{"id":6598,"date":"2021-01-10T14:59:27","date_gmt":"2021-01-10T14:59:27","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6598"},"modified":"2021-06-14T08:12:49","modified_gmt":"2021-06-14T08:12:49","slug":"celecoxib-krka","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/celecoxib-krka\/","title":{"rendered":"Celecoxib Krka &#8211; Celecoxib uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n100 mg and 200 mg&nbsp;capsules, hard&nbsp;<br>celecoxib<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Celecoxib Krka is and what it is used for<\/h2>\n\n\n\n<p>Celecoxib Krka is used in adults for the relief of symptoms in the treatment of&nbsp;<strong>chronic&nbsp;rheumatoid arthritis<\/strong>,&nbsp;<strong>osteoarthritis,<\/strong>&nbsp;and&nbsp;<strong>pelvic pondylitis<\/strong>&nbsp;.&nbsp;<br><\/p>\n\n\n\n<p>Celecoxib Krka belongs to a group of medicines called non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;), and more specifically to the subgroup inhibitors of&nbsp;cyclooxygenase&nbsp;-2&nbsp;(&nbsp;COX-2&nbsp;inhibitors).&nbsp;Your body produces&nbsp;prostaglandins&nbsp;that can cause pain and&nbsp;inflammation&nbsp;and in conditions such as&nbsp;rheumatoid arthritis&nbsp;and&nbsp;osteoarthritis, your body produces more of them.&nbsp;Celecoxib Krka works by reducing the production of&nbsp;prostaglandins&nbsp;and thus reducing pain and&nbsp;inflammation.<br><\/p>\n\n\n\n<p>You can expect the medicine to start working within a few hours of taking the first&nbsp;dose, but it may take several days before it takes full effect.<br><\/p>\n\n\n\n<p>Celecoxib contained in Celecoxib Krka may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professional if you have any further questions and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Celecoxib Krka<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Celecoxib Krka<\/h2>\n\n\n\n<p>You have been prescribed Celecoxib Krka by your doctor.&nbsp;The following information will help you get the best results from your treatment.&nbsp;If you have any further questions, ask your doctor or pharmacist.<br><\/p>\n\n\n\n<p><strong>Do not take Celecoxib Krka<\/strong><\/p>\n\n\n\n<p><strong>Tell your doctor if any of the following apply to you as patients with these conditions should not take Celecoxib Krka.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to celecoxib or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have had an&nbsp;allergic reaction&nbsp;to a group of medicines called &#8216;sulfonamides&#8217; (eg some&nbsp;antibiotics&nbsp;used to treat&nbsp;infections&nbsp;)<\/li><li>if you&nbsp;currently&nbsp;have ulcers or bleeding in the stomach\/intestines<\/li><li>if you have had&nbsp;asthma, nasal polyps, severe nasal congestion, or an&nbsp;allergic reaction&nbsp;such as itchy skin rash, swelling of the face, lips, tongue, or throat, difficulty breathing or wheezing after taking&nbsp;acetylsalicylic acid&nbsp;or any other anti-inflammatory and analgesic medicine (&nbsp;NSAID&nbsp;)<\/li><li>if you are pregnant.&nbsp;If you are likely to become pregnant during treatment, you should discuss appropriate contraceptive methods with your doctor<\/li><li>if you are breast-feeding<\/li><li>if you have severe liver disease<\/li><li>if you have severe kidney disease<\/li><li>if you have an&nbsp;inflammatory&nbsp;bowel disease, such as ulcerative colitis or&nbsp;Crohn&#8217;s disease<\/li><li>if you have&nbsp;heart failure&nbsp;or known ischemic heart disease or disease of the blood vessels of the brain, for example, if you have had a heart attack,&nbsp;stroke, temporarily reduced blood flow to the brain (also known as &#8220;mini-stroke&#8221;), angina or narrowing of the blood vessels to the heart or brain<\/li><li>if you have or have had problems with blood circulation (&nbsp;peripheral&nbsp;vascular disease) or if you have had surgery on the blood vessels in your legs<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Celecoxib