{"id":6522,"date":"2021-01-09T09:40:11","date_gmt":"2021-01-09T09:40:11","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6522"},"modified":"2021-06-18T05:50:39","modified_gmt":"2021-06-18T05:50:39","slug":"cardizem-cardizem-retard","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/cardizem-cardizem-retard\/","title":{"rendered":"Cardizem \/ Cardizem Retard &#8211; Diltiazem hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n60 mg film-coated tablets, 90 mg prolonged-release tablets, 120 mg prolonged-release tablets, 180 mg prolonged-release tablets&nbsp;<br>Diltiazem hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Cardizem \/ Cardizem Retard is and what it is used for<\/h2>\n\n\n\n<p>Cardizem and Cardizem&nbsp;Retard&nbsp;are so-called calcium antagonists that inhibit the influx of&nbsp;calcium&nbsp;into certain cells.&nbsp;For the heart, it means a reduced amount of work and thus a reduced risk of overexertion of the heart muscle.<\/p>\n\n\n\n<p>The risk of angina in the heart decreases.&nbsp;With high&nbsp;blood pressure, the blood vessels dilate, causing the&nbsp;blood pressure to&nbsp;drop.&nbsp;Cardizem&nbsp;Retard&nbsp;prolonged-release tablets&nbsp;contain&nbsp;diltiazem&nbsp;in a core surrounded by a small hole.&nbsp;The tablet shell passes unaffected through the intestine, while the active substance is released during the passage through the gastrointestinal tract.<\/p>\n\n\n\n<p>Treatment of angina in the heart (stable&nbsp;angina pectoris&nbsp;) and high&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Cardizem \/ Cardizem Retard<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Cardizem \/ Cardizem Retard<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to diltiazem hydrochloride or any of the other ingredients of this medicine (listed in section 6).<\/li><li>If you suffer from severe heart problems (eg certain types of heart block,&nbsp;acute myocardial infarction,&nbsp;heart failure,&nbsp;or heart rhythm disorders).<\/li><li>If you suffer from digitalis poisoning.<\/li><li>If you are already taking a medicine containing&nbsp;ivabradine&nbsp;to treat certain heart conditions.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Cardizem \/ Cardizem&nbsp;Retard.<br><\/p>\n\n\n\n<p>If you have any of the following conditions, you should consult a doctor before starting treatment with Cardizem \/ Cardizem&nbsp;Retard&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;blood pressure<\/li><li>narrowing of the great carotid artery<\/li><li>any heart disease that affects the rhythm of the heart<\/li><li>impaired renal or hepatic function<\/li><li>risk of developing intestinal obstruction (intestinal obstruction).<\/li><\/ul>\n\n\n\n<p>Calcium antagonists such as&nbsp;diltiazem&nbsp;may cause mood swings, including depression.<br><\/p>\n\n\n\n<p>Stop taking Cardizem \/ Cardizem&nbsp;Retard&nbsp;and contact a doctor immediately if you get any of the following symptoms (&nbsp;angioedema&nbsp;)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, or throat<\/li><li>difficulty swallowing<\/li><li>hives&nbsp;and difficulty breathing.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Cardizem \/ Cardizem Retard<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>Some medicines may affect or be affected by treatment with Cardizem \/ Cardizem&nbsp;Retard, e.g.&nbsp;certain medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>for high&nbsp;blood pressure&nbsp;(nifedipine,&nbsp;beta-blockers,&nbsp;alpha-blockers&nbsp;and calcium&nbsp;channel&nbsp;blockers&nbsp;)<\/li><li>for high&nbsp;blood pressure&nbsp;and angina (amlodipine)<\/li><li>against angina (nitrate derivatives)<\/li><li>against heart rhythm disorders (eg&nbsp;amiodarone&nbsp;)<\/li><li>lipid-lowering drugs (&nbsp;simvastatin&nbsp;)<\/li><li>against&nbsp;epilepsy&nbsp;(carbamazepine)<\/li><li>with sedative and hypnotic effect (midazolam, triazolam)<\/li><li>against anxiety and depression (buspirone, imipramine)<\/li><li>against pain during surgery (alfentanil)<\/li><li>in transplantation (cyclosporine)<\/li><li>against manic-depressive illness (lithium)<\/li><li>drugs which inhibit the formation of&nbsp;hydrochloric acid&nbsp;and which are used against e.g.&nbsp;gastric ulcer (ranitidine, cimetidine)<\/li><li>against&nbsp;tuberculosis&nbsp;(rifampicin)<\/li><li>against inflammatory diseases such as rheumatism,&nbsp;ulcerative colitis,&nbsp;and&nbsp;asthma(methylprednisolone)<\/li><li>drugs that suppress the immune system (sirolimus, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/torisel\/\">temsirolimus<\/a>, and everolimus).