{"id":6526,"date":"2021-01-09T09:42:09","date_gmt":"2021-01-09T09:42:09","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6526"},"modified":"2021-06-17T07:50:12","modified_gmt":"2021-06-17T07:50:12","slug":"cardizem-unotard","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/cardizem-unotard\/","title":{"rendered":"Cardizem Unotard &#8211; Hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n180 mg, 240 mg, 300 mg&nbsp;prolonged-&nbsp;release tablets&nbsp;Diltiazem&nbsp;<br>hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Cardizem Unotard is and what it is used for<\/h2>\n\n\n\n<p>Cardizem Unotard is a so-called calcium antagonist that inhibits the influx of&nbsp;calcium into certain cells.&nbsp;For the heart, it means a reduced amount of work and thus a reduced risk of overexertion of the heart muscle.&nbsp;The risk of angina decreases.&nbsp;With high&nbsp;blood pressure, the blood vessels dilate, causing the&nbsp;blood pressure to&nbsp;drop.&nbsp;Cardizem Unotard&nbsp;prolonged-release tablets&nbsp;contain&nbsp;diltiazem&nbsp;in a core surrounded by a small hole.&nbsp;The tablet shell passes unaffected through the intestine, while the active substance is released during the passage through the gastrointestinal tract.<\/p>\n\n\n\n<p>Treatment of high&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;) and angina in the heart (stable&nbsp;angina pectoris&nbsp;).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Cardizem Unotard<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Cardizem Unotard<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to diltiazem hydrochloride or any of the other ingredients of this medicine (listed in section 6).<\/li><li>If you suffer from severe heart problems (eg certain types of heart block,&nbsp;acute myocardial infarction,&nbsp;heart failure,&nbsp;or heart rhythm disorders).<\/li><li>If you suffer from digitalis poisoning.<\/li><li>If you are already taking a medicine containing&nbsp;ivabradine&nbsp;to treat certain heart conditions.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Cardizem Unotard.<br><\/p>\n\n\n\n<p>If you have any of the following conditions, you should consult a doctor before starting treatment with Cardizem Unotard:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;blood pressure<\/li><li>narrowing of the great carotid artery<\/li><li>any heart disease that affects the rhythm of the heart<\/li><li>impaired renal or hepatic function<\/li><li>risk of developing intestinal obstruction (intestinal obstruction).<\/li><\/ul>\n\n\n\n<p>Calcium antagonists such as&nbsp;diltiazem&nbsp;may cause mood swings, including depression.<br><\/p>\n\n\n\n<p>Stop taking Cardizem Unotard and contact your doctor immediately if you get any of the following symptoms (&nbsp;angioedema&nbsp;)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, or throat<\/li><li>difficulty swallowing<\/li><li>hives&nbsp;and difficulty breathing.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Cardizem Unotard<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>Some medicines can affect or be affected by treatment with Cardizem Unotard, e.g.&nbsp;certain medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>for high&nbsp;blood pressure&nbsp;(nifedipine,&nbsp;beta-blockers,&nbsp;alpha-blockers,&nbsp;and calcium&nbsp;channel&nbsp;blockers&nbsp;)<\/li><li>for high&nbsp;blood pressure&nbsp;and angina (amlodipine)<\/li><li>against angina (nitrate derivatives)<\/li><li>against heart rhythm disorders (eg&nbsp;amiodarone&nbsp;)<\/li><li>lipid-lowering drugs (&nbsp;simvastatin&nbsp;)<\/li><li>against&nbsp;epilepsy&nbsp;(carbamazepine)<\/li><li>with sedative and hypnotic effect (midazolam, triazolam)<\/li><li>against anxiety and depression (buspirone, imipramine)<\/li><li>against pain during surgery (alfentanil)<\/li><li>in transplantation (cyclosporine)<\/li><li>against manic-depressive illness (lithium)<\/li><li>drugs which inhibit the formation of&nbsp;hydrochloric acid&nbsp;and which are used against e.g.