{"id":6197,"date":"2021-01-03T14:33:30","date_gmt":"2021-01-03T14:33:30","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6197"},"modified":"2021-06-28T07:38:49","modified_gmt":"2021-06-28T07:38:49","slug":"bosulif","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/bosulif\/","title":{"rendered":"Bosulif &#8211; Bosutinib uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n100 mg, 400 mg, 500 mg&nbsp;film-coated tablets&nbsp;<br>bosutinib<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Bosulif is and what it is used for<\/h2>\n\n\n\n<p>Bosulif contains the active substance bosutinib.<br><\/p>\n\n\n\n<p>It is used to treat adult patients who have a type of&nbsp;leukemia&nbsp;called&nbsp;Philadelphia chromosome-positive (&nbsp;Ph-positive)&nbsp;chronic myeloid leukemia&nbsp;(CML) that has been recently diagnosed, and when previous drugs for the treatment of CML have not worked or are no longer suitable to use.&nbsp;Ph-positive KML is a blood cancer that causes the body to produce too many of a special type of&nbsp;white blood cell, so-called&nbsp;granulocytes.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of Bosulif or why it has been prescribed for you, ask your doctor.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Bosulif<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Bosulif<\/h2>\n\n\n\n<p>&#8211; if you are allergic to bosutinib or any of the other ingredients of this medicine (listed in section 6)<\/p>\n\n\n\n<p>&#8211; if your doctor has informed you that your liver is damaged and not functioning normally.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Bosulif:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you have or have had, liver problems.&nbsp;<\/strong>Tell your doctor if you have previously had liver problems such as&nbsp;hepatitis&nbsp;(&nbsp;infection&nbsp;or&nbsp;inflammation&nbsp;of the liver) of any kind, or have had any of the following signs and symptoms of liver problems:&nbsp;itching, yellowing of the eyes or skin, dark urine or pain or discomfort on the right side of the upper abdomen.&nbsp;Your doctor should then take blood samples to examine your liver function before starting treatment with Bosulif and during the first 3 months of treatment, and whenever justified.<\/li><li><strong>if you get diarrhea or vomiting.&nbsp;<\/strong>Tell your doctor if you get any of the following signs and symptoms: increased bowel movements per day (more than normal), more vomiting than before, blood in the vomit, stool, or urine, or if you have black stools (tar-colored).&nbsp;Ask your doctor if the treatment you receive for vomiting may increase the risk of developing&nbsp;cardiac arrhythmia&nbsp;(irregular heartbeat).&nbsp;It is especially important to consult your doctor if you want to use a medicine that contains domperidone for nausea and vomiting.&nbsp;If nausea and vomiting are treated with this type of medicine while taking Bosulif, the risk of dangerous cardiac arrhythmias (&nbsp;arrhythmias&nbsp;) may increase.<\/li><li><strong>if you have problems with bleeding.&nbsp;<\/strong>Tell your doctor if you notice any of the following signs and symptoms e.g.&nbsp;abnormal bleeding or bruising without injury.<\/li><li><strong>if you have an&nbsp;infection.&nbsp;<\/strong>Tell your doctor if you notice any of the following signs and symptoms e.g.&nbsp;fever, problems when you urinate such as a burning sensation, cough that you have not had before, or sore throat that you have not had before.<\/li><li>if you accumulate fluid.&nbsp;Tell your doctor if you notice any of the following signs and symptoms of fluid retention while you are being treated with Bosulif, such as swollen ankles, feet, or legs, difficulty breathing, chest pain, or cough (these may be signs of fluid retention in your lungs or chest).<\/li><li><strong>if you have heart problems.&nbsp;<\/strong>Tell your doctor if you have any heart disease such as irregular heartbeat (&nbsp;arrhythmia&nbsp;) or an abnormal electrical signal, the so-called &#8220;prolonged&nbsp;QT&nbsp;interval&#8221;.