<\/li><\/ul>\n\n\n\n<p>The treating physician, therefore, needs to be aware of such concomitant medication.&nbsp;If you need anesthesia during an operation, the anesthetist should be informed that you are taking Cardizem \/ Cardizem&nbsp;Retard.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p>There is a risk that the fetus is affected.&nbsp;Therefore, always&nbsp;consult&nbsp;a doctor&nbsp;<span style=\"background-color: rgba(51, 51, 51, 0.2);\"><i>bef<\/i><\/span><em>ore using<\/em> Cardizem \/ Cardizem&nbsp;Retard&nbsp;during pregnancy.<br><\/p>\n\n\n\n<p>It is possible that a breastfed baby may be affected.&nbsp;Therefore, do not use Cardizem \/ Cardizem&nbsp;Retard&nbsp;during breastfeeding other than on a&nbsp;doctor&#8217;s&nbsp;prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>During treatment with Cardizem \/ Cardizem&nbsp;Retard,&nbsp;side effects&nbsp;such as dizziness and malaise may occur.&nbsp;This should be taken into account when sharper attention is required, e.g.&nbsp;while driving or precision work.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cardizem contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<p><strong>Cardizem&nbsp;Retard&nbsp;contains sucrose and&nbsp;sodium<\/strong><\/p>\n\n\n\n<p><em>Sucrose<\/em><\/p>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<p><em>Sodium<\/em><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per&nbsp;prolonged-release tablet, ie is essential &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Cardizem \/ Cardizem Retard<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor who adjusts it individually for you.<\/p>\n\n\n\n<p>Cardizem tablets should be&nbsp;<em>swallowed with at least \u00bd glass of liquid, can be divided but must not be chewed.<\/em><\/p>\n\n\n\n<p>Cardizem&nbsp;Retard&nbsp;prolonged-release tablets&nbsp;should be&nbsp;<em>swallowed whole with at least \u00bd glass of liquid for at least 15 minutes<\/em><\/p>\n\n\n\n<p><em>before a meal.&nbsp;The prolonged-release tablets&nbsp;must not be divided or chewed.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Cardizem \/ Cardizem Retard<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p>Stop taking Cardizem \/ Cardizem&nbsp;Retard&nbsp;and contact your doctor immediately if you get any of the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, or throat, difficulty swallowing,&nbsp;hives,&nbsp;and difficulty breathing (&nbsp;angioedema&nbsp;).&nbsp;May affect up to 1 in 1,000 users.<\/li><li>an extremely severe&nbsp;allergic reaction&nbsp;with skin rash usually in the form of blisters or sores in the oral cavity and eyes as well as other mucous membranes such as genitals (&nbsp;Stevens-Johnson syndrome&nbsp;).&nbsp;May affect up to 1 in 1,000 users.<\/li><li>severe skin damage (skin peeling and superficial mucosa) (&nbsp;toxic epidermal necrolysis&nbsp;).&nbsp;May affect up to 1 in 1,000 users.<\/li><\/ul>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fluid retention, swelling of the arms and legs (peripheral&nbsp;edema&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>dizziness<\/li><li>fatigue<\/li><li>heart block (&nbsp;AV block&nbsp;I, II, or III)<\/li><li>herds<\/li><li>nausea<\/li><li>constipation<\/li><li>heartburn and acid reflux (&nbsp;dyspepsia&nbsp;)<\/li><li>abdominal pain<\/li><li>rash<\/li><li>itching<\/li><li>feeling sick<\/li><li>flushing with a feeling of warmth<\/li><li>palpitation<\/li><li>liver effects<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nervousness<\/li><li>difficulty falling asleep<\/li><li>low&nbsp;heart rate<\/li><li>a sudden drop in blood pressure when getting up<\/li><li>vomiting<\/li><li>diarrhea<\/li><li>increased liver values \u200b\u200b(&nbsp;AST,&nbsp;ALT, LDH, or ALP)<\/li><\/ul>\n\n\n\n<p><em>Rare (may&nbsp;<\/em><em>affect up to 1 in 1,000 people&nbsp;<\/em><em>):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart rhythm disorders (such as fast&nbsp;heart rate&nbsp;, extra beats)<\/li><li>aggravated angina<\/li><li>low&nbsp;blood pressure<\/li><li>dry mouth<\/li><li>hives<\/li><li>ankle swelling<\/li><li>muscle and joint pain<\/li><li>skin and mucosal disorders (sometimes severe)<\/li><li>sleep disorders<\/li><li>confusion<\/li><li>hepatitis<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased&nbsp;platelet count&nbsp;in the blood<\/li><li>mood swings (including depression)<\/li><li>involuntary muscle movements (extrapyramidal syndrome)<\/li><li>short, involuntary muscle twitching (myoclonus)<\/li><li>heart failure<\/li><li>inflammation&nbsp;of a vessel wall (&nbsp;vasculitis&nbsp;)<\/li><li>gum swelling<\/li><li>photosensitivity (&nbsp;photosensitivity&nbsp;)<\/li><li>rash<\/li><li>scaly skin inflammation (exfoliative&nbsp;dermatitis&nbsp;)<\/li><li>blisters on the body (&nbsp;pustulosis&nbsp;)<\/li><li>sometimes scaly redness with or without fever (desquamative&nbsp;erythema&nbsp;)<\/li><li>sweating<\/li><li>enlargement of the mammary glands.