{"id":6520,"date":"2021-01-09T09:39:07","date_gmt":"2021-01-09T09:39:07","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6520"},"modified":"2021-06-18T05:56:02","modified_gmt":"2021-06-18T05:56:02","slug":"carboplatin-rivopharm","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/carboplatin-rivopharm\/","title":{"rendered":"Carboplatin Rivopharm &#8211; Carboplatin uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n10 mg \/ ml concentrate for solution for infusion&nbsp;<br>carboplatin<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Carboplatin Rivopharm is and what it is used for<\/h2>\n\n\n\n<p>Carboplatin Rivopharm contains carboplatin which belongs to a group of medicines called platinum compounds which are used to treat cancer.<br><\/p>\n\n\n\n<p>Carboplatin Rivopharm is used to treat advanced ovarian cancer.<br><\/p>\n\n\n\n<p>Carboplatin contained in Carboplatin Rivopharm may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist or other healthcare professional if you have any further questions and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Carboplatin Rivopharm<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Carboplatin Rivopharm<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to carboplatin or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have severe kidney problems.&nbsp;Carboplatin Rivopharm can in exceptional cases be used despite severe kidney problems.<\/li><li>if you have impaired bone marrow function (impaired ability to produce&nbsp;blood cells&nbsp;in the&nbsp;bone marrow&nbsp;).<\/li><li>if you have a bleeding&nbsp;tumor&nbsp;s<\/li><li>when taking the yellow fever vaccine at the same time (see Other medicines and Carboplatin Rivopharm)<\/li><li>if you are breast-feeding (see Pregnancy, breast-feeding and&nbsp;fertility&nbsp;)<\/li><\/ul>\n\n\n\n<p>Tell your doctor if any of the above apply to you before you start using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Carboplatin Rivopharm should only be prescribed by a doctor with extensive experience in cancer treatment.<br><\/p>\n\n\n\n<p>Talk to your doctor or nurse before taking Carboplatin Rivopharm.<br><\/p>\n\n\n\n<p>Your kidney function, liver function and blood counts will be monitored before and during treatment with Carboplatin Rivopharm.&nbsp;If you get deviating results from these tests, the treatment can be stopped until the test values \u200b\u200breturn to more normal results.&nbsp;The function of the nerves may also need to be examined.<br><\/p>\n\n\n\n<p>During treatment with carboplatin, you are given medicines to reduce the risk of a potentially life-threatening complication called tumor lysis syndrome, which is caused by a chemical imbalance in the blood due to the breakdown of dying tumor cells that release their contents into the bloodstream.<br><\/p>\n\n\n\n<p>Tell your doctor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you get symptoms such as confusion, cramps or changes in vision during treatment with this medicine.<\/li><li>if you experience extreme fatigue associated with decreased&nbsp;red blood cell countsand shortness of breath (&nbsp;hemolytic anemia&nbsp;), alone or in combination with low&nbsp;platelet counts&nbsp;, abnormal bruising (&nbsp;thrombocytopenia&nbsp;) and kidney disease when you have decreased urine output or no urine at all (symptoms of Hemolytic-uremic syndrome)<\/li><li>if you get a fever (temperature higher than or equal to 38&nbsp;<sup>o<\/sup>&nbsp;C), or chills, which may be a sign of&nbsp;infection&nbsp;, contact a doctor immediately.&nbsp;There is a risk of blood infection.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Carboplatin Rivopharm<\/h2>\n\n\n\n<p>Tell your doctor or nurse if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n<p>Tell your doctor if you are taking any of the following medicines as they may affect or be affected by Carboplatin Rivopharm:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood-thinning drugs.&nbsp;Blood clotting ability needs to be checked more often during combination therapy with Carboplatin Rivopharm.<\/li><li>antibiotics&nbsp;of the type&nbsp;aminoglycoside&nbsp;s.<\/li><li>ciclosporin, tacrolimus, sirolimus (medicines that inhibit the immune system).<\/li><li>diuretics&nbsp;(&nbsp;diuretics&nbsp;) used to lower&nbsp;blood pressure&nbsp;et.<\/li><li>phenytoin&nbsp;and fosfenytoin (used to treat various types of seizures).<br><\/li><\/ul>\n\n\n\n<p>When you are being treated with Carboplatin Rivopharm, you must not be vaccinated against yellow fever.<\/p>\n\n\n\n<p>If you are planning to be vaccinated with another vaccine while you are being treated with Carboplatin Rivopharm, you should discuss this with your doctor before vaccination.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Carboplatin Rivopharm with alcohol<\/h2>\n\n\n\n<p>There is no known&nbsp;interaction&nbsp;between Carboplatin Rivopharm and alcohol.&nbsp;However, you should consult your doctor as Carboplatin Rivopharm may affect the liver&#8217;s ability to handle alcohol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine.