{"id":6092,"date":"2020-12-31T15:23:17","date_gmt":"2020-12-31T15:23:17","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6092"},"modified":"2021-07-02T06:45:33","modified_gmt":"2021-07-02T06:45:33","slug":"bioclavid","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/bioclavid\/","title":{"rendered":"Bioclavid &#8211; Amoxicillin \/ Clavulanic acid uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n500 mg \/ 125 mg&nbsp;film-coated tablets&nbsp;<br>amoxicillin \/ clavulanic acid<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Bioclavid is and what it is used for<\/h2>\n\n\n\n<p>Bioclavid is an&nbsp;antibiotic&nbsp;that works by killing bacteria that cause&nbsp;infection.&nbsp;It contains two different drugs called amoxicillin and&nbsp;clavulanic acid.&nbsp;Amoxicillin belongs to a group of medicines called &#8220;penicillins&#8221; which can sometimes stop working (become inactive).&nbsp;The other active substance (&nbsp;clavulanic acid&nbsp;) prevents this from happening.<br><\/p>\n\n\n\n<p>Bioclavide is used in adults and children to treat the following infections:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection&nbsp;of the middle ear and sinus infections<\/li><li>respiratory infections<\/li><li>urinary tract infections<\/li><li>skin and soft tissue infections including dental infections<\/li><li>skeletal and joint infections.<\/li><\/ul>\n\n\n\n<p>Amoxicillin \/ clavulanic acid contained in Bioclavid may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professional if you have any further questions and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you take Bioclavid<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Bioclavid<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to amoxicillin,&nbsp;clavulanic acid,&nbsp;penicilli,&nbsp;or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have had a severe&nbsp;allergic reaction&nbsp;(&nbsp;hypersensitivity reaction&nbsp;) to any other&nbsp;antibiotic.&nbsp;This may include a rash or swelling of the face or neck.<\/li><li>if you have had liver problems or jaundice (yellowish skin) after taking an&nbsp;antibiotic.<\/li><\/ul>\n\n\n\n<p>Do not take Bioclavid if any of the above apply to you.&nbsp;If you are not sure, talk to your doctor or pharmacist before taking Bioclavid.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Bioclavid if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have glandular fever<\/li><li>treated for liver or kidney problems<\/li><li>do not urinate regularly.<\/li><\/ul>\n\n\n\n<p>If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before taking Bioclavid.<br><\/p>\n\n\n\n<p>In some cases, your doctor may check the type of&nbsp;bacteria&nbsp;that is causing your&nbsp;infection.&nbsp;Depending on the result, you may receive a different strength of Bioclavid or another drug.<br><\/p>\n\n\n\n<p><strong>Conditions you must be observant of<\/strong><\/p>\n\n\n\n<p>Bioclavide may aggravate certain existing conditions or cause serious&nbsp;side effects.&nbsp;These include allergic reactions, seizures, and&nbsp;inflammation&nbsp;of the colon.&nbsp;You must be observant of certain symptoms while taking Bioclavid to reduce the risk of any problems.&nbsp;See \u201cConditions you must be observant of\u201d in section 4.<br><\/p>\n\n\n\n<p><strong>Blood and urine samples<\/strong><\/p>\n\n\n\n<p>If you are taking blood samples (eg to check for&nbsp;red blood cells&nbsp;or liver function tests) or urine samples (for&nbsp;glucose&nbsp;), tell your doctor or nurse that you are taking Bioclavid.&nbsp;This is because Bioclavid may affect the results of this type of test.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Bioclavid<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>If you take allopurinol (for&nbsp;gout&nbsp;) together with Bioclavid, the risk of an allergic skin reaction may be greater.<br><\/p>\n\n\n\n<p>If you are taking probenecid (for&nbsp;gout&nbsp;)&nbsp;your&nbsp;doctor may change the&nbsp;dose of&nbsp;Bioclavid.<br><\/p>\n\n\n\n<p>If you are taking blood-thinning medicines to prevent blood clots (eg&nbsp;warfarin&nbsp;) with Bioclavid, you may need to submit additional blood samples.<br><\/p>\n\n\n\n<p>Bioclavide may affect the action of methotrexate (a medicine used to treat cancer or rheumatic diseases).<br><\/p>\n\n\n\n<p>Bioclavide may affect the function of mycophenolate mofetil (a medicine used to prevent the rejection of new organs after a transplant).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Bioclavid may have&nbsp;side effects&nbsp;and the symptoms may make you unsuitable as a driver.<\/p>\n\n\n\n<p>Do not drive or use machines if you feel unwell.