{"id":6478,"date":"2021-01-07T10:40:39","date_gmt":"2021-01-07T10:40:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6478"},"modified":"2021-06-18T06:24:26","modified_gmt":"2021-06-18T06:24:26","slug":"caprelsa","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/caprelsa\/","title":{"rendered":"Caprelsa &#8211; Vandetanib uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n100 mg, 300 mg&nbsp;film-coated tablets&nbsp;<br>vandetanib<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Caprelsa is and what it is used for<\/h2>\n\n\n\n<p><strong>Caprelsa is a treatment for adults and children from 5 years with:<\/strong><br><\/p>\n\n\n\n<p>Medullary thyroid cancer cannot be removed with&nbsp;surgery&nbsp;or has spread to other parts of the body.<br><\/p>\n\n\n\n<p>Caprelsa works by slowing down the growth of new blood vessels in (cancer)&nbsp;tumors.&nbsp;In this way, the supply of nutrients and oxygen to the&nbsp;tumor is restricted.&nbsp;Caprelsa can also have a direct effect on cancer cells by killing the cells or slowing down the growth.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Caprelsa<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Caprelsa:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to vandetanib or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have a congenital heart disease called &#8216;long QTc&#8217; syndrome.&nbsp;This can be seen on the electrocardiogram (&nbsp;ECG&nbsp;).<\/li><li>if you are breast-feeding.<\/li><li>if you are taking any of the following medicines: arsenic, cisapride (used to treat heartburn),&nbsp;intravenous&nbsp;erythromycin and moxifloxacin (used to treat&nbsp;infection&nbsp;), toremifene (used to treat breast cancer), mizolastine (used to treat&nbsp;allergies&nbsp;),&nbsp;class IA&nbsp;antiarrhythmics&nbsp;and III (for heart rhythm control).<\/li><\/ul>\n\n\n\n<p>Do not take Caprelsa if any of the above apply to you.&nbsp;Talk to your doctor if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Caprelsa:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are sensitive to sunlight.&nbsp;Some people who use Caprelsa become more sensitive to the sun.&nbsp;This can cause harmful sunburn.&nbsp;When using Caprelsa, you must protect yourself when you are outdoors by always using sunscreen and clothing to avoid sun exposure.<\/li><li>If you have high&nbsp;blood pressure.<\/li><li>If you have or have had an&nbsp;aneurysm&nbsp;(enlargement and weakening of a vessel wall) or a rupture in a vessel wall.<\/li><\/ul>\n\n\n\n<p>Checking your blood levels and your heart:<\/p>\n\n\n\n<p>Your doctor or nurse should take samples to check the levels of&nbsp;potassium,&nbsp;calcium,&nbsp;magnesium,&nbsp;and thyroid-stimulating hormone (&nbsp;TSH&nbsp;) in your blood and check the electrical activity of the heart with a test called an electrocardiogram (&nbsp;ECG&nbsp;).&nbsp;The tests must be performed:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Before you start with Caprelsa<\/li><li>Regularly during treatment with Caprelsa<\/li><li>1, 3, and 6 weeks after starting Caprelsa<\/li><li>12 weeks after starting Caprelsa<\/li><li>Every 3 months thereafter<\/li><li>If your&nbsp;dose of&nbsp;Caprelsa is changed by a doctor or pharmacist<\/li><li>If you start taking medicines that affect the heart<\/li><li>According to the instructions of a doctor or pharmacist<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Caprelsa should not be given to children under 5 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Caprelsa<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription, herbal medicines, or other herbal medicines.