{"id":6085,"date":"2020-12-31T15:19:58","date_gmt":"2020-12-31T15:19:58","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6085"},"modified":"2023-01-31T17:29:39","modified_gmt":"2023-01-31T17:29:39","slug":"binocrit","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/binocrit\/","title":{"rendered":"Binocrit &#8211; Epoetin Alfa Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>Binocrit 1000 IU \/ 0.5 ml, 2000 IU \/ 1 ml, 3000 IU \/ 0.3 ml, 4000 IU \/ 0.4 ml, 5000 IU \/ 0.5 ml, 6000 IU \/ 0.6 ml, 7000 IU \/ 0, 7 mL, 8000 IU \/ 0.8mL, 9000 IU \/ 0.9 ml, 10,000 IU \/ 1 ml, 20,000 IU \/ 0.5 ml, 30000 IU \/ 0.75 ml and 40,000 IU \/ 1 ml&nbsp;injection&nbsp;solution, Epoetin Alfa in a Pre Filled&nbsp;Syringe&nbsp;<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Binocrit Is And What Is Binocrit Used For<\/h2>\n\n\n\n<p>Binocrit contains the active substance epoetin alfa, a\u00a0protein\u00a0that stimulates\u00a0the bone marrow\u00a0to form more\u00a0red blood cells\u00a0that contain\u00a0haemoglobin\u00a0(a substance that carries oxygen).\u00a0Epoetin alfa is a copy of the human\u00a0protein\u00a0et erythropoietin and works similarly.<br><strong>Binocrit is used to treat\u00a0symptomatic\u00a0anaemia\u00a0caused by kidney disease:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>In children undergoing\u00a0hemodialysis<\/li><li>In adults undergoing\u00a0hemodialysis\u00a0or\u00a0peritoneal dialysis<\/li><li>In adults with severe\u00a0anaemia\u00a0not yet undergoing\u00a0dialysis\u00a0(given as an\u00a0injection\u00a0into a vein)<\/li><\/ul>\n\n\n\n<p>If you have kidney disease and do not produce enough erythropoietin, you may have too few\u00a0red blood cells.\u00a0Erythropoietin is needed for the production of\u00a0red blood cells.\u00a0Binocrit has been prescribed to stimulate your\u00a0bone marrow\u00a0to produce more\u00a0red blood cells.<\/p>\n\n\n\n<p><strong>Binocrit is used to treat\u00a0anaemia<\/strong>\u00a0if you are receiving\u00a0chemotherapy\u00a0for solid\u00a0tumours, lymph node\u00a0tumours\u00a0(malignant\u00a0lymphoma\u00a0), or multiple\u00a0myeloma\u00a0(bone marrow cancer) and your doctor thinks you need a\u00a0blood transfusion.\u00a0Binocrit may reduce the need for a\u00a0blood transfusion.<\/p>\n\n\n\n<p>Binocrit is used for patients with moderate\u00a0anaemia\u00a0who donate a certain amount of their blood before their operation\u00a0to get it back during or after the operation.\u00a0Because Binocrit stimulates the production of\u00a0red blood cells, a larger volume of blood can be taken from these individuals.<\/p>\n\n\n\n<p>Binocrit injection is used in people with moderate\u00a0anaemia\u00a0who\u00a0need\u00a0major\u00a0orthopaedic surgery\u00a0(eg hip and knee surgery) to reduce the need for\u00a0blood transfusions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What You Need To Know Before You Use Binocrit<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Binocrit<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic\u00a0to epoetin alfa or any of the other ingredients of this medicine (listed in section 6)<\/li><li>If you have been diagnosed with pure erythrocyte aplasia\u00a0(meaning that\u00a0your bone marrow cannot produce enough\u00a0red blood cells\u00a0) after previous treatment with any product that stimulates the formation of\u00a0red blood cells(including Binocrit), see section 4.<\/li><li>If you have high\u00a0blood pressure, which can not be controlled enough with drugs.<\/li><li>To stimulate the production of your\u00a0red blood cells\u00a0(so that doctors can take more blood from you)<\/li><li>If you can not get your blood transfusion\u00a0during or after the operation.<\/li><li>If you are going to undergo a major, planned (elective) operation<\/li><li>Have a serious heart disease<\/li><li>Severe diseases of the veins or\u00a0arteries\u00a0are<\/li><li>Recently had a heart attack or\u00a0stroke<\/li><li>Can not take blood thinners<\/li><\/ul>\n\n\n\n<p>Binocrit may be inappropriate for you.