<br><\/p>\n\n\n\n<p>If any of these apply to you and you have not already discussed this with your doctor or nurse, you should do so as soon as possible and before receiving&nbsp;an infusion&nbsp;.<br><\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>You should not be treated with Carboplatin Rivopharm while you are pregnant unless your doctor considers it absolutely necessary.<\/p>\n\n\n\n<p>Animal studies have shown that there is a risk of malformations in the fetus.&nbsp;If you are being treated with Carboplatin Rivopharm while you are pregnant, talk to your doctor about the possible risks for the unborn baby.<\/p>\n\n\n\n<p>Women of&nbsp;childbearing potential&nbsp;must use effective contraception during treatment with carboplatin.<br><\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>It is not known whether carboplatin is excreted in human milk.&nbsp;Therefore, you should not breast-feed while you are being treated with Carboplatin Rivopharm.<br><\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>Women of&nbsp;childbearing potential&nbsp;should avoid becoming pregnant by using effective contraception during treatment.<\/p>\n\n\n\n<p>Men treated with carboplatin should refrain from becoming the father of a child during the treatment period and for at least six months after the end of treatment.&nbsp;Sperm storage should be considered before treatment due to the risk of persistent&nbsp;infertility&nbsp;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Carboplatin Rivopharm can cause&nbsp;side effects&nbsp;that may affect your ability to drive or use machines.&nbsp;You should be especially careful if you feel dizzy or have an effect on your vision or hearing.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and \/ or&nbsp;side effects&nbsp;.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Carboplatin Rivopharm<\/h2>\n\n\n\n<p>Infusion&nbsp;one is always given by a nurse or doctor.&nbsp;It is usually given as a drip into a vein (&nbsp;intravenously&nbsp;) and usually takes between 15 and 60 minutes.<\/p>\n\n\n\n<p>Ask the doctor or nurse who gives \/ has given the&nbsp;infusion&nbsp;one if you want more information.<br><\/p>\n\n\n\n<p>How large a&nbsp;dose&nbsp;you receive depends on your height and weight, how good your blood formation is and on your kidney function.&nbsp;The doctor will choose the&nbsp;dose&nbsp;that is best for you.&nbsp;The infusion solution is diluted before use.<br><\/p>\n\n\n\n<p>You may feel unwell while being treated with Carboplatin Rivopharm.&nbsp;Your doctor may give you another medicine to reduce nausea before you are treated with Carboplatin Rivopharm.<br><\/p>\n\n\n\n<p>Dose&nbsp;limits of Carboplatin Rivopharm are normally given four weeks apart.&nbsp;Your doctor may want to take blood samples every week after you receive Carboplatin Rivopharm to determine the correct&nbsp;dose&nbsp;for your next&nbsp;infusion&nbsp;.<br><\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p>Usual&nbsp;dose&nbsp;is 400 mg \/ m\u00b2 body surface area (calculated using your height and weight).<br><\/p>\n\n\n\n<p><strong>Older<\/strong><\/p>\n\n\n\n<p>For elderly patients, the&nbsp;dose&nbsp;may be adjusted depending on the general condition.<br><\/p>\n\n\n\n<p><strong>Kidney problems<\/strong><\/p>\n\n\n\n<p>The amount of medicine you receive may vary depending on how well your kidneys are working.&nbsp;If you have kidney problems, your doctor may reduce the&nbsp;dose&nbsp;one and also often want to take blood samples and monitor your kidney function.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Carboplatin has not been used in children sufficiently to provide recommendations for a specific&nbsp;dose&nbsp;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Carboplatin Rivopharm than you should<\/h2>\n\n\n\n<p>It is unlikely that you are getting too much carboplatin.&nbsp;If this happens, you may suffer from certain kidney, liver, vision and hearing problems and impaired bone marrow function.&nbsp;If you are worried that you have been given too high a&nbsp;dose&nbsp;or if you have any questions about the&nbsp;dose&nbsp;you have been given, talk to the doctor or nurse who is giving you the medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Carboplatin Rivopharm<\/h2>\n\n\n\n<p>It is very unlikely that you will miss a&nbsp;dose&nbsp;because your doctor has instructions on when to get the medicine.&nbsp;If you think you have not been given a&nbsp;dose&nbsp;, talk to your doctor or nurse.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<br><\/p>\n\n\n\n<p>If any of the following occur,&nbsp;tell your doctor&nbsp;<strong>immediately<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have difficulty breathing.<\/li><li>you get raised red spots that can feel hot and itchy.<\/li><li>the face swells.<\/li><li>infection&nbsp;and \/ or bleeding.<\/li><li>allergic reactions (eg rash, fever,&nbsp;itching&nbsp;)<\/li><\/ul>\n\n\n\n<p>The above&nbsp;side effects&nbsp;are very serious and can occur more often if you have been treated with platinum-containing medicines.&nbsp;You may need medical attention immediately.<br><\/p>\n\n\n\n<p>The side effects&nbsp;below are also very serious and it is very important that your doctor finds out if they occur.