsp;and rifampicin (used to treat fungal and bacterial infections)<\/li><li>warfarin&nbsp;or other warfarin-like medicines (blood thinners that reduce blood clotting) including newer medicines like apixaban<\/li><li>lithium (used to treat certain types of depression)<\/li><li>Other medicines for depression, sleep disorders, high&nbsp;blood pressure&nbsp;or irregular heartbeat<\/li><li>neuroleptics&nbsp;(used to treat certain mental illnesses)<\/li><li>methotrexate (used to treat rheumatic joint disease,&nbsp;psoriasis&nbsp;and&nbsp;leukemia&nbsp;)<\/li><li>carbamazepine (used to treat epilepsy \/ seizures and certain forms of pain or depression)<\/li><li>barbiturates&nbsp;(used to treat epilepsy \/ seizures and certain sleep disorders)<\/li><li>ciclosporin and tacrolimus (used to suppress the immune system, eg after transplants)<\/li><\/ul>\n\n\n\n<p>Celecoxib Orion can be taken with a low&nbsp;dose&nbsp;of&nbsp;acetylsalicylic acid&nbsp;(75 mg or less per day).&nbsp;Ask your doctor for advice before taking these medicines at the same time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>Celecoxib Orion must not be used by women who are pregnant or may become pregnant during treatment (ie women of&nbsp;childbearing potential&nbsp;not using adequate contraception).&nbsp;If you become pregnant during treatment with Celecoxib Orion, you should stop treatment and contact your doctor for other treatment.<br><\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Celecoxib Orion must not be used during breast-feeding.<br><\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>NSAIDs&nbsp;including Celecoxib Orion may make it harder to get pregnant.&nbsp;Tell your doctor if you are planning to become pregnant or have problems getting pregnant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You should know how to react to Celecoxib Orion before driving or using machines.&nbsp;If you feel dizzy or drowsy after taking Celecoxib Orion, do not drive or use machines until these effects have subsided.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Celecoxib Orion<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>Your doctor will tell you which&nbsp;dose&nbsp;to take.&nbsp;As the risk of heart side effects may increase with high&nbsp;doses&nbsp;and long-term treatment, it is important that you do not take a higher&nbsp;dose&nbsp;or use Celecoxib Orion for longer than you need to control your symptoms.<br><\/p>\n\n\n\n<p><strong>Method of administration<\/strong><\/p>\n\n\n\n<p>Celecoxib Orion is for&nbsp;oral&nbsp;use&nbsp;<strong>.&nbsp;<\/strong>Your&nbsp;dose&nbsp;can be taken at any time of the day, with or without food.<\/p>\n\n\n\n<p>Try to take each&nbsp;dose&nbsp;at the same time of day.<br><\/p>\n\n\n\n<p>If you have difficulty swallowing capsules: All the contents of the capsule can be sprinkled on a teaspoon of semi-solid food (eg cold or room-warm apple puree, rice gruel, yoghurt or mashed banana) and swallowed immediately with about 240 ml of water.<br><\/p>\n\n\n\n<p>Open the capsule by holding it upright so that the&nbsp;granules&nbsp;collect at the bottom, then gently squeeze the upper part and remove it with a twisting motion.&nbsp;Be careful not to spill any of the contents.<\/p>\n\n\n\n<p><strong>Granules&nbsp;must not be chewed or crushed.<\/strong><br><\/p>\n\n\n\n<p>Contact your doctor if you do not experience any improvement after two weeks of treatment.<br><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is:<br><\/p>\n\n\n\n<p><strong>In&nbsp;osteoarthritis&nbsp;<\/strong>, the usual&nbsp;dose is&nbsp;200 mg daily, which can be increased to a maximum of 400 mg if your doctor deems it necessary.