{"id":6195,"date":"2021-01-03T14:31:59","date_gmt":"2021-01-03T14:31:59","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6195"},"modified":"2021-06-29T07:10:54","modified_gmt":"2021-06-29T07:10:54","slug":"bosentan-aurobindo","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/bosentan-aurobindo\/","title":{"rendered":"Bosentan Aurobindo &#8211; Bosentan uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n62.5 mg, 125 mg&nbsp;film-coated tablets&nbsp;<br><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tracleer\/\">bosentan<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Bosentan Aurobindo is and what it is used for<\/h2>\n\n\n\n<p>Bosentan&nbsp;Aurobindo tablets contain&nbsp;bosentan, which blocks a naturally occurring&nbsp;hormone&nbsp;called endothelin-1 (ET-1) which causes the blood vessels to become narrow.&nbsp;Bosentan&nbsp;Aurobindo, therefore, causes the blood vessels to dilate and belongs to a group of medicines called &#8220;endothelin receptor antagonists&#8221;.<br><\/p>\n\n\n\n<p>Bosentan&nbsp;Aurobindo is used to treat:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Pulmonary&nbsp;arterial&nbsp;hypertension&nbsp;(PAH):<\/strong>&nbsp;PAH is a disease that leads to severe narrowing of the blood vessels in the lungs.&nbsp;As a result, high&nbsp;blood pressure occurs in the blood vessels in the lungs (pulmonary arteries) that transport blood from the heart to the lungs.&nbsp;This pressure reduces the amount of oxygen that can enter the blood in the lungs, making physical activity more difficult.&nbsp;BosentanAurobindo&nbsp;dilates the&nbsp;pulmonary arteries and makes it easier for the heart to pump blood through them.&nbsp;This lowers&nbsp;blood pressure&nbsp;and relieves symptoms.<\/li><\/ul>\n\n\n\n<p>Bosentan&nbsp;Aurobindo is used to treat patients with&nbsp;pulmonary&nbsp;arterial&nbsp;hypertension(PAH) class III to improve their ability to work (the ability to perform physical activity) and their symptoms.&nbsp;The class shows the severity of the disease, where class III means that physical activity is markedly limited.&nbsp;Class II means that physical activity is easily limited.&nbsp;PAHs for which&nbsp;Bosentan&nbsp;Aurobindo is used may be:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>primary (without identified cause or hereditary);<\/li><li>caused by&nbsp;scleroderma&nbsp;(also called systemic sclerosis, a disease with abnormal growth of connective tissue that supports the skin and other organs);<\/li><li>caused by congenital (congenital) heart defects where&nbsp;shunts&nbsp;(abnormal connections) cause an abnormal blood flow through the heart and lungs.<br><\/li><li><strong>Digital sores<\/strong>&nbsp;(sores on the fingers and toes) in adult patients with a condition called&nbsp;scleroderma.&nbsp;Bosentan&nbsp;Aurobindo reduces the number of new wounds on fingers and toes that occur.<\/li><\/ul>\n\n\n\n<p>Bosentan contained&nbsp;in&nbsp;Bosentan&nbsp;Aurobindo may also be approved for the treatment of other diseases not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have further questions and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Bosentan Aurobindo<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Bosentan Aurobindo<\/h2>\n\n\n\n<p><strong>Do not&nbsp;take Bosentan&nbsp;Aurobindo:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic to bosentan <\/strong>or any of the other ingredients of this medicine (listed in section 6).<\/li><li><strong>if you have liver problems<\/strong>&nbsp;(ask your doctor)<\/li><li><strong>if you are pregnant or may become pregnant<\/strong>&nbsp;because you are not using reliable contraception.&nbsp;Read the information under &#8220;Contraceptives&#8221; and &#8220;Other drugs and&nbsp;Bosentan&nbsp;Aurobindo&#8221;<\/li><li><strong>if you are taking ciclosporin A<\/strong>&nbsp;(a medicine used after a transplant or to treat&nbsp;psoriasis&nbsp;)<\/li><\/ul>\n\n\n\n<p>If any of these apply to you, talk to your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using&nbsp;Bosentan&nbsp;Aurobindo.