{"id":6227,"date":"2021-01-03T15:26:14","date_gmt":"2021-01-03T15:26:14","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6227"},"modified":"2021-06-26T07:45:52","modified_gmt":"2021-06-26T07:45:52","slug":"brimonidine-hexal","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/brimonidine-hexal\/","title":{"rendered":"Brimonidine Hexal &#8211; Brimonidine Tartrate uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n2 mg \/ ml&nbsp;eye drops&nbsp;, solution&nbsp;<br>brimonidine tartrate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Brimonidine Hexal is and what it is used for<\/h2>\n\n\n\n<p>Brimonidine Hexal contains brimonidine tartrate which acts by lowering the pressure in the eyeball.<br><\/p>\n\n\n\n<p>The eye drops used in adults with&nbsp;glaucoma&nbsp;(&nbsp;glaucoma&nbsp;) and ocular hypertension (elevated intraocular pressure) to&nbsp;<strong>reduce the increased pressure in the eye<\/strong>&nbsp;that is caused by an accumulation of fluid.&nbsp;The drops can be used either as a single drug or in combination with other&nbsp;eye drops&nbsp;that lower the elevated pressure in the eyeball.<br><\/p>\n\n\n\n<p>Brimonidine tartrate contained in Brimonidine Hexal may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professional if you have any further questions and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Brimonidine Hexal<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Brimonidine Hexal<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>For newborns and toddlers (from birth to 2 years of age).<\/li><li>If you are allergic to brimonidine tartrate or any of the other ingredients of this medicine (listed in section 6).<\/li><li>If you are taking certain antidepressants (monoamine oxidase [MAO] inhibitors and certain other antidepressants).<\/li><\/ul>\n\n\n\n<p>You must tell your doctor if you are taking any medicine for depression.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Brimonidin Hexal:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or have had depression<\/li><li>if you have reduced mental capacity<\/li><li>if you have heart problems<\/li><li>if you have a reduced blood supply to the brain<\/li><li>if you have reduced blood supply to your arms and legs<\/li><li>if you have low&nbsp;blood pressure&nbsp;problems, especially when getting up<\/li><li>if you have or have had kidney or liver problems<\/li><li>if you wear soft contact lenses (see section 3)<\/li><li>if it is given to a child over 2 years of age as Brimonidine Hexal is not recommended for this age group.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Brimonidine Hexal<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>Tell your doctor if you are taking or have recently taken any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>painkillers, sedatives<\/li><li>medicines used to treat severe pain or cough or as replacement therapy (opiates)<\/li><li>medicines to treat&nbsp;epilepsy&nbsp;or other diseases (&nbsp;barbiturates&nbsp;)<\/li><li>anesthetics<\/li><li>medicines to treat heart problems or lower high&nbsp;blood pressure<\/li><li>drugs for the treatment of diseases of the nervous system (chlorpromazine, methylphenidate, and reserpine)<\/li><li>drugs that act in the same place in the body as brimonidine, e.g.&nbsp;isoprenaline&nbsp;and prazosin<\/li><li>monoamine oxidase (MAO) inhibitors and other antidepressants<\/li><li>medicine for any other disease, even if it has nothing to do with the eye disease.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Brimonidine Hexal with alcohol<\/h2>\n\n\n\n<p>Tell your doctor if you regularly drink alcohol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p>If you are pregnant or likely to be pregnant, do not use Brimonidine Hexal unless your doctor tells you it is absolutely necessary.<br><\/p>\n\n\n\n<p>These&nbsp;eye drops&nbsp;should not be used during breast-feeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>These&nbsp;eye drops&nbsp;may cause blurred vision or altered vision.&nbsp;This effect can be aggravated at night or at&nbsp;reduced&nbsp;lighting.&nbsp;Brimonidine Hexal may also cause drowsiness or fatigue in some patients.<br><\/p>\n\n\n\n<p>If you get any of these symptoms, do not drive or use machines until the symptoms have disappeared.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Brimonidine Hexal contains benzalkonium chloride<\/h2>\n\n\n\n<p>This medicine contains 0.05 mg of benzalkonium chloride per ml.&nbsp;Benzalkonium chloride can be absorbed by soft contact lenses and can discolor the contact lenses.&nbsp;Remove contact lenses before using the medicine and wait at least 15 minutes before re-inserting the contact lenses.&nbsp;Benzalkonium chloride can be irritating to the eyes, especially if you have dry eyes or problems with the cornea (the clear membrane at the front of the eye).&nbsp;If you experience irritation, tingling, or pain in the eye after using the medicine, consult a doctor.