<br><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>one 200 mg capsule once a day, or<\/li><li>one capsule of 100 mg twice a day.<\/li><\/ul>\n\n\n\n<p><strong>In&nbsp;chronic&nbsp;rheumatoid arthritis&nbsp;<\/strong>, the usual&nbsp;dose is&nbsp;200 mg daily, which can be increased to a maximum of 400 mg if your doctor deems it necessary.<br><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>one capsule of 100 mg twice a day.<\/li><\/ul>\n\n\n\n<p><strong>For Celecoxib Orion 200 mg only:<\/strong><\/p>\n\n\n\n<p>Contact your doctor if the prescribed&nbsp;dose is&nbsp;not available in this strength of the medicine.&nbsp;Other strengths of the drug are available to achieve&nbsp;dose&nbsp;one.<br><\/p>\n\n\n\n<p><strong>In the case of&nbsp;pelvic spondylitis&nbsp;<\/strong>, the usual&nbsp;dose is&nbsp;200 mg daily, which can be increased to a maximum of 400 mg if your doctor deems it necessary.<br><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>one 200 mg capsule once a day;&nbsp;or<\/li><li>one capsule of 100 mg twice a day.<\/li><\/ul>\n\n\n\n<p><strong>Kidney or liver failure:<\/strong>&nbsp;If you have kidney or liver failure, tell your doctor as you may need to take a lower&nbsp;dose&nbsp;.<br><\/p>\n\n\n\n<p><strong>Elderly people, especially those weighing less than 50 kg:<\/strong>&nbsp;If you are over 65, and especially if you weigh less than 50 kg, your doctor may want to check you more closely.<br><\/p>\n\n\n\n<p>You should not take more than 400 mg per day.<br><\/p>\n\n\n\n<p><strong>Use in children:<\/strong>&nbsp;Celecoxib Orion is for adults only and should not be used in children.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Celecoxib Orion<\/h2>\n\n\n\n<p>If you forget to take your&nbsp;dose, take it as soon as you remember.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Celecoxib Orion<\/h2>\n\n\n\n<p>If you suddenly stop taking Celecoxib Orion, your symptoms may get worse.&nbsp;Do not stop taking Celecoxib Orion unless your doctor tells you to.&nbsp;Your doctor may ask you to reduce your&nbsp;dose&nbsp;for a few days before stopping treatment altogether.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p>The adverse reactions&nbsp;listed below have been observed in patients with&nbsp;osteoarthritisusing celecoxib.&nbsp;Side effects marked with an asterisk (*) are indicated with the higher frequency seen in patients using celecoxib to prevent colon polyps.&nbsp;These patients took celecoxib in high&nbsp;doses&nbsp;and for a long time.<br><\/p>\n\n\n\n<p>If any of the following occur, stop taking Celecoxib Orion and contact your doctor immediately:<\/p>\n\n\n\n<p>If you experience:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>an&nbsp;allergic reaction&nbsp;such as skin rash, swelling of the face, wheezing, or difficulty breathing<\/li><li>heart problems such as chest pain<\/li><li>severe stomach pain or signs of bleeding in the stomach or intestines, e.g.&nbsp;black or blood &#8211; stained stools or vomiting with blood in<\/li><li>a skin reaction such as rash, blistering, or flaking<\/li><li>liver failure with symptoms that may include nausea, diarrhea, jaundice (your skin or whites of the eyes look yellowish).