&nbsp;This is always important, but especially if you get diarrhea often or if the diarrhea is prolonged, as described above.&nbsp;Tell your doctor immediately if you faint (lose consciousness) or have irregular heartbeats while taking Bosulif, as it may be a sign of a serious heart condition.<\/li><li><strong>if you have been told that you have kidney problems.&nbsp;<\/strong>Tell your doctor if you urinate more often and produce more light-colored urine, or if you urinate less frequently and produce less urine with a darker color.&nbsp;Also tell your doctor if you lose weight or get swollen feet, ankles, legs, hands, and face.<\/li><li><strong>if you have ever had or may have a&nbsp;hepatitis&nbsp;B&nbsp;infection<\/strong>.&nbsp;The reason for this is that Bosulif can cause your&nbsp;hepatitis&nbsp;B to become active again, which in some cases can be fatal.&nbsp;Patients will be closely monitored by their doctor for signs of this&nbsp;infection&nbsp;before starting treatment.<\/li><li><strong>if you have or have had problems with the pancreas.&nbsp;<\/strong>Tell your doctor if you experience severe pain or discomfort in your abdomen.<\/li><li><strong>if you get any of the following symptoms: severe rash.&nbsp;<\/strong>Tell your doctor if you get signs or symptoms such as painful red or purple rashes that spread and blisters and\/or other injuries to the mucous membranes (eg in the mouth or on the lips).<\/li><li>if you get any of the following symptoms: pain in the side, blood in the urine,<strong> or decreased amount of urine.&nbsp;<\/strong>If your disease is very serious, your body may not be able to get rid of all the waste products from the dying cancer cells.&nbsp;This is called &#8220;tumor lysis syndrome&#8221; and can lead to&nbsp;kidney failure&nbsp;and heart problems within 48 hours after the first&nbsp;dose of&nbsp;Bosulif.&nbsp;Your doctor is aware of this and can prevent the problem by making sure you have a good enough fluid balance as well as by giving you other medicines.<\/li><\/ul>\n\n\n\n<p><strong>Sun \/ UV protection<\/strong><\/p>\n\n\n\n<p>You may become more sensitive to sun or UV rays while taking bosutinib.&nbsp;It is important to protect skin exposed to the sun and to use a sunscreen with a high sun protection factor (SPF).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Bosulif is not recommended for people under 18 years of age.&nbsp;The drug has not been studied in children and adolescents.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Bosulif<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription,&nbsp;vitamins&nbsp;and herbal medicines.&nbsp;Some medicines can affect the amount of Bosulif in your body.&nbsp;Tell your doctor if you are taking medicines containing the active substances listed below:<br><\/p>\n\n\n\n<p><strong>The following active substances may increase the risk of&nbsp;side effects&nbsp;from Bosulif:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ketoconazole&nbsp;, itraconazole, voriconazole, posaconazole and&nbsp;fluconazole&nbsp;used against fungal infections<\/li><li>clarithromycin, telithromycin, erythromycin and&nbsp;ciprofloxacin&nbsp;, used against bacterial infections<\/li><li>nefazodone, an antidepressant<\/li><li>mibefradil,&nbsp;diltiazem&nbsp;and verapamil, which are used to lower&nbsp;blood pressure&nbsp;in people with high&nbsp;blood pressure<\/li><li>ritonavir, lopinavir \/ ritonavir, indinavir, nelfinavir, saquvinavir, atazanavir, amprenavir, fosamprenavir and darunavir, used to treat&nbsp;HIV&nbsp;infections \/ AIDS<\/li><li>boceprevir and telaprevir, which are used to treat&nbsp;hepatitis&nbsp;C.<\/li><li>aprepitant, which is used to prevent and control nausea and vomiting<\/li><li>imatinib, which is used for a specific type of&nbsp;leukemia<\/li><li>crizotinib, which is used to treat a type of lung cancer called non-small cell lung cancer&nbsp;.