{"id":6201,"date":"2021-01-03T14:39:36","date_gmt":"2021-01-03T14:39:36","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6201"},"modified":"2021-06-28T07:38:35","modified_gmt":"2021-06-28T07:38:35","slug":"braftovi","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/braftovi\/","title":{"rendered":"Braftovi &#8211; Encorafenib uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n50 mg, 75 mg&nbsp;hard capsules&nbsp;<br>encorafenib<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Braftovi is and what it is used for<\/h2>\n\n\n\n<p>Braftovi is a cancer medicine that contains the active substance encorafenib.&nbsp;Changes (&nbsp;mutations&nbsp;) in the BRAF gene can give rise to&nbsp;proteins&nbsp;that cause the cancer to grow.&nbsp;Braftovi focuses on the&nbsp;proteins&nbsp;produced by this altered BRAF gene.<br><\/p>\n\n\n\n<p>It is used in combination with another medicine that contains binimetinib to treat adult patients with a type of skin cancer called&nbsp;melanoma&nbsp;when it has<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a specific change (&nbsp;mutation&nbsp;) in a gene responsible for producing a&nbsp;protein&nbsp;called BRAF, and<\/li><li>spread to other parts of the body, or can not be removed by surgery.<\/li><\/ul>\n\n\n\n<p>When Braftovi is used in combination with binimetinib, which targets another&nbsp;proteinthat stimulates the growth of cancer cells, the combination slows down the growth of the cancer or stops it completely.<br><\/p>\n\n\n\n<p>Braftovi is also used in combination with another medicine containing cetuximab for the treatment of adult patients with a type of colon cancer when it has<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a specific change (&nbsp;mutation&nbsp;) in a gene responsible for producing a&nbsp;protein&nbsp;called BRAF, and<\/li><li>spread to other parts of the body in patients who have previously been treated with other anticancer medicines.<\/li><\/ul>\n\n\n\n<p>When Braftovi is used in combination with cetuximab (which binds to the&nbsp;epidermalgrowth&nbsp;factor&nbsp;receptor (EGFR), a&nbsp;protein&nbsp;on the surface of certain cancer cells), the combination slows down or stops the growth of the cancer completely.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before taking Braftovi&nbsp;<\/h2>\n\n\n\n<p>Before starting treatment, your doctor will check if you have a&nbsp;mutation&nbsp;in the BRAF gene.<br><\/p>\n\n\n\n<p>Because Braftovi is to be used in combination with binimetinib to treat&nbsp;melanoma&nbsp;, you should read both the binimetinib leaflet and this leaflet carefully.<br><\/p>\n\n\n\n<p>Because Braftovi is to be used in combination with cetuximab to treat colon cancer, you should read both the cetuximab package leaflet and this leaflet carefully.<br><\/p>\n\n\n\n<p><strong>Do not take Braftovi<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to encorafenib or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist or nurse before taking Braftovi and tell us about all your medical problems, especially if you have any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart problems, e.g.&nbsp;change in the electrical activity of the heart (prolongation of&nbsp;QT interval&nbsp;)<\/li><li>bleeding problems or if you are taking any medicine that may cause bleeding<\/li><li>eye problems<\/li><li>liver or kidney problems.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you have had any type of cancer other than&nbsp;melanoma&nbsp;or colon cancer, as Braftovi may make certain types of cancer worse.<br><\/p>\n\n\n\n<p>Tell your doctor, pharmacist or nurse immediately if you receive any of the following while taking this medicine:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Heart problems: Braftovi taken with binimetinib may make your heart work worse, alter the heart&#8217;s electrical activity in a way called \u201c&nbsp;QT&nbsp;prolongation\u201d or aggravate pre-existing heart problems.