Krka:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have&nbsp;<strong>previously<\/strong>&nbsp;had ulcers or bleeding in the stomach or intestines(&nbsp;<strong>Do not take Celecoxib Krka<\/strong>&nbsp;if you&nbsp;<strong>currently<\/strong>&nbsp;have ulcers or bleeding in the stomach or intestines)<\/li><li>if you are taking medicines that reduce the formation of&nbsp;platelets<\/li><li>if you are taking&nbsp;acetylsalicylic acid&nbsp;(even at low&nbsp;doses&nbsp;in order to protect your heart)<\/li><li>if you are taking medicines to reduce blood clots (eg warfarin \/ warfarin-like&nbsp;anticoagulants&nbsp;or new oral blood thinners, eg apixaban)<\/li><li>if you are taking medicines called&nbsp;corticosteroids&nbsp;(eg prednisone)<\/li><li>if you are taking Celecoxib Krka at the same time as other&nbsp;NSAIDs&nbsp;(besides&nbsp;acetylsalicylic acid&nbsp;), such as&nbsp;ibuprofen&nbsp;or&nbsp;diclofenac.&nbsp;Concomitant use of these drugs should be avoided<\/li><li>if you smoke, have&nbsp;diabetes, high&nbsp;blood pressure,&nbsp;or high cholesterol<\/li><li>If your heart, liver or kidneys are not working properly, your doctor may want to check you regularly<\/li><li>if you have fluid retention in your body (such as swollen ankles and feet)<\/li><li>if you are dehydrated, for example, due to vomiting, diarrhea or if you are taking&nbsp;diuretics&nbsp;(to treat fluid retention in the body)<\/li><li>if you have had a severe&nbsp;allergic reaction&nbsp;or a severe skin reaction to any medicine<\/li><li>if you have an&nbsp;infection&nbsp;or suspect you&nbsp;may&nbsp;have an&nbsp;infection&nbsp;, as Celecoxib Krka may mask a fever or other signs of infection and&nbsp;inflammation<\/li><li>if you are over 65, your doctor will check you regularly&nbsp;<\/li><li>Intake of alcohol and&nbsp;NSAIDs&nbsp;may increase the risk of gastrointestinal upset<\/li><\/ul>\n\n\n\n<p>Like other&nbsp;NSAIDs&nbsp;(eg&nbsp;ibuprofen&nbsp;or&nbsp;diclofenac&nbsp;), this medicine may cause high&nbsp;blood pressure, so your doctor may ask you to have your&nbsp;blood pressure&nbsp;checked&nbsp;regularly.<br><\/p>\n\n\n\n<p>Some cases of severe hepatic reaction have been reported following the use of celecoxib, such as severe hepatitis, liver damage, liver failure (some cases fatal, or requiring liver transplantation).&nbsp;In cases where the onset of symptoms was reported, most severe liver reactions were seen within one month of starting treatment.<br><\/p>\n\n\n\n<p>Celecoxib Krka can make it harder to get pregnant.&nbsp;You should tell your doctor if you are planning to become pregnant or if you are having difficulty getting pregnant (see the section on Pregnancy, breast-feeding and&nbsp;fertility&nbsp;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Celecoxib Krka<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dextromethorphan (used to treat cough)<\/li><li>ACE inhibitors,&nbsp;angiotensin&nbsp;II&nbsp;antagonists,&nbsp;beta-blockers,&nbsp;and&nbsp;diuretics&nbsp;(used to treat high&nbsp;blood pressure&nbsp;and&nbsp;heart failure&nbsp;)<\/li><li>Fluconazole&nbsp;and rifampicin (used to treat fungal and bacterial infections)<\/li><li>Warfarin&nbsp;or other warfarin-like medicines (blood thinners that reduce blood clotting) including newer medicines like apixaban<\/li><li>Lithium (used to treat certain types of depression)<\/li><li>Other medicines for depression, sleep disorders, high&nbsp;blood pressure,&nbsp;or irregular heartbeat<\/li><li>Neuroleptics&nbsp;(used to treat certain mental illnesses)<\/li><li>Methotrexate (used to treat rheumatic joint disease,&nbsp;psoriasis,&nbsp;and&nbsp;leukemia&nbsp;)<\/li><li>Carbamazepine (used to treat epilepsy\/seizures and certain forms of pain or depression)<\/li><li>Barbiturates&nbsp;(used to treat epilepsy\/seizures and certain sleep disorders)<\/li><li>Ciclosporin and tacrolimus (used to suppress the immune system, eg after transplants)<\/li><\/ul>\n\n\n\n<p>Celecoxib Krka can be taken with a low&nbsp;dose&nbsp;of&nbsp;acetylsalicylic acid&nbsp;(75 mg or less per day).