<\/li><\/ul>\n\n\n\n<p><strong>The following active substances may reduce the effect of Bosulif:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rifampicin used to&nbsp;treat tuberculosis<\/li><li>phenytoin&nbsp;and carbamazepine used for&nbsp;epilepsy<\/li><li>bosentan&nbsp;, which is used to lower high blood pressure in the lungs (&nbsp;pulmonaryarterial&nbsp;hypertension&nbsp;)<\/li><li>nafcillin, an&nbsp;antibiotic&nbsp;for bacterial infections<\/li><li>St. John&#8217;s wort&nbsp;(a traditional herbal medicine), is used for mild depression<\/li><li>efavirenz and etravirine, which are used to treat&nbsp;HIV&nbsp;infections \/ AIDS<\/li><li>modafinil, which is used in certain sleep disorders.<\/li><\/ul>\n\n\n\n<p>These medicines should be avoided when you are treated with Bosulif.&nbsp;Tell your doctor if you are taking any of these medicines.&nbsp;Your doctor may change the&nbsp;dose ofone of these medicines, change the&nbsp;dose of&nbsp;one of Bosulif or give you another medicine.<br><\/p>\n\n\n\n<p><strong>The following active substances may affect the heart rhythm:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>amiodarone&nbsp;,&nbsp;disopyramide&nbsp;,&nbsp;procainamide&nbsp;,&nbsp;quinidine&nbsp;and sotalol, used in heart disease<\/li><li>chloroquine and halofantrine used against&nbsp;malaria<\/li><li>clarithromycin and moxifloxacin, which are&nbsp;antibiotics&nbsp;for bacterial infections<\/li><li>haloperidol&nbsp;, which is used in psychotic diseases such as&nbsp;schizophrenia<\/li><li>domperidone, which is used to treat nausea and vomiting or to stimulate the production of breast milk<\/li><li>methadone&nbsp;, a painkiller.<\/li><\/ul>\n\n\n\n<p>These medicines should be taken with caution when you are being treated with Bosulif.&nbsp;Tell your doctor if you are taking any of these medicines.<br><\/p>\n\n\n\n<p>There may also be other medicines than those mentioned here that can affect or be affected by Bosulif.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Bosulif with food, drink and alcohol<\/h2>\n\n\n\n<p>Do not take Bosulif with grapefruit or grapefruit juice, as it may increase the risk of&nbsp;side effects&nbsp;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Bosulif should not be used during pregnancy unless clearly necessary because it can harm the unborn baby.<\/p>\n\n\n\n<p>Talk to your doctor before taking Bosulif if you are pregnant or could become pregnant<\/p>\n\n\n\n<p>pregnant.<br><\/p>\n\n\n\n<p>Women taking Bosulif are advised to use effective contraception during treatment and for at least 1 month after the last&nbsp;dose&nbsp;.&nbsp;Vomiting and diarrhea can reduce the effect of&nbsp;birth control pills&nbsp;.<br><\/p>\n\n\n\n<p>There is a risk that treatment with Bosulif will lead to reduced&nbsp;fertility&nbsp;and you can therefore consult a doctor regarding the preservation of semen before starting treatment.<br><\/p>\n\n\n\n<p>Tell your doctor if you are breast-feeding.&nbsp;You should not breast-feed while you are being treated with Bosulif as it may harm your baby<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>If you feel dizzy, blurred or unusually tired, do not drive or use machines until these&nbsp;side effects&nbsp;have disappeared.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Bosulif contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per 100 mg, 400 mg or 500 mg tablet, ie it is essentially &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Bosulif<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>Bosulif is only prescribed by a doctor who has experience in the treatment of leukemia.<br><\/p>\n\n\n\n<p><strong>Dosage&nbsp;and&nbsp;administration<\/strong><br><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 400 mg once daily in patients with newly diagnosed CML.&nbsp;The recommended&nbsp;dose&nbsp;is 500 mg once daily in patients whose previous KML medications have not worked or are no longer suitable for use.&nbsp;If you have moderate or severe renal impairment, your doctor will reduce your&nbsp;dose&nbsp;by 100 mg once daily for moderate renal impairment and by an additional 100 mg once daily for severe renal impairment.&nbsp;Your doctor may adjust the&nbsp;dose&nbsp;using the 100 mg tablets depending on how you feel, how you react to the treatment and \/ or any&nbsp;side effects.are.