&nbsp;Discuss it with your doctor.&nbsp;Some people who use Binocrit may also need medicines that reduce the risk of blood clots.&nbsp;<strong>If you can not take blood-thinning drugs, do not use Binocrit.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Binocrit.<\/p>\n\n\n\n<p><strong>Binocrit and other drugs that stimulate the production of\u00a0red blood cells\u00a0may increase the risk of developing blood clots in all patients.\u00a0This risk may be higher if you have other risk factors<\/strong>\u00a0for developing blood clots\u00a0<em>(eg if you have a history of blood clots or if you are overweight, have\u00a0diabetes, have heart disease, or if you are bedridden for a long time as a result of surgery or disease)<\/em>.<\/p>\n\n\n\n<p>Tell your doctor if you have any of these.\u00a0Your doctor will help you determine if the injection is right for you.<br><strong>You must tell your doctor<\/strong>\u00a0if any of the following apply to you.\u00a0You may still be able to use Binocrit, but discuss it with your doctor first.<br>If you know you are suffering from or have suffered from:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>High\u00a0blood pressure<\/li><li>Epileptic seizures<\/li><li>Liver disease<\/li><li>Anaemia\u00a0of other causes<\/li><li>Porphyria\u00a0(a rare blood disease)<\/li><\/ul>\n\n\n\n<p>If you are a cancer patient, you should be aware that products that stimulate the formation of\u00a0red blood cells\u00a0(such as Binocrit) can act as a growth factor and could, therefore, theoretically affect the development of your cancer.<br>Depending on your condition, a\u00a0blood transfusion\u00a0may be preferable.\u00a0Discuss this with your doctor.<br>Suppose you are a patient with hepatitis C and are receiving interferon and ribavirin.<\/p>\n\n\n\n<p>In that case, you should discuss this with your doctor because epoetin alfa in combination with\u00a0interferon\u00a0and ribavirin has, in rare cases, led to poor efficacy and development of the condition pure erythrocyte aplasia (PRCA), which is a severe form of\u00a0anaemia.\u00a0Binocrit is not approved for the treatment of\u00a0hepatitis\u00a0C-associated\u00a0anaemia.<br>If you are a patient with\u00a0chronic\u00a0kidney failure,\u00a0and especially if you do not respond properly to Binocrit, your doctor will check your\u00a0dose\u00a0of Binocrit injection as repeated\u00a0dose\u00a0increases; if you do not respond to treatment may increase the risk of problems with heart or blood vessels and may increase the risk of\u00a0myocardial infarction,\u00a0stroke,\u00a0and death.<br><strong>Take special care with other drugs that stimulate the production of red blood cells:<\/strong><\/p>\n\n\n\n<p>Binocrit belongs to a group of products that stimulate the production of\u00a0red blood cells\u00a0in the same way as the human\u00a0protein\u00a0et erythropoietin does.<\/p>\n\n\n\n<p>Your doctor will always note exactly which product you are using.\u00a0If you get any medicine other than Binocrit that belongs to this group during treatment, talk to your doctor or pharmacist before using it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Binocrit<\/h2>\n\n\n\n<p>Normally, Binocrit does not react with other medicines but tell your doctor or pharmacist if you have recently taken or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p><br><b>Suppose you take a medicine called ciclosporin (used after a kidney transplant, for example). In that case,<\/b> your doctor may\u00a0prescribe\u00a0blood tests to check your ciclosporin levels while taking it.<br>Iron supplements and other blood stimulants\u00a0can increase the effect of Binocrit.\u00a0Your doctor will decide if you should take such.<\/p>\n\n\n\n<p>If you go to a hospital, reception, or GP, tell them you are being treated with this medicine.\u00a0It may affect other treatments or test results.