{"id":6217,"date":"2021-01-03T14:57:11","date_gmt":"2021-01-03T14:57:11","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6217"},"modified":"2021-06-28T06:24:22","modified_gmt":"2021-06-28T06:24:22","slug":"bridion","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/bridion\/","title":{"rendered":"Bridion &#8211; Sugammadex uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n100 mg \/ ml&nbsp;injection&nbsp;solution&nbsp;<br>sugammadex<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Bridion is and what it is used for<\/h2>\n\n\n\n<p><strong>What Bridion is<\/strong><\/p>\n\n\n\n<p>Bridion contains the active substance sugammadex.&nbsp;Bridion is considered a&nbsp;<em>selective reversing agent<\/em>&nbsp;as it only works with specific muscle relaxants, rocuronium bromide and vecuronium bromide<br><\/p>\n\n\n\n<p><strong>What Bridion is used for<\/strong><\/p>\n\n\n\n<p>When undergoing certain types of surgeries, the muscles must be completely relaxed.&nbsp;This makes it easier for the&nbsp;surgeon&nbsp;to operate.&nbsp;For this reason, it contains the general anesthesia that you are given drugs that make the muscles relax.&nbsp;These are called&nbsp;<em>muscle relaxants<\/em>&nbsp;and include e.g.&nbsp;rocuronium bromide and vecuronium bromide.&nbsp;As these medicines also relax your respiratory muscles, you will need help to breathe (artificial respiration) during and after the operation until you can breathe again.<\/p>\n\n\n\n<p>Bridion is used to speed up the recovery of your muscles after an operation so that you can breathe again more quickly.&nbsp;It does this by binding to rocuronium bromide or vecuronium bromide in your body.&nbsp;It can be used by adults when rocuronium bromide or vecuronium bromide is used and by children and adolescents (aged 2 to 17 years) when rocuronium bromide is used for a moderate level of relaxation.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Bridion<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Bridion<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to sugammadex or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>\u2192 Tell your anesthetist if this applies to you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to an anesthetist before using Bridion<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or have had kidney disease.&nbsp;This is important because Bridion disappears from your body through the kidneys.<\/li><li>if you have or have had liver disease.<\/li><li>if you have fluid retention (&nbsp;edema&nbsp;).<\/li><li>if you have any disease that is known to increase the risk of bleeding (coagulation disorders) or if you are given blood thinners.<br><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine is not recommended for children under 2 years.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Bridion<\/h2>\n\n\n\n<p>\u2192 Tell your anesthetist if you are taking, have recently taken or might take any other medicines.&nbsp;Bridion may affect or be affected by other medicines.<br><\/p>\n\n\n\n<p><strong>Some medicines reduce the effect of Bridion<\/strong><\/p>\n\n\n\n<p>\u2192 It is especially important that you tell your anesthetist if you have recently taken:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>toremifene (used to treat breast cancer).<\/li><li>fusidic acid (an&nbsp;antibiotic&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Bridion may affect hormonal contraceptives<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bridion can make hormonal contraceptives &#8211; such as&nbsp;birth control pills,&nbsp;vaginal rings,&nbsp;implants,&nbsp;or IUDs &#8211; less effective, as it reduces the amount of the progestogen&nbsp;hormone.&nbsp;The amount of&nbsp;progestogen&nbsp;you lose is&nbsp;roughly equivalent to a forgotten tablet.<br><\/li><\/ul>\n\n\n\n<p>\u2192 If you are taking a&nbsp;<strong>pill<\/strong>&nbsp;on the same day as you receive Bridion, follow the advice given for a forgotten tablet in the package leaflet for the pill.<br><\/p>\n\n\n\n<p>\u2192 If you are using any&nbsp;<strong>other<\/strong>&nbsp;hormonal contraceptive (eg a&nbsp;vaginal ring,&nbsp;implant,&nbsp;or IUD), you should use an additional non-hormonal contraceptive (eg a condom) for the next 7 days and follow the advice given in the package leaflet.<br><\/p>\n\n\n\n<p><strong>Effect on blood tests<\/strong><\/p>\n\n\n\n<p>In general, Bridion does not affect laboratory tests.&nbsp;However, it can affect the results of blood tests for a&nbsp;hormone&nbsp;called&nbsp;progestogen&nbsp;.&nbsp;Tell your doctor if your progestogen levels need to be checked the day you receive Bridion.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>\u2192 Tell your anesthetist if you are or may be pregnant or if you are breast-feeding.