<br><\/p>\n\n\n\n<p><strong>Checks that your doctor will do before treatment<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood tests to check liver function<\/li><li>blood tests to check&nbsp;anemia&nbsp;(&nbsp;anemia, low&nbsp;hemoglobin&nbsp;)<\/li><li>pregnancy test, if you are a woman of childbearing age<\/li><\/ul>\n\n\n\n<p>Some patients&nbsp;taking Bosentan&nbsp;Aurobindo have had abnormal liver function tests and&nbsp;anemia&nbsp;(low&nbsp;hemoglobin&nbsp;).<br><\/p>\n\n\n\n<p><strong>Checks that your doctor will do during treatment<\/strong><\/p>\n\n\n\n<p>Your doctor will arrange regular blood tests to check for changes in liver function and hemoglobin levels during treatment with&nbsp;Bosentan&nbsp;Aurobindo.<br><\/p>\n\n\n\n<p>For all these tests, see also the patient care (in the package of&nbsp;Bosentan&nbsp;Aurobindo tablets).&nbsp;It is important that these regular blood tests are taken throughout the time you take&nbsp;Bosentan&nbsp;Aurobindo.&nbsp;We suggest that you write down the date of the last test and also the next test (ask your doctor about the date) on the patient card, as help to remember when the next test is to be taken.<br><\/p>\n\n\n\n<p><strong>Blood tests for liver function<\/strong><\/p>\n\n\n\n<p>These will be taken once a month throughout treatment with&nbsp;Bosentan&nbsp;Aurobindo.&nbsp;After an increase in&nbsp;dose&nbsp;one, an extra sample will be taken after 2 weeks.<br><\/p>\n\n\n\n<p><strong>Blood tests for&nbsp;anemia&nbsp;(&nbsp;anemia&nbsp;)<\/strong><\/p>\n\n\n\n<p>This will be done once a month during the first 4 months of treatment and then once every 3 months, as patients taking&nbsp;Bosentan&nbsp;Aurobindo may&nbsp;develop&nbsp;anemia.<br><\/p>\n\n\n\n<p>If the results are abnormal, your doctor may decide to reduce the&nbsp;dose&nbsp;one or stop treatment with&nbsp;Bosentan&nbsp;Aurobindo and do further&nbsp;tests&nbsp;to investigate the cause.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Bosentan&nbsp;Aurobindo is not recommended for children with systemic sclerosis and ongoing disease with digital ulcers.&nbsp;See also section 3, How to take&nbsp;BosentanAurobindo.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Bosentan Aurobindo<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.&nbsp;It is especially important that you tell your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ciclosporin A (a medicine used after transplants and to treat&nbsp;psoriasis&nbsp;), which should not be used with&nbsp;Bosentan&nbsp;Aurobindo.<\/li><li>sirolimus or tacrolimus, which are medicines used after transplants, as these are not recommended for use with&nbsp;Bosentan&nbsp;Aurobindo<\/li><li>glibenclamide (for&nbsp;diabetes&nbsp;), rifampicin (for the treatment of&nbsp;tuberculosis&nbsp;)&nbsp;fluconazole&nbsp;and&nbsp;ketoconazole&nbsp;(for the treatment of fungal infections), nevirapine (for the treatment of&nbsp;HIV&nbsp;) as these medicines are not recommended for use with&nbsp;Bosentan&nbsp;Aurobindo<\/li><li>other medications for treating&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;that can be checked particularly if used in combination with&nbsp;bosentan&nbsp;Aurobindo<\/li><li>hormonal contraceptives, which are not effective as the only method of contraception when taking&nbsp;Bosentan&nbsp;Aurobindo.&nbsp;Inside your&nbsp;Bosentan&nbsp;Aurobindo&nbsp;packaging&nbsp;is patient care for patients that you should read carefully.&nbsp;Your doctor and\/or gynecologist will determine which contraceptives are right for you<\/li><li>other medicines for the treatment of pulmonary hypertension: sildenafil and tadalafil<\/li><li>warfarin&nbsp;(a blood thinner)<\/li><li>simvastatin&nbsp;(used to treat&nbsp;hypercholesterolemia&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Bosentan Aurobindo with food, drink, and alcohol<\/h2>\n\n\n\n<p>Bosentan&nbsp;Aurobindo can be taken with or without food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p><strong>Women of&nbsp;childbearing&nbsp;age<\/strong><\/p>\n\n\n\n<p>Do NOT&nbsp;take Bosentan&nbsp;Aurobindo if you are pregnant or planning to become pregnant.<br><\/p>\n\n\n\n<p><strong>Pregnancy test<\/strong><\/p>\n\n\n\n<p>Bosentan&nbsp;Aurobindo can harm unborn babies born before or during treatment.&nbsp;If you are a woman and could become pregnant, your doctor will ask you to undergo a pregnancy test before you start taking&nbsp;Bosentan&nbsp;Aurobindo, and regularly during the time you are taking&nbsp;Bosentan&nbsp;Aurobindo.