&nbsp;Your doctor will check that your heart is functioning properly before and during treatment with these medicines.&nbsp;Talk to your doctor immediately if you experience any symptoms of heart problems such as feeling dizzy, tired or fainting, if you are short of breath, if you feel your heart pounding, rushing or beating irregularly, or if your legs are swollen.<br><\/li><li>Bleeding problems: Braftovi can cause serious bleeding problems.&nbsp;Tell your doctor immediately if you experience any symptoms of bleeding problems such as coughing up blood, having blood clots, vomiting blood or something resembling coffee grounds, red or black stools that look like tar, blood in the urine, abdominal pain or unusual vaginal bleeding.&nbsp;Also tell your doctor if you have a headache, feel dizzy or feel weak.<br><\/li><li>Eye problems: Braftovi can cause serious eye problems when taken with binimetinib.&nbsp;Talk to your doctor immediately if you get blurred vision, vision loss or other vision changes (eg colored dots in the&nbsp;field of vision&nbsp;) or halo (blurred contour around objects).&nbsp;Your doctor will examine your eyes for any vision problems when you take Braftovi.<br><\/li><li>Skin changes: Braftovi can cause other types of skin cancer such as squamous cell carcinoma of the skin.&nbsp;New&nbsp;melanoma&nbsp;can also occur when taking Braftovi.&nbsp;Your doctor will check your skin for new skin cancer before treatment, every two months during treatment and for up to 6 months after you stop taking Braftovi.&nbsp;Tell your doctor immediately if you notice any skin changes during or after treatment such as:&nbsp;a new wart&nbsp;<strong>,<\/strong>&nbsp;a wound or a reddish lump that is bleeding or does not want to heal or if you have a birthmark that grows or changes color.&nbsp;Your doctor will also need to examine you for squamous cell carcinoma of your head, neck, mouth and&nbsp;lymph nodes&nbsp;, and you will be examined by&nbsp;computed tomography.periodically.&nbsp;This is a precaution in the event that squamous cell carcinoma develops inside your body.&nbsp;Examination of the genitals (for women) and the anal area is also recommended before treatment and when it ends.<br><\/li><li>Liver problems: Braftovi can cause abnormal blood tests related to how your liver works (increased levels of liver enzymes).&nbsp;Your doctor will take blood samples to check your liver before and during treatment.<br><\/li><li>Kidney problems: Braftovi may alter renal function (usually abnormal blood tests, more rare dehydration and vomiting).&nbsp;Your doctor will take blood samples to check your kidneys before and during treatment.&nbsp;Drink plenty of fluids during treatment.&nbsp;Tell your doctor immediately if you vomit and become dehydrated.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Braftovi is not recommended for children and adolescents under 18 years of age.&nbsp;This drug has not been studied in this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Braftovi<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n<p>Some medicines may affect the way Braftovi works or increase the likelihood of&nbsp;side effects&nbsp;.<\/p>\n\n\n\n<p>It is especially important that you tell your doctor if you are taking any medicine on this list or any other medicine:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some medicines used to treat fungal infections (eg itraconazole, posaconazole,&nbsp;fluconazole&nbsp;)<\/li><li>Some medicines used to treat bacterial&nbsp;infections&nbsp;(eg rifampicin, clarithromycin, telithromycin, erythromycin,&nbsp;penicillin&nbsp;)<\/li><li>Drugs commonly used to treat&nbsp;epilepsy&nbsp;(seizures) (eg&nbsp;phenytoin&nbsp;, carbamazepine)<\/li><li>Drugs commonly used to treat