&nbsp;Take the tablet (s) in the morning with food.&nbsp;Swallow the tablets whole with water.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Bosulif than you should&nbsp;<\/h2>\n\n\n\n<p>If you happen to take too many Bosulif tablets or a higher&nbsp;dose&nbsp;than you need, contact your doctor immediately for advice.&nbsp;Show the package or this information to your doctor, if possible.&nbsp;You may need medical attention.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Bosulif<\/h2>\n\n\n\n<p>If you forget to take a&nbsp;dose&nbsp;and it has not been 12 hours since you should have taken it, you should take your recommended&nbsp;dose&nbsp;.&nbsp;If more than 12 hours have passed, take the next&nbsp;dose the&nbsp;following day at the usual time.<\/p>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Bosulif<\/h2>\n\n\n\n<p>Do not stop taking Bosulif unless your doctor tells you to.&nbsp;If you can not take the medicine as prescribed by your doctor or if you no longer need it, contact your doctor immediately.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>You must contact your doctor immediately if you get any of these serious&nbsp;side effects(see also section 2, \u201cWhat you need to know before taking Bosulif\u201d):<br><\/p>\n\n\n\n<p><strong>Blood diseases.&nbsp;<\/strong>Tell your doctor immediately if you get any of the following symptoms: bleeding, fever, or bruising easily (you may have a blood disorder or&nbsp;lymphatic system&nbsp;disease&nbsp;).<br><\/p>\n\n\n\n<p><strong>Liver disease.&nbsp;<\/strong>Tell your doctor immediately if you get any of the following symptoms:&nbsp;itching&nbsp;, yellowing of the eyes or skin, dark urine and pain or discomfort in the upper right part of the stomach, or fever.<br><\/p>\n\n\n\n<p><strong>Diseases of the stomach \/ intestines.&nbsp;<\/strong>Tell your doctor immediately if you get stomach pain, heartburn, diarrhea, constipation, nausea or vomiting.<br><\/p>\n\n\n\n<p><strong>Heart problems.&nbsp;<\/strong>Tell your doctor if you have any heart disease such as an abnormal electrical signal, so-called &#8220;prolonged&nbsp;QT&nbsp;interval&#8221;, or if you faint (lose consciousness) or have irregular heartbeats while taking Bosulif.<br><\/p>\n\n\n\n<p><strong>Hepatitis&nbsp;B reactivation.&nbsp;<\/strong>Recurrence (reactivation) of&nbsp;hepatitis&nbsp;B&nbsp;infection&nbsp;when you have previously had&nbsp;hepatitis&nbsp;B (a liver infection).<br><\/p>\n\n\n\n<p><strong>Severe skin reactions.&nbsp;<\/strong>Tell your doctor immediately if you get any of these symptoms: painful red or purple rash that spreads, blisters and \/ or other damage to the mucous membranes (eg in the mouth or on the lips).<br><\/p>\n\n\n\n<p>Side effects&nbsp;of Bosulif may include:<br><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(may affect more than 1 in 10 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of&nbsp;platelets&nbsp;,&nbsp;red blood cells&nbsp;and \/ or&nbsp;neutrophils&nbsp;(a type of&nbsp;white blood cell&nbsp;)<\/li><li>diarrhea, vomiting, abdominal pain, nausea<\/li><li>fever, swollen hands, feet or swollen face, fatigue, weakness<\/li><li>respiratory tract infection<\/li><li>inflammation&nbsp;of the nose and throat (&nbsp;nasopharyngitis&nbsp;)<\/li><li>change of blood samples taken to see if Bosulif is affecting your liver and \/ or&nbsp;pancreas<\/li><li>reduced appetite<\/li><li>joint pain, back pain<\/li><li>headache<\/li><li>skin rash, which may be itchy and \/ or spread throughout the body<\/li><li>cough<\/li><li>shortness of breath<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;white blood cell count&nbsp;(&nbsp;leukopenia&nbsp;)<\/li><li>irritation of the stomach (&nbsp;gastritis&nbsp;), bleeding in the stomach or intestines<\/li><li>chest pain, pain<\/li><li>liver damage, abnormal liver function and liver disease<\/li><li>lung&nbsp;infection&nbsp;(&nbsp;pneumonia&nbsp;),&nbsp;influenza&nbsp;,&nbsp;bronchitis<\/li><li>abnormal heart rhythm that can lead to fainting, dizziness