<br><\/p>\n\n\n\n<p><strong>Contraceptive<\/strong><\/p>\n\n\n\n<p>If it is possible that you may become pregnant, use a safe method of contraception when taking&nbsp;Bosentan&nbsp;Aurobindo.&nbsp;Your doctor or gynecologist can advise you on reliable contraceptive methods while using&nbsp;Bosentan&nbsp;Aurobindo.&nbsp;Since&nbsp;BosentanAurobindo may make hormonal contraception (e.g., oral, injectable, implantable, or p-&nbsp;patches&nbsp;) ineffective, this alone no sure method.&nbsp;Therefore, if you use hormonal contraceptives, you must also use a&nbsp;barrier method&nbsp;(eg condoms for women,&nbsp;diapers, contraceptive pillows or your partner must also use a condom).&nbsp;Inside the&nbsp;BosentanAurobindo packaging is a patient card.&nbsp;You should complete this card and take it with you to your doctor at your next visit so that your doctor or gynecologist can evaluate whether you need additional or alternative reliable contraceptive methods.&nbsp;Pregnancy tests are recommended every month while you are taking&nbsp;Bosentan&nbsp;Aurobindo if you are of&nbsp;childbearing potential.<br><\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Tell your doctor immediately if you are breast-feeding.&nbsp;It is recommended that you&nbsp;stop breastfeeding&nbsp;if you are&nbsp;prescribed Bosentan&nbsp;Aurobindo.&nbsp;It is not known whether this medicine is passed on to breast milk.<br><\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>If you are a man and use&nbsp;Bosentan&nbsp;Aurobindo, it is possible that the medicine may reduce the number of sperm.&nbsp;It can not be ruled out that this may affect your ability to have children.&nbsp;Talk to your doctor if you have any questions or concerns about this.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Bosentan&nbsp;Aurobindo has no or negligible influence on the ability to drive and use machines.&nbsp;Bosentan&nbsp;Aurobindo may cause&nbsp;hypotension&nbsp;(low&nbsp;blood pressure&nbsp;) which may make you feel dizzy, affect your vision and your ability to drive and use machines.&nbsp;Therefore, if you feel dizzy or if your vision is impaired while taking&nbsp;Bosentan&nbsp;Aurobindo, do not drive or use any tools or machines.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Bosentan Aurobindo<\/h2>\n\n\n\n<p>Treatment with&nbsp;Bosentan&nbsp;Aurobindo should only be started and followed up by a doctor who has experience in the treatment of PAH or systemic sclerosis.&nbsp;Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p><strong>Recommended&nbsp;dose<\/strong><\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p>Treatment is usually started with 62.5 mg twice daily (morning and evening) for the first 4 weeks.&nbsp;Thereafter, your doctor will usually prescribe a 125 mg tablet twice daily, depending on how you react to&nbsp;bosentan.<br><\/p>\n\n\n\n<p><strong>How to take&nbsp;Bosentan&nbsp;Aurobindo<\/strong><\/p>\n\n\n\n<p>The tablets should be taken twice daily (morning and evening), should be swallowed with water, and can be taken with or without food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>The dose&nbsp;recommended for children only applies to PAHs.&nbsp;In children 1 year of age and older, treatment is usually started at 2 mg\/kg body weight twice daily (morning and evening).&nbsp;Your doctor will tell you how to dose.<br><\/p>\n\n\n\n<p>Please note&nbsp;that other&nbsp;preparations&nbsp;of&nbsp;bosentan are&nbsp;also available, which may facilitate the correct&nbsp;dosing&nbsp;for children and patients with low body weight or patients who have difficulty swallowing film-coated tablets.<br><\/p>\n\n\n\n<p>If you have the impression that the effect of&nbsp;Bosentan&nbsp;Aurobindo is too strong or too weak, talk to your doctor as your&nbsp;dose&nbsp;may need to be changed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Bosentan Aurobindo<\/h2>\n\n\n\n<p>If you forget to take&nbsp;Bosentan&nbsp;Aurobindo, take a&nbsp;dose&nbsp;as soon as you remember.&nbsp;Then continue to take your tablets at the usual times.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for forgotten tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Bosentan Aurobindo<\/h2>\n\n\n\n<p>If you suddenly stop&nbsp;taking Bosentan&nbsp;Aurobindo treatment,&nbsp;your&nbsp;symptoms may getworse.