&nbsp;gastric ulcer (ranitidine, cimetidine)<\/li><li>against&nbsp;tuberculosis&nbsp;(rifampicin)<\/li><li>against inflammatory diseases such as rheumatism,&nbsp;ulcerative colitis,&nbsp;and&nbsp;asthma(methylprednisolone)<\/li><li>drugs that suppress the immune system (sirolimus, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/torisel\/\">temsirolimus<\/a>, and everolimus).<\/li><\/ul>\n\n\n\n<p>The treating physician, therefore, needs to be aware of such concomitant medication.&nbsp;If you need anesthesia during an operation, tell the anesthetist that you are taking Cardizem Unotard.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p>There is a risk that the fetus is affected.&nbsp;Therefore, always&nbsp;consult&nbsp;a doctor&nbsp;<i>before using<\/i> Cardizem Unotard during pregnancy.<br><\/p>\n\n\n\n<p>It is possible that a breastfed baby may be affected.&nbsp;Therefore, do not use Cardizem Unotard during breast-feeding unless specifically&nbsp;prescribed&nbsp;by a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>During treatment with Cardizem Unotard,&nbsp;side effects&nbsp;such as dizziness and malaise may occur.&nbsp;This should be taken into account when sharper attention is required, e.g.&nbsp;while driving or precision work.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cardizem Unotard contains sucrose and sodium<\/h2>\n\n\n\n<p><em>Sucrose<\/em><\/p>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<p><em>Sodium<\/em><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per&nbsp;prolonged-release tablet, ie is essential &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Cardizem Unotard<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor who adjusts it individually for you.<\/p>\n\n\n\n<p>Cardizem Unotard&nbsp;prolonged-release tablets&nbsp;should be taken once daily and&nbsp;<em>swallowed whole with at least \u00bd glass of liquid 15 minutes before a meal at approximately the same time each day.&nbsp;The tablets must not be divided or chewed.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Cardizem Unotard<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p>Stop taking Cardizem Unotard and contact your doctor immediately if you get any of the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, or throat, difficulty swallowing,&nbsp;hives&nbsp;and difficulty breathing (&nbsp;angioedema&nbsp;).&nbsp;May affect up to 1 in 1,000 users.<\/li><li>an extremely severe&nbsp;allergic reaction&nbsp;with skin rash usually in the form of blisters or sores in the oral cavity and eyes as well as other mucous membranes such as genitals (&nbsp;Stevens-Johnson syndrome&nbsp;).&nbsp;May affect up to 1 in 1,000 users.<\/li><li>severe skin damage (skin peeling and superficial mucosa) (&nbsp;toxic epidermal necrolysis&nbsp;).&nbsp;May affect up to 1 in 1,000 users.<\/li><\/ul>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fluid retention, swelling of the arms and legs (peripheral&nbsp;edema&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>dizziness<\/li><li>fatigue<\/li><li>heart block (&nbsp;AV block&nbsp;I, II, or III)<\/li><li>herds<\/li><li>nausea<\/li><li>constipation<\/li><li>heartburn and acid reflux (&nbsp;dyspepsia&nbsp;)<\/li><li>abdominal pain<\/li><li>rash<\/li><li>itching<\/li><li>feeling sick<\/li><li>flushing with a feeling of warmth<\/li><li>palpitation<\/li><li>liver effects<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nervousness<\/li><li>difficulty falling asleep<\/li><li>low&nbsp;heart rate<\/li><li>a sudden drop in blood pressure when getting up<\/li><li>vomiting<\/li><li>diarrhea<\/li><li>increased liver values \u200b\u200b(&nbsp;AST,&nbsp;ALT, LDH, or ALP)<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people&nbsp;<\/em><em>):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart rhythm disorders (such as fast&nbsp;heart rate, extra beats)<\/li><li>aggravated angina<\/li><li>low&nbsp;blood