<\/li><\/ul>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 user in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high&nbsp;blood pressure&nbsp;including increase in already high&nbsp;blood pressure&nbsp;. *<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>myocardial infarction*<\/li><li>fluid accumulation in the body that can cause swelling in the ankles, legs, and\/or hands<\/li><li>urinary tract infection<\/li><li>difficulty breathing *, sinusitis, nasal congestion or runny nose, sore throat, cough, cold,&nbsp;flu-like symptoms<\/li><li>dizziness, difficulty sleeping<\/li><li>vomiting *, stomach pain, diarrhea, digestive problems, flatulence<\/li><li>rash,&nbsp;itching<\/li><li>uuskel tensions<\/li><li>difficulty swallowing *<\/li><li>headache<\/li><li>nausea<\/li><li>joint pain<\/li><li>deterioration of existing&nbsp;allergy&nbsp;s<\/li><li>damage in the event of an accident.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>stroke*<\/li><li>heart failure&nbsp;, palpitations, rapid heartbeat<\/li><li>changes in liver values \u200b\u200bduring blood tests<\/li><li>changes in kidney values \u200b\u200bduring blood tests<\/li><li>anemia&nbsp;(decreased number of&nbsp;red blood cells&nbsp;, which can cause weakness and shortness of breath)<\/li><li>anxiety, depression, fatigue, drowsiness, ant crawling<\/li><li>increased amount of potassium in the blood (may cause nausea, fatigue, muscle weakness or palpitations)<\/li><li>impaired vision or blurred vision,&nbsp;tinnitus&nbsp;, soreness in the mouth, cold sores, hearing loss *<\/li><li>constipation, belching, gastritis (indigestion, stomach pain or vomiting), worsening&nbsp;inflammation&nbsp;of the stomach or intestines<\/li><li>leg cramps<\/li><li>raised, itchy rash (&nbsp;hives&nbsp;)<\/li><li>eye inflammation<\/li><li>breathing difficulties<\/li><li>discolored skin (bruises)<\/li><li>chest pain (general pain not related to the heart)<\/li><li>facial swelling.<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ulcers (bleeding) in the stomach, esophagus and intestines, ruptured intestines (may cause abdominal pain, fever, nausea, vomiting, intestinal obstruction), dark or black stools,&nbsp;inflammation&nbsp;of the pancreas (may cause abdominal pain),&nbsp;inflammation&nbsp;of the esophagus (&nbsp;esophagitis&nbsp;)<\/li><li>decreased amount of sodium in the blood (a condition known as&nbsp;hyponatremia&nbsp;)<\/li><li>decreased&nbsp;white blood cell count&nbsp;(which helps protect the body against&nbsp;infection&nbsp;) and&nbsp;platelets&nbsp;(increased risk of bleeding or bruising)<\/li><li>difficulty coordinating muscle movements<\/li><li>confusion, taste changes<\/li><li>increased photosensitivity<\/li><li>hair loss<\/li><li>hallucinations<\/li><li>bleeding in the eye<\/li><li>the acute&nbsp;reaction that can lead to&nbsp;pneumonia<\/li><li>irregular heartbeats<\/li><li>herds<\/li><li>blood clots in the blood vessels of the lungs.&nbsp;Symptoms may include sudden shortness of breath, sharp pain when breathing, or collapse<\/li><li>bleeding in the stomach or intestines (may cause bloody stools or vomiting), intestinal inflammation<\/li><li>serious liver inflammation (&nbsp;hepatitis&nbsp;).&nbsp;Symptoms may include nausea, diarrhea, jaundice (yellowing of the skin or eyes), dark urine, pale stools, increased tendency to bleed,&nbsp;itching&nbsp;or chills.<\/li><li>acute&nbsp;renal failure<\/li><li>menstrual disorders<\/li><li>swelling of the face, lips, mouth, tongue or throat, wheezing or difficulty swallowing.<\/li><\/ul>\n\n\n\n<p><strong>Very rare<\/strong>&nbsp;(may affect up to 1 in 10,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe skin reactions (including anaphylactic&nbsp;shock&nbsp;, which may be life-threatening)<\/li><li>severe skin conditions such as&nbsp;Stevens-Johnson syndrome&nbsp;, exfoliative&nbsp;dermatitisand&nbsp;toxic epidermal necrolysis&nbsp;(which may cause rash, blistering or flaking of the skin) and&nbsp;acute&nbsp;skin rash-like generalized&nbsp;pustulosis&nbsp;(red, swollen area with many small blisters)<\/li><li>a delayed&nbsp;allergic reaction&nbsp;with possible symptoms such as rash, swelling of the face, fever, swollen&nbsp;glands&nbsp;and abnormal test results in e.g.