&nbsp;Ask your doctor for advice before taking these medicines at the same time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>Celecoxib Krka must not be used by women who are pregnant or may become pregnant during treatment (ie women of&nbsp;childbearing potential&nbsp;not using adequate contraception).&nbsp;If you become pregnant during treatment with Celecoxib Krka, you should stop treatment and contact your doctor for other treatment.<br><\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Celecoxib Krka must not be used during breast-feeding.<br><\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>NSAIDs,&nbsp;including Celecoxib Krka, can make it harder to get pregnant.&nbsp;Tell your doctor if you are planning to become pregnant or have problems getting pregnant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You should know how you react to Celecoxib Krka before driving or using machines.&nbsp;If you feel dizzy or drowsy after taking Celecoxib Krka, do not drive or use machines until these effects have subsided.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Celecoxib Krka contains lactose and sodium<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per capsule, ie&nbsp;essentially &#8216;&nbsp;sodium-free&#8217;.&nbsp;is next to &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Celecoxib Krka<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.&nbsp;If you have the impression that the effect of Celecoxib Krka is too strong or too weak, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<p>Your doctor will tell you which&nbsp;dose&nbsp;to take.&nbsp;As the risk of heart side effects may increase with high&nbsp;doses&nbsp;and long-term treatment, it is important that you do not take higher&nbsp;doses&nbsp;or use Celecoxib Krka for longer than you need to control your symptoms.<br><\/p>\n\n\n\n<p><strong>Celecoxib Krka should be swallowed whole with some water.&nbsp;<\/strong>Your&nbsp;dose&nbsp;can be taken at any time of the day, with or without food, but try to take each&nbsp;dose&nbsp;at the same time of day.<br><\/p>\n\n\n\n<p>Contact your doctor if you do not experience any improvement after two weeks of treatment.<br><\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;is:<\/strong><\/p>\n\n\n\n<p><strong>In&nbsp;osteoarthritis<\/strong>&nbsp;, the recommended&nbsp;dose is&nbsp;200 mg daily, which can be increased to a maximum of 400 mg if your doctor deems it necessary.<\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>one 200 mg capsule once a day, or<\/li><li>one capsule of 100 mg twice a day.<\/li><\/ul>\n\n\n\n<p><strong>In&nbsp;chronic&nbsp;rheumatoid arthritis<\/strong>, the recommended&nbsp;dose is&nbsp;200 mg daily, which can be increased to a maximum of 400 mg if your doctor deems it necessary.<\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>one capsule of 100 mg twice a day.<\/li><\/ul>\n\n\n\n<p><strong>For&nbsp;pelvic pondylitis<\/strong>&nbsp;, the recommended&nbsp;dose is&nbsp;200 mg daily, which can be increased to a maximum of 400 mg if your doctor deems it necessary.<\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>one 200 mg capsule once a day, or<\/li><li>one capsule of 100 mg twice a day.<\/li><\/ul>\n\n\n\n<p><strong>Kidney or liver failure:<\/strong>&nbsp;if you have kidney or liver failure, tell your doctor as you may need to take a lower&nbsp;dose.<br><\/p>\n\n\n\n<p><strong>Elderly people, especially those weighing less than 50 kg:<\/strong>&nbsp;If you are over 65, and especially if you weigh less than 50 kg, your doctor may want to check you more closely.<br><\/p>\n\n\n\n<p><strong>Use in children:<\/strong>&nbsp;Celecoxib Krka is for adults only and should not be used in children.<br><\/p>\n\n\n\n<p><strong>Maximum daily dose:<\/strong><\/p>\n\n\n\n<p>You should not take more than 400 mg daily (4 capsules Celecoxib Krka 100 mg or 2 capsules Celecoxib Krka 200 mg).