and palpitations<\/li><li>increased&nbsp;blood pressure<\/li><li>high potassium content in the blood, low phosphorus content in the blood, large fluid losses (dehydration)<\/li><li>muscle aches<\/li><li>a feeling of instability (dizziness), altered taste sensations (&nbsp;dysgeusia&nbsp;)<\/li><li>acute&nbsp;renal failure&nbsp;,&nbsp;renal failure&nbsp;, renal impairment<\/li><li>fluid around the lungs (fluid shedding in the alveoli)<\/li><li>fluid around the heart (fluid outflow into the pericardium)<\/li><li>tinnitus (&nbsp;tinnitus&nbsp;)<\/li><li>itching&nbsp;,&nbsp;hives&nbsp;,&nbsp;acne<\/li><li>photosensitivity reactions (sensitivity to UV rays from the sun and other light sources).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever associated with low&nbsp;white blood cell count&nbsp;(febrile&nbsp;neutropenia&nbsp;)<\/li><li>acute&nbsp;pancreatitis (&nbsp;acute&nbsp;pancreatitis&nbsp;)<\/li><li>liver damage<\/li><li>life-threatening&nbsp;allergic reaction&nbsp;(anaphylactic&nbsp;shock&nbsp;)<\/li><li>abnormal fluid accumulation in the lungs (&nbsp;acute&nbsp;pulmonary edema&nbsp;)<\/li><li>respiratory failure<\/li><li>allergic reaction<\/li><li>abnormally high&nbsp;blood pressure&nbsp;in the&nbsp;pulmonary&nbsp;artery&nbsp;(&nbsp;pulmonaryhypertension&nbsp;)<\/li><li>rash<\/li><li>inflammation&nbsp;of the pericardium (pericarditis).<\/li><li>significant decrease in the number of&nbsp;granulocytes&nbsp;(a type of&nbsp;white blood cell&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe skin disease (erythema multiforme,&nbsp;Stevens-Johnson syndrome&nbsp;,&nbsp;toxic epidermal necrolysis&nbsp;) due to an&nbsp;allergic reaction&nbsp;, scaly rash.<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Bosulif<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the blister and carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/li><li>No special storage instructions.<\/li><li>Do not use this medicine if the package is damaged or appears to have been tampered with.<\/li><li>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>&#8211; The active substance is bosutinib.&nbsp;Bosulif film-coated tablets are available in different strengths.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bosulif 100 mg: each film-coated tablet contains 100 mg bosutinib (as monohydrate).<\/li><li>Bosulif 400 mg: each film-coated tablet contains 400 mg bosutinib (as monohydrate).<\/li><li>Bosulif 500 mg: each film-coated tablet contains 500 mg bosutinib (as monohydrate).<\/li><li>The other ingredients are: microcrystalline cellulose (E460), croscarmellose sodium (E468), poloxamer 188, povidone (E1201) and magnesium stearate (E470b).&nbsp;The film coating of the tablet contains polyvinyl alcohol, titanium dioxide (E171), macrogol 3350, talc (E553b) and yellow iron oxide (E172, in Bosulif 100 mg and 400 mg) or red iron oxide (E172, in Bosulif 400 mg and 500 mg).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Bosulif 100 mg film-coated tablets are yellow, oval, biconvex, with \u201cPfizer\u201d debossed on one side and \u201c100\u201d on the other.<\/p>\n\n\n\n<p>Bosulif 100 mg comes in blister packs of either 14 or 15 film-coated tablets in cartons of 28, 30 or 112 film-coated tablets.<br><\/p>\n\n\n\n<p>Bosulif 400 mg film-coated tablets are orange, oval, biconvex, with \u201cPfizer\u201d debossed on one side and \u201c400\u201d on the other.<\/p>\n\n\n\n<p>Bosulif 400 mg comes in blister cards of either 14 or 15 film-coated tablets in cartons of 28 or 30 film-coated tablets.<br><\/p>\n\n\n\n<p>Bosulif 500 mg film-coated tablets are red, oval, biconvex, with \u201cPfizer\u201d debossed on one side and \u201c500\u201d on the other.<\/p>\n\n\n\n<p>Bosulif 500 mg comes in blister packs of either 14 or 15 film-coated tablets in cartons of 28 or 30 film-coated tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Pfizer Europe MA EEIG<\/p>\n\n\n\n<p>Boulevard de la Plaine 17<\/p>\n\n\n\n<p>1050 Brussels<\/p>\n\n\n\n<p>Belgium<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Pfizer Manufacturing Deutschland GmbH<\/p>\n\n\n\n<p>Company Freiburg<\/p>\n\n\n\n<p>Mooswaldallee 1<\/p>\n\n\n\n<p>79090 Freiburg<\/p>\n\n\n\n<p>Germany<br><\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgique \/ Belgi\u00eb \/ Belgien<\/strong>Pfizer SA \/ NVTel: +32 (0) 2 554 62 11<\/td><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel.