{"id":6514,"date":"2021-01-09T09:35:46","date_gmt":"2021-01-09T09:35:46","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6514"},"modified":"2021-06-18T05:59:57","modified_gmt":"2021-06-18T05:59:57","slug":"carboplatin-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/carboplatin-accord\/","title":{"rendered":"Carboplatin Accord &#8211; Carboplatin uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n10 mg \/ ml concentrate for solution for infusion&nbsp;<br>carboplatin<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Carboplatin Accord is and what it is used for<\/h2>\n\n\n\n<p>Carboplatin Accord contains carboplatin which is part of a group of medicines called platinum compounds.&nbsp;These are used to treat cancer.<br><\/p>\n\n\n\n<p>Carboplatin Accord is used for advanced ovarian cancer and&nbsp;small cell lung cancer&nbsp;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Carboplatin Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Carboplatin Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to carboplatin or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have severe kidney disease<\/li><li>if you have fewer&nbsp;blood cells&nbsp;than normal (your doctor will check this with a blood test)<\/li><li>if you have bleeding tumors<\/li><li>if you are planning to get vaccinated against yellow fever or have just done so.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if any of the above apply before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Carboplatin Accord<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are pregnant or could be pregnant<\/li><li>if you are breast-feeding<\/li><li>if you have mild kidney disease.&nbsp;Your doctor will check on you more regularly<\/li><li>if you are older (over 65 years)<\/li><li>if you have previously been treated with cisplatin or similar anticancer medicines;&nbsp;Carboplatin can affect the nervous system and cause tingling or hearing or vision problems.&nbsp;Your doctor may want to assess you more regularly<\/li><li>if you get headaches, altered mental function, seizures and visual disturbances, from blurred vision to visual impairment<\/li><li>if you develop extreme fatigue and shortness of breath with decreased&nbsp;red blood cell count&nbsp;(&nbsp;haemolytic anemia&nbsp;), alone or in combination with low&nbsp;platelet count&nbsp;, abnormal bruising (&nbsp;thrombocytopenia&nbsp;) and kidney disease that causes you to urinate little or not at all (symptoms of&nbsp;haemolytic uremic syndrome&nbsp;)<\/li><li>if you get a fever (body temperature of at least 38 \u00b0 C) or chills, which may be a sign of&nbsp;infection&nbsp;.&nbsp;There is a risk that you will get an&nbsp;infection&nbsp;in the blood.<\/li><\/ul>\n\n\n\n<p>During treatment with carboplatin, you may&nbsp;<strong>in some cases<\/strong>&nbsp;be given medicines to reduce the risk of a life-threatening complication called tumor lysis syndrome, which is caused by chemical imbalances in the blood due to the breakdown of dying cancer cells that release their contents into the bloodstream.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Carboplatin Accord<\/h2>\n\n\n\n<p>Special care is required if you are taking \/ using other medicines as these may affect carboplatin, eg:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs that can reduce the number of&nbsp;blood cells&nbsp;at the same time as carboplatin may require a&nbsp;dose&nbsp;change and the frequency of carboplatin treatment<\/li><li>Some&nbsp;antibiotics&nbsp;called&nbsp;aminoglycosides&nbsp;, vancomycin or capreomycin at the same time as carboplatin may increase the risk of kidney or hearing problems<\/li><li>water tablets (&nbsp;diuretics&nbsp;) simultaneously with carboplatin may increase the risk of kidney problems or hearing<\/li><li>live or live attenuated vaccines (for yellow fever vaccine, see section 2 Do not use Carboplatin Accord)<\/li><li>blood-thinning drugs, e.g.