{"id":6160,"date":"2021-01-02T15:16:19","date_gmt":"2021-01-02T15:16:19","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6160"},"modified":"2021-06-29T07:12:08","modified_gmt":"2021-06-29T07:12:08","slug":"bondulc","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/bondulc\/","title":{"rendered":"Bondulc &#8211; Travoprost uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n40 micrograms \/ ml eye drops, solution&nbsp;<br><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/travatan\/\">travoprost<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Bondulc is and what it is used for<\/h2>\n\n\n\n<p>Bondulc&nbsp;<strong>contains travoprost<\/strong>&nbsp;and belongs to a group of medicines called&nbsp;<strong>prostaglandin analogue&nbsp;you<\/strong>&nbsp;.&nbsp;It works by reducing the pressure in the eye.&nbsp;It can be used alone or together with other drops e.g.&nbsp;beta blockers&nbsp;that also lower the pressure.<br><\/p>\n\n\n\n<p>Bondulc&nbsp;<strong>is used to lower high pressure in the eye in adults, adolescents and children from 2 months of age.&nbsp;<\/strong>This pressure can lead to a disease called&nbsp;<strong>glaucoma<\/strong>&nbsp;.<br><\/p>\n\n\n\n<p>Travoprost contained in Bondulc may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist or other healthcare professional if you have any further questions and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Bondulc<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Bondulc<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic<\/strong>&nbsp;to travoprost or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Bondulc<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bondulc&nbsp;<strong>can increase<\/strong>&nbsp;the length, thickness, color and \/ or number of your&nbsp;<strong>eyelashes&nbsp;are<\/strong>&nbsp;.&nbsp;Changes in the eyelids including unusual hair growth or&nbsp;tissuearound the eye have also been observed.<\/li><li>Bondulc&nbsp;<strong>can change the color of the&nbsp;iris<\/strong>&nbsp;(the colored part of your eye).&nbsp;This change may be permanent.&nbsp;A change in the skin color around the eye may also occur.<\/li><li>If you have had&nbsp;<strong>cataract surgery<\/strong>&nbsp;, talk to your doctor before using Bondulc.<\/li><li>If you have or have had an&nbsp;<strong>eye infection<\/strong>&nbsp;(&nbsp;iritis&nbsp;or&nbsp;uveitis&nbsp;), talk to your doctor before using Bondulc.<\/li><li>Bondulc may in rare cases cause&nbsp;<strong>shortness of breath<\/strong>&nbsp;or&nbsp;<strong>wheezing<\/strong>&nbsp;or worsen&nbsp;<strong>asthma<\/strong>&nbsp;symptoms&nbsp;<strong>.&nbsp;<\/strong>If you are concerned about changes in your breathing patterns while using this medicine, talk to your doctor as soon as possible.<\/li><li>Bondulc&nbsp;<strong>can be absorbed through the skin.&nbsp;<\/strong>&nbsp;<strong>If any<\/strong>&nbsp;of the medicine comes into&nbsp;<strong>contact with the skin<\/strong>&nbsp;, it should be&nbsp;<strong>washed off<\/strong>&nbsp;immediately.&nbsp;This is especially important in women who are pregnant or trying to become pregnant.<\/li><li>If you use soft contact lenses, do not take the drops while the lenses are in. Wait at least 15 minutes after using the drops before inserting the lenses into the eye again.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Bondulc can be used in children from 2 months to 18 years with the same&nbsp;dosage&nbsp;as for adults.<\/p>\n\n\n\n<p>Bondulc is not recommended for use in children below 2 months.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Bondulc<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p><strong>Do not use Bondulc if you are pregnant.&nbsp;<\/strong>If you think you may be pregnant, talk to your doctor straight away.&nbsp;If you can get pregnant, you must use a suitable contraceptive while using this medicine.<br><\/p>\n\n\n\n<p><strong>Do not use Bondulc if you are breast-feeding.&nbsp;<\/strong>Bondulc can pass into breast milk.