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, Breastfeeding, And Fertility<\/h2>\n\n\n\n<p>You must tell your doctor if any of the following apply to you.\u00a0You may still be able to take Binocrit, but discuss with your doctor first:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant\u00a0or think you may be pregnant<\/li><li>If you are breast-feeding<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Binocrit Contains Sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose, essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How To Use Binocrit<\/h2>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Binocrit uses<\/span><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Always use this medicine exactly as your doctor has told you.\u00a0Consult a doctor if you are unsure.<\/li><li>Your doctor has taken blood samples\u00a0and decided that you need Binocrit.<\/li><li>Binocrit is given by\u00a0injection.<ul><li>Either\u00a0in a vein or a tube that enters a vein (\u00a0intravenously\u00a0)<\/li><li>Or\u00a0under the skin (\u00a0subcutaneously\u00a0).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Your doctor will decide how to inject.\u00a0You will usually receive the\u00a0injection from a doctor, nurse, or other healthcare professionals.<\/p>\n\n\n\n<p>Depending on why they need Binocrit treatment, some people may later learn to inject themselves under the skin: see\u00a0<em>Instructions for giving yourself an\u00a0injection<\/em>\u00a0at the end of this leaflet.<\/p>\n\n\n\n<p>Binocrit should not be used:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>After the expiry date stated on the label and the outer carton.<\/li><li>If you know or think it may have been frozen by mistake, or<\/li><li>If a fault has occurred with the refrigerator.<\/li><\/ul>\n\n\n\n<p>Dose\u00a0one of Binocrit is based on your kilograms (kg) body weight.\u00a0The cause of your\u00a0anaemia\u00a0is also included when your doctor decides which\u00a0dose\u00a0is right for you.<\/p>\n\n\n\n<p><strong>Your doctor will monitor your\u00a0blood pressure<\/strong>\u00a0regularly while you are using Binocrit.<\/p>\n\n\n\n<p><strong>People with kidney disease<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will keep your haemoglobin level between 10 and 12 g \/ dl, as a high haemoglobin level may increase the risk of blood clots and death.<\/li><li>Usual starting dose<\/li><li>Adults and children are provided<\/li><li>Your doctor will\u00a0prescribe\u00a0regular blood tests to see how your\u00a0anaemia\u00a0responds to treatment and may adjust\u00a0dose\u00a0one, usually no more often than every four weeks.<\/li><li>Once your\u00a0anaemia has been\u00a0corrected, your doctor will regularly check your blood.\u00a0Your\u00a0dose of\u00a0Binocrit and the frequency of administration (how often it is given to you) can be further adjusted to maintain your response to treatment.\u00a0Your doctor will use the lowest effective\u00a0dose\u00a0to control your anaemia symptoms.<\/li><li>If you do not respond properly to Binocrit, your doctor will check your\u00a0dose\u00a0and tell you if you need to change the\u00a0doses\u00a0of Binocrit.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Suppose you are on an extended dosing interval (less frequently than once a week) with Binocrit. In that case, you may not maintain adequate haemoglobin levels and need to increase the Binocrit-\u00a0a dose of\u00a0one or the frequency of administration.<\/li><li>You can get iron supplements before and during treatment with Binocrit to make it more effective.<\/li><li>If you are undergoing dialysis treatment when you start treatment with Binocrit, your dialysis treatment may need to be adjusted.\u00a0Your doctor will decide this.<\/li><\/ul>\n\n\n\n<p><strong>Adults undergoing&nbsp;chemotherapy<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor may start treatment with Binocrit if your haemoglobin level is 10 g \/ dl or lower.