&nbsp;Do not&nbsp;stop taking Bosentan&nbsp;Aurobindo unless your doctor&nbsp;tells&nbsp;you to.&nbsp;Your doctor may instruct you to reduce your&nbsp;dose&nbsp;for a few days before stopping completely.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<br><\/p>\n\n\n\n<p>The most serious&nbsp;side effects&nbsp;with&nbsp;Bosentan&nbsp;Aurobindo are<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Abnormal liver function, which may occur in more than 1 in 10 people<\/li><li>Anemia&nbsp;(low blood count), which can occur in up to 1 in 10 people.&nbsp;Anemia&nbsp;can sometimes require blood&nbsp;transfusions.<\/li><\/ul>\n\n\n\n<p>Your liver and blood levels will be monitored during your treatment with&nbsp;BosentanAurobindo (see section 2).&nbsp;It is important that you take these samples as prescribed by your doctor.<br><\/p>\n\n\n\n<p>Symptoms that indicate that your liver is not functioning normally include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea (feeling the need to vomit)<\/li><li>vomiting<\/li><li>fever<\/li><li>stomach ache<\/li><li>jaundice (yellowing of the skin or whites of the eyes)<\/li><li>dark-colored urine<\/li><li>skin itching<\/li><li>listlessness or fatigue (unusual tiredness or fatigue)<\/li><li>flu-like symptoms&nbsp;(muscle and joint pain with fever)<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor immediately if<\/strong>&nbsp;you experience any of these&nbsp;side effects.<br><\/p>\n\n\n\n<p><strong>Other side effects:<\/strong><br><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect&nbsp;<strong>more than 1 in 10<\/strong>&nbsp;people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Edema&nbsp;(swelling of the legs and ankles or other symptoms of fluid retention)<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect&nbsp;<strong>up to 1&nbsp;<\/strong>&nbsp;<strong>in&nbsp;<\/strong>&nbsp;<strong>10<\/strong>&nbsp;people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sudden reddening of the face or redness of the skin<\/li><li>Hypersensitivity reaction&nbsp;(with skin inflammation,&nbsp;itching,&nbsp;and rash)<\/li><li>Gastroesophageal reflux disease&nbsp;(acid reflux)<\/li><li>Diarrhea<\/li><li>Short-term loss of consciousness (fainting)<\/li><li>Palpitations (fast or irregular heartbeat)<\/li><li>Low&nbsp;blood pressure<\/li><li>Nasal congestion<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect&nbsp;<strong>up to 1<\/strong>&nbsp;in&nbsp;<strong>100<\/strong>&nbsp;people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Thrombocytopenia&nbsp;(lack of&nbsp;platelets&nbsp;)<\/li><li>Neutropenia\/leukopenia (low&nbsp;white blood cell count&nbsp;)<\/li><li>Elevated liver enzyme levels with&nbsp;hepatitis&nbsp;(&nbsp;inflammation&nbsp;of the liver) including possible worsening of underlying&nbsp;hepatitis&nbsp;and\/or jaundice (yellowing of the skin or whites of the eyes).<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect&nbsp;<strong>up to 1<\/strong>&nbsp;in&nbsp;<strong>1,000<\/strong>&nbsp;people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anaphylactic reactions (general&nbsp;allergic reaction&nbsp;),&nbsp;angioedema&nbsp;(swelling, usually around the eyes, lips, tongue, or throat)<\/li><li>Cirrhosis&nbsp;(scarring) in the liver, liver failure (a severe disorder of liver function)<\/li><\/ul>\n\n\n\n<p>Blurred vision has also been reported with an unknown frequency (frequency cannot be calculated from available data).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Additional side effects in children and adolescents<\/h2>\n\n\n\n<p>Children treated with&nbsp;Bosentan&nbsp;Aurobindo have the same reported&nbsp;side effects&nbsp;as adults.<br><\/p>\n\n\n\n<p><strong>Reporting of&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>If you get&nbsp;any side effects&nbsp;, talk to your doctor or pharmacist.&nbsp;This also applies to&nbsp;side effects&nbsp;that are not mentioned in this information.&nbsp;You can also report&nbsp;side effectsdirectly via<\/p>\n\n\n\n<p>The Medical Products Agency<\/p>\n\n\n\n<p>Box 26<\/p>\n\n\n\n<p>751 03 Uppsala<\/p>\n\n\n\n<p>Website:&nbsp;www.lakemedelsverket.se<\/p>\n\n\n\n<p>By reporting&nbsp;side effects&nbsp;, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Bosentan Aurobindo<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>No special storage instructions.