<br><\/p>\n\n\n\n<p>Talk to your doctor before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You may find that your vision becomes foggy immediately after using Bondulc.&nbsp;Do not drive or operate machinery until it has disappeared.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<p><strong>Bondulc contains benzalkonium chloride<\/strong><\/p>\n\n\n\n<p>This medicine contains 0.15 mg of benzalkonium chloride per ml.<br><\/p>\n\n\n\n<p>Benzalkonium chloride can be absorbed by soft contact lenses and can discolor the contact lenses.&nbsp;Remove contact lenses before using the medicine and wait at least 15 minutes for the contact lenses to be re-inserted.<br><\/p>\n\n\n\n<p>Benzalkonium chloride can be irritating to the eyes, especially if you have dry eyes or problems with the cornea (the clear membrane at the front of the eye).&nbsp;If you experience irritation, tingling or pain in the eye after using the medicine, consult a doctor.<br><\/p>\n\n\n\n<p><strong>Bondulc contains macrogolglycerol hydroxystearate<\/strong><\/p>\n\n\n\n<p>May cause skin reactions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Bondulc<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or your doctor has told you.&nbsp;If you are not sure, talk to your or your child&#8217;s doctor or pharmacist.<br><\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;is:<\/strong><\/p>\n\n\n\n<p>A drop in the affected eye or eyes, once daily &#8211; in the evening.&nbsp;Only use Bondulc in both eyes if your doctor has prescribed it.&nbsp;Use this medicine for as long as your or your child&#8217;s doctor prescribes it.<br><\/p>\n\n\n\n<p>Use Bondulc only to drip into your or your child&#8217;s eye (s).<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140513000075#\" rel=\"noopener\"><\/a><\/td><td><br>Immediately before using a bottle for the first time, tear open the protective bag&nbsp;<strong>(Fig. 1)<\/strong>&nbsp;.&nbsp;Take out the bottle and write down the date when you opened the bottle in the space provided on the label.Take the bottle with the medicine and a mirror.Wash your hands.Unscrew the lid.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140513000075#\" rel=\"noopener\"><\/a><\/td><td><br>Hold the bottle pointing down between your thumb and fingers. Gently tilt your or your child&#8217;s head back.&nbsp;Pull the eyelid down with a clean finger until a &#8220;pocket&#8221; is formed between the eyelid and the eye.&nbsp;The eye drop should be dripped here&nbsp;<strong>(picture 2)<\/strong>&nbsp;. Move the bottle tip close to the eye.&nbsp;Use a mirror if it helps.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140513000075#\" rel=\"noopener\"><\/a><\/td><td><br><strong>Do not touch the eye or eyelid, surrounding areas or other surfaces with the drip tip.&nbsp;<\/strong>It can contaminate the drops.Gently press on the bottle to release one drop of the drug at a time&nbsp;<strong>(Fig. 3)<\/strong>&nbsp;.After taking the medicine, make sure that your eyelid is closed and gently press with a finger in the corner of your eye&nbsp;<strong>(Fig. 4)<\/strong>&nbsp;for at least 1 minute.&nbsp;This prevents the drug from entering the rest of the body.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140513000075#\" rel=\"noopener\"><\/a><\/td><td><br>If you use drops in both eyes, repeat the steps for the other eye. Close the bottle cap firmly immediately after use. Use only one bottle at a time.&nbsp;Do not open the protective bag until you need to use the bottle.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>If a drop misses the eye, try again.<br><\/p>\n\n\n\n<p><strong>If you&nbsp;<\/strong><strong>or your child&nbsp;<\/strong><strong>use other eye preparations<\/strong>&nbsp;, e.g.&nbsp;eye drops&nbsp;or eye ointment, wait at least 5 minutes between the use of Bondulc and the other eye preparations.<br><\/p>\n\n\n\n<p><strong>If you forget to use Bondulc<\/strong><\/p>\n\n\n\n<p>Continue with the next&nbsp;dose&nbsp;as planned.