pressure<\/li><li>dry mouth<\/li><li>hives<\/li><li>ankle swelling<\/li><li>muscle and joint pain<\/li><li>skin and mucosal disorders (sometimes severe)<\/li><li>sleep disorders<\/li><li>confusion<\/li><li>hepatitis<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased&nbsp;platelet count&nbsp;in the blood<\/li><li>mood swings (including depression)<\/li><li>involuntary muscle movements (extrapyramidal syndrome)<\/li><li>short, involuntary muscle twitching (myoclonus)<\/li><li>heart failure<\/li><li>inflammation&nbsp;of a vessel wall (&nbsp;vasculitis&nbsp;)<\/li><li>gum swelling<\/li><li>photosensitivity (&nbsp;photosensitivity&nbsp;)<\/li><li>rash<\/li><li>scaly inflammation (exfoliative&nbsp;dermatitis&nbsp;)<\/li><li>blisters on the body (&nbsp;pustulosis&nbsp;)<\/li><li>sometimes scaly redness with or without fever (desquamative&nbsp;erythema&nbsp;)<\/li><li>sweating<\/li><li>enlargement of the mammary glands.<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Cardizem Unotard<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p><em>The active substance is<\/em>&nbsp;Diltiazem hydrochloride 180 mg, 240 mg, and 300 mg respectively per tablet.<\/p>\n\n\n\n<p><em>The other ingredients are<\/em>&nbsp;Sodium dihydrogen citrate, sucrose (33 mg, 38 mg, and 38 mg per tablet respectively), povidone, magnesium stearate, macrogol, acetyl tributyl citrate, polymerized castor oil, sodium bicarbonate, ethylvanillin, titanium dioxide (dye coating E171).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p><em>Appearance:<\/em><\/p>\n\n\n\n<p>180 mg and 240 mg&nbsp;prolonged-release tablets&nbsp;are white, cupped and oval.<\/p>\n\n\n\n<p>300 mg&nbsp;prolonged-release tablets&nbsp;are white, cupped and round.<br><\/p>\n\n\n\n<p><em>Pack sizes:<\/em><\/p>\n\n\n\n<p><em>Cardizem Unotard 180 mg&nbsp;prolonged-release tablet&nbsp;is<\/em><\/p>\n\n\n\n<p>HDPE jar with a child-resistant lid in polypropylene (PP) containing 30 and 100 tablets respectively.<\/p>\n\n\n\n<p><em>Cardizem Unotard 240 mg&nbsp;prolonged-release tablet&nbsp;is<\/em><\/p>\n\n\n\n<p>HDPE jar with a child-resistant lid in polypropylene (PP) containing 30 and 100 tablets respectively.<\/p>\n\n\n\n<p><em>Cardizem Unotard 300 mg&nbsp;prolonged-release tablet&nbsp;is<\/em><\/p>\n\n\n\n<p>HDPE jar with a child-resistant lid in polypropylene (PP) containing 100 tablets.<\/p>\n\n\n\n<p>The jar with the child-resistant lid is opened by holding the lid down and screwing it counterclockwise.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Pfizer AB<\/p>\n\n\n\n<p>191 90 Sollentuna<\/p>\n\n\n\n<p>Tel: 08-550 520 00<\/p>\n\n\n\n<p>Email: eumedinfo@pfizer.com<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cardizem Unotard is a so-called calcium antagonist that inhibits the influx of calcium into certain cells. For the heart, it means a reduced amount of work and thus a reduced risk of overexertion of the heart muscle. The risk of angina decreases. With high blood pressure, the blood vessels dilate, causing the blood pressure to drop. Cardizem Unotard prolonged-release tablets contain diltiazem in a core surrounded by a small hole. The tablet shell passes unaffected through the intestine, while the active substance is released during the passage through the gastrointestinal tract.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[7732,7734,7735,7730,7731,2211,7733,7729],"class_list":["post-6526","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-cardizem-unotard","tag-cardizem-unotard-side-effects","tag-cardizem-unotard-tablet","tag-hydrochloride-side-effects","tag-hydrochloride-tablet","tag-tablets","tag-what-is-cardizem-unotard","tag-what-is-hydrochloride"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6526"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6526\/revisions"}],"predecessor-version":[{"id":11602,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6526\/revisions\/11602"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}