{"id":6170,"date":"2021-01-02T15:29:06","date_gmt":"2021-01-02T15:29:06","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6170"},"modified":"2021-06-29T06:23:57","modified_gmt":"2021-06-29T06:23:57","slug":"bosentan-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/bosentan-accord\/","title":{"rendered":"Bosentan Accord &#8211; Bosentan uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n62.5 mg and 125 mg&nbsp;film-coated tablets&nbsp;<br><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tracleer\/\">bosentan<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Bosentan Accord is and what it is used for<\/h2>\n\n\n\n<p>Bosentan&nbsp;Accord tablets contain&nbsp;bosentan, which blocks a naturally occurring&nbsp;hormone&nbsp;called endothelin-1 (ET-1) which causes the blood vessels to become narrow.&nbsp;Bosentan&nbsp;Accord, therefore, causes the blood vessels to dilate and belongs to a group of medicines called &#8216;endothelin receptor antagonists&#8217;.<br><\/p>\n\n\n\n<p>Bosentan&nbsp;Accord is used to treat:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Pulmonary&nbsp;arterial&nbsp;hypertension&nbsp;<\/strong>(PAH): PAH is a disease that leads to severe narrowing of the blood vessels in the lungs.&nbsp;As a result, high&nbsp;blood pressure occurs in the blood vessels in the lungs (pulmonary arteries) that transport blood from the heart to the lungs.&nbsp;This pressure reduces the amount of oxygen that can enter the blood in the lungs, making physical activity more difficult.&nbsp;Bosentan Accord dilates the pulmonary arteries and makes it easier for the heart to pump blood through them.&nbsp;This lowers&nbsp;blood pressure&nbsp;and relieves symptoms.<\/li><\/ul>\n\n\n\n<p>Bosentan&nbsp;Accord is used for treating patients with&nbsp;pulmonary&nbsp;arterial&nbsp;hypertension(PAH) class III to improve their ability to work (the ability to perform physical activity) and symptoms.&nbsp;The class shows the severity of the disease, where class III means that physical activity is markedly limited.&nbsp;Class II means that physical activity is easily limited.&nbsp;PAHs for which&nbsp;Bosentan&nbsp;Accord is used can be:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>primary (without identified cause or hereditary),<\/li><li>caused by&nbsp;scleroderma&nbsp;(also called systemic sclerosis, a disease with abnormal growth of connective tissue that supports the skin and other organs),<\/li><li>caused by congenital (congenital) heart defects where&nbsp;shunts&nbsp;(abnormal connections) cause an abnormal blood flow through the heart and lungs.<br><\/li><li><strong>Finger and toe ulcers<\/strong>&nbsp;in adult patients with a condition called scleroderma.&nbsp;Bosentan&nbsp;Accord reduces the number of new wounds on fingers and toes that occur.<\/li><\/ul>\n\n\n\n<p>Bosentan contained&nbsp;in the&nbsp;Bosentan&nbsp;Accord may also be approved for the treatment of other diseases not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Bosentan Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Bosentan Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic to&nbsp;bosentan<\/strong>&nbsp;or any of the other ingredients of this medicine (listed in section 6),<\/li><li><strong>if you have liver problems<\/strong>&nbsp;(ask your doctor),<\/li><li><strong>if you are pregnant or may become pregnant<\/strong>&nbsp;because you are not using reliable contraception.&nbsp;Read the information under &#8220;Contraceptives&#8221; and &#8220;Other medicines and&nbsp;Bosentan&nbsp;Accord&#8221;,<\/li><li><strong>if you are taking ciclosporin A<\/strong>&nbsp;(a medicine used after a transplant or to treat&nbsp;psoriasis&nbsp;).<\/li><\/ul>\n\n\n\n<p>If any of these apply to you, talk to your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking&nbsp;Bosentan&nbsp;Accord.<br><\/p>\n\n\n\n<p><strong>Checks that your doctor will do before treatment:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood tests to check liver function,<\/li><li>blood tests to check for&nbsp;anemia&nbsp;(&nbsp;anemia, low&nbsp;hemoglobin&nbsp;),<\/li><li>pregnancy test if you are a woman of&nbsp;childbearing potential.