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Brimonidine Hexal<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p><strong>Dosage&nbsp;and how often to take Brimonidine Hexal<\/strong><\/p>\n\n\n\n<p>Take 1 drop of Brimonidine Hexal in the affected eye (s)&nbsp;<strong>twice daily<\/strong>&nbsp;at approximately 12-hour intervals.&nbsp;If you use it with other&nbsp;eye drops, wait 5-15 minutes before taking the other eye drops.<\/p>\n\n\n\n<p>The eye drops must be taken every day to be effective.<br><\/p>\n\n\n\n<p><strong>Children under 12 years<\/strong><\/p>\n\n\n\n<p>Brimonidine Hexal is not recommended for children under 12 years of age.&nbsp;Brimonidine Hexal must not be used in particular for toddlers under 2 years of age.<br><\/p>\n\n\n\n<p><strong>Method of administration<\/strong><\/p>\n\n\n\n<p>Brimonidine Hexal is intended for use in the eye (s).<br><\/p>\n\n\n\n<p>Follow the instructions on the prescription label carefully, and ask your doctor or pharmacist to explain what you do not understand.<\/p>\n\n\n\n<p>Always wash your hands before applying&nbsp;eye drops.&nbsp;Take the drops as follows:<\/p>\n\n\n\n<p>1. Tilt your head back and look at the ceiling.<\/p>\n\n\n\n<p>Carefully pull the lower eyelid down until a small pocket is formed.<\/p>\n\n\n\n<p>3. Hold the bottle upside down and squeeze until there is a drop in the eye.<\/p>\n\n\n\n<p>4. Keep the eye closed and press the finger towards the corner of the eye (the side where the eye meets the nose) and hold for 1 minute.<\/p>\n\n\n\n<p>Do not allow the drip device to come into contact with the eyes or anything else.&nbsp;Replace and tighten the cover immediately after use.<\/p>\n\n\n\n<p>If you wear&nbsp;<strong>soft contact lenses<\/strong>, remove them before using the eye drops and wait 15 minutes after taking the drops before reinserting the lenses.&nbsp;The preservative in these&nbsp;eye drops&nbsp;discolors soft contact lenses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Brimonidine Hexal than you should<\/h2>\n\n\n\n<p><em>Adults<\/em><\/p>\n\n\n\n<p>There is limited experience with overdose of Brimonidine Hexal in adults.&nbsp;This is unlikely when given as&nbsp;eye drops.&nbsp;In the cases reported, the symptoms have generally been those already listed as&nbsp;side effects.&nbsp;Adults who inadvertently swallow brimonidine experienced a drop in blood pressure, which in some patients was followed by an increase in&nbsp;blood pressure.<br><\/p>\n\n\n\n<p><em>Children<\/em><\/p>\n\n\n\n<p>Several cases of overdose have been reported in children receiving brimonidine Hexal as part of medical treatment for&nbsp;glaucoma&nbsp;(&nbsp;glaucoma&nbsp;).&nbsp;Symptoms include temporary&nbsp;coma&nbsp;or decreased consciousness, fatigue, drowsiness, lethargy, slow heartbeat, low body temperature, paleness, and difficulty breathing.&nbsp;Contact a doctor immediately if any of these symptoms occur.<br><\/p>\n\n\n\n<p><em>Adults and children<\/em><\/p>\n\n\n\n<p>For other&nbsp;alpha-2 agonist&nbsp;s, a group of drugs also brimonidine belong, oral (oral) of dosages reported to cause symptoms such as low&nbsp;blood pressure, weakness, vomiting, lethargy, drowsiness, slow heart rate, irregular heartbeat, contraction of the&nbsp;pupil&nbsp;are, weakness in the body, low body temperature, difficulty breathing and cramps.&nbsp;Brimonidine Hexal may cause similar symptoms.<br><\/p>\n\n\n\n<p>Brimonidine Hexal is for eye application only.&nbsp;If you or a child accidentally swallows these&nbsp;eye drops&nbsp;or uses more than you or your child should, contact a doctor immediately.<br><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Brimonidine Hexal<\/h2>\n\n\n\n<p>If you forget to use this medicine, take it as soon as you remember.&nbsp;If it is almost time for your next&nbsp;dose, do not take the drops but wait until the usual time and follow the normal routine.<br><\/p>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Brimonidine Hexal<\/h2>\n\n\n\n<p>You must use Brimonidine Hexal every day for it to be effective.&nbsp;Do not stop using this medicine until your doctor tells you to.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>Some of the&nbsp;side effects&nbsp;in the eye\/eyes may be due to&nbsp;allergy&nbsp;to the active substance or any of the other ingredients (see the end of section 2 and section 6).<br><\/p>\n\n\n\n<p>You may experience the following&nbsp;side effects&nbsp;that affect your eyes:<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;&nbsp;(may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>an&nbsp;allergic reaction&nbsp;in the eye<\/li><li>blisters or white spots on the conjunctiva that cover the surface of the eye<\/li><li>cloudy vision<\/li><li>Red eyes<\/li><li>burning sensation, stinging sensation, feeling of having something in the eye<\/li><li>itching<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>changes in the surface of the eye<\/li><li>eyelid inflammation<\/li><li>conjunctivitis<\/li><li>visual disturbances<\/li><li>sticky eyes<\/li><li>swelling of the eyelid or conjunctiva<\/li><li>photosensitivity<\/li><li>irritation<\/li><li>red eyelids<\/li><li>pain in the eye<\/li><li>dry eyes<\/li><li>abrasion