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Bioclavide contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie it is essentially &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Bioclavid<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p><strong>Use for adults and children weighing 40 kg or more<\/strong><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>1 tablet 3 times daily<\/li><\/ul>\n\n\n\n<p><strong>Use for children weighing less than 40 kg<\/strong><\/p>\n\n\n\n<p>Children 6 years of age or younger should preferably be treated with&nbsp;oral&nbsp;suspension or sachets containing amoxicillin \/ clavulanic acid.<br><\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice when administering Bioclavid tablets to children weighing less than 40 kg.<br><\/p>\n\n\n\n<p><strong>Patients with kidney and liver problems<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dose&nbsp;one can be changed if you have kidney problems.&nbsp;Your doctor may choose a different strength or different medicine.<\/li><li>If you have liver problems, you may need to have blood tests more often to check how your liver is working.<\/li><\/ul>\n\n\n\n<p><strong>How to take Bioclavid<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swallow the tablets whole with a glass of water at the beginning of a meal or just before.&nbsp;The notch is only for you to be able to divide the tablet if you have difficulty swallowing it whole.<\/li><li>Distribute the&nbsp;doses&nbsp;evenly throughout the day, at least 4 hours apart.&nbsp;Do not take 2&nbsp;doses&nbsp;for 1 hour.<\/li><li>Do not take Bioclavid for more than 2 weeks.&nbsp;If you still feel unwell, see a doctor again.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Bioclavid<\/h2>\n\n\n\n<p>If you miss a&nbsp;dose, take it as soon as you remember.&nbsp;You should not take the next&nbsp;dose&nbsp;too early, but wait about 4 hours before taking it.<\/p>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Bioclavid<\/h2>\n\n\n\n<p>Keep taking Bioclavid until the end of treatment, even if you feel better.&nbsp;You need each&nbsp;dose&nbsp;to fight&nbsp;infection&nbsp;one.&nbsp;If some bacteria survive, it can lead to&nbsp;a recurrence of&nbsp;infection.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Conditions you must be observant of:<\/strong><br><\/p>\n\n\n\n<p><strong>Allergic reactions:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>inflammation&nbsp;of blood vessels (&nbsp;vasculitis&nbsp;) that can be seen as red or purple, raised spots on the skin but can affect other parts of the body<\/li><li>fever, joint pain, swollen&nbsp;glands&nbsp;in the neck, armpits, or groin<\/li><li>swelling, sometimes of the face or mouth (&nbsp;angioedema&nbsp;) leading to difficulty breathing<\/li><li>collapse.<\/li><\/ul>\n\n\n\n<p><strong>Contact a doctor immediately if you get any of these symptoms.&nbsp;Stop taking Bioclavid.<\/strong><br><\/p>\n\n\n\n<p><strong>Inflammation&nbsp;of the colon<\/strong><\/p>\n\n\n\n<p>Inflammation&nbsp;of the colon that causes watering diarrhea, usually with blood and mucus, stomach pain, and\/or fever.<\/p>\n\n\n\n<p><strong>Contact a doctor as soon as possible<\/strong>&nbsp;for advice if you get these symptoms.<br><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 user in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea (in adults).<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cod (&nbsp;<em>candidiasis<\/em>&nbsp;&#8211; a yeast infection in the vagina, mouth, or skin fold)<\/li><li>nausea, especially&nbsp;if you take&nbsp;high&nbsp;doses&nbsp;\u2192 if you suffer from this, take Bioclavid before a meal<\/li><li>vomiting<\/li><li>diarrhea (in children).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash,&nbsp;itching<\/li><li>raised, itchy rash (hives)<\/li><li>indigestion<\/li><li>dizziness<\/li><li>headache.<\/li><\/ul>\n\n\n\n<p>Uncommon&nbsp;side effects&nbsp;that may show up in blood tests:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increase of some substances (&nbsp;<em>enzyme-&nbsp;s<\/em>&nbsp;) produced in the liver.<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>skin rash, which can turn into blisters and look like small targets (a dark dot in the middle surrounded by a paler area with a dark ring around the edge &#8211;&nbsp;<em>erythema multiforme<\/em>&nbsp;) \u2192 contact a doctor immediately if you notice any of these symptoms.<\/li><\/ul>\n\n\n\n<p>Rare&nbsp;side effects&nbsp;that may show up in blood tests:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the low number of&nbsp;blood cells&nbsp;involved in the coagulation of the blood<\/li><li>low&nbsp;white blood cell count.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;have occurred in a very small number of patients but their exact occurrence is unknown.