cancer (eg methotrexate, imatinib)<\/li><li>Drugs commonly used to treat high&nbsp;cholesterol&nbsp;(eg rosuvastatin, atorvastatin)<\/li><li>(Traditional) herbal medicines for depression:&nbsp;St. John&#8217;s wort<\/li><li>Some medicines used to treat&nbsp;HIV&nbsp;(eg ritonavir, amprenavir, raltegravir, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tivicay\/\">dolutegravir<\/a>)<\/li><li>Contraceptives containing&nbsp;the hormone&nbsp;s<\/li><li>Medicines commonly used to treat high&nbsp;blood pressure&nbsp;(eg&nbsp;diltiazem&nbsp;,&nbsp;bosentan&nbsp;,&nbsp;furosemide&nbsp;)<\/li><li>One drug to treat irregular heartbeats:&nbsp;amiodarone<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Braftovi with food and drink<\/h2>\n\n\n\n<p>During your treatment with Braftovi, do not drink grapefruit juice, as Braftovi&#8217;s&nbsp;side effects&nbsp;may increase.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>Braftovi is not recommended during pregnancy.&nbsp;It can cause damage or malformations in the fetus.<\/p>\n\n\n\n<p>If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.<\/p>\n\n\n\n<p>If you are a woman and could become pregnant, you must use a reliable contraceptive while taking Braftovi, and you must continue to use a reliable contraceptive for at least one month after the last&nbsp;dose&nbsp;.&nbsp;Contraceptives that contain&nbsp;hormones&nbsp;(eg on&nbsp;pills&nbsp;, on syringes, on&nbsp;patches&nbsp;,&nbsp;implants&nbsp;and some&nbsp;IUDs&nbsp;that release&nbsp;hormones&nbsp;) may not work as well as expected while you are taking Braftovi.&nbsp;You should therefore use another reliable contraceptive method, e.g.&nbsp;a&nbsp;barrier method(such as a condom) so that you do not get pregnant while taking this medicine.&nbsp;Consult your doctor, pharmacist or nurse.<\/p>\n\n\n\n<p>Contact your doctor immediately if you become pregnant while taking Braftovi.<br><\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Braftovi is not recommended during breast-feeding.&nbsp;It is unknown whether Braftovi is excreted in human milk.&nbsp;If you are breast-feeding or planning to breast-feed, ask your doctor for advice before taking this medicine.<br><\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>Braftovi can reduce the number of sperm in men.&nbsp;It can affect the ability to get a woman pregnant.&nbsp;Talk to your doctor if you are worried about this.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Braftovi may affect your ability to drive or use machines.&nbsp;Avoid driving or using machines if you experience vision problems, or have any other&nbsp;side effects&nbsp;that may affect your ability to drive or use machines (see section 4) while taking Braftovi.<\/p>\n\n\n\n<p>Consult your doctor if you are unsure of your ability to drive.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Braftovi<\/h2>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p><em>For the treatment of&nbsp;melanoma<\/em><\/p>\n\n\n\n<p>The recommended&nbsp;dose of&nbsp;Braftovi for the treatment of&nbsp;melanoma&nbsp;is 6 capsules with 75 mg once daily (equivalent to a daily&nbsp;dose&nbsp;of 450 mg).&nbsp;You will also be treated with another medicine, binimetinib.<br><\/p>\n\n\n\n<p><em>For the treatment of colon cancer<\/em><\/p>\n\n\n\n<p>The recommended&nbsp;dose of&nbsp;Braftovi for the treatment of colon cancer is 4 capsules with 75 mg once daily (equivalent to a daily&nbsp;dose&nbsp;of 300 mg).&nbsp;You will also be treated with another medicine, cetuximab.<br><\/p>\n\n\n\n<p>If you have liver or kidney problems, your doctor may prescribe a lower&nbsp;dose&nbsp;.<\/p>\n\n\n\n<p>If you experience serious&nbsp;side effects&nbsp;(eg problems with your heart, eyes or bleeding), your doctor may reduce your&nbsp;dose&nbsp;, stop treatment or stop it altogether.