&nbsp;liver tests and blood cell tests (&nbsp;eosinophilia&nbsp;, a type of increased&nbsp;white blood cell count&nbsp;)<\/li><li>cerebral hemorrhage, which can be life-threatening<\/li><li>meningitis&nbsp;(&nbsp;inflammation&nbsp;of the&nbsp;meninges&nbsp;)<\/li><li>liver failure, liver damage and severe hepatitis (&nbsp;fulminant&nbsp;hepatitis&nbsp;) which in some cases had a fatal outcome or required liver transplantation.&nbsp;Symptoms may include nausea, diarrhea, jaundice (yellowing of the skin or eyes), dark urine, pale stools, increased tendency to bleed,&nbsp;itching&nbsp;or chills.<\/li><li>liver problems (eg cholestasis and cholestatic&nbsp;hepatitis&nbsp;, which may be accompanied by symptoms such as discolored stools, nausea and yellow skin or yellow eyes)<\/li><li>nephritis and other kidney problems (eg&nbsp;nephrotic syndrome&nbsp;and minimal change disease which may be accompanied by symptoms such as&nbsp;fluid retention&nbsp;(&nbsp;edema), frothy urine, fatigue and loss of appetite)<\/li><li>worsening&nbsp;epilepsy&nbsp;(possibly increased number of seizures and \/ or increased severity)<\/li><li>partial or complete loss of vision, caused by blockage of a blood vessel in the eye<\/li><li>inflammation&nbsp;of the blood vessels (may cause fever, aches, dark purple spots on the skin)<\/li><li>deficiency of all blood cells (may cause fatigue, increase the tendency to get bruises, frequent nosebleeds and increased risk of infection)<\/li><li>muscle aches and weakness<\/li><li>impaired sense of smell<\/li><li>loss of taste.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurs in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased&nbsp;fertility&nbsp;in women, which is usually transient at the end of treatment.<\/li><\/ul>\n\n\n\n<p>In&nbsp;clinical trials&nbsp;of conditions other than&nbsp;osteoarthritis&nbsp;or joint pain, which Celecoxib Orion was taken in&nbsp;dose&nbsp;you about 400 mg daily for up to 3 years, the following additional&nbsp;adverse reactions&nbsp;are observed:<br><\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>angina (chest pain)<\/li><li>irritated colon (may include abdominal pain, diarrhea, digestive problems, flatulence)<\/li><li>kidney stones&nbsp;(may cause abdominal or back pain, blood in the urine), urinary incontinence<\/li><li>weight gain.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>deep&nbsp;vein thrombosis&nbsp;(blood clot, usually in the legs, which may cause pain, swelling or&nbsp;redness&nbsp;in the calf or difficulty breathing)<\/li><li>stomach infection (which can cause irritation and ulcers in the stomach and intestines)<\/li><li>fracture&nbsp;of forearm \/ lower leg<\/li><li>shingles&nbsp;, skin infection,&nbsp;eczema&nbsp;(dry itchy rash),&nbsp;pneumonia&nbsp;(cough, fever, difficulty breathing)<\/li><li>visual impairment caused by small spots in the&nbsp;visual field&nbsp;, dizziness caused by problems in the inner ear, tender, inflamed or bleeding gums, cold sores<\/li><li>need to urinate frequently at night, bleeding from&nbsp;hemorrhoids&nbsp;, upset bowel<\/li><li>lumps of fat in the subcutaneous tissue,&nbsp;ganglion&nbsp;(harmless swelling of the wrist and ankle tendons), speech difficulties, abdominal bleeding, tenderness in the breasts<\/li><li>increased amount of sodium in the blood.<\/li><\/ul>\n\n\n\n<p><strong>Reporting of&nbsp;<\/strong><strong>side effects<\/strong><strong>&nbsp;is<\/strong>&nbsp;if you get&nbsp;side effects&nbsp;are, speak with your doctor or pharmacist.