&nbsp;+ 370 52 51 4000<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Pfizer Luxembourg SAAR\u041b, Clone of BulgariaTel: +359 2 970 4333<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Pfizer SATel: +32 (0) 2 554 62 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer, spol.sroTel .: + 420-283-004-111<\/td><td><strong>Hungary<\/strong>Pfizer Kft.Tel .: + 36-1-488-37-00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Pfizer ApSTel: +45 44 20 11 00<\/td><td><strong>Malta<\/strong>Vivian Corporation Ltd.Tel: +356 21344610<\/td><\/tr><tr><td><strong>Germany<\/strong>Pfizer Pharma GmbHTel: +49 (0) 30 550055 51000<\/td><td><strong>The Netherlands<\/strong>Pfizer BVTel: +31 (0) 10 406 43 01<\/td><\/tr><tr><td><strong>Eesti<\/strong>Pfizer Luxembourg SARL Eesti subsidiaryTel .: +372 666 7500<\/td><td><strong>Norway<\/strong>Pfizer ASTel: +47 67 52 61 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Pfizer A\u03bb\u03bb\u03ac\u03c2 AE:\u0397\u03bb: +30 210 6785 800<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHTel: +43 (0) 1 521 15-0<\/td><\/tr><tr><td><strong>Spain<\/strong>Pfizer, SLTel: +34 91 490 99 00<\/td><td><strong>Poland<\/strong>Pfizer Polska Sp.&nbsp;z oo&nbsp;Tel: +48 22 335 61 00<\/td><\/tr><tr><td><strong>France<\/strong>PfizerTel: +33 (0) 1 58 07 34 40<\/td><td><strong>Portugal<\/strong>Pfizer Laboratories, Lda.Tel: +351 21 423 5500<\/td><\/tr><tr><td><strong>Croatia<\/strong>Pfizer Croatia dooTel: +385 1 3908 777<\/td><td><strong>Romania<\/strong>Pfizer Romania SRLTel: +40 (0) 21 207 28 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandTel: 1800 633 363 (toll free)+44 (0) 1304 616161<\/td><td><strong>Slovenia<\/strong>Pfizer Luxembourg SARLPfizer, a company in the field of pharmaceuticals, LjubljanaTel .: + 386 (0) 1 52 11 400<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hf.Phone: +354 540 8000<\/td><td><strong>Slovak Republic<\/strong>Pfizer Luxembourg SARL, organizerTel .: + 421 2 3355 5500<\/td><\/tr><tr><td><strong>Italy<\/strong>Pfizer SrlTel: +39 06 33 18 21<\/td><td><strong>Finland \/ Finland<\/strong>Pfizer OyPuh.\/Tel: +358 (0) 9 43 00 40<\/td><\/tr><tr><td><strong>\u038e\u03c0\u03c1\u03bf\u03c2<\/strong>Pfizer \u0391\u03bb\u03bb\u03ac\u03c2 \u0391.\u0395.&nbsp;(Cyprus Branch)T\u03b7\u03bb .: + 357 22 81 7690<\/td><td><\/td><\/tr><tr><td><strong>Latvia<\/strong>Pfizer Luxembourg SARL subsidiary Latvij\u0101Tel .: + 371 670 35 775<\/td><td><strong>United Kingdom<\/strong>Pfizer LimitedTel: +44 (0) 1304 616161<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>It is used to treat adult patients who have a type of leukemia called Philadelphia chromosome-positive ( Ph-positive) chronic myeloid leukemia (CML) that has been recently diagnosed, and when previous drugs for the treatment of CML have not worked or are no longer suitable to use. Ph-positive KML is a blood cancer that causes the body to produce too many of a special type of white blood cell, so-called granulocytes.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2202,2200],"tags":[8554,8556,8558,8549,8551,8553,2210,8557,8552,8555,8550],"class_list":["post-6197","post","type-post","status-publish","format-standard","hentry","category-b","category-medicines","tag-bosulif","tag-bosulif-side-effects","tag-bosulif-tablet","tag-bosutinib","tag-bosutinib-side-effects","tag-bosutinib-tablet","tag-tablet","tag-what-bosulif-is-used-for","tag-what-bosutinib-is-used-for","tag-what-is-bosulif","tag-what-is-bosutinib"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6197"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6197\/revisions"}],"predecessor-version":[{"id":11880,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6197\/revisions\/11880"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}