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;bosentan&nbsp;in the form of the monohydrate.&nbsp;<br>Each film-coated tablet contains 62.5 mg&nbsp;bosentan&nbsp;(monohydrate).&nbsp;<br>Each film-coated tablet contains 125 mg&nbsp;bosentan&nbsp;(monohydrate).<\/li><li>The other ingredients are&nbsp;<em>Tablet core:<\/em>&nbsp;&nbsp;Pregelatinized&nbsp;starch,&nbsp;maize&nbsp;starch,&nbsp;sodium&nbsp;starch&nbsp;glycolate&nbsp;(Type-A), crospovidone (Type-B), povidone (k-90), glycerol dibehanate, magnesium stearate.&nbsp;<em>Tablet coating:<\/em>&nbsp;Hypromellose (E464), ethylcellulose, triacetin, titanium dioxide (E171), yellow iron oxide, red iron oxide.<em>&nbsp;<br><br><\/em><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Film-coated tablet.&nbsp;<br><\/p>\n\n\n\n<p><em>Bosentan&nbsp;Aurobindo 62.5 mg film-coated tablets<\/em><\/p>\n\n\n\n<p>Orange-white colored, round [Diameter: 6.1mm], biconvex, film-coated tablets debossed with &#8220;K&#8221; on one side and &#8220;21&#8221; on the other side.<br><\/p>\n\n\n\n<p><em>Bosentan&nbsp;Aurobindo 125 mg film-coated tablets<\/em><\/p>\n\n\n\n<p>Orange-white colored, oval, biconvex, film-coated tablets debossed with &#8220;K&#8221; on one side and &#8220;22&#8221; on the other side, separated by the notch.&nbsp;The tablet can be divided into two equal&nbsp;doses&nbsp;.&nbsp;The size is 11.2 mm x 5.2 mm.<br><\/p>\n\n\n\n<p>Bosentan&nbsp;Aurobindo film-coated tablets are available in triple-laminated, white, opaque PVC \/ PE \/ PVdC-Aluminum blister pack and HDPE jar with polypropylene lid.<br><\/p>\n\n\n\n<p>Blister pack:<\/p>\n\n\n\n<p>62.5 mg&nbsp;<em>:<\/em>&nbsp;14, 28, 30, 50, 56, 60, 90, 98 and 112 film-coated tablets<\/p>\n\n\n\n<p>125 mg&nbsp;<em>:<\/em>&nbsp;10, 14, 28, 30, 50, 56, 60, 90, 98, 100 and 112 film-coated tablets.<br><\/p>\n\n\n\n<p>HDPE jar: 30, 100, and 1000 film-coated tablets<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Aurobindo Pharma (Malta) Limited<\/p>\n\n\n\n<p>Vault 14, Level 2, Valletta Waterfront<\/p>\n\n\n\n<p>Floriana FRN 1913<\/p>\n\n\n\n<p>Malta<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Milpharm Limited<\/p>\n\n\n\n<p>Ares Block, Odyssey Business Park<\/p>\n\n\n\n<p>West End Road<\/p>\n\n\n\n<p>Ruislip HA4 6QD<\/p>\n\n\n\n<p>UK<br><\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>APL Swift Services (Malta) Limited<\/p>\n\n\n\n<p>HF26, Hal Far Industrial Estate, Hal Far<\/p>\n\n\n\n<p>Birzebbugia, BBG 3000<\/p>\n\n\n\n<p>Malta<br><\/p>\n\n\n\n<p>or<br><\/p>\n\n\n\n<p>Orion Corporation<\/p>\n\n\n\n<p>Orion Pharma<\/p>\n\n\n\n<p>Orionintie 1<\/p>\n\n\n\n<p>02200 Espoo<\/p>\n\n\n\n<p>Finland<br><\/p>\n\n\n\n<p>For further information on this medicine, please contact your local representative:<\/p>\n\n\n\n<p>Orion Pharma AB, Danderyd<\/p>\n\n\n\n<p>medinfo@orionpharma.com<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bosentan Aurobindo tablets contain bosentan, which blocks a naturally occurring hormone called endothelin-1 (ET-1) which causes the blood vessels to become narrow. Bosentan Aurobindo, therefore, causes the blood vessels to dilate and belongs to a group of medicines called &#8220;endothelin receptor antagonists&#8221;.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2202,2200],"tags":[8559,8564,8566,8568,8561,8563,8567,8562,8560,8565],"class_list":["post-6195","post","type-post","status-publish","format-standard","hentry","category-b","category-medicines","tag-bosentan","tag-bosentan-aurobindo","tag-bosentan-aurobindo-side-effects","tag-bosentan-aurobindo-tablet","tag-bosentan-side-effects","tag-bosentan-tablet","tag-what-bosentan-aurobindo-is-used-for","tag-what-bosentan-is-used-for","tag-what-is-bosentan","tag-what-is-bosentan-aurobindo"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6195","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6195"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6195\/revisions"}],"predecessor-version":[{"id":11902,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6195\/revisions\/11902"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6195"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6195"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6195"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}