on the surface of the eye and discoloration<\/li><li>tears<\/li><li>whitening of the conjunctiva<\/li><\/ul>\n\n\n\n<p><strong>Very rare<\/strong>&nbsp;&nbsp;(may affect up to 1 in 10,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation&nbsp;of the eye<\/li><li>reduced&nbsp;pupil size<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurs in an unknown number of users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation&nbsp;inside the eye that causes pain and&nbsp;redness<\/li><li>eyelid itching<\/li><\/ul>\n\n\n\n<p>You may experience the following&nbsp;side effects&nbsp;that affect the&nbsp;<strong>rest of your body<\/strong>&nbsp;:<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;&nbsp;(may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>fatigue \/ drowsiness<\/li><li>dry mouth<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>symptoms of the gastrointestinal tract<\/li><li>cold symptoms<\/li><li>general weakness<\/li><li>general allergic reactions<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Depression<\/li><li>palpitation<\/li><li>changes in heart rate<\/li><li>dryness of the nose<\/li><li>sore throat<\/li><li>nausea<\/li><li>taste influence<\/li><li>dermatitis with rash<\/li><li>thirst<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;&nbsp;(may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>shortness of breath<\/li><li>seasonal allergy<\/li><li>high or low&nbsp;blood pressure<\/li><li>impact on the voice<\/li><li>cough<\/li><li>nasal congestion<\/li><li>dry throat<\/li><\/ul>\n\n\n\n<p><strong>Very rare<\/strong>&nbsp;&nbsp;(may affect up to 1 in 10,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fainting<\/li><li>insomnia<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurs in an unknown number of users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>skin reactions including&nbsp;redness, swelling of the face,&nbsp;itching, rash, and dilation of blood vessels<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Brimonidine Hexal<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>This medicine does not require any special storage conditions.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the bottle and carton after EXP.&nbsp;or EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>After first opening: used within 28 days.<br><\/p>\n\n\n\n<p>Do not use this medicine if the warranty seal on the bottle is broken before first use.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is brimonidine tartrate.&nbsp;Each ml of solution contains 2 mg of brimonidine tartrate, equivalent to 1.3 mg of brimonidine.<\/li><li>The other ingredients are benzalkonium chloride, polyvinyl alcohol, sodium chloride, sodium citrate, citric acid monohydrate, purified water and sodium hydroxide, and&nbsp;hydrochloric acid&nbsp;for&nbsp;pH&nbsp;control.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Clear, slightly greenish-yellow solution.<br><\/p>\n\n\n\n<p>The eye drops are packaged in a white low-density polyethylene (LDPE)&nbsp;drip bottle with a&nbsp;transparent&nbsp;low-density polyethylene (LDPE) drip device (which produces about 35 microliters) and a white high-density polyethylene (HDPE) drip device cap and placed in a carton.<br><\/p>\n\n\n\n<p>Pack sizes:<\/p>\n\n\n\n<p>1&#215;5 ml, 3&#215;5 ml, 6x5ml<\/p>\n\n\n\n<p>1&#215;10 ml, 3&#215;10 ml<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Hexal A \/ S, Edvard Thomsens Vej 14, 2300 Copenhagen S, Denmark<br><\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Pharma Stulln GmbH, Werksstrasse 3, 9251 Stulln, Germany<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Salutas Pharma GmbH, Otto-von-Guericke-Allee 1, 39179 Barleben, Germany<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>UAB Santonikas, 134B Veiveriu Street, 46353 Kaunas, Lithuania<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Brimonidine Hexal contains brimonidine tartrate which acts by lowering the pressure in the eyeball.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2202,2200],"tags":[8426,8428,8308,8312,8310,4501,8429,8311,8427,8309],"class_list":["post-6227","post","type-post","status-publish","format-standard","hentry","category-b","category-medicines","tag-brimonidine-hexal","tag-brimonidine-hexal-eye-drops","tag-brimonidine-tartrate","tag-brimonidine-tartrate-eye-drops","tag-brimonidine-tartrate-side-effects","tag-eye-drops","tag-what-brimonidine-hexal-is-used-for","tag-what-brimonidine-tartrate-is-used-for","tag-what-is-brimonidine-hexal","tag-what-is-brimonidine-tartrate"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6227","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6227"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6227\/revisions"}],"predecessor-version":[{"id":11834,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6227\/revisions\/11834"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6227"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6227"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6227"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}