&nbsp;If you experience any of the following, tell your doctor&nbsp;<strong>as soon as possible:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever, chills.<\/li><li>flu-like symptoms&nbsp;.<\/li><li>impotence.<\/li><li>diarrhea or constipation.<\/li><li>heart effect.<br><\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 user in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood effects such as&nbsp;anemia&nbsp;, decreased&nbsp;blood cell counts&nbsp;and&nbsp;platelets&nbsp;.<\/li><li>Vomiting, nausea, abdominal pain.<\/li><li>Altered results in tests of kidney and liver function, altered levels of salts in the blood.<br><\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Peripheral&nbsp;nerve disease (in nerve pathways outside the brain), abnormal sensation sensations in the skin (creeps, tingling, numbness), decreased tendon reflexes, taste disturbance.<\/li><li>Visual disturbances, in rare cases loss of vision.<\/li><li>Hearing impairment.<\/li><li>Cardiovascular disease.<\/li><li>Mucosal problems in the gastrointestinal tract.<\/li><li>Hair loss, skin problems.<\/li><li>Disease of the skeleton and muscles.<\/li><li>Disease of the urinary and \/ or genital organs.<\/li><li>Increased amount of&nbsp;bilirubin&nbsp;(slag product from the breakdown of&nbsp;red blood cells&nbsp;) in the blood, increased level of&nbsp;creatinine&nbsp;(slag product from the muscles), increased amount of&nbsp;uric acid&nbsp;in the blood.<br><\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurs in unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tumor disease due to treatment.<\/li><li>Severe bone marrow exposure (bone marrow failure).<\/li><li>Disease that affects the blood and kidneys (hemolytic-uremic syndrome &#8211; HUS).<\/li><li>Dehydration, decreased appetite, decreased sodium levels in the blood.<\/li><li>Vascular effects in the brain such as stroke or blood clot.<\/li><li>Headache, confusion, convulsions or changes in vision from blurring to loss of vision (symptoms of reversible posterior leukoencephalopathy syndrome (RPLS), a rare neurological disease).<\/li><li>Heart failure&nbsp;, migratory blood clots (emboli), high or low&nbsp;blood pressure&nbsp;.<\/li><li>Inflammation&nbsp;of the oral&nbsp;mucosa&nbsp;.<\/li><li>Inflammation&nbsp;of the pancreas<\/li><li>Hives&nbsp;, rash, redness,&nbsp;itching&nbsp;.<\/li><li>Injection site reactions.<\/li><li>Pneumonia&nbsp;.<\/li><li>Muscle cramps, muscle weakness, confusion, visual impairment or visual disturbances, irregular heartbeat,&nbsp;renal failure,&nbsp;or abnormal blood test results (symptoms of tumor lysis syndrome that can be caused by rapidly disintegrating tumor cells, see section 2).<br><strong>Reporting of&nbsp;side effects&nbsp;ar<\/strong>If you get&nbsp;any side effects&nbsp;, talk to your doctor or nurse.&nbsp;This also applies to any&nbsp;side effects&nbsp;not mentioned in this information.&nbsp;You can also report&nbsp;side effectsdirectly (see details below).&nbsp;By reporting&nbsp;side effects&nbsp;, you can help increase drug safety information. The Medical Products AgencyBox 26751 03 Uppsala&nbsp;www.lakemedelsverket.se<br><\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Carboplatin Rivopharm<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Store in the outer carton.&nbsp;Sensitive to light.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is carboplatin.&nbsp;1 ml contains 10 mg of carboplatin.<\/li><li>The other ingredients are mannitol 10 mg and water for injections.&nbsp;<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Vial&nbsp;of glass.<br><\/p>\n\n\n\n<p>Pack size: 1 x 5 ml, 10 x 5 ml, 1 x 15 ml, 10 x 15 ml, 1 x 45 ml, 10 x 45 ml, 1 x 60 ml, 10 x 60 ml.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Rivopharm Ltd.<\/p>\n\n\n\n<p>17 Corrig Road<\/p>\n\n\n\n<p>Sandyford, Dublin 18<\/p>\n\n\n\n<p>Ireland<br><\/p>\n\n\n\n<p><strong>Agent<\/strong><\/p>\n\n\n\n<p>SanoSwiss UAB<\/p>\n\n\n\n<p>Aukstaiciu str.&nbsp;26A<\/p>\n\n\n\n<p>LT-44169 Kaunas<\/p>\n\n\n\n<p>Lithuania<\/p>\n\n\n\n<p>+370 700 01320<\/p>\n\n\n\n<p>info@sanoswiss.com<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Pharmachemie BV<\/p>\n\n\n\n<p>Swensweg 5<\/p>\n\n\n\n<p>2031 GA Haarlem<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Carboplatin Rivopharm contains carboplatin which belongs to a group of medicines called platinum compounds which are used to treat cancer.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[7748,7753,7755,7756,7750,7752,2212,7751,7757,7749,7754],"class_list":["post-6520","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-carboplatin","tag-carboplatin-rivopharm","tag-carboplatin-rivopharm-side-effects","tag-carboplatin-rivopharm-uses","tag-carboplatin-side-effects","tag-carboplatin-uses","tag-medicine","tag-side-effects-of-carboplatin","tag-side-effects-of-carboplatin-rivopharm","tag-what-is-carboplatin","tag-what-is-carboplatin-rivopharm"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6520"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6520\/revisions"}],"predecessor-version":[{"id":11608,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6520\/revisions\/11608"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}