&nbsp;warfarin&nbsp;, together with carboplatin may require closer monitoring of blood&nbsp;coagulation capacity<\/li><li>Phenytoin&nbsp;or phosphenytoin (used to treat seizures and seizures) at the same time as carboplatin may increase the risk of seizures<\/li><li>other drugs that reduce the activity of the immune system (eg cyclosporine, tacrolimus, sirolimus).<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Carboplatin Accord with food and drink<\/h2>\n\n\n\n<p>There is no known&nbsp;interaction&nbsp;between carboplatin and alcohol.&nbsp;However, check with your doctor, as carboplatin may affect the liver&#8217;s ability to handle alcohol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>Due to the potential risk of malformations, female patients who may become pregnant should use contraceptives before and during treatment with carboplatin.<br><\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>It is unknown whether carboplatin is excreted in human milk.&nbsp;Thus, during treatment with Carboplatin Accord, you should stop breast-feeding.<br><\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>Men treated with this drug are advised against having children during and up to 6 months after treatment.&nbsp;There is a risk that the drug may cause permanent sterility and men should therefore seek advice on storing sperm before treatment.<br><\/p>\n\n\n\n<p>Treatment with carboplatin may temporarily or permanently reduce fertility in men and women.&nbsp;Talk to your doctor if you are worried.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Do not drive or use machines if you experience&nbsp;side effects&nbsp;that may impair your ability to do so, such as nausea, vomiting, changes in vision or hearing.&nbsp;You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and \/ or&nbsp;side effects&nbsp;.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.<\/p>\n\n\n\n<p>If you are not sure, talk to your doctor or pharmacist&nbsp;<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The stopper of the vial of Carboplatin Accord contains natural rubber<\/h2>\n\n\n\n<p>The stopper of the vial contains dry natural rubber (a&nbsp;derivative&nbsp;of latex), which may cause allergic reactions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Carboplatin Accord<\/h2>\n\n\n\n<p>This medicine is given as an&nbsp;infusion&nbsp;(drip) into a vein for 15\u201160 minutes.<br><\/p>\n\n\n\n<p><strong>Dose<\/strong><\/p>\n\n\n\n<p>Your doctor will determine which&nbsp;dose&nbsp;of carboplatin is right for you and how often you should get it.<br><\/p>\n\n\n\n<p>Dose&nbsp;one depends on your medical condition, your size and how your kidneys are working.&nbsp;Your doctor will give you information on how your kidneys are working using blood and urine tests.&nbsp;After your&nbsp;dose&nbsp;of carboplatin, you should have regular blood tests.&nbsp;You may also undergo checks for nerve damage and hearing loss.<br><\/p>\n\n\n\n<p>It normally takes 4 weeks between each&nbsp;dose of&nbsp;carboplatin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Carboplatin Accord than you should&nbsp;<\/h2>\n\n\n\n<p>As this medicine is given in a hospital under the supervision of a doctor, it is unlikely that you will get too much or too little, but talk to a doctor or healthcare professional if you are worried.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Carboplatin Accord<\/h2>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Carboplatin Accord can cause&nbsp;side effects&nbsp;, although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>If any of the following occur, tell your doctor immediately<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Abnormal bruising, bleeding, or signs of&nbsp;infection, such as sore throat and fever.<\/li><li>Severe&nbsp;allergic reaction&nbsp;(anaphylaxis \/ anaphylactic reactions) &#8211; you may suddenly experience itchy rash (&nbsp;hives&nbsp;) swelling of the hands, feet, ankles, face or throat (which may make it difficult to swallow or breathe) and you may have a feeling that you will faint.