&nbsp;<strong>Never take a double&nbsp;dose<\/strong>&nbsp;to make up for a forgotten&nbsp;dose&nbsp;.&nbsp;Never use more than 1 drop per day in the affected eye (s).<br><\/p>\n\n\n\n<p><strong>If you stop using Bondulc<\/strong><\/p>\n\n\n\n<p>Do not stop using this medicine without first talking to your or your child&#8217;s doctor.&nbsp;Otherwise, the pressure in your or your child&#8217;s eye can not be controlled and this can lead to vision loss.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist&nbsp;<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<br><\/p>\n\n\n\n<p>You can usually continue to use the drops unless the&nbsp;side effects&nbsp;are severe.&nbsp;If you are concerned, talk to a doctor or pharmacist.&nbsp;Do not stop using Bondulc without first talking to your or your child&#8217;s doctor.<br><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been seen with Bondulc<br><\/p>\n\n\n\n<p><strong>Very common&nbsp;<\/strong><strong>: may affect more than 1 in 10 people<\/strong><br><\/p>\n\n\n\n<p><strong><em>Eye effects:<\/em><\/strong>&nbsp;&nbsp;redness of the eye<br><\/p>\n\n\n\n<p><strong>Common: may affect up to 1 in 10 people<\/strong><br><\/p>\n\n\n\n<p><strong><em>Effects in the eyes:<\/em><\/strong>&nbsp;change in iris color (the colored part of the eye), pain or discomfort in the eye, dryness in the eye,&nbsp;itching&nbsp;in the eye, irritation in the eye.<br><\/p>\n\n\n\n<p><strong>Uncommon: may affect up to 1 in 100 people<\/strong><br><\/p>\n\n\n\n<p><strong><em>Effects in the eyes:<\/em><\/strong>&nbsp;disorders of the cornea, eye inflammation, iris&nbsp;inflammation&nbsp;,inflammation&nbsp;of the eye,&nbsp;inflammation&nbsp;of the surface of the eye with \/ without damage to the surface, photosensitivity,&nbsp;secretions&nbsp;from the eye, eyelid inflammation,&nbsp;redness&nbsp;of the eyelid, swelling around the eye,&nbsp;itching&nbsp;of the eyelid, poor eyesight, blurred vision, increased tear production,&nbsp;infection&nbsp;or&nbsp;inflammation&nbsp;of the conjunctiva (&nbsp;conjunctivitis&nbsp;), the lower eyelid is turned out in an abnormal way, cloudiness in the eye, crust formation on the eyelid, growth of the&nbsp;eyelash&nbsp;one, discoloration of the&nbsp;eyelashes&nbsp;, tired eyes.<br><\/p>\n\n\n\n<p><strong><em>General side effects:<\/em><\/strong>&nbsp;&nbsp;increased allergic symptoms, headache, dizziness, irregular heartbeat, shortness of breath,&nbsp;asthma&nbsp;, nasal congestion, throat irritation, darker skin around the eye \/ eyes, darker skin, abnormal hair structure, excessive hair growth.<br><\/p>\n\n\n\n<p><strong>Rare: may affect up to 1 in 1,000 people<\/strong><br><\/p>\n\n\n\n<p><strong><em>Effects in the eyes:<\/em><\/strong>&nbsp;flashes of light,&nbsp;eczema&nbsp;on the eyelids, eye swelling, halo effect, decreased sensation in the eye,&nbsp;inflammation&nbsp;of the&nbsp;glands&nbsp;in the eyelids,pigmentation&nbsp;in the eye, increased pupil size, altered structure of the&nbsp;eyelashes&nbsp;.<br><\/p>\n\n\n\n<p><strong><em>Common&nbsp;side effects&nbsp;are<\/em><\/strong>&nbsp;: viral infection of the eye, bad taste in the mouth, irregular or slower heart rate, increased or decreased&nbsp;blood pressure&nbsp;, cough, voice changes, stomach upset or&nbsp;ulcers&nbsp;, constipation,&nbsp;dry mouth&nbsp;,&nbsp;redness&nbsp;or&nbsp;itching&nbsp;of the skin, rash, altered hair color, loss of&nbsp;eyelashes&nbsp;, musculoskeletal pain, general weakness, breathing problems, sore throat.<br><\/p>\n\n\n\n<p><strong>No known frequency: cannot be calculated from the available data<\/strong><br><\/p>\n\n\n\n<p><strong><em>Effects in the eyes:<\/em><\/strong>&nbsp;&nbsp;inflammation in the back of the eye, the eyes look sunken<br><\/p>\n\n\n\n<p><strong><em>General side effects:<\/em><\/strong>&nbsp;depression, anxiety, feeling of false movements, ringing in the ears, chest pain, worsening&nbsp;asthma&nbsp;, diarrhea, abdominal pain, nausea,&nbsp;itching&nbsp;, abnormal hair growth, joint pain, pain when urinating and involuntary urination, increased prostate-&nbsp;specific antigen&nbsp;, increased heart rate&nbsp;antigen&nbsp;.