<\/p>\n\n\n\n<p>You may still get Bridion, but you should discuss it first.<\/p>\n\n\n\n<p>It is unknown whether sugammadex is excreted in human milk.&nbsp;Your anesthetist will help you decide whether to discontinue breast-feeding or refrain from treatment with sugammadex after taking into account the benefit of breast-feeding to your baby and the benefit of Bridion to your mother.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Bridion has no known effect on your ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Bridion contains sodium<\/h2>\n\n\n\n<p>This medicine contains up to 9.7 mg&nbsp;sodium&nbsp;(the main ingredient in table salt \/ table salt) per milliliter.&nbsp;This corresponds to 0.5% of the maximum recommended daily&nbsp;sodium&nbsp;intake&nbsp;for adults.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How Bridion is given<\/h2>\n\n\n\n<p>Bridion will be given by an anesthetist, or under the supervision of an anesthetist.<br><\/p>\n\n\n\n<p><strong>Dos&nbsp;en<\/strong><\/p>\n\n\n\n<p>Your anesthetist will calculate the&nbsp;dose of&nbsp;Bridion you need based on:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>your weight.<\/li><li>how much the muscle relaxant drug still affects you.<\/li><\/ul>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is 2-4 mg per kg body weight.&nbsp;A&nbsp;dose&nbsp;of 16 mg \/ kg can be used in adults if a faster recovery from muscle relaxation is needed.<br><\/p>\n\n\n\n<p>Bridione&nbsp;dose&nbsp;one for children is 2 mg \/ kg (children and adolescents between 2-17 years).<br><\/p>\n\n\n\n<p><strong>How Bridion is given<\/strong><\/p>\n\n\n\n<p>Bridion will be given to you by your anesthetist.&nbsp;It is given as a single injection via an&nbsp;intravenous&nbsp;infarction.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Bridion than you should<\/h2>\n\n\n\n<p>Because your anesthesiologist will monitor your condition closely, you are unlikely to receive too much Bridion.&nbsp;Even if it did, it is unlikely to lead to any problems.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your anesthetist or another doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If these&nbsp;side effects&nbsp;occur while you are anesthetized, they will be noticed and treated by your anesthesiologist.<br><\/p>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Cough<\/li><li>Respiratory problems that may include coughing or movements such as waking up or taking a breath<\/li><li>Mild&nbsp;anesthesia&nbsp;&#8211; you may start to wake up from your deep sleep and need more&nbsp;anesthesia&nbsp;.&nbsp;This may cause you to move or cough at the end of the operation<\/li><li>Complications during treatment such as changes in heart rate, cough, or movements<\/li><li>Decreased&nbsp;blood pressure&nbsp;due to the surgery<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Shortness of breath caused by muscle spasms in the airways (&nbsp;bronchospasm&nbsp;), occurred in patients with a history of lung problems<\/li><li>Allergic reactions (drug hypersensitivity) &#8211; such as skin rash, redness of the skin, swelling of your tongue and\/or throat, shortness of breath, changes in&nbsp;blood pressure&nbsp;or heart rhythm, which sometimes lead to a severe drop in&nbsp;blood pressure.&nbsp;Severe allergic or allergy-like reactions that can be life-threatening.&nbsp;Allergic reactions were reported more frequently in healthy subjects who were conscious<\/li><li>Return of muscle relaxation after surgery<\/li><\/ul>\n\n\n\n<p><strong>Side effects&nbsp;are with no known frequency<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe cardiac arrest and cardiac arrest to cardiac arrest may occur when Bridion is given<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Bridion<\/h2>\n\n\n\n<p>The storage is handled by the medical staff.<br><\/p>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and label after &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.&nbsp;Do not freeze.&nbsp;Store the vials in the outer carton.&nbsp;Sensitive to light.<br><\/p>\n\n\n\n<p>After first opening and dilution, store at 2-8 \u00b0 C and use within 24 hours.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is sugammadex.&nbsp;<br>1 ml&nbsp;solution for injection&nbsp;contains sugammadex sodium equivalent to 100 mg sugammadex.&nbsp;<br>Each&nbsp;vial&nbsp;of 2 ml contains sugammadex corresponding to 200 mg sugammadex.&nbsp;<br>Each&nbsp;vial&nbsp;of 5 ml contains sugammadex equivalent to 500 mg sugammadex.<br><\/li><li>The other ingredients are water for injections, hydrochloric acid 3.7% and \/ or sodium hydroxide.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Bridion is a clear and colorless to slightly yellow&nbsp;solution for injection&nbsp;.<\/p>\n\n\n\n<p>It is available in two different packs, containing either 10 vials of 2 ml or 10 vials of 5 ml&nbsp;solution for injection&nbsp;.