<\/li><li>Muscle cramps, muscle weakness, confusion, visual impairments or disorders, irregular heartbeat,&nbsp;renal failure&nbsp;or abnormal blood test results (symptoms of tumor lysis syndrome that may be caused by the rapid degradation of tumor cells (see section 2).<\/li><\/ul>\n\n\n\n<p>These are serious&nbsp;side effects&nbsp;.&nbsp;You may need&nbsp;urgent&nbsp;medical attention.<br><\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 user in 10)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Changes in red and&nbsp;white blood cells&nbsp;and&nbsp;platelets&nbsp;(bone marrow inhibition).<\/li><li>Fatigue, shortness of breath and paleness caused by&nbsp;anemia&nbsp;(a condition that reduces the number of&nbsp;red blood cells&nbsp;).<\/li><li>Increase in the level of&nbsp;urea&nbsp;in the blood.<\/li><li>Deviating content of liver enzymes.<\/li><li>Nausea or vomiting.<\/li><li>Stomach pain and stomach cramps.<\/li><li>Decreased levels of&nbsp;sodium&nbsp;,&nbsp;potassium&nbsp;,&nbsp;calcium&nbsp;and&nbsp;magnesium&nbsp;in the blood.<\/li><li>Decreased creatine clearance in the kidneys.<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea or constipation.<\/li><li>Rash and \/ or&nbsp;itching<\/li><li>Earring or hearing changes.<\/li><li>Hair loss.<\/li><li>Flu-like symptoms&nbsp;.<\/li><li>Signs of&nbsp;infection&nbsp;such as fever or sore throat.<\/li><li>Symptoms of severe&nbsp;allergic reaction&nbsp;including sudden wheezing and tightness of the chest, swelling of the eyelids, face or lips, flushing, low&nbsp;blood pressure&nbsp;, rapid heartbeat, shortness of breath, dizziness and anaphylactic&nbsp;shock&nbsp;.<\/li><li>Tingling or numbness in hands, feet, arms or legs.<\/li><li>Burning or stinging sensation.<\/li><li>Reduced tendon reflex.<\/li><li>Taste changes or loss of taste.<\/li><li>Temporary deterioration of vision or changes in vision.<\/li><li>Heart disease.<\/li><li>Chest tightness or wheezing.<\/li><li>Interstitial lung disease (a group of lung diseases that causes the deep lung tissue to become inflamed).<\/li><li>Sores on the lips or cold sores (mucous membrane diseases).<\/li><li>Pain or discomfort in the skeleton, joints, muscles or surrounding structures (musculoskeletal disease).<\/li><li>Kidney or urine problems.<\/li><li>Extreme fatigue\/weakness (&nbsp;asthenia&nbsp;).<\/li><li>Increased levels of&nbsp;bilirubin&nbsp;and&nbsp;creatinine&nbsp;in the blood.<\/li><li>Increased levels of&nbsp;uric acid&nbsp;in the blood that can lead to&nbsp;gout&nbsp;.<br><\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Temporary vision loss.<\/li><li>Feeling sick with high fever due to low levels of&nbsp;white blood cells&nbsp;(febrile&nbsp;neutropenia&nbsp;).<br><\/li><\/ul>\n\n\n\n<p><strong>Very rare (may affect up to 1 in 10,000 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Scarring in the lungs leading to shortness of breath and \/ or cough (&nbsp;pulmonary fibrosis&nbsp;).<br><\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurs in an unknown number of users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Cancer caused by treatment with carboplatin (secondary&nbsp;malignancy&nbsp;).<\/li><li>Hemolytic uremic syndrome&nbsp;(a disease characterized by&nbsp;acute&nbsp;renal failure&nbsp;).<\/li><li>Dry mouth&nbsp;, fatigue and headache due to severe fluid loss (dehydration).<\/li><li>Decreased appetite,&nbsp;anorexia&nbsp;.<\/li><li>Stroke&nbsp;.<\/li><li>Severe hepatic impairment, damaged or dead liver cells.<\/li><li>Heart failure&nbsp;.<\/li><li>Obstruction&nbsp;in blood vessels (emboli).<\/li><li>Changes in blood pressure (&nbsp;hypertension&nbsp;or&nbsp;hypotension&nbsp;).<\/li><li>Skin disease such as&nbsp;hives&nbsp;, rash, redness (&nbsp;erythema&nbsp;) and&nbsp;itching&nbsp;.