<br><\/p>\n\n\n\n<p><strong>How to take Braftovi<\/strong><\/p>\n\n\n\n<p>Swallow the capsules whole with water.<\/p>\n\n\n\n<p>Braftovi can be taken with food or between meals.<br><\/p>\n\n\n\n<p><strong>If you vomit<\/strong><\/p>\n\n\n\n<p>If you vomit after taking Braftovi, do not take any extra&nbsp;dose&nbsp;.&nbsp;Take the next&nbsp;dose&nbsp;at the usual time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Braftovi than you should<\/h2>\n\n\n\n<p>If you take more than one capsule, contact your doctor, pharmacist or nurse immediately.&nbsp;Side effects&nbsp;of Braftovi such as nausea, vomiting, dehydration and blurred vision may occur or worsen.&nbsp;If possible, show this leaflet and the package leaflet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Braftovi<\/h2>\n\n\n\n<p>If you forget a&nbsp;dose of&nbsp;Braftovi, take it as soon as you remember.&nbsp;However, if the missed&nbsp;dose&nbsp;one should have been taken more than 12 hours ago, skip the one&nbsp;doseand take the next&nbsp;dose&nbsp;at the usual time.&nbsp;Then continue taking your capsules as usual.<\/p>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose&nbsp;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Braftovi<\/h2>\n\n\n\n<p>It is important that you take Braftovi for as long as your doctor prescribes it.&nbsp;Do not stop taking this medicine unless your doctor tells you to.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><br><\/p>\n\n\n\n<p><strong>Braftovi can cause serious&nbsp;side effects&nbsp;.&nbsp;Tell<\/strong>&nbsp;your&nbsp;<strong>doctor immediately if<\/strong>&nbsp;you get any of the following serious&nbsp;side effects&nbsp;, either for the first time or if they get worse (see also section 2):<br><\/p>\n\n\n\n<p>Heart problems: Braftovi may affect how well your heart is functioning (reducing the&nbsp;ejection fraction of the&nbsp;left ventricle&nbsp;) when taken with binimetinib.&nbsp;Signs and symptoms of this can be:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness, tiredness or feeling unsteady<\/li><li>shortness of breath<\/li><li>hard, fast or irregular heartbeat<\/li><li>swollen legs.<\/li><\/ul>\n\n\n\n<p>Eye problems: Braftovi can cause serious eye problems when taken with binimetinib, such as fluid leakage under the retina that causes different layers of the retina to become detached in the eye (retinal detachment).&nbsp;Contact your doctor immediately if you experience the following symptoms of eye problems:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blurred vision, vision loss, or other vision changes (eg colored dots in the&nbsp;field of view&nbsp;)<\/li><li>halo (blurred contour around objects)<\/li><li>eye pain.&nbsp;swelling or redness<\/li><\/ul>\n\n\n\n<p>Bleeding problems: Braftovi can cause serious bleeding problems.&nbsp;Tell your doctor immediately if you get any unusual signs of bleeding, for example:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache, dizziness or weakness<\/li><li>you cough up blood or coagulated blood<\/li><li>you vomit blood or something resembling coffee grounds<\/li><li>red or black stools that look like tar<\/li><li>blood in the urine<\/li><li>abdominal pain<\/li><li>unusual bleeding from the&nbsp;vagina&nbsp;.<\/li><\/ul>\n\n\n\n<p>Muscle problems: Braftovi may cause muscle breakdown (&nbsp;rhabdomyolysis&nbsp;) when taken with binimethinib.&nbsp;This can lead to&nbsp;kidney failure&nbsp;and can be life threatening.&nbsp;Signs and symptoms can be:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>muscle pain, cramps, stiffness or&nbsp;spasm&nbsp;s<\/li><li>dark-colored urine.<\/li><\/ul>\n\n\n\n<p>Other skin cancer:&nbsp;<strong>Treatment with Braftovi can result in a type of skin cancer, such as squamous cell carcinoma of the skin.&nbsp;These types of skin changes (see also section 2) are usually limited to a small area and can be removed by surgery.