&nbsp;This also applies to&nbsp;side effects&nbsp;that are not mentioned in this information.&nbsp;You can also report&nbsp;side effects&nbsp;directly (see details below).&nbsp;By reporting&nbsp;side effects&nbsp;, you can help increase drug safety information.<strong>&nbsp;<\/strong><br><br><\/p>\n\n\n\n<p>The Medical Products Agency<\/p>\n\n\n\n<p>Box 26<\/p>\n\n\n\n<p>751 03 Uppsala<\/p>\n\n\n\n<p>www.lakemedelsverket.se<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Celecoxib Orion<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label, carton and container after EXP.&nbsp;The expiration date is the last day of the specified month.&nbsp;<br><\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is celecoxib.&nbsp;<br>Each capsule contains 100 mg of celecoxib.&nbsp;<br>Each capsule contains 200 mg of celecoxib.<\/li><li>Other ingredients are:&nbsp;<em>Capsule contents:<\/em>&nbsp;&nbsp;lactose monohydrate, hydroxypropylcellulose, Crospovidone (Type B) (E1202), sodium (E487), povidone (K-30) (E1201), sodium&nbsp;<em>Capsule shells:<\/em>&nbsp;titanium dioxide (E171), gelatin (E441)&nbsp;<em>Capsule labeling:<\/em>&nbsp;shellac (E904), indigo carmine E132 (only 100 mg), yellow iron oxide (E172) (only 200 mg)<em>&nbsp;<br><\/em><br><em><\/em><em><br><\/em><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Celecoxib Orion is available as hard capsules.<br><\/p>\n\n\n\n<p><em>Celecoxib Orion 100 mg hard capsules<\/em><\/p>\n\n\n\n<p>White, hard gelatin capsule in size &#8216;4&#8217;, filled with a white to off-white powder, marked with &#8216;Y&#8217; and &#8216;100&#8217; in blue.<br><\/p>\n\n\n\n<p><em>Celecoxib Orion 200 mg hard capsules<\/em><\/p>\n\n\n\n<p>White, hard gelatin capsule in size &#8216;2&#8217;, filled with a white to off-white powder, marked with &#8216;Y&#8217; and &#8216;200&#8217; with a golden color.<br><\/p>\n\n\n\n<p>Celecoxib Orion capsules are supplied in blisters and in HDPE cans.<br><\/p>\n\n\n\n<p><strong>Pack sizes:<\/strong><\/p>\n\n\n\n<p><em>Blister packs<\/em>&nbsp;: 10, 20, 30, 50, 60, 90 and 100 capsules<\/p>\n\n\n\n<p><em>HDPE cans:<\/em>&nbsp;<\/p>\n\n\n\n<p>100 mg: 60, 100, 250 and 500 capsules<\/p>\n\n\n\n<p>200 mg: 30, 100, 250 and 500 capsules<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Aurobindo Pharma (Malta) Limited<\/p>\n\n\n\n<p>Vault 14, Level 2, Valletta Waterfront, Floriana FRN 1913<\/p>\n\n\n\n<p>Malta<br><\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>APL Swift Services (Malta) Limited,<\/p>\n\n\n\n<p>HF26, Hal Far Industrial Estate, Hal Far, Birzebbugia, BBG 3000<\/p>\n\n\n\n<p>Malta<br><\/p>\n\n\n\n<p>For further information on this medicine, please contact your local representative:<\/p>\n\n\n\n<p>Orion Pharma AB<\/p>\n\n\n\n<p>medinfo@orionpharma.com<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Celecoxib Orion is used in adults for symptom relief in the treatment of chronicrheumatoid arthritis , osteoarthritis and pelvic pondylitis (Mb. Bechterews, rheumatic back disease). <\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[2239,7551,7554,7563,7566,7565,7553,2212,7564],"class_list":["post-6600","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-capsule","tag-celecoxib","tag-celecoxib-capsule","tag-celecoxib-orion","tag-celecoxib-orion-capsule","tag-celecoxib-orion-side-effects","tag-celecoxib-side-effects","tag-medicine","tag-what-is-celecoxib-orion"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6600"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6600\/revisions"}],"predecessor-version":[{"id":11551,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6600\/revisions\/11551"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}