{"id":6508,"date":"2021-01-09T09:31:42","date_gmt":"2021-01-09T09:31:42","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6508"},"modified":"2021-06-18T06:14:40","modified_gmt":"2021-06-18T06:14:40","slug":"carbocaine-adrenaline","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/carbocaine-adrenaline\/","title":{"rendered":"Carbocaine Adrenaline &#8211; Mepivacaine hydrochloride and adrenaline uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n5 mg \/ ml + 5 micrograms \/ mL, 10 mg \/ ml + 5 micrograms \/ mL, 20 mg \/ ml + 5 micrograms \/ ml&nbsp;injection&nbsp;solution&nbsp;<br>mepivacaine hydrochloride and&nbsp;adrenaline<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Carbocaine Adrenaline is and what it is used for<\/h2>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;contains two different active substances.&nbsp;One is mepivacaine hydrochloride, which is a local anesthetic that temporarily blocks the nerve signals in the area where it is injected.&nbsp;The other is&nbsp;adrenaline, which gives mepivacaine hydrochloride a longer-lasting effect.&nbsp;Adrenaline also&nbsp;reduces the risk of&nbsp;side effects.<br><\/p>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;is used to temporarily reduce or remove the sensation in a part of the body.<br><\/p>\n\n\n\n<p>Mepivacaine hydrochloride and&nbsp;adrenaline&nbsp;contained in Carbocaine&nbsp;adrenaline&nbsp;may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professional if you have any further questions and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you are given Carbocaine adrenaline<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Carbocaine adrenaline should not be given:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to mepivacaine hydrochloride,&nbsp;adrenaline,&nbsp;or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are allergic to other&nbsp;local anesthetics&nbsp;belonging to the same group (eg bupivacaine,&nbsp;lidocaine&nbsp;)<\/li><li>if you are allergic to the preservatives methyl or propyl parahydroxybenzoate (parabens) or para amino benzoic acid (PABA) or are allergic to other&nbsp;local anesthetics&nbsp;belonging to a group called&nbsp;ester&nbsp;&#8211;&nbsp;local anesthetics<\/li><li>if you are allergic to the preservative sodium metabisulfite.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before giving Carbocaine adrenaline:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are older or have a reduced general condition<\/li><li>if you have a type of arrhythmia in your heart called&nbsp;AV block&nbsp;II or III<\/li><li>if you are being treated with antiarrhythmic drugs<\/li><li>if you have severe liver disease<\/li><li>if you have severe renal impairment<\/li><li>if you have very high&nbsp;blood pressure&nbsp;or&nbsp;untreated&nbsp;high&nbsp;blood pressure<\/li><li>if you have too much&nbsp;hormone&nbsp;production in the thyroid gland (&nbsp;hyperthyroidism)<\/li><li>if you have heart disease<\/li><li>if you have severe&nbsp;diabetes<\/li><li>if you have problems with blood circulation in the brain<\/li><li>if you have&nbsp;acute&nbsp;porphyria&nbsp;(a hereditary disease that affects the nervous system)<\/li><\/ul>\n\n\n\n<p>The doctor will be observant of any&nbsp;side effects&nbsp;that may occur in connection with the administration of the drug in the eye.<br><\/p>\n\n\n\n<p>The doctor will also be careful when giving the medicine in peripheral parts of the body such as fingers (or parts of the body that otherwise have a low blood supply) and when giving large amounts.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;should not be given to newborns and infants under 6 weeks of age, as their liver has a harder time breaking down the drug.<br><\/p>\n\n\n\n<p>For the treatment of small children over 6 weeks of age, no data are available and the doctor must therefore be especially careful.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Carbocaine adrenaline<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or another healthcare professional if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;can affect or be affected by other drugs, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other local anesthetics<\/li><li>drugs for arrhythmias in the heart<\/li><\/ul>\n\n\n\n<p>Adrenaline&nbsp;can affect or be affected by other drugs, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines for high&nbsp;blood pressure, angina,&nbsp;heart failure, arrhythmias, and&nbsp;glaucoma, for the prevention of&nbsp;migraines&nbsp;and after myocardial infarction (non-selective&nbsp;beta-blockers, eg propranolol)<\/li><li>inhaled anesthetics<\/li><li>antidepressants&nbsp;(&nbsp;tricyclic antidepressants&nbsp;)<\/li><li>medicines used to expel the placenta and reduce bleeding after childbirth (medicines of the&nbsp;ergotamine&nbsp;type&nbsp;)<\/li><li>medicines used to&nbsp;treat psychosis, such as sleeping pills and nausea (phenothiazines and butyrophenones).