&nbsp;Braftovi treatment can be continued without interruption.&nbsp;Some people taking Braftovi may discover new&nbsp;melanoma&nbsp;.&nbsp;These&nbsp;melanomas&nbsp;are usually removed surgically and treatment with Braftovi can be continued without interruption.<\/strong><br><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>In addition to the serious&nbsp;side effects&nbsp;mentioned above, people taking Braftovi may also experience other&nbsp;side effects&nbsp;.<br><\/p>\n\n\n\n<p><strong>Side effects&nbsp;are when Braftovi and binimetinib are taken together&nbsp;<\/strong><strong>to treat&nbsp;melanoma<\/strong><br><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;)<\/li><li>problems with the nerves that can lead to pain, decreased sensation or tingling in the hands and feet<\/li><li>headache<\/li><li>dizziness<\/li><li>bleeding in various places in the body<\/li><li>high&nbsp;blood pressure<\/li><li>problems with your vision (visual impairment)<\/li><li>abdominal pain<\/li><li>diarrhea<\/li><li>vomiting<\/li><li>nausea<\/li><li>constipation<\/li><li>itching<\/li><li>dry skin<\/li><li>hair loss or thinning hair (&nbsp;alopecia&nbsp;)<\/li><li>different types of skin rashes<\/li><li>thickening of the outer layer of the skin<\/li><li>joint pain (&nbsp;arthralgia&nbsp;)<\/li><li>muscle pain, weakness or&nbsp;spasm&nbsp;s<\/li><li>back pain<\/li><li>pain in arms and legs<\/li><li>fever<\/li><li>swollen hands or feet (peripheral&nbsp;edema&nbsp;), local swelling<\/li><li>fatigue<\/li><li>abnormal results on blood tests for liver function<\/li><li>abnormal results on samples that measure creatine kinase in the blood (an&nbsp;enzyme present&nbsp;in the blood that may indicate muscle inflammation or muscle damage)<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>certain types of skin tumors such as skin papilloma and&nbsp;basal cell carcinoma<\/li><li>allergic reaction&nbsp;which may include swelling of the face and difficulty breathing<\/li><li>altered sense of taste<\/li><li>inflammation&nbsp;of the eye (&nbsp;uveitis&nbsp;)<\/li><li>blood clots<\/li><li>inflammation&nbsp;of the colon (&nbsp;colitis&nbsp;)<\/li><li>redness&nbsp;or cracked skin<\/li><li>inflammation&nbsp;of the fat layer under the skin, symptoms can be sore lumps in the skin<\/li><li>skin rash with flat discolored areas or raised lumps reminiscent of&nbsp;acne(acneiform&nbsp;dermatitis&nbsp;)<\/li><li>redness&nbsp;, flaky skin or blisters on hands and feet (&nbsp;palmar-plantar erythrodysesthesia&nbsp;or hand-foot syndrome)<\/li><li>kidney failure<\/li><li>abnormal results on kidney tests (increased&nbsp;creatinine&nbsp;)<\/li><li>abnormal results on blood tests for liver function (alkaline phosphatase in the blood)<\/li><li>abnormal results on blood tests for pancreatic function (amylase,&nbsp;lipase&nbsp;)<\/li><li>increased skin sensitivity to sunlight<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>weakness and paralysis of facial muscles<\/li><li>inflammation&nbsp;of the pancreas (&nbsp;pancreatitis&nbsp;) with severe abdominal pain.<\/li><\/ul>\n\n\n\n<p><strong>Side effects&nbsp;are when only Braftovi is used in&nbsp;clinical trials&nbsp;in patients with&nbsp;melanoma<\/strong><br><\/p>\n\n\n\n<p>If you continue to take Braftovi alone when you are temporarily taking the other medicine (binimetinib) as decided by your doctor, you may experience some of the&nbsp;side effects&nbsp;listed above, but the frequency may change (&nbsp;side effect&nbsp;may be more common or more unusual).