<\/li><\/ul>\n\n\n\n<p>Some patients who have used&nbsp;bosentan&nbsp;have had abnormal liver function tests and&nbsp;anemia&nbsp;(low&nbsp;hemoglobin&nbsp;).<br><\/p>\n\n\n\n<p><strong>Checks that your doctor will do during treatment<\/strong><\/p>\n\n\n\n<p>Your doctor will arrange regular blood tests to check for changes in liver function and hemoglobin levels during treatment with&nbsp;Bosentan&nbsp;Accord.<br><\/p>\n\n\n\n<p>For all these tests, see also the patient care (in the package with&nbsp;Bosentan&nbsp;Accord).&nbsp;It is important that these regular blood tests are taken throughout the time you are taking&nbsp;Bosentan&nbsp;Accord.&nbsp;We suggest that you write down the date of the last test and also the next test (ask your doctor about the date) on the patient card, as help to remember when the next test is to be taken.<br><\/p>\n\n\n\n<p><strong><em>Blood tests for liver function<\/em><\/strong><\/p>\n\n\n\n<p>These will be taken once a month throughout the treatment with&nbsp;Bosentan&nbsp;Accord.&nbsp;After an increase in&nbsp;dose&nbsp;one, an extra sample will be taken after 2 weeks.<br><\/p>\n\n\n\n<p><strong>Blood tests for&nbsp;anemia&nbsp;(&nbsp;anemia&nbsp;)<\/strong><\/p>\n\n\n\n<p>This will be done once a month during the first 4 months of treatment and then once every 3 months, as patients taking&nbsp;Bosentan&nbsp;Accord may&nbsp;develop&nbsp;anemia.<br><\/p>\n\n\n\n<p>If the results are abnormal, your doctor may decide to reduce the&nbsp;dose&nbsp;one or stop treatment with&nbsp;Bosentan&nbsp;Accord and do further research to investigate the cause.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>There is only limited clinical experience in children under 2 years of age with&nbsp;pulmonary&nbsp;arterial&nbsp;hypertension.&nbsp;Bosentan&nbsp;Accord is not recommended for children with systemic sclerosis and ongoing illness with digital wounds.&nbsp;See also section 3, \u201cHow to take&nbsp;Bosentan&nbsp;Accord\u201d.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Bosentan Accord<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines, including medicines obtained without a prescription.&nbsp;It is especially important that you tell your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ciclosporin A (a medicine used after transplants and to treat&nbsp;psoriasis&nbsp;), not to be used with&nbsp;Bosentan&nbsp;Accord,<\/li><li>sirolimus or tacrolimus, which are medicines used after transplants, as these are not recommended for use with&nbsp;Bosentan&nbsp;Accord,<\/li><li>glibenclamide (for&nbsp;diabetes&nbsp;), rifampicin (for the treatment of&nbsp;tuberculosis&nbsp;),&nbsp;fluconazole&nbsp;and&nbsp;ketoconazole&nbsp;(for the treatment of fungal infections), nevirapine (for the treatment of&nbsp;HIV&nbsp;) as these medicines are not recommended for use with&nbsp;Bosentan&nbsp;Accord,<\/li><li>other drugs for the treatment of&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;that can be checked particularly if used in combination with&nbsp;bosentan&nbsp;Accord<\/li><li>hormonal contraceptives, which are not effective as the only method of contraception when taking&nbsp;Bosentan&nbsp;Accord.&nbsp;Inside your&nbsp;Bosentan&nbsp;Accord packaging is patient care for patients that you should read carefully.&nbsp;Your doctor and\/or gynecologist will determine which contraceptives are right for you.<\/li><li>other medicines used to treat pulmonary hypertension: sildenafil and tadalafil.<\/li><li>warfarin&nbsp;(a blood thinner)<\/li><li>simvastatin&nbsp;(used to treat&nbsp;hypercholesterolemia&nbsp;)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Bosentan&nbsp;Accord has no or negligible influence on the ability to drive and use machines.&nbsp;Bosentan&nbsp;Accord may cause&nbsp;hypotension&nbsp;(low&nbsp;blood pressure&nbsp;) which may make you feel dizzy, affect your vision and your ability to drive and use machines.&nbsp;Therefore, if you feel dizzy or if your vision is impaired when you take&nbsp;BosentanAccord, do not drive or use any tools or machines.