<\/li><li>Your doctor will keep your haemoglobin level between 10 and 12 g \/ dl, as a high haemoglobin level may increase the risk of blood clots and death.<\/li><li>The usual starting dose is\u00a0either\u00a0150 IU per kg body weight 3 times a week\u00a0or\u00a0450 IU per kilogram body weight once a week.<\/li><li>Binocrit is given as an\u00a0injection\u00a0under the skin.<\/li><li>Your doctor will\u00a0prescribe\u00a0blood tests and adjust the\u00a0dose\u00a0depending on how the anaemia responds to treatment with Binocrit.<\/li><li>You may receive iron supplements before and during treatment with Binocrit to make it more effective.<\/li><li>Treatment with this medicine usually continues for one month after chemotherapy treatment.<\/li><\/ul>\n\n\n\n<p><strong>Adults who donate their blood<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The usual starting dose<\/strong>\u00a0is 600 IU per kilogram of body weight twice weekly.<\/li><li>After you donate blood, this medicine is given immediately by\u00a0injection\u00a0into a vein 3 weeks before your operation.<\/li><li>You may receive iron supplements before and during treatment with Binocrit to make it more effective.<\/li><\/ul>\n\n\n\n<p><strong>Adults undergoing major\u00a0orthopaedic\u00a0surgery<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The recommended\u00a0dose<\/strong>\u00a0is 600 IU per kg of body weight once a week.<\/li><li>Binocrit is given as an\u00a0injection\u00a0under the skin every week for three weeks before and on the day of surgery.<\/li><li>Suppose there is a medical need to shorten the time until your surgery. In that case, you will receive a daily\u00a0dose\u00a0of 300 IU \/ kg for up to 10 days before surgery, on the day of surgery, and for 4 days immediately after surgery.<\/li><li>If blood tests show that the haemoglobin levels are too high before the operation, treatment will be stopped.<\/li><li>You may receive iron supplements before and during treatment with Binocrit to make it more effective.<\/li><\/ul>\n\n\n\n<p><strong>Instruction for\u00a0injection\u00a0of Binocrit under the skin<\/strong><\/p>\n\n\n\n<p>When starting treatment, Binocrit is usually injected by healthcare professionals.\u00a0Later, the doctor may suggest that you learn yourself or the person caring for you learn to inject Binocrit under the skin (\u00a0<em>subcutaneously<\/em>\u00a0).<\/p>\n\n\n\n<p>Note!\u00a0If you are a kidney patient, Binocrit must be injected into a vein.\u00a0Do not inject under the skin (\u00a0subcutaneously\u00a0).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not try to give yourself an\u00a0injection\u00a0unless your doctor or nurse has trained you to do so.<\/li><li>Always use Binocrit exactly as your doctor or nurse has told you.<\/li><li>Ensure you only inject the amount of fluid your doctor or nurse has prescribed.<\/li><li>Use Binocrit only if it has been stored correctly &#8211; see section 5, How to store Binocrit.<\/li><li>Before use, the syringe with Binocrit should be taken out and allowed to stand until it reaches room temperature.\u00a0This usually takes between 15 and 30 minutes.\u00a0Use the syringe within 3 days after removing it from the refrigerator.<\/li><\/ul>\n\n\n\n<p><strong>Take only one\u00a0dose of\u00a0Binocrit from each\u00a0syringe.<\/strong> If Binocrit is injected under the skin (\u00a0subcutaneously\u00a0), the amount injected is normally no more than one millilitre (1 ml) in one\u00a0injection.<br>Binocrit is given alone and should not be mixed with other injections.<br><strong>Do not shake syringes with Binocrit.\u00a0<\/strong>Violent shaking for a long time can damage the product.\u00a0If the product has been shaken violently, it must not be used. Instructions on injecting yourself with Binocrit can be found at the end of this leaflet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Use More Binocrit Than You Should\u00a0<\/h2>\n\n\n\n<p>Tell your doctor or nurse immediately if you think too much Binocrit has been injected.