{"id":6343,"date":"2021-01-05T09:45:26","date_gmt":"2021-01-05T09:45:26","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6343"},"modified":"2021-06-22T19:09:53","modified_gmt":"2021-06-22T19:09:53","slug":"burinex","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/burinex\/","title":{"rendered":"Burinex &#8211; Bumetanide uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n0.5 mg \/ ml&nbsp;injection&nbsp;solution&nbsp;<br>bumetanide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Burinex is and what it is used for<\/h2>\n\n\n\n<p>Burinex is a diuretic that accelerates the excretion of urine.<\/p>\n\n\n\n<p>Burinex is used in adults to treat the accumulation of fluid in the body (&nbsp;edema&nbsp;), which can occur in connection with&nbsp;heart failure&nbsp;,&nbsp;liver cirrhosis&nbsp;or kidney disease.<br><\/p>\n\n\n\n<p>Bumetanide contained in Burinex may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist or other healthcare professional if you have any further questions and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Burinex<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Burinex<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to bumetanide, formaldehyde or any of the other ingredients of this medicine (listed in section 6)<\/li><li>in severe hepatic impairment (hepatic encephalopathy)<\/li><li>if you have&nbsp;kidney failure&nbsp;with little or no urine excretion<\/li><li>in conditions of altered fluid and salt balance in the body.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Burinex.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>There are very small amounts of formaldehyde in the medicine.&nbsp;Due to the risk of developing a severe&nbsp;allergic reaction&nbsp;(&nbsp;anaphylactic reaction&nbsp;), caution should be exercised.<\/li><li>In case of severe hepatic impairment, low&nbsp;blood pressure&nbsp;or&nbsp;hypomagnesaemia(low magnesium content in the blood).&nbsp;Regular monitoring of the blood concentration of certain&nbsp;electrolytes&nbsp;will be done because Burinex can change the fluid and salt balance in the body.<\/li><li>If you have a narrowing of the urinary tract.<\/li><li>If you have severe renal impairment or elevated levels of&nbsp;urea&nbsp;or&nbsp;creatinine&nbsp;in your blood.<\/li><li>If you have&nbsp;diabetes, your urine and blood glucose should be checked regularly.<\/li><li>If you are hypersensitive to&nbsp;sulphonamides&nbsp;, you may also be hypersensitive to Burinex.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Burinex is not recommended for use in children due to insufficient information on safety, efficacy and&nbsp;dosage&nbsp;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Burinex<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n<p>The effect of treatment can be affected if this medicine is taken at the same time as certain other medicines.<\/p>\n\n\n\n<p>Caution should be exercised when using Burinex and concomitantly<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>certain types of heart medicine (&nbsp;digitalis glycosides&nbsp;)<\/li><li>antiarrhythmic&nbsp;drugs (&nbsp;antiarrhythmics&nbsp;)<\/li><li>certain medicines are given for manic-depressive illness (lithium)<\/li><li>certain painkillers (&nbsp;NSAIDs&nbsp;)<\/li><li>other&nbsp;diuretics&nbsp;(&nbsp;diuretics&nbsp;)<\/li><li>some medicines for high&nbsp;blood pressure<\/li><li>certain medicines that can lower&nbsp;blood pressure&nbsp;(eg&nbsp;tricyclic antidepressants&nbsp;)<\/li><li>substances that reduce the potassium level in the blood<\/li><li>certain medicines for&nbsp;gout&nbsp;(probenecid)<\/li><li>certain&nbsp;antibiotics&nbsp;(&nbsp;aminoglycosides&nbsp;,&nbsp;cephalosporins&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>Bumetanide should not be used during pregnancy unless your doctor tells you it&#8217;s absolutely necessary.&nbsp;It should only be used by pregnant women in&nbsp;heart failure&nbsp;as the benefits of the treatment outweigh the risks to the fetus.<br><\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Burinex should not be used during breast-feeding.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Dizziness may occur and this should be taken into account when driving or using machines.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and \/ or&nbsp;side effects&nbsp;.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Burinex<\/h2>\n\n\n\n<p>Burinex will be administered by healthcare professionals.<br><\/p>\n\n\n\n<p>You will receive this medicine as an&nbsp;injection&nbsp;into a vein (&nbsp;intravenous&nbsp;injection&nbsp;) or into a muscle (&nbsp;intramuscular&nbsp;injection&nbsp;).