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p><em>Women of&nbsp;childbearing&nbsp;age<\/em><\/p>\n\n\n\n<p>Do NOT&nbsp;take Bosentan&nbsp;Accord if you are pregnant or planning to become pregnant.<br><\/p>\n\n\n\n<p><em>Pregnancy tests<\/em><\/p>\n\n\n\n<p>Bosentan&nbsp;Accord can harm unborn babies born before or during treatment.&nbsp;If you are a woman and could become pregnant, your doctor will ask you to undergo a pregnancy test before you start taking&nbsp;Bosentan&nbsp;Accord, and regularly during the time you are taking&nbsp;Bosentan&nbsp;Accord.<br><\/p>\n\n\n\n<p><em>Contraceptive<\/em><\/p>\n\n\n\n<p>If it is possible that you may become pregnant, use a safe method of contraception when taking&nbsp;Bosentan&nbsp;Accord.&nbsp;Your doctor or gynecologist can advise you on reliable contraceptive methods while using&nbsp;Bosentan&nbsp;Accord.&nbsp;Since&nbsp;Bosentan&nbsp;Accord can make hormonal contraception (e.g., oral, injectable, implantable, or p-&nbsp;patches&nbsp;) ineffective, this alone no sure method.&nbsp;Therefore, if you use hormonal contraceptives, you must also use a&nbsp;barrier method&nbsp;(eg condoms for women,&nbsp;diapers, contraceptive pillows or your partner must also use a condom).&nbsp;Inside the&nbsp;BosentanAccord packaging includes a patient card.&nbsp;You should complete this card and take it with you to your doctor at your next visit so that your doctor or gynecologist can evaluate whether you need additional or alternative reliable contraceptive methods.&nbsp;Pregnancy tests are recommended every month while you are taking&nbsp;Bosentan&nbsp;Accord if you are of&nbsp;childbearing potential.<br><\/p>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p><strong>Tell&nbsp;your doctor immediately&nbsp;if you are breast-feeding.&nbsp;&nbsp;It is recommended that you&nbsp;stop breastfeeding<\/strong>&nbsp;if you are&nbsp;prescribed Bosentan&nbsp;Accord.&nbsp;It is not known whether this medicine is passed on to breast milk.<br><\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>In infertility studies in animals, no effects on sperm or&nbsp;fertility&nbsp;parameters were seen.<\/p>\n\n\n\n<p>If you are a man and use&nbsp;the Bosentan&nbsp;Accord, it is possible that the medicine may reduce the number of sperm.&nbsp;It can not be ruled out that this may affect your ability to have children.&nbsp;Talk to your doctor if you have any questions or concerns about this.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Bosentan Accord<\/h2>\n\n\n\n<p>Treatment with&nbsp;Bosentan&nbsp;Accord should only be started and followed up by a doctor who has experience in the treatment of PAH or systemic sclerosis.&nbsp;Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p><strong>Bosentan&nbsp;Accord with food and drink<\/strong><\/p>\n\n\n\n<p>Bosentan&nbsp;Accord can be taken with or without food.<br><\/p>\n\n\n\n<p><strong>Recommended&nbsp;dose<\/strong><br><\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p>Treatment is usually started with 62.5 mg twice daily (morning and evening) for the first 4 weeks.&nbsp;Thereafter, your doctor will usually prescribe a 125 mg tablet twice daily, depending on how you react to&nbsp;Bosentan&nbsp;Accord.<br><\/p>\n\n\n\n<p><strong>Use for children and adolescents<\/strong><\/p>\n\n\n\n<p>The dose&nbsp;recommended for children only applies to PAHs.&nbsp;In children 2 years of age and older, treatment is usually started at 2 mg\/kg body weight twice daily (morning and evening).&nbsp;Your doctor will tell you how to dose.<\/p>\n\n\n\n<p>Note that there are other formulations of&nbsp;bosentan&nbsp;that may facilitate the correct&nbsp;dosing&nbsp;for children and patients with low body weight or patients who have difficulty swallowing film-coated tablets.<br><\/p>\n\n\n\n<p>If you have the impression that the effect of&nbsp;Bosentan&nbsp;Accord is too strong or too weak, talk to your doctor as your&nbsp;dose&nbsp;may need to be changed.