&nbsp;Caprelsa can affect the way some medicines work and some medicines can have an effect on Caprelsa.<br><\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>itraconazole,&nbsp;ketoconazole, ritonavir, clarithromycin, rifampicin, and moxifloxacin (medicines used to treat&nbsp;infections&nbsp;)<\/li><li>carbamazepine and phenobarbital (used to control seizures)<\/li><li>ondansetron (used to treat nausea and vomiting)<\/li><li>cisapride (used to treat heartburn), pimozide (used to treat uncontrolled repetitive motion and verbal outbursts), and halofantrine and lumefantrine (used to treat&nbsp;malaria&nbsp;)<\/li><li>methadone&nbsp;(used to treat drug addiction),&nbsp;haloperidol&nbsp;, chlorpromazine, sulpiride, amisulpride, and zuclopenthixol (used to treat mental illness)<\/li><li>pentamidine (used to treat&nbsp;infection&nbsp;)<\/li><li>Vitamin&nbsp;K&nbsp;antagonist&nbsp;er and dabigatran commonly referred to as blood thinners<\/li><li>cyclosporine and tacrolimus (used to prevent rejection of transplanted organs),&nbsp;digoxin&nbsp;(used to treat irregular heartbeat), and&nbsp;metformin&nbsp;(used to stabilize blood sugar levels)<\/li><li>proton pump inhibitor&nbsp;(used in the treatment of heartburn)<\/li><\/ul>\n\n\n\n<p>This information can also be found in the patient care that you received from your doctor.&nbsp;It is important that you bring the patient card with you and show it to your partner or caregiver.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p>Caprelsa can harm an unborn baby.&nbsp;Your doctor will discuss the benefits and risks of taking Caprelsa during this time.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are likely to become pregnant, you must use effective contraception when taking Caprelsa and at least four months after the last&nbsp;dose&nbsp;of Caprelsa.<\/li><\/ul>\n\n\n\n<p>To protect your baby, you must not breast-feed during treatment with Caprelsa.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Be careful when driving or using machines.&nbsp;Keep in mind that Caprelsa can make you feel tired and weak and can make you look blurry.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Caprelsa<\/h2>\n\n\n\n<p><strong>Use for adults<\/strong><\/p>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended&nbsp;dose&nbsp;is 300 mg every day.<\/li><li>Take Caprelsa at about the same time each day.<\/li><li>Caprelsa can be taken with or without food.<\/li><\/ul>\n\n\n\n<p><strong>Use for children<\/strong><\/p>\n\n\n\n<p>Your doctor will tell you how many Caprelsa tablets to give to your child.&nbsp;The amount of Caprelsa given depends on the baby&#8217;s body weight and height.&nbsp;The total daily&nbsp;dose for children should not exceed 300 mg.&nbsp;The treatment can either be given to your child as a single daily dose, a&nbsp;dose&nbsp;every other day, or according to a repeated 7-day schedule given in the dosing guide given to you by your doctor.&nbsp;It is important that you keep this dosing guide and show it to caregivers.<br><\/p>\n\n\n\n<p><strong>If you have difficulty swallowing the tablet<\/strong><\/p>\n\n\n\n<p>If you have difficulty swallowing the tablet, you can mix it with water as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take half a glass of plain (non-carbonated) water.&nbsp;Use only water, not other liquids.<\/li><li>Put the tablet in the water.<\/li><li>Stir until the tablet has dissolved in the water.&nbsp;It may take about 10 minutes.<\/li><li>Drink the liquid immediately.<\/li><\/ul>\n\n\n\n<p>To be sure that you have ingested all the medicine, fill the glass halfway with water again and drink it up.