<br><\/p>\n\n\n\n<p>In children and adolescents, the most common&nbsp;side effects&nbsp;with Bondulc are&nbsp;rednessof the eye and growth of the&nbsp;eyelashes&nbsp;.&nbsp;The incidence of these two&nbsp;side effects&nbsp;was higher in children and adolescents than in adults.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Bondulc<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the bottle and carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not use this medicine if you notice that the seal has been broken or damaged before opening it for the first time.<br><\/p>\n\n\n\n<p>Before opening, store the bottle in the protective bag.&nbsp;Moisture sensitive.<br><\/p>\n\n\n\n<p>After first opening, no special storage instructions.<br><\/p>\n\n\n\n<p><strong>You must discard the bottle 4 weeks after you first opened it<\/strong>&nbsp;to prevent&nbsp;infection, and use a new bottle.&nbsp;Write down the date you opened the bottle in the space provided on the bottle label and carton.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is travoprost.&nbsp;Each ml contains 40 micrograms travoprost.<\/li><li>The other ingredients are benzalkonium chloride solution, macrogolglycerol hydroxystearate 40, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tribonate\/\">trometamol<\/a>, disodium edetate, boric acid (E284), mannitol (E421), sodium hydroxide for&nbsp;pH&nbsp;adjustment, and water for injections or purified water.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Bondulc&nbsp;eye drops&nbsp;, solution is a clear, colorless solution contained in transparent 5-mL polypropylene bottles with transparent low-density polyethylene (LDPE) dropper tips and white high-density polyethylene (HDPE) guarantee sealed screw cap packaged in protective bags.&nbsp;Each bottle contains 2.5 ml of solution.<br><\/p>\n\n\n\n<p>The medicine is available in the following pack sizes:<\/p>\n\n\n\n<p>Cardboard packaging with 1 or 3 bottles.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Actavis Group PTC ehf.<\/p>\n\n\n\n<p>Reykjav\u00edkurvegur 76-78, IS-220 Hafnarfj\u00f6r\u00f0ur, Iceland<br><\/p>\n\n\n\n<p><strong>Local representative<\/strong><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>BALKANPHARMA-RAZGRAD AD<\/p>\n\n\n\n<p>68 April Blvd., Razgrad, 7200, Bulgaria<br><\/p>\n\n\n\n<p>PHARMATHEN SA<\/p>\n\n\n\n<p>Dervenakion 6, Pallini 15351, Attikis, Greece<br><\/p>\n\n\n\n<p>JADRAN &#8211; GALENSKI LABORATORIJ dd<\/p>\n\n\n\n<p>Svilno 20, Rijeka 51000<\/p>\n\n\n\n<p>Croatia<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bondulc contains travoprost and belongs to a group of medicines called prostaglandin analogue you . It works by reducing the pressure in the eye. It can be used alone or together with other drops e.g. beta blockers that also lower the pressure.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2202,2200],"tags":[8610,8614,8612,4984,4986,8613,8611,4985,8609],"class_list":["post-6160","post","type-post","status-publish","format-standard","hentry","category-b","category-medicines","tag-bondulc","tag-bondulc-eye-drops","tag-bondulc-side-effects","tag-travoprost","tag-travoprost-side-effects","tag-what-bondulc-is-used-for","tag-what-is-bondulc","tag-what-is-travoprost","tag-what-travoprost-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6160","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6160"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6160\/revisions"}],"predecessor-version":[{"id":11908,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6160\/revisions\/11908"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6160"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6160"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6160"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}