<br><\/p>\n\n\n\n<p><strong>How to take&nbsp;Bosentan&nbsp;Accord<\/strong><\/p>\n\n\n\n<p>The tablets should be taken twice daily (morning and evening), should be swallowed with water, and can be taken with or without food.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Bosentan Accord<\/h2>\n\n\n\n<p>If you forget to take&nbsp;Bosentan&nbsp;Accord, take a&nbsp;dose&nbsp;as soon as you remember and then continue to take your tablets at the usual times.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Bosentan Accord<\/h2>\n\n\n\n<p>If you suddenly stop&nbsp;taking Bosentan&nbsp;Accord,&nbsp;your&nbsp;symptoms may get&nbsp;worse.&nbsp;Do not&nbsp;stop taking Bosentan&nbsp;Accord&nbsp;unless instructed&nbsp;to&nbsp;do&nbsp;so by your doctor.&nbsp;Your doctor may instruct you to reduce your&nbsp;dose&nbsp;for a few days before stopping completely.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>The most serious&nbsp;side effects&nbsp;of&nbsp;the Bosentan&nbsp;Accord are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal liver function, which may occur in more than 1 in 10 people,<\/li><li>anemia&nbsp;(low blood count), which can occur in up to 1 in 10 people.&nbsp;Anemia&nbsp;can sometimes require&nbsp;blood transfusions.<\/li><\/ul>\n\n\n\n<p>Your liver and blood levels will be monitored during your treatment with&nbsp;BosentanAccord (see section 2).&nbsp;It is important that you take these samples as prescribed by your doctor.<br><\/p>\n\n\n\n<p>Symptoms that indicate that your liver is not functioning normally include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea (feeling the need to vomit)<\/li><li>vomiting<\/li><li>fever<\/li><li>stomach ache<\/li><li>jaundice (yellowing of the skin or whites of the eyes)<\/li><li>dark-colored urine<\/li><li>skin itching,<\/li><li>listlessness or fatigue (unusual tiredness or fatigue)<\/li><li>flu-like symptoms&nbsp;(muscle and joint pain with fever).<br><\/li><\/ul>\n\n\n\n<p><strong>Tell&nbsp;your doctor <\/strong>immediately if&nbsp;you experience any of these&nbsp;side effects.<br><\/p>\n\n\n\n<p><strong><em>Other&nbsp;side effects&nbsp;are<\/em><\/strong><br><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect&nbsp;<strong>more than 1 in 10<\/strong>&nbsp;people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>edema&nbsp;(swelling of the legs and ankles or other symptoms of fluid retention).<br><\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect&nbsp;<strong>up to 1 in 10<\/strong>&nbsp;people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sudden flushing or reddening of the skin<\/li><li>hypersensitivity reaction&nbsp;(with skin inflammation,&nbsp;itching,&nbsp;and rash)<\/li><li>gastroesophageal reflux disease&nbsp;(acid reflux)<\/li><li>diarrhea<\/li><li>short-term loss of consciousness (fainting)<\/li><li>palpitations (fast or irregular heartbeat)<\/li><li>low&nbsp;blood pressure<\/li><li>nasal congestion.<br><\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect&nbsp;<strong>up to 1 in 100<\/strong>&nbsp;people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>thrombocytopenia&nbsp;(lack of&nbsp;platelets&nbsp;)<\/li><li>neutropenia\/leukopenia (low&nbsp;white blood cell count&nbsp;)elevated liver enzyme levels with&nbsp;hepatitis&nbsp;(&nbsp;inflammation&nbsp;of the liver) including possible worsening of underlying&nbsp;hepatitis&nbsp;and \/ or jaundice (yellowing of the skin or whites of the eyes).<br><\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect&nbsp;<strong>up to 1 in 1,000<\/strong>&nbsp;people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>anaphylactic reactions (general&nbsp;allergic reaction&nbsp;),&nbsp;angioedema&nbsp;(swelling, usually around the eyes, lips, tongue, or throat)<\/li><li>cirrhosis&nbsp;(scarring) in the liver, liver failure (a severe disorder of liver function).<\/li><\/ul>\n\n\n\n<p>Blurred vision has been reported (may occur in an unknown number of users).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Side effects in children and adolescents<\/h2>\n\n\n\n<p>Children treated with&nbsp;Bosentan&nbsp;Accord have the same reported&nbsp;side effects&nbsp;as adults.