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Celecoxib Krka<\/h2>\n\n\n\n<p>If you forget to take your&nbsp;dose&nbsp;, take it as soon as you remember.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Celecoxib Krka<\/h2>\n\n\n\n<p>If you suddenly stop taking Celecoxib Krka, your symptoms may get worse.&nbsp;Do not stop taking Celecoxib Krka unless your doctor tells you to.&nbsp;Your doctor may ask you to reduce your&nbsp;dose&nbsp;for a few days before stopping treatment altogether.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>If any of the&nbsp;side effects&nbsp;gets serious, or if you notice any&nbsp;side effects&nbsp;not listed in this leaflet, please tell your doctor or pharmacist.<br><\/p>\n\n\n\n<p><strong>The side effects&nbsp;listed below have been observed in patients with&nbsp;osteoarthritis who have used Celecoxib Krka.&nbsp;Adverse reactions&nbsp;marked with an asterisk (*) are indicated with the higher frequency seen in patients who used Celecoxib Krka to prevent colon polyps.&nbsp;These patients took Celecoxib Krka in high&nbsp;doses and for a long time.<\/strong><br><\/p>\n\n\n\n<p><strong>If any of the following occur, stop taking Celecoxib Krka and contact a doctor immediately:<\/strong><\/p>\n\n\n\n<p><strong>If you experience:&nbsp;<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>an&nbsp;allergic reaction&nbsp;such as skin rash, swelling of the face, wheezing, or difficulty breathing<\/li><li>heart problems such as chest pain<\/li><li>severe stomach pain or signs of bleeding in the stomach or intestines, such as black or blood-stained stools or vomiting with blood in<\/li><li>a skin reaction such as rash, blistering, or flaking<\/li><li>liver failure (symptoms may include nausea, diarrhea, jaundice (your skin or whites of the eyes look yellowish)).<\/li><\/ul>\n\n\n\n<p><strong>Very common (may affect more than 1 user in 10):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>High&nbsp;blood pressure&nbsp;including an increase in already high blood pressure *<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Myocardial infarction*<\/li><li>Accumulation of fluid in the body that can cause swelling in the ankles, legs, and\/or hands<\/li><li>Urinary tract infection<\/li><li>Difficulty breathing *, sinusitis, nasal congestion or runny nose, sore throat, cough, cold,&nbsp;flu-like symptoms<\/li><li>Dizziness, difficulty sleeping&nbsp;<\/li><li>Vomiting *, stomach pain, diarrhea, digestive problems, flatulence<\/li><li>Rash,&nbsp;itching<\/li><li>Muscle tension<\/li><li>Difficulty swallowing *<\/li><li>Headache<\/li><li>Nausea<\/li><li>Joint pain<\/li><li>Worsening of existing&nbsp;allergies&nbsp;you<\/li><li>Damage in the event of an accident<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stroke*<\/li><li>Heart failure, palpitations, rapid heartbeat<\/li><li>Changes in liver values \u200b\u200bduring blood tests<\/li><li>Changes in kidney values \u200b\u200bduring blood tests<\/li><li>Anemia&nbsp;(decreased number of&nbsp;red blood cells, which can cause weakness and shortness of breath)<\/li><li>Anxiety, depression, fatigue, drowsiness, and crawling<\/li><li>Increased potassium in the blood (may cause nausea, fatigue, muscle weakness, or palpitations)<\/li><li>Impaired vision or blurred vision,&nbsp;tinnitus, soreness in the mouth, cold sores, hearing loss *<\/li><li>Constipation, belching, inflammation of the stomach (digestive problems, stomach pain, or vomiting), worsening&nbsp;inflammation&nbsp;of the stomach or intestines.