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Merck Sharp &amp; Dohme BV<\/p>\n\n\n\n<p>Waarderweg 39<\/p>\n\n\n\n<p>2031 BN Haarlem<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>NV Organon, Kloosterstraat 6, 5349 AB Oss, The Netherlands<\/li><\/ul>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>MSD Belgium BVBA \/ SPRLTel \/ Tel: +32 (0) 27766211dpoc_belux@merck.com<\/td><td><strong>Lithuania<\/strong>UAB Merck Sharp &amp; DohmeTel .: +370 5 278 02 47msd_lietuva@merck.com<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Mark Harp and Doom Bulgaria BulgariaTel: +359 2 819 3737info-msdbg@merck.com<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>MSD Belgium BVBA \/ SPRLTel \/ Tel: +32 (0) 27766211dpoc_belux@merck.com<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Merck Sharp &amp; Dohme sroTel .: +420 233 010 111dpoc_czechslovak@merck.com<\/td><td><strong>Hungary<\/strong>MSD Pharma Hungary Kft.Tel .: +36 1 888 5300hungary_msd@merck.com<\/td><\/tr><tr><td><strong>Denmark<\/strong>MSD Danmark ApSTel: +45 4482 4000dkmail@merck.com<\/td><td><strong>Malta<\/strong>Merck Sharp &amp; Dohme Cyprus LimitedTel: 8007 4433 (+356 99917558)malta&nbsp;<strong>_<\/strong>&nbsp;info @ merck&nbsp;<strong>.&nbsp;<\/strong>com<\/td><\/tr><tr><td><strong>Germany<\/strong>Gr\u00fcnenthal GmbHTel: +49 (0) 241 569 1111service@grunenthal.com<\/td><td><strong>The Netherlands<\/strong>Merck Sharp &amp; Dohme BVTel .: 0800 9999000 (+31 23 5153153)medicalinfo.nl@merck.com<\/td><\/tr><tr><td><strong>Eesti<\/strong>Merck Sharp &amp; Dohme O\u00dcTel: + 372 6144 200msdeesti@merck.com<\/td><td><strong>Norway<\/strong>MSD (Norway) ASTel: +47 32 20 73 00msdnorge@msd.no<\/td><\/tr><tr><td><strong>Elad<\/strong>MSD \u0391.\u03a6.\u0392.\u0395.\u0395.:\u0397\u03bb: + 30 210 98 97 300dpoc_greece@merck.com<\/td><td><strong>Austria<\/strong>Merck Sharp &amp; Dohme Ges.mbHTel: +43 (0) 1 26 044msd-medizin@merck.com<\/td><\/tr><tr><td><strong>Spain<\/strong>Merck Sharp &amp; Dohme de Espa\u00f1a, SATel: +34 91 321 06 00msd_info@merck.com<\/td><td><strong>Poland<\/strong>MSD Polska Sp.&nbsp;z ooTel .: +48 22 549 51 00msdpolska@merck.com<\/td><\/tr><tr><td><strong>France<\/strong>MSD FranceTel: + 33- (0) 1 80 46 40 40<\/td><td><strong>Portugal<\/strong>Merck Sharp &amp; Dohme, LdaTel: + 351 21 446 57 00inform_pt@merck.com<\/td><\/tr><tr><td><strong>Croatia<\/strong>Merck Sharp &amp; Dohme dooTel: + 385 1 6611 333croatia_info@merck.com<\/td><td><strong>Romania<\/strong>Merck Sharp &amp; Dohme Romania SRLTel: + 40 21 529 29 00msdromania@merck.com<\/td><\/tr><tr><td><strong>Ireland<\/strong>Merck Sharp and Dohme Ireland (&nbsp;Human&nbsp;Health) LimitedTel: +353 (0) 1 2998700medinfo_ireland@merck.com<\/td><td><strong>Slovenia<\/strong>Merck Sharp &amp; Dohme, an innovative freelance dooTel: + 386 1 5204201msd_slovenia@merck.com<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>Merck Sharp &amp; Dohme, sroTel: +421 2 58282010dpoc_czechslovak@merck.com<\/td><\/tr><tr><td><strong>Italy<\/strong>MSD Italia SrlTel: +39 06 361911medicalinformation.it@merck.com<\/td><td><strong>Finland \/ Finland<\/strong>MSD Finland OyPuh \/ Tel: +358 (0) 9 804650info@msd.fi<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>Merck Sharp &amp; Dohme Cyprus Limited:\u0397\u03bb: 800 00 673 (+357 22866700)cyprus&nbsp;<strong>_<\/strong>&nbsp;info @ merck&nbsp;<strong>.&nbsp;<\/strong>com<\/td><td><\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Merck Sharp &amp; Dohme LatvijaTel: + 371 67 364224msd_lv@merck.com<\/td><td><strong>United Kingdom<\/strong>Merck Sharp &amp; Dohme LimitedTel: + 44 (0) 1992 467272medicalinformationuk@merck.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Bridion contains the active substance sugammadex. Bridion is considered a selective reversing agent as it only works with specific muscle relaxants, rocuronium bromide and vecuronium bromide<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2202,2200],"tags":[8465,8469,8467,2215,8460,8462,8463,8468,8466,8461,8464],"class_list":["post-6217","post","type-post","status-publish","format-standard","hentry","category-b","category-medicines","tag-bridion","tag-bridion-injection","tag-bridion-side-effects","tag-injection","tag-sugammadex","tag-sugammadex-injection","tag-sugammadex-side-effects","tag-what-bridion-is-used-for","tag-what-is-bridion","tag-what-is-sugammadex","tag-what-sugammadex-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6217","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6217"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6217\/revisions"}],"predecessor-version":[{"id":11850,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6217\/revisions\/11850"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}