<\/li><li>Swelling or tenderness at the injection site.<\/li><li>A group of symptoms such as headache, altered mental function, seizures and visual disturbances from blurred vision to visual impairment (symptoms of reversible posterior leukoencephalopathy syndrome, a rare neurological disease)<\/li><li>Pancreatitis&nbsp;.<\/li><li>Sores or information in the mouth (&nbsp;stomatitis&nbsp;).<\/li><li>Lung infection.<\/li><\/ul>\n\n\n\n<p>Carboplatin can lead to problems with blood, liver and kidneys.&nbsp;Your doctor will take blood samples to check for these problems.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Carboplatin Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;Store in a cold place.&nbsp;Do not freeze.&nbsp;Keep the vial in the outer carton.&nbsp;Sensitive to light.<br><\/p>\n\n\n\n<p>After reconstitution: Chemical and physical in-use stability of the product after&nbsp;reconstitution&nbsp;has been demonstrated for 24 hours at room temperature and for 30 hours at 2-8 \u00b0 C.<br><\/p>\n\n\n\n<p>From a microbiological perspective, the product should be used immediately.&nbsp;If the reconstituted product is not used immediately, the user is responsible for the storage time and storage conditions before use.&nbsp;Normally the product should not be stored for longer than 24 hours at 2-8 \u00b0 C, unless dilution has taken place under controlled and validated antiseptic conditions.<br><\/p>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance in Carboplatin Accord is carboplatin.<\/p>\n\n\n\n<p>Each 1 ml concentrate for&nbsp;solution&nbsp;for&nbsp;infusion&nbsp;contains 10 mg carboplatin.<br><\/p>\n\n\n\n<p>Each 5 ml&nbsp;vial&nbsp;contains 50 mg of carboplatin.<\/p>\n\n\n\n<p>Each 15 ml&nbsp;vial&nbsp;contains 150 mg of carboplatin.<\/p>\n\n\n\n<p>Each 45 ml&nbsp;vial&nbsp;contains 450 mg of carboplatin.<\/p>\n\n\n\n<p>Each 60 ml&nbsp;vial&nbsp;contains 600 mg of carboplatin.<br><\/p>\n\n\n\n<p>The other ingredients are water for injections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Concentrate for&nbsp;infusion&nbsp;solution<\/p>\n\n\n\n<p>Carboplatin Accord is a clear colorless to pale yellow solution.<br><\/p>\n\n\n\n<p>5 ml, 15 ml, 45 ml or 60 ml concentrate for&nbsp;solution&nbsp;for&nbsp;infusion is&nbsp;supplied in 5 ml \/ 15 ml \/ 45 ml \/ 60 ml amber&nbsp;vial&nbsp;of type I glass.<\/p>\n\n\n\n<p>The vials are sealed with a gray chlorobutyl rubber stopper \/ gray Westar prewashed silicone rubber stopper with a tear-off aluminum seal.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 kV Utrecht<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Limited Sage House,<\/p>\n\n\n\n<p>319, Pinner Road,<\/p>\n\n\n\n<p>North Harrow, Middlesex, HA1 4HF,<\/p>\n\n\n\n<p>UK<br><\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomierska 50,95-200 Pabianice, Poland<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Carboplatin Accord contains carboplatin which is part of a group of medicines called platinum compounds. These are used to treat cancer.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[7748,7768,7770,7764,7750,7752,2212,7751,7771,7749,7769],"class_list":["post-6514","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-carboplatin","tag-carboplatin-accord","tag-carboplatin-accord-side-effects","tag-carboplatin-dose","tag-carboplatin-side-effects","tag-carboplatin-uses","tag-medicine","tag-side-effects-of-carboplatin","tag-what-carboplatin-accord-is-used-for","tag-what-is-carboplatin","tag-what-is-carboplatin-accord"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6514","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6514"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6514\/revisions"}],"predecessor-version":[{"id":11614,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6514\/revisions\/11614"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6514"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}