<br><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fatigue<\/li><li>nausea<\/li><li>vomiting<\/li><li>constipation<\/li><li>different types of skin rashes<\/li><li>redness&nbsp;, flaky skin or blisters on hands and feet (&nbsp;palmar-plantar erythrodysesthesia&nbsp;or hand-foot syndrome)<\/li><li>thickening of the outer layer of the skin (&nbsp;hyperkeratosis&nbsp;)<\/li><li>dry skin<\/li><li>itching<\/li><li>abnormal hair loss or thinning hair (&nbsp;alopecia&nbsp;)<\/li><li>redness&nbsp;or cracked skin<\/li><li>darker skin<\/li><li>reduced appetite<\/li><li>sleep disorders (&nbsp;insomnia&nbsp;)<\/li><li>headache<\/li><li>problems with the nerves that can lead to pain, decreased sensation or tingling in the hands and feet<\/li><li>altered sense of taste<\/li><li>joint pain (&nbsp;arthralgia&nbsp;)<\/li><li>muscle aches, muscle spasms or muscle weakness<\/li><li>pain in the&nbsp;extremity&nbsp;er<\/li><li>back pain<\/li><li>fever<\/li><li>certain types of benign skin tumors such as pigment nevus (liver spots) and skin papillomas<\/li><li>abnormal results on blood tests showing liver function.<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reaction&nbsp;which may include swelling of the face and difficulty breathing<\/li><li>weakness and paralysis of facial muscles<\/li><li>fast heartbeat<\/li><li>skin rash with flat discolored areas or raised lumps reminiscent of&nbsp;acne(acneiform&nbsp;dermatitis&nbsp;)<\/li><li>flaky or scaly skin<\/li><li>inflammation&nbsp;of the joints (&nbsp;arthritis&nbsp;)<\/li><li>kidney failure<\/li><li>abnormal results on kidney tests (increased&nbsp;creatinine&nbsp;)<\/li><li>increased skin sensitivity to sunlight<\/li><li>abnormal results on blood tests for pancreatic function (&nbsp;lipase&nbsp;)&nbsp;<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a type of skin cancer called&nbsp;basal cell carcinoma<\/li><li>inflammation&nbsp;of the eye (&nbsp;uveitis&nbsp;)<\/li><li>inflammation&nbsp;of the pancreas (&nbsp;pancreatitis&nbsp;) with severe abdominal pain.<\/li><li>abnormal results on blood tests for pancreatic function (amylase)<\/li><\/ul>\n\n\n\n<p><strong>Side effects&nbsp;are when Braftovi and cetuximab are taken together to treat colon cancer<\/strong><\/p>\n\n\n\n<p>In addition to the serious&nbsp;side effects&nbsp;mentioned above, people taking Braftovi with cetuximab may also experience the following&nbsp;side effects&nbsp;.<br><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>new liver spots, so-called \u201cpigment nevus\u201d<\/li><li>reduced appetite<\/li><li>sleep disorders (&nbsp;insomnia&nbsp;)<\/li><li>problems with the nerves that can lead to pain, decreased sensation or tingling in the hands and feet<\/li><li>headache<\/li><li>bleeding in various places in the body<\/li><li>diarrhea<\/li><li>abdominal pain<\/li><li>nausea<\/li><li>vomiting<\/li><li>constipation<\/li><li>skin rash with flat discolored areas or raised lumps reminiscent of&nbsp;acne(acneiform&nbsp;dermatitis&nbsp;)<\/li><li>different types of skin rashes<\/li><li>dry skin<\/li><li>itching<\/li><li>joint pain (&nbsp;arthralgia&nbsp;) and musculoskeletal pain (musculoskeletal pain)<\/li><li>muscle aches, muscle weakness or muscle spasms<\/li><li>pain in the&nbsp;extremity&nbsp;er<\/li><li>back pain<\/li><li>fatigue<\/li><li>fever<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>certain types of skin tumors such as skin papillomas<\/li><li>allergic reaction&nbsp;which may include swelling of the face and difficulty breathing<\/li><li>dizziness<\/li><li>altered sense of taste<\/li><li>fast heartbeat<\/li><li>darker skin<\/li><li>redness&nbsp;, flaky skin or blisters on hands and feet (&nbsp;palmar-plantar erythrodysesthesia&nbsp;or hand-foot syndrome)<\/li><li>thickening of the outer layer of the skin (&nbsp;hyperkeratosis&nbsp;)<\/li><li>redness&nbsp;or cracked skin<\/li><li>hair loss or thinning hair (&nbsp;alopecia&nbsp;)<\/li><li>kidney failure<\/li><li>abnormal results on kidney tests (increased&nbsp;creatinine&nbsp;)<\/li><li>abnormal results on blood tests for liver function<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a type of skin cancer called&nbsp;basal cell carcinoma<\/li><li>inflammation&nbsp;of the pancreas (&nbsp;pancreatitis&nbsp;) which causes severe abdominal pain<\/li><li>flaky skin<\/li><li>abnormal results on blood tests for pancreatic function (amylase,&nbsp;lipase&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Braftovi<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Moisture sensitive.