<\/li><li>Leg cramps<\/li><li>Elevated, itchy rash (&nbsp;hives&nbsp;)<\/li><li>Eye inflammation<\/li><li>Breathing difficulties<\/li><li>Discolored skin (bruises)<\/li><li>Chest pain (general pain not related to the heart)<\/li><li>Facial swelling<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ulcers (bleeding) in the stomach, esophagus or intestine, or ruptured intestine (may cause abdominal pain, fever, nausea, vomiting, intestinal obstruction), dark or black stools,&nbsp;inflammation&nbsp;of the pancreas (may cause abdominal pain),&nbsp;inflammation&nbsp;of the esophagus (&nbsp;esophagitis&nbsp;)<\/li><li>Decreased amount of sodium in the blood (a condition known as&nbsp;hyponatremia&nbsp;)<\/li><li>Reduced&nbsp;white blood cell count&nbsp;(which helps protect the body against&nbsp;infection&nbsp;) and&nbsp;platelets&nbsp;(increased risk of bleeding or bruising)<\/li><li>Difficulty coordinating muscle movements<\/li><li>Confusion, taste changes<\/li><li>Increased light sensitivity<\/li><li>Hair loss<\/li><li>Hallucinations<\/li><li>Bleeding in the eye<\/li><li>The acute&nbsp;reaction that can lead to&nbsp;pneumonia<\/li><li>Irregular heartbeats<\/li><li>Pastures<\/li><li>Blood clots in the blood vessels of the lungs.&nbsp;Symptoms may include sudden shortness of breath, sharp pain when breathing, or collapse<\/li><li>Bleeding in the stomach or intestines (may lead to bloody stools or vomiting), intestinal inflammation<\/li><li>Serious liver inflammation (&nbsp;hepatitis&nbsp;).&nbsp;Symptoms may include nausea, diarrhea, jaundice (yellowing of the skin or eyes), dark urine, pale stools, increased tendency to bleed,&nbsp;itching,&nbsp;or chills<\/li><li>Acute&nbsp;renal failure<\/li><li>Menstrual disorders<\/li><li>Swelling of the face, lips, mouth, tongue or throat, wheezing or difficulty swallowing<\/li><\/ul>\n\n\n\n<p><strong>Very rare (may affect up to 1 in 10,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe skin reactions (including anaphylactic&nbsp;shock, which may be life-threatening)<\/li><li>Severe skin conditions such as&nbsp;Stevens-Johnson syndrome&nbsp;, exfoliative&nbsp;dermatitis and&nbsp;toxic epidermal necrolysis&nbsp;(which may cause a rash, blistering or flaking of the skin) and&nbsp;acute&nbsp;rash-like generalized&nbsp;pustulosis&nbsp;(red, swollen area with many small blisters)<\/li><li>A delayed&nbsp;allergic reaction&nbsp;with possible symptoms such as rash, swelling of the face, fever, swollen&nbsp;glands,&nbsp;and abnormal test results (eg in liver tests and blood cell tests (&nbsp;eosinophilia, a type of increased amount of&nbsp;white blood cells&nbsp;))<\/li><li>Cerebral hemorrhage, which can be life-threatening<\/li><li>Meningitis&nbsp;(&nbsp;inflammation&nbsp;of the meninges)<\/li><li>Liver failure, liver damage, and severe liver inflammation (&nbsp;fulminant&nbsp;hepatitis&nbsp;) (some cases with fatal outcome or requiring liver transplantation).&nbsp;Symptoms may include nausea, diarrhea, jaundice (yellowing of the skin or eyes), dark urine, pale stools, increased tendency to bleed,&nbsp;itching,&nbsp;or chills<\/li><li>Liver problems (eg cholestasis and cholestatic&nbsp;hepatitis, which may be accompanied by symptoms such as discolored stools, nausea, and yellowing of the skin or eyes)<\/li><li>Kidney inflammation and other kidney problems (eg&nbsp;nephrotic syndrome&nbsp;and minimal change disease that may be accompanied by symptoms such as&nbsp;fluid retention&nbsp;(&nbsp;edema&nbsp;), frothy urine, fatigue, and loss of appetite)<\/li><li>Impaired&nbsp;epilepsy&nbsp;(possibly increased number of seizures and\/or increased severity)<\/li><li>Partial or complete vision loss, caused by blockage of a blood vessel in the eye<\/li><li>Inflammation&nbsp;of the blood vessels (may cause fever, aches, dark purple spots on the skin)<\/li><li>Deficiency of all blood cells (may cause fatigue, increased tendency to get bruises, frequent nosebleeds, and increased risk of infection)<\/li><li>Muscle aches and weakness<\/li><li>Impaired sense of smell<\/li><li>Loss of taste<\/li><\/ul>\n\n\n\n<p><strong>No known frequency (occurrence cannot be calculated from the available data):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased&nbsp;fertility&nbsp;in women, which is usually transient at the end of treatment<\/li><\/ul>\n\n\n\n<p><strong>In&nbsp;clinical trials&nbsp;of conditions other