&nbsp;The dosage&nbsp;one and the way to give the&nbsp;injection&nbsp;one depends on your special needs and your illness and is decided by your doctor.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Burinex is not recommended for use in children.<br><\/p>\n\n\n\n<p>Overdose can cause dehydration of the body, very large amounts of urine and electrolyte disturbances.&nbsp;Symptoms of electrolyte disturbances&nbsp;include dry mouth&nbsp;, thirst, weakness, drowsiness, confusion, nausea, vomiting, abdominal pain, restlessness, muscle aches, muscle cramps and seizures.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>Burinex can in rare cases affect the white&nbsp;blood cells&nbsp;so that the&nbsp;defense against&nbsp;infection deteriorates.&nbsp;If you get an&nbsp;infection&nbsp;with symptoms such as fever with severe general deterioration or fever with local infection symptoms such as sore throat\/throat\/mouth or difficulty urinating, you should see a doctor as soon as possible so that blood tests can rule out a lack of&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis&nbsp;).&nbsp;It is important that you then information about your medication.<br><\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>alteration of fluid and salt balance (low levels of&nbsp;potassium&nbsp;,&nbsp;sodium&nbsp;and chlorine or high levels of&nbsp;potassium&nbsp;in the blood)<\/li><li>dizziness, fatigue, headache<\/li><li>abdominal pain, nausea<\/li><li>muscle pain<\/li><li>urination problem.<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>elevated blood sugar<\/li><li>high level of&nbsp;uric acid&nbsp;in the blood,&nbsp;gout<\/li><li>fainting<\/li><li>low&nbsp;blood pressure<\/li><li>vomiting, diarrhea, constipation<\/li><li>skin reactions such as rash,&nbsp;hives&nbsp;,&nbsp;itching&nbsp;, increased sensitivity to light<\/li><li>renal impairment (including&nbsp;renal failure&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased&nbsp;platelet count,&nbsp;anemia<\/li><li>hearing disorders<\/li><li>dermatitis,&nbsp;eczema<\/li><li>dehydration.<\/li><\/ul>\n\n\n\n<p><strong>Reporting of&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>If you get&nbsp;any side effects&nbsp;, talk to your doctor, nurse or pharmacist.&nbsp;This also applies to&nbsp;side effects&nbsp;that are not mentioned in this information.&nbsp;You can also report&nbsp;side effects&nbsp;directly (see details below).&nbsp;By reporting&nbsp;side effects&nbsp;, you can help increase drug safety information.<br><\/p>\n\n\n\n<p>The Medical Products Agency<\/p>\n\n\n\n<p>Box 26<\/p>\n\n\n\n<p>751 03 Uppsala<\/p>\n\n\n\n<p><br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Burinex<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Keep the&nbsp;vial&nbsp;are in the outer carton.&nbsp;Sensitive to light.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<br><\/p>\n\n\n\n<p>Burinex should be used before the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is bumetanide 0.5 mg\/ml.<\/li><li>The other ingredients are: Disodium phosphate dihydrate, sodium dihydrogen phosphate dihydrate, xylitol, water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Each&nbsp;ampoule&nbsp;contains 4 ml&nbsp;solution for injection&nbsp;.<\/p>\n\n\n\n<p>Pack size: 5 \u00d7 4 ml.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>medinfo@karopharma.com<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Cenexi<\/p>\n\n\n\n<p>52, rue Marcel and Jacques Gaucher<\/p>\n\n\n\n<p>94120 Fontenay-sous-Bois<\/p>\n\n\n\n<p>France<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Burinex is a diuretic that accelerates the excretion of urine.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2202,2200],"tags":[8159,8162,8161,8164,8166,8168,8163,8167,8160,8165],"class_list":["post-6343","post","type-post","status-publish","format-standard","hentry","category-b","category-medicines","tag-bumetanide","tag-bumetanide-injection","tag-bumetanide-side-effects","tag-burinex","tag-burinex-injection","tag-burinex-side-effects","tag-what-bumetanide-is-used-for","tag-what-burinex-is-used-for","tag-what-is-bumetanide","tag-what-is-burinex"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6343","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6343"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6343\/revisions"}],"predecessor-version":[{"id":11724,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6343\/revisions\/11724"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6343"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6343"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}