<br><\/p>\n\n\n\n<p><strong>If you get&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>If you get&nbsp;any side effects, talk to your doctor at all times.&nbsp;Your doctor may then&nbsp;prescribe&nbsp;a lower or higher&nbsp;dose&nbsp;of Caprelsa (eg two 100 mg tablets or one 100 mg tablet).&nbsp;Your doctor may also prescribe other medicines to help you control the&nbsp;side effects.&nbsp;The side effects&nbsp;of Caprelsa are described in section 4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Caprelsa than you should<\/h2>\n\n\n\n<p>If you take more Caprelsa than you should, contact a doctor or hospital immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Caprelsa<\/h2>\n\n\n\n<p>What to do if you forget to take a tablet depends on how much time is left until the next&nbsp;dose.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If it is 12 hours or more until you take the next dose:<\/strong>&nbsp;Take the forgotten tablet as soon as you remember that you forgot to take the tablet.&nbsp;Then take the next&nbsp;dose&nbsp;at the usual time.<\/li><li><strong>If it is less than 12 hours until you take the next dose:<\/strong>&nbsp;Skip the missed&nbsp;dose.&nbsp;Then take the next&nbsp;dose&nbsp;at the usual time.<\/li><\/ul>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;(two&nbsp;doses&nbsp;at the same time) to compensate for a missed&nbsp;dose.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;If you get&nbsp;side effects, your doctor may ask you to take a lower&nbsp;dose&nbsp;of Caprelsa.&nbsp;Your doctor may also prescribe other medicines to help you control the&nbsp;side effects&nbsp;.<br><\/p>\n\n\n\n<p><strong>Contact your doctor immediately if you get any of the following&nbsp;side effects&nbsp;&#8211; you may need immediate medical attention:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fainting attacks, dizziness, or altered heart rhythm.&nbsp;This may be a sign of a change in the electrical activity of the heart.&nbsp;This can be seen in 8% of people taking Caprelsa for medullary thyroid cancer.&nbsp;Your doctor may recommend that you take a lower&nbsp;dose&nbsp;of Caprelsa or stop taking Caprelsa.&nbsp;Caprelsa has in less common cases been associated with life-threatening changes in heart rhythm.<\/li><li>Severe skin reactions affecting large parts of the body.&nbsp;Signs of this can be&nbsp;redness, pain, sores, blisters, and flaking of the skin.&nbsp;Lips, nose, eyes, and genitals can also be affected.&nbsp;This can be common (affects less than 1 in 10 people) or less common (affects less than 1 in 100 people) depending on the type of skin reaction.<\/li><li>Severe diarrhea.<\/li><li>Severe shortness of breath, or sudden worsening of shortness of breath and possibly also cough and fever.&nbsp;This may mean that you have an&nbsp;inflammation&nbsp;of the lungs called interstitial lung disease.&nbsp;This is less common (affects less than 1 in 100 people) but can be life-threatening.<\/li><li>Seizures, headaches, confusion, or difficulty concentrating.&nbsp;This may be a sign of a condition called RPLS (reversible posterior leukoencephalopathy syndrome).&nbsp;The side effects&nbsp;usually disappear when treatment with Caprelsa is stopped.&nbsp;RPLS is less common (affects less than 1 in 100 people).<\/li><\/ul>\n\n\n\n<p>Contact your doctor immediately if you get any of the&nbsp;side effects&nbsp;listed above.<br><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are:<\/strong><\/p>\n\n\n\n<p><strong>Very common (affects more than 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea.&nbsp;Your doctor may&nbsp;prescribe&nbsp;medication to treat this.&nbsp;If it gets worse, contact your doctor immediately.