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p><strong>Content declaration<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is encorafenib.Braftovi 50 mg: One hard capsule contains 50 mg of encorafenib.Braftovi 75 mg: One hard capsule contains 75 mg of encorafenib.<\/li><li>Other ingredients are:<ul><li>Capsule contents &#8211; copovidone (E1208), poloxamer 188, microcrystalline cellulose (E460i), succinic acid (E363), crospovidone (E1202),&nbsp;colloidalanhydrous silica (E551), magnesium stearate (E470b)<\/li><li>Capsule shell &#8211; gelatin (E441), titanium dioxide (E171), red iron oxide (E172), yellow iron oxide (E172), black iron oxide (E172).<\/li><li>Ink: shellac (E904), black iron oxide (E172), propylene glycol (E1520).<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p><strong>Braftovi 50 mg hard capsules<\/strong><\/p>\n\n\n\n<p>The hard capsule (capsule) has an orange opaque top and skin-colored opaque bottom, marked with a stylized &#8220;A&#8221; on the top and &#8220;LGX 50mg&#8221; on the bottom.<\/p>\n\n\n\n<p>Braftovi 50 mg is available in packs of 28 capsules (7 blisters with 4 capsules in each) or 112 capsules (28 blisters with 4 capsules in each).&nbsp;Not all pack sizes may be marketed.<br><\/p>\n\n\n\n<p><strong>Braftovi 75 mg hard capsules<\/strong><\/p>\n\n\n\n<p>The hard capsule (capsule) has a skin-colored opaque upper part and a white opaque lower part, marked with a stylized &#8220;A&#8221; on the upper part and &#8220;LGX 75mg&#8221; on the lower part.<\/p>\n\n\n\n<p>Braftovi 75 mg is available in packs of 42 capsules (7 blisters with 6 capsules each) or 168 capsules (28 blisters with 6 capsules each).&nbsp;Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Pierre Fabre Medicine<\/p>\n\n\n\n<p>45, place Abel Gance<\/p>\n\n\n\n<p>92100 Boulogne-Billancourt<\/p>\n\n\n\n<p>France<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Pierre Fabre Medicine Production<\/p>\n\n\n\n<p>Aquitaine Pharm International 1<\/p>\n\n\n\n<p>Avenue du B\u00e9arn<\/p>\n\n\n\n<p>64320 Idron<\/p>\n\n\n\n<p>France<br><\/p>\n\n\n\n<p>or<br><\/p>\n\n\n\n<p>PIERRE FABRE MEDICAMENT PRODUCTION<\/p>\n\n\n\n<p>Progipharm site, rue du Lyc\u00e9e<\/p>\n\n\n\n<p>45500 GIEN<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Braftovi is a cancer medicine that contains the active substance encorafenib. Changes ( mutations ) in the BRAF gene can give rise to proteins that cause the cancer to grow. Braftovi focuses on the proteins produced by this altered BRAF gene.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2202,2200],"tags":[8532,8535,8534,8527,8530,8529,8536,8531,8533,8528],"class_list":["post-6201","post","type-post","status-publish","format-standard","hentry","category-b","category-medicines","tag-braftovi","tag-braftovi-capsule","tag-braftovi-side-effects","tag-encorafenib","tag-encorafenib-capsule","tag-encorafenib-side-effects","tag-what-braftovi-is-used-for","tag-what-encorafenib-is-used-for","tag-what-is-braftovi","tag-what-is-encorafenib"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6201","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6201"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6201\/revisions"}],"predecessor-version":[{"id":11878,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6201\/revisions\/11878"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6201"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6201"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6201"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}