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.<br><\/p>\n\n\n\n<p><em>Pregnancy:<\/em>&nbsp;<\/p>\n\n\n\n<p>There are no known risks of using this medicine during pregnancy.<\/p>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;is not recommended for so-called cervical anesthesia during childbirth.<br><\/p>\n\n\n\n<p><em>Breast-feeding:<\/em><\/p>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;passes into breast milk, but it is unlikely to have any effects on the breast-fed baby.&nbsp;It is not known whether&nbsp;adrenaline&nbsp;passes into breast milk, but it is unlikely that breastfed babies can be affected.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Depending on the&nbsp;dose&nbsp;you receive and how it is given, Carbocaine&nbsp;adrenaline can have a transient effect on your mobility, coordination, and attention.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<p><strong>Carbocaine&nbsp;adrenaline&nbsp;contains sodium metabisulfite, methyl parahydroxybenzoate, and sodium chloride<\/strong><\/p>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;contains sodium metabisulfite (E223) which in rare cases can cause severe&nbsp;hypersensitivity reactions&nbsp;and convulsions in the trachea.&nbsp;Tell your healthcare provider if you are allergic to sodium metabisulfite.<br><\/p>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;contains methyl parahydroxybenzoate (E218), which may cause allergic reactions (possibly delayed) and, exceptionally, convulsions in the trachea.<br><\/p>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;5 mg \/ ml + 5 micrograms \/ ml contains 0.142 mmol (3.23 mg)&nbsp;sodium&nbsp;per milliliter.&nbsp;This should be considered by patients on a low-salt diet.<\/p>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;10 mg \/ ml + 5 micrograms \/ ml contains 0.133 mmol (3.10 mg)&nbsp;sodium&nbsp;per milliliter.&nbsp;This should be considered by patients on a low-salt diet.<\/p>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;20 mg \/ ml + 5 micrograms \/ ml contains 0.116 mmol (2.67 mg)&nbsp;sodium&nbsp;per milliliter.&nbsp;This should be considered by patients on a low-salt diet.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Carbocaine Adrenaline is given<\/h2>\n\n\n\n<p>You will receive the medicine from a doctor or nurse, in the form of an&nbsp;injection.&nbsp;Dose&nbsp;one of Carbocaine&nbsp;adrenaline&nbsp;is determined by the doctor and depends on the type of anesthesia you need, the area to be anesthetized, and the duration of the anesthesia.&nbsp;The doctor adjusts the&nbsp;dose&nbsp;to your age, weight, and general health and uses the lowest possible&nbsp;dose&nbsp;that provides adequate anesthesia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children<\/h2>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;should not be given to newborns and infants under 6 weeks of age.&nbsp;For children between 6 weeks of age and 12 years of age, the doctor calculates the appropriate&nbsp;dose&nbsp;based on the patient&#8217;s weight.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Carbocaine adrenaline than you should<\/h2>\n\n\n\n<p>If you think you have been given too much medicine, tell your doctor or nurse immediately.<br><\/p>\n\n\n\n<p>In case of overdose, poisoning reactions can occur, usually within 15\u201160 minutes.&nbsp;If Carbocaine&nbsp;adrenaline&nbsp;is accidentally injected into a blood vessel,&nbsp;intoxication reactions may occur&nbsp;immediately (within seconds or minutes).&nbsp;The reactions mainly affect the&nbsp;central nervous system&nbsp;and the cardiovascular system.&nbsp;The first symptoms are usually a feeling of intoxication, numbness around the mouth and in the tongue, visual disturbances,&nbsp;tinnitus, and sensitivity to sound.&nbsp;Then you may have more severe symptoms, such as difficulty speaking clearly, muscle twitching or shaking, and finally cramps and unconsciousness.&nbsp;In addition, you may have difficulty breathing.&nbsp;In severe cases, you can get a drop in blood pressure, slow heart rate, irregular heartbeat, and even cardiac arrest and respiratory arrest.&nbsp;Such reactions must be treated immediately.&nbsp;Therefore, your doctor always makes sure that there is resuscitation equipment nearby when using Carbocaine&nbsp;adrenaline.