<\/li><li>Stomach pain.<\/li><li>Skin rash or&nbsp;acne.<\/li><li>Depression.<\/li><li>Fatigue.<\/li><li>Nausea.<\/li><li>Stomach upset (&nbsp;dyspepsia&nbsp;).<\/li><li>Nail diseases.<\/li><li>Vomiting.<\/li><li>Loss of appetite (&nbsp;anorexia&nbsp;).<\/li><li>Weakness (&nbsp;asthenia&nbsp;).<\/li><li>High&nbsp;blood pressure.&nbsp;Your doctor may&nbsp;prescribe&nbsp;a medicine to treat this.<\/li><li>Headache.<\/li><li>Extreme fatigue.<\/li><li>Difficulty sleeping (insomnia).<\/li><li>Inflammation&nbsp;of the nasal passages.<\/li><li>Inflammation&nbsp;of the major airways to the lungs.<\/li><li>Infection&nbsp;is in the upper respiratory tract.<\/li><li>Urinary tract infections.<\/li><li>Numbness or tingling in the skin.<\/li><li>Abnormal sensation in the skin.<\/li><li>Dizziness.<\/li><li>Pain.<\/li><li>Swelling caused by an excess of fluid (&nbsp;edema&nbsp;).<\/li><li>Stones or calcium deposits in the urinary tract (&nbsp;nephrolithiasis&nbsp;).<\/li><li>Blurred vision, including minor changes in the eye that can lead to blurred vision (corneal opacity).<\/li><li>Sun-sensitive skin.&nbsp;When using Caprelsa, you must protect yourself when you are outdoors by always using sunscreen and clothing to avoid sun exposure.<\/li><\/ul>\n\n\n\n<p><strong>Common (affects less than 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dehydration.<\/li><li>Very high&nbsp;blood pressure.<\/li><li>Weight loss.<\/li><li>Stroke&nbsp;or other conditions with insufficient blood supply to the brain.<\/li><li>A type of rash that affects the hands and feet (hand-foot syndrome).<\/li><li>Soreness in the mouth (&nbsp;stomatitis&nbsp;).<\/li><li>Dry mouth.<\/li><li>Pneumonia.<\/li><li>The toxin&nbsp;is in the blood as a complication of&nbsp;infection&nbsp;is.<\/li><li>Influenza.<\/li><li>Inflammation&nbsp;of the bladder.<\/li><li>Inflammation&nbsp;of the sinuses.<\/li><li>Inflammation&nbsp;of the larynx (&nbsp;larynx&nbsp;).<\/li><li>Inflammation&nbsp;of the&nbsp;follicles, especially the hair follicles.<\/li><li>Boils.<\/li><li>Fungal infection.<\/li><li>Kidney infection.<\/li><li>Loss of body fluid (&nbsp;dehydration&nbsp;).<\/li><li>Concern.<\/li><li>Tremors.<\/li><li>Drowsiness.<\/li><li>Fainting attack.<\/li><li>Instability.<\/li><li>Increased intraocular pressure (&nbsp;glaucoma&nbsp;).<\/li><li>Blood in vomit.<\/li><li>Inflammation&nbsp;of the lung tissue.<\/li><li>Difficulty swallowing.<\/li><li>Constipation.<\/li><li>Inflammation&nbsp;of the gastric mucosa (&nbsp;gastritis&nbsp;).<\/li><li>Gastrointestinal bleeding.<\/li><li>Gallstones&nbsp;(&nbsp;cholelithiasis&nbsp;).<\/li><li>Pain when urinating.<\/li><li>Kidney failure.<\/li><li>Frequent urination.<\/li><li>Urgent&nbsp;need to pee.<\/li><li>Fever.<\/li><li>Nasal blood&nbsp;(&nbsp;epistaxis&nbsp;).<\/li><li>Eye dryness.<\/li><li>Eye irritation (&nbsp;conjunctivitis&nbsp;).<\/li><li>Visual impairment.<\/li><li>Halo effect on vision.<\/li><li>Flashes of light in the&nbsp;field of view&nbsp;(&nbsp;photos&nbsp;).<\/li><li>Corneal disease (&nbsp;keratopathy&nbsp;).<\/li><li>A certain type of diarrhea (&nbsp;colitis&nbsp;).<\/li><li>Hair loss from head or body (&nbsp;alopecia&nbsp;).<\/li><li>Taste disorders (&nbsp;dysgeusia&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (affects less than 1 in 100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Heart failure.<\/li><li>Appendicitis (&nbsp;appendicitis&nbsp;).<\/li><li>Bacterial infection.<\/li><li>Inflammation&nbsp;of the diverticula (small bulging sacs that can form in the digestive system).<\/li><li>Bacterial skin infection.<\/li><li>Abdominal wall abscess.<\/li><li>Malnutrition.