than&nbsp;osteoarthritis&nbsp;or joint pain, which Celecoxib Krka was the&nbsp;dose&nbsp;you about 400 mg daily for up to 3 years, the following additional&nbsp;adverse reactions&nbsp;are observed:<\/strong><br><\/p>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Angina (chest pain)<\/li><li>Irritable bowel syndrome (may include abdominal pain, diarrhea, digestive problems, flatulence)<\/li><li>Kidney stones&nbsp;(may cause pain in the abdomen or back, blood in the urine), urinary incontinence<\/li><li>Weight gain<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Deep&nbsp;vein thrombosis&nbsp;(blood clot, usually in the legs, which can cause pain, swelling or&nbsp;redness&nbsp;in the calf or difficulty breathing)<\/li><li>Stomach infection (which can cause irritation and ulcers in the stomach and intestines)<\/li><li>Fracture&nbsp;of forearm \/ lower leg<\/li><li>Shingles&nbsp;, skin infection,&nbsp;eczema&nbsp;(dry itchy rash),&nbsp;pneumonia&nbsp;(cough, fever, difficulty breathing)<\/li><li>Visual impairment caused by small spots in the&nbsp;visual field, dizziness caused by problems in the inner ear, tender, inflamed or bleeding gums, cold sores<\/li><li>Need to urinate frequently at night, bleeding from&nbsp;hemorrhoids, upset bowel<\/li><li>Lumps of fat in the subcutaneous tissue,&nbsp;ganglion&nbsp;(harmless swelling of the wrist and ankle tendons), speech difficulties, abdominal bleeding, tenderness in the breasts<\/li><li>The increased amount of sodium in the blood.<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Celecoxib Krka<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is celecoxib. Each 100 mg hard capsule contains 100 mg of celecoxib. Each 200 mg hard capsule contains 200 mg of celecoxib.<\/li><li>The other ingredients (excipients) in 100 mg hard capsules are&nbsp;lactose monohydrate, povidone K30, croscarmellose sodium, sodium lauryl sulfate, magnesium stearate (E470b) in the capsule, and gelatin and titanium dioxide (E171) in the capsule shell.<\/li><li>The other ingredients (excipients) in 200 mg hard capsules are&nbsp;lactose monohydrate, povidone K30, croscarmellose sodium, sodium lauryl sulfate, magnesium stearate (E470b) in the capsule and gelatin, titanium dioxide (E171), and yellow iron oxide (E172) in the capsule shell.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>100 mg hard capsule is white, 15.4 mm-16.2 mm long.&nbsp;The capsule contains white or almost white&nbsp;granules.<\/p>\n\n\n\n<p>200 mg hard capsule is a brownish yellow, 18.9 mm-19.7 mm long.&nbsp;The capsule contains white or almost white&nbsp;granules.<br><\/p>\n\n\n\n<p>100 mg and 200 mg capsules are available in pack sizes of 10, 20, 30, 40, 50, 60, 90, or 100 blister capsules.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>KRKA Sverige AB, G\u00f6ta Ark 175, 118 72 Stockholm,<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>KRKA, dd, Novo mesto, \u0160marje\u0161ka cesta 6, 8501 Novo mesto, Slovenia<\/p>\n\n\n\n<p>TAD Pharma GmbH, Heinz-Lohmann-Stra\u00dfe 5, 27472 Cuxhaven, Germany<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Celecoxib Krka is used in adults for the relief of symptoms in the treatment of chronic rheumatoid arthritis, osteoarthritis, and pelvic pondylitis . <\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[2240,7551,7554,7567,7570,7569,7553,2212,7552,7568],"class_list":["post-6598","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-capsules","tag-celecoxib","tag-celecoxib-capsule","tag-celecoxib-krka","tag-celecoxib-krka-capsule","tag-celecoxib-krka-side-effects","tag-celecoxib-side-effects","tag-medicine","tag-what-is-celecoxib","tag-what-is-celecoxib-krka"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6598"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6598\/revisions"}],"predecessor-version":[{"id":11553,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6598\/revisions\/11553"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}