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Bosentan Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Aluminum-aluminum blister card<\/p>\n\n\n\n<p>No special storage instructions.<br><\/p>\n\n\n\n<p>PVC \/ PE \/ PVDC aluminum blister card<\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Bosentan&nbsp;Accord 62.5 mg film-coated tablets:&nbsp;the active substance is&nbsp;bosentan as<\/strong> monohydrate.&nbsp;Each tablet contains 62.5 mg&nbsp;bosentan&nbsp;(as monohydrate).<\/li><li><strong>Bosentan&nbsp;Accord 125 mg film-coated tablets:<\/strong>&nbsp;the active substance is&nbsp;bosentan as monohydrate.&nbsp;Each tablet contains 125 mg&nbsp;bosentan&nbsp;(as monohydrate).<\/li><li><strong>The other excipients in the tablet are<\/strong>&nbsp;maize&nbsp;starch, pregelatinized&nbsp;starch(maize), sodium&nbsp;starch&nbsp;glycolate&nbsp;(type A), povidone, and magnesium stearate.&nbsp;<strong>The film coating<\/strong>&nbsp;contains hypromellose, triacetin, talc, titanium dioxide (E171), yellow iron oxide (E172), and red iron oxide (E172).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Bosentan&nbsp;Accord 62.5 mg film-coated tablets are light orange, round, approximately 6.20 mm in diameter, biconvex, film-coated tablets with \u201cIB1\u201d embossed on one side and the other side is completely smooth.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Bosentan&nbsp;Accord 125 mg film-coated tablets are light orange, oval, approximately 11.00 mm long, 5.00 mm wide, biconvex, film-coated tablets with \u201cIB2\u201d embossed on one side and the other side completely smooth.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Bosentan&nbsp;Accord 62.5 mg film-coated tablets are packaged in aluminum-aluminum&nbsp;blister cards&nbsp;and in PVC \/ PE \/ PVDC \/ aluminum&nbsp;blister cards&nbsp;containing 14 film-coated tablets.&nbsp;The cartons contain 14, 56, or 112 film-coated tablets.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Bosentan&nbsp;Accord 125 mg film-coated tablets are packaged in aluminum-aluminum&nbsp;blister cards&nbsp;and in PVC \/ PE \/ PVDC \/ aluminum&nbsp;blister cards&nbsp;containing 14 film-coated tablets.&nbsp;The cartons contain 56 or 112 film-coated tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder:<\/strong><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 kV Utrecht<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Ltd<\/p>\n\n\n\n<p>Sage House<\/p>\n\n\n\n<p>319, Pinner Road<\/p>\n\n\n\n<p>North Harrow<\/p>\n\n\n\n<p>Middlesex HA1 4 HF<\/p>\n\n\n\n<p>UK<br><\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomierska 50,95-200 Pabianice, Poland<br><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 KV Utrecht<\/p>\n\n\n\n<p>The Netherlands<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bosentan Accord tablets contain bosentan, which blocks a naturally occurring hormone called endothelin-1 (ET-1) which causes the blood vessels to become narrow. Bosentan Accord, therefore, causes the blood vessels to dilate and belongs to a group of medicines called &#8216;endothelin receptor antagonists&#8217;.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2202,2200],"tags":[8559,8574,8576,8578,8561,8563,8577,8562,8560,8575],"class_list":["post-6170","post","type-post","status-publish","format-standard","hentry","category-b","category-medicines","tag-bosentan","tag-bosentan-accord","tag-bosentan-accord-side-effects","tag-bosentan-accord-tablet","tag-bosentan-side-effects","tag-bosentan-tablet","tag-what-bosentan-accord-is-used-for","tag-what-bosentan-is-used-for","tag-what-is-bosentan","tag-what-is-bosentan-accord"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6170","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6170"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6170\/revisions"}],"predecessor-version":[{"id":11887,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6170\/revisions\/11887"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6170"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6170"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}