&nbsp;Side effects&nbsp;from an overdose of Binocrit are unlikely.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Use Binocrit<\/h2>\n\n\n\n<p>Take the next\u00a0injection\u00a0as soon as you remember.\u00a0If it is less than a day until your next\u00a0injection, you can skip the one you missed and continue according to your usual schedule.\u00a0Do not inject a double\u00a0dose.<\/p>\n\n\n\n<p>If you have any further questions about the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible Binocrit Side Effects<\/h2>\n\n\n\n<p>This medicine can cause side effects like all medicines, although not everybody gets them. Please tell your doctor or nurse if you notice any side effects not listed in this leaflet.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may occur in more than 1 in 10 people using Binocrit.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhoea<\/li><li>Nausea<\/li><li>Vomiting<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">Fever<\/a><\/li><li>Narrow airways, e.g.\u00a0<ul><li>Nasal congestion and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sore-throat\/\">sore throat<\/a> have been reported in patients with kidney disease who have not yet been treated with\u00a0dialysis.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in up to 1 in 10 people who use Binocrit.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Increased\u00a0blood pressure.\u00a0Headaches, especially sudden, stabbing migraine-like headaches, feelings of\u00a0confusion or seizures\u00a0can be signs of a sudden increase in\u00a0blood pressure.\u00a0These require urgent treatment.\u00a0High\u00a0blood pressure may require treatment with certain other medicines (or adjustment of any medicines you are already taking for high\u00a0blood pressure\u00a0).<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Blood clots (<\/strong>\u00a0including\u00a0deep vein thrombosis\u00a0and embolism) may require immediate treatment.\u00a0As symptoms, you may experience chest pain, shortness of breath, and painful swelling and redness, usually in the leg.<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">Cough<\/a><\/li><li>Skin rash, which is an allergic reaction, can cause<\/li><li>Skeletal or muscle pain.<\/li><li>Influenza-like symptoms, such as <ul><li>Headache<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/joint-pain\/\">Joint pain<\/a><\/li><li>Pain<\/li><li>Feeling weak<\/li><li>Chills<\/li><li>Fatigue<\/li><li>Dizziness.\u00a0These may be more common at the beginning of treatment.\u00a0If you get these symptoms during\u00a0a\u00a0vein\u00a0injection, they can be avoided by giving the\u00a0injection\u00a0more slowly.<\/li><\/ul><\/li><li>Redness, burning, and pain at the injection site.<\/li><li>Swelling of the ankles, feet, or fingers.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in up to 1 in 10,000 people who use Binocrit.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Symptoms of pure erythrocyte plasma (PRCA)Pure erythrocyte plasma means that the\u00a0bone marrow\u00a0does not produce enough\u00a0red blood cells.\u00a0Pure erythrocyte plasma leads to sudden and severe\u00a0anaemia<strong>.<\/strong>\u00a0The symptoms are:<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Abnormal fatigue<\/li><li>Dizziness<\/li><li>Shortness of breath<\/li><\/ul>\n\n\n\n<p>Pure erythrocyte plasma has, in rare cases, been reported mainly in patients with kidney disease after months to years of treatment with epoetin alfa and other products that stimulate the formation of\u00a0red blood cells.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>An increase in the levels of small\u00a0blood cells\u00a0(so-called\u00a0platelets\u00a0) is normally involved in forming a blood clot, especially at the beginning of treatment.\u00a0Your doctor will check this.