<\/li><li>Involuntary muscle contractions (cramps).<\/li><li>Rapidly alternating between muscle contraction and muscle relaxation (clonus).<\/li><li>Swelling of the brain.<\/li><li>Cloudy eye lens.<\/li><li>Disorders of heart rate and heart rate.<\/li><li>Impaired heart function.<\/li><li>The inability of the lungs to function normally.<\/li><li>Pneumonia&nbsp;occurs when foreign matter inhales into the lungs.<\/li><li>Intestinal obstruction.<\/li><li>Holes in the intestine.<\/li><li>Inability to control bowel movements.<\/li><li>Discolored urine.<\/li><li>Lack of urine.<\/li><li>Inability to normal wound healing.<\/li><li>Inflammation&nbsp;of the pancreas (&nbsp;pancreatitis&nbsp;).<\/li><li>Skin blisters (bullous&nbsp;dermatitis&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>No known frequency (cannot be calculated from the available data)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>An enlargement and weakening of a vessel wall or a rupture in a vessel wall (&nbsp;aneurysms&nbsp;and arterial dissections).<\/li><\/ul>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;can be detected by tests performed by a doctor:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Protein&nbsp;or blood in the urine (detected by urine sample).<\/li><li>Altered heart rhythm (detected by&nbsp;ECG&nbsp;).&nbsp;Your doctor may ask you to stop taking Caprelsa or to take a lower&nbsp;dose&nbsp;of Caprelsa.<\/li><li>Deviations in the liver or pancreas (detected by a blood test).&nbsp;The abnormalities usually do not cause any symptoms, but your doctor may want to monitor them.<\/li><li>Decreased levels of&nbsp;calcium&nbsp;in the blood.&nbsp;Your doctor may need to&nbsp;prescribe&nbsp;or change your thyroid hormone treatment.<\/li><li>Decreased levels of&nbsp;potassium&nbsp;in the blood.<\/li><li>Increased levels of&nbsp;calcium&nbsp;in the blood.<\/li><li>Increased levels of&nbsp;glucose&nbsp;in the blood.<\/li><li>Decreased levels of&nbsp;sodium&nbsp;in the blood.<\/li><li>Impaired thyroid function.<\/li><li>Elevated levels of&nbsp;red blood cells&nbsp;in the blood.<\/li><\/ul>\n\n\n\n<p>If any of the&nbsp;side effects&nbsp;gets serious, or if you notice any&nbsp;side effects&nbsp;not listed in this leaflet, please tell your doctor or pharmacist&nbsp;<strong>immediately<\/strong>.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Caprelsa<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the blister and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is vandetanib.&nbsp;Each tablet contains 100 or 300 mg of vandetanib.<\/li><li>The other ingredients are calcium hydrogen phosphate dihydrate, microcrystalline cellulose, crospovidone (type A), povidone (K29-32), magnesium stearate, hypromellose, macrogol, and titanium dioxide (E171).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Caprelsa 100 mg is a white, round film-coated tablet marked \u201cZ100\u201d on one side.<\/p>\n\n\n\n<p>Caprelsa 300 mg is a white, oval film-coated tablet marked \u201cZ300\u201d on one side.<br><\/p>\n\n\n\n<p>Caprelsa is supplied in blister packs of 30 tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Genzyme Europe BV, Paasheuvelweg 25, 1105 BP Amsterdam, The Netherlands<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>AstraZeneca UK Limited, Macclesfield, Cheshire, SK10 2NA, UK<br><\/p>\n\n\n\n<p>or<br><\/p>\n\n\n\n<p>Genzyme Ltd., 37 Hollands Road, Haverhill, Suffolk, CB9 8PU, UK<br><\/p>\n\n\n\n<p>or<br><\/p>\n\n\n\n<p>Genzyme Ireland Ltd., IDA Industrial Park, Old Kilmeaden Road, Waterford, Ireland<br><\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgium \/ Belgium \/&nbsp;<br>Luxembourg \/ Luxembourg<\/strong>Sanofi BelgiumTel: + 32 (0) 2 710 54 00<\/td><td><strong>Hungary<\/strong>SANOFI-AVENTIS Zrt.Tel: +36 1 505 0050<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>SANOFI Bulgaria EOODPhone: +35 9 (0) 2 970 53 00<\/td><td><strong>Malta<\/strong>Sanofi SrlTel: +39 02 39394275<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>sanofi-aventis, sroTel: +42 0 233 086 111<\/td><td><strong>The Netherlands<\/strong>Genzyme Europe BVTel: +31 20 245 4000<\/td><\/tr><tr><td><strong>Denmark<\/strong>Sanofi A \/ STel: +45 45 16 70 00<\/td><td><strong>Norway<\/strong>sanofi-aventis Norge ASTel: + 47 67 10 71 00<\/td><\/tr><tr><td><strong>Germany<\/strong>Sanofi-Aventis Deutschland GmbHTel .: 0800 04 36 996Tel.&nbsp;from abroad: +49 69 305 70 13<\/td><td><strong>Austria<\/strong>sanofi-aventis GmbHTel: + 43 1 80 185 &#8211; 0<\/td><\/tr><tr><td><strong>Eesti<\/strong>sanofi-aventis Estonia O\u00dcTel.&nbsp;+372 6 273 488<\/td><td><strong>Poland<\/strong>sanofi-aventis Sp.&nbsp;z ooTel .: +48 22 280 00 00<\/td><\/tr><tr><td><strong>Greece<\/strong>sanofi-aventis AEBE:\u0397\u03bb: +30 210 900 16 00<\/td><td><strong>Portugal<\/strong>Sanofi &#8211; Pharmaceutical Products, Lda.Tel: +351 21 35 89 400<\/td><\/tr><tr><td><strong>Spain<\/strong>sanofi-aventis, SATel: +34 93 485 94 00<\/td><td><strong>Romania<\/strong>Sanofi Romania SRLTel: +40 (0) 21 317 31 36<\/td><\/tr><tr><td><strong>France<\/strong>sanofi-aventis FranceTel: 0 800 222 555Call from abroad: +33 1 57 63 23 23<\/td><td><strong>Slovenia<\/strong>sanofi-aventis dooTel: +386 1 560 4800<\/td><\/tr><tr><td><strong>Croatia<\/strong>sanofi-aventis Croatia dooTel: +385 1 600 3 4 00<\/td><td><strong>Slovak Republic<\/strong>sanofi-aventis Slovakia sroTel: +421 2 33 100 100<\/td><\/tr><tr><td><strong>Ireland<\/strong>sanofi-aventis Ireland Ltd.&nbsp;T \/ A SANOFITel: +353 (0) 1 403 56 00<\/td><td><strong>Finland \/ Finland<\/strong>Sanofi OyPuh \/ Tel: + 358 201 200 300<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><\/td><\/tr><tr><td><strong>Italy<\/strong>Sanofi SrlTel: +800 536 389<\/td><td><strong>United Kingdom<\/strong>SanofiTel: +44 (0) 845 372 7101<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>sanofi-aventis Cyprus Ltd.:\u0397\u03bb: +357 22 871600<\/td><td><br><\/td><\/tr><tr><td><strong>Latvia<\/strong>sanofi-aventis Latvia SIATel: +371 67 33 24 51<\/td><td><br><\/td><\/tr><tr><td><strong>Lithuania<\/strong>UAB &#8220;SANOFI-AVENTIS LIETUVA&#8221;Tel.&nbsp;+370 5 275 5224<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Caprelsa is a treatment for adults and children from 5 years with:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2203,2200],"tags":[7845,7848,7847,2211,7840,7842,7843,7849,7846,7841,7844],"class_list":["post-6478","post","type-post","status-publish","format-standard","hentry","category-c","category-medicines","tag-caprelsa","tag-caprelsa-side-effects","tag-caprelsa-tablet","tag-tablets","tag-vandetanib","tag-vandetanib-side-effects","tag-vandetanib-tablet","tag-what-caprelsa-is-used-for","tag-what-is-caprelsa","tag-what-is-vandetanib","tag-what-vandetanib-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6478","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6478"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6478\/revisions"}],"predecessor-version":[{"id":11630,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6478\/revisions\/11630"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6478"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6478"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6478"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}