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions (see above)<\/li><li>inflammation&nbsp;of the colon (see above)<\/li><li>inflammation&nbsp;of the membranes around the brain and spinal cord (aseptic&nbsp;meningitis&nbsp;)<\/li><li>inflammation&nbsp;of the liver (&nbsp;hepatitis&nbsp;)<\/li><li>jaundice caused by increases in&nbsp;bilirubin&nbsp;in the blood (a substance produced in the liver) that can make the skin and whites of the eyes look yellow<\/li><li>inflammation&nbsp;of the kidneys<\/li><li>it takes longer for the blood to coagulate<\/li><li>hyperactivity<\/li><li>seizures (in people taking high&nbsp;doses&nbsp;of Bioclavid or having kidney problems)<\/li><li>the black tongue that looks hairy<\/li><li>stains on the teeth (in children), usually go away with toothbrushing.<\/li><li>severe skin reactions (contact a doctor immediately if you get any of the following symptoms):<ul><li>a widespread rash with blisters and flaking skin, especially around the mouth, nose, eyes, and genitals (&nbsp;Stevens-Johnson syndrome&nbsp;) and a more severe form that causes extensive flaking of the skin (more than 30% of body surface area &#8211;&nbsp;toxic epidermal necrolysis&nbsp;)<\/li><li>an extensive red rash with small blisters with var (bullous exfoliative&nbsp;dermatitis&nbsp;)<\/li><li>a red, scaly rash with lumps under the skin and blisters (exanthematous&nbsp;pustulosis&nbsp;)<\/li><li>flu-like symptoms&nbsp;with rash, fever, swollen&nbsp;glands,&nbsp;and abnormal results from blood tests (including increased&nbsp;white blood cell count&nbsp;(&nbsp;<em>eosinophilia<\/em>&nbsp;) and liver enzymes) (Drug reaction with&nbsp;eosinophilia&nbsp;and systemic symptoms (&nbsp;<em>DRESS<\/em>&nbsp;)).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Side effects&nbsp;that may appear in blood or urine tests:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe decrease in&nbsp;white blood cell count<\/li><li>low&nbsp;red blood cell count&nbsp;(hemolytic anemia&nbsp;)<\/li><li>crystals in the urine.<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Bioclavid<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;Store in the original package.&nbsp;Moisture sensitive<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are amoxicillin trihydrate corresponding to amoxicillin 500 mg and potassium&nbsp;clavulanate&nbsp;corresponding to&nbsp;clavulanic acid&nbsp;125 mg.<\/li><li>The other ingredients are magnesium stearate, talc, povidone, microcrystalline cellulose, croscarmellose sodium, triethyl citrate, hypromellose, ethylcellulose, and titanium dioxide (E 171).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Off-white, oval, biconvex, with a notch<br><\/p>\n\n\n\n<p>Blister pack of 20, 30, 100, 100&#215;1 film-coated tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Sandoz GmbH<\/p>\n\n\n\n<p>Biochemiestrasse 10,<\/p>\n\n\n\n<p>A-6250 Kundl,<\/p>\n\n\n\n<p>Austria<br><\/p>\n\n\n\n<p>Information provided by:<br><\/p>\n\n\n\n<p>Sandoz A \/ S<\/p>\n\n\n\n<p>Edvard Thomsens Vej 14<\/p>\n\n\n\n<p>2300 Copenhagen S<\/p>\n\n\n\n<p>Denmark<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bioclavid is an antibiotic that works by killing bacteria that cause infection. It contains two different drugs called amoxicillin and clavulanic acid. Amoxicillin belongs to a group of medicines called &#8220;penicillins&#8221; which can sometimes stop working (become inactive). The other active substance ( clavulanic acid ) prevents this from happening.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2202,2200],"tags":[8787,8789,8791,8782,8784,8786,8792,8795,8790,8785,8796,8788,8783,8793],"class_list":["post-6092","post","type-post","status-publish","format-standard","hentry","category-b","category-medicines","tag-amoxicillin","tag-amoxicillin-side-effects","tag-amoxicillin-tablet","tag-bioclavid","tag-bioclavid-side-effects","tag-bioclavid-tablet","tag-clavulanic-acid","tag-clavulanic-acid-tablet","tag-what-amoxicillin-is-used-for","tag-what-bioclavid-is-used-for","tag-what-clavulanic-acid-is-used-for","tag-what-is-amoxicillin","tag-what-is-bioclavid","tag-what-is-clavulanic-acid"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6092","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6092"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6092\/revisions"}],"predecessor-version":[{"id":12003,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6092\/revisions\/12003"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6092"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6092"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6092"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}