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>If you experience the following symptoms, stop treatment, and&nbsp;contact&nbsp;a doctor&nbsp;<strong>immediately<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>signs of intoxication reactions in the&nbsp;central nervous system, such as cramps, tingling or numbness around the mouth, numbness in the tongue, increased sensitivity to sound, visual disturbances, loss of consciousness, tremors, intoxication,&nbsp;tinnitus, difficulty speaking clearly,&nbsp;CNS&nbsp;depression (drowsiness, impaired breathing declining&nbsp;heart rate, unconsciousness,&nbsp;coma&nbsp;)&nbsp;<em>(uncommon&nbsp;side effects, may affect up to 1 in 100 people)<\/em><\/li><li>cardiac arrest (&nbsp;<em>rare&nbsp;side effect&nbsp;)<\/em><\/li><li>a severe&nbsp;allergic reaction&nbsp;that may be life-threatening, with symptoms such as difficulty breathing, swelling of the lips, throat, and tongue, and low&nbsp;blood pressure(anaphylactic&nbsp;shock&nbsp;) (&nbsp;<em>rare&nbsp;side effect&nbsp;)<\/em><br><\/li><\/ul>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that may occur:<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10)<\/em>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;blood pressure<\/li><li>nausea.<br><\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people)<\/em>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high&nbsp;blood pressure<\/li><li>dizziness<\/li><li>tingling sensation in the skin<\/li><li>slow heart rate<\/li><li>vomiting.<br><\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>irregular heartbeat<\/li><li>allergic reactions<\/li><li>breathing difficulties<\/li><li>pathological changes or damage to the nerves<\/li><li>Inflammation&nbsp;of the arachnoid membrane (the middle meninges)<\/li><li>double vision<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Carbocaine adrenaline<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not store above 15 \u00b0 C.&nbsp;Do not freeze.&nbsp;Sensitive to light.&nbsp;Store in the outer carton.<br><\/p>\n\n\n\n<p>The vial may be used for a maximum of three days after opening.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the bottle and on the carton after EXP.&nbsp;date.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are mepivacaine hydrochloride and&nbsp;adrenaline.&nbsp;One ml contains 5 mg, 10 mg, and 20 mg of mepivacaine hydrochloride and 5 micrograms of&nbsp;adrenaline respectively.<\/li><li>The other ingredients are sodium chloride, sodium metabisulfite (E223), methyl parahydroxybenzoate (E218) (&nbsp;preservative&nbsp;), sodium hydroxide and\/or&nbsp;hydrochloric acid&nbsp;(for&nbsp;pH&nbsp;adjustment), and water for injections.&nbsp;See section 2 &#8220;Carbocaine&nbsp;adrenaline&nbsp;contains sodium metabisulphite, methyl parahydroxybenzoate, and sodium chloride&#8221; for further information.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Carbocaine&nbsp;adrenaline&nbsp;is a&nbsp;solution for injection&nbsp;provided in glass vials.<\/p>\n\n\n\n<p>One&nbsp;vial&nbsp;contains 20 ml.<br><\/p>\n\n\n\n<p>One pack contains 5 vials.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong><em>Marketing Authorisation Holder<\/em><\/strong><\/p>\n\n\n\n<p>Aspen Pharma Trading Limited<\/p>\n\n\n\n<p>3016 Lake Drive, Citywest Business Campus<\/p>\n\n\n\n<p>Dublin 24, Ireland<\/p>\n\n\n\n<p>Tel .: 0046 856642572<br><\/p>\n\n\n\n<p><strong><em>Manufacturer<\/em><\/strong><\/p>\n\n\n\n<p>AstraZeneca AB<\/p>\n\n\n\n<p>151 85 S\u00f6dert\u00e4lje<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Carbocaine adrenaline contains two different active substances. One is mepivacaine hydrochloride, which is a local anesthetic that temporarily blocks the nerve signals in the area where it is injected. The other is adrenaline, which gives mepivacaine hydrochloride a longer-lasting effect. Adrenaline also reduces the risk of side effects.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[7795,7797,7798,2212,7790,7792,7793,7799,7796,7791,7794],"class_list":["post-6508","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-carbocaine-adrenaline","tag-carbocaine-adrenaline-side-effects","tag-carbocaine-adrenaline-uses","tag-medicine","tag-mepivacaine-hydrochloride-and-adrenaline","tag-mepivacaine-hydrochloride-and-adrenaline-side-effects","tag-mepivacaine-hydrochloride-and-adrenaline-uses","tag-what-carbocaine-adrenaline-is-used-for","tag-what-is-carbocaine-adrenaline","tag-what-is-mepivacaine-hydrochloride-and-adrenaline","tag-what-mepivacaine-hydrochloride-and-adrenaline-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6508"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6508\/revisions"}],"predecessor-version":[{"id":11620,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6508\/revisions\/11620"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}