<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Cardizem \/ Cardizem Retard<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p><em>Cardizem<\/em><\/p>\n\n\n\n<p>The active substance is Diltiazem hydrochloride 60 mg per tablet.<\/p>\n\n\n\n<p>The other ingredients are Povidone, magnesium stearate, macrogol 6000, anhydrous&nbsp;lactose&nbsp;260 mg\/tablet, vegetable oil, talc, hypromellose, ethylcellulose.<br><\/p>\n\n\n\n<p><em>Cardizem&nbsp;Retard<\/em><\/p>\n\n\n\n<p>The active substance is Diltiazem hydrochloride 90 mg, 120 mg, and 180 mg per tablet respectively.<\/p>\n\n\n\n<p>The other ingredients are: Povidone, magnesium stearate, macrogol 6000, sodium dihydrogen citrate, sucrose 50 mg, 69 mg and 155 mg per&nbsp;prolonged-release tablet, polymer coating, acetyl tributyl citrate, polymerized castor oil, sodium bicarbonate, ethylvanillin, titanium dioxide (dye E1) (dye).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p><em>Appearance:<\/em><\/p>\n\n\n\n<p>Cardizem 60 mg: white, round, film-coated tablet, scored on one side.&nbsp;The notch is not intended for splitting the tablet.<\/p>\n\n\n\n<p>Cardizem&nbsp;Retard&nbsp;90 mg, 120 mg, 180 mg: white, cupped, round tablet.<br><\/p>\n\n\n\n<p><em>Pack sizes:<\/em><\/p>\n\n\n\n<p><em>Cardizem 60 mg film-coated tablets<\/em><\/p>\n\n\n\n<p>PVC \/ PVDC \/ aluminum blister pack containing 49&#215;1 tablets (single dose pack).<\/p>\n\n\n\n<p>HDPE jar with a lid in polyethylene (PE) containing 300 tablets.<br><\/p>\n\n\n\n<p><em>Cardizem&nbsp;Retard<\/em><em>&nbsp;90 mg&nbsp;prolonged-release tablet&nbsp;is<\/em><\/p>\n\n\n\n<p>PVC \/ PVDC \/ aluminum blister pack containing 49&#215;1 tablets (single-dose pack) and HDPE jar with a child-resistant lid in polypropylene (PP) containing 30 and 200 tablets respectively.<br><\/p>\n\n\n\n<p><em>Cardizem&nbsp;Retard&nbsp;120 mg&nbsp;prolonged-release tablet&nbsp;is<\/em><\/p>\n\n\n\n<p>PVC \/ PVDC \/ aluminum blister pack containing 49&#215;1 tablets (single-dose pack) and HDPE jar with a child-resistant lid in polypropylene (PP&nbsp;<strong>)<\/strong>&nbsp;containing 30 and 200 tablets respectively.<br><\/p>\n\n\n\n<p><em>Cardizem&nbsp;Retard&nbsp;180 mg&nbsp;prolonged-release tablet&nbsp;is<\/em><\/p>\n\n\n\n<p>PVC \/ PVDC \/ aluminum blister pack containing 49&#215;1 tablets (single-dose pack) and HDPE jar with a child-resistant lid in polypropylene (PP) containing 200 tablets.<br><\/p>\n\n\n\n<p>The jar with the child-resistant lid is opened by holding the lid down and screwing it counterclockwise.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Pfizer AB<\/p>\n\n\n\n<p>191 90 Sollentuna<\/p>\n\n\n\n<p>Tel: 08-550 52 00<\/p>\n\n\n\n<p>Email: eumedinfo@pfizer.com<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cardizem and Cardizem Retard are so-called calcium antagonists that inhibit the influx of calcium into certain cells. For the heart, it means a reduced amount of work and thus a reduced risk of overexertion of the heart muscle.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[7744,7740,7743,7742,7746,7747,7736,7738,7739,7745,7741,7737],"class_list":["post-6522","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-cardizem","tag-cardizem-retard","tag-cardizem-retard-side-effects","tag-cardizem-retard-tablet","tag-cardizem-side-effects","tag-cardizem-tablet","tag-diltiazem-hydrochloride","tag-diltiazem-hydrochloride-side-effects","tag-diltiazem-hydrochloride-tablet","tag-what-is-cardizem","tag-what-is-cardizem-retard","tag-what-is-diltiazem-hydrochloride"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6522","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6522"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6522\/revisions"}],"predecessor-version":[{"id":11606,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6522\/revisions\/11606"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6522"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6522"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6522"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}