<\/li><\/ul>\n\n\n\n<p>If you are undergoing hemodialysis:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood clots<\/li><li>Blood\u00a0clots\u00a0can also form\u00a0in your hemodialysis system.\u00a0Your doctor may decide to increase your heparin dose during\u00a0dialysis.<\/li><\/ul>\n\n\n\n<p>Tell\u00a0your\u00a0doctor or nurse immediately if\u00a0you notice any of these\u00a0or\u00a0other\u00a0side effects\u00a0with this medicine. If any side effects get serious, or if you notice any\u00a0side effects\u00a0not listed in this leaflet, please tell your doctor, nurse, or pharmacist.<\/p>\n\n\n\n<p><strong>Reporting of\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse if you get any side effects.\u00a0This also applies to\u00a0side effects\u00a0that are not mentioned in this information.\u00a0You can also report\u00a0side effects\u00a0directly (see details below).\u00a0By reporting\u00a0side effects, you can help increase the information about the medicine&#8217;s safety.<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse if you get any side effects.\u00a0This includes any possible side effects not listed in this leaflet.\u00a0You can also report side effects directly to the Medical Products Agency,\u00a0www.lakemedelsverket.se.\u00a0By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How To Store Binocrit<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of sight and reach of children<strong>.<\/strong><\/li><li>Do not use this medicine after the expiry date, which is stated on the<\/li><li>Store and transport <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">cold<\/a> (2 \u00b0 C \u2011 8 \u00b0 C).<\/li><li>You can remove Binocrit from the refrigerator and store it at room temperature (up to 25 \u00b0 C) for up to 3 days.\u00a0Once a\u00a0syringe\u00a0has been removed from the refrigerator and has reached room temperature (up to 25 \u00b0 C), it must be used within 3 days or discarded.<\/li><li>Do not freeze.\u00a0Do not shake.<\/li><li>Store in the original package.\u00a0Sensitive to light. Do not re-use this medicine.<\/li><li>The liquid may have been accidentally frozen.<\/li><li>There has been something wrong with the refrigerator.<\/li><li>The liquid is discoloured, or you can see particles floating in it.<\/li><li>The seal is broken. Medicines should not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines that are no longer required.\u00a0These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents Of The Packaging And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is epoetin alfa (see table below for amounts).<\/li><li>The other ingredients are sodium dihydrogen phosphate dihydrate, disodium phosphate dihydrate, sodium chloride,\u00a0glycine, polysorbate 80,\u00a0hydrochloric acid\u00a0(for\u00a0pH\u00a0adjustment), sodium hydroxide (for\u00a0pH\u00a0adjustment), and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And The Contents Of The Pack<\/h2>\n\n\n\n<p>Binocrit is a clear, colourless\u00a0solution for injection\u00a0in a pre-filled\u00a0syringe.\u00a0The syringes are sealed in a blister pack.<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\">Presentation<\/th><th scope=\"col\">Corresponding presentations in quantity\/volume for each strength<\/th><th scope=\"col\">Amountepoetin alfa<\/th><\/tr><\/thead><tbody><tr><td>Pre-filled syringes *<\/td><td><strong>2,000 IU \/ ml:<\/strong><\/td><\/tr><tr><td>1,000 IU \/ 0.5 ml<\/td><td>8.4 micrograms<\/td><\/tr><tr><td>2,000 IU \/ 1 ml<\/td><td>16.8 micrograms<\/td><\/tr><tr><td><strong>10,000 IU \/ ml:<\/strong><\/td><\/tr><tr><td>3,000 IU \/ 0.3 ml<\/td><td>25.2 micrograms<\/td><\/tr><tr><td>4,000 IU \/ 0.4 ml<\/td><td>33.6 micrograms<\/td><\/tr><tr><td>5,000 IU \/ 0.5 ml<\/td><td>42.0 micrograms<\/td><\/tr><tr><td>6,000 IU \/ 0.6 ml<\/td><td>50.4 micrograms<\/td><\/tr><tr><td>7,000 IU \/ 0.7 ml<\/td><td>58.8 micrograms<\/td><\/tr><tr><td>8,000 IU \/ 0.8 ml<\/td><td>67.2 micrograms<\/td><\/tr><tr><td>9,000 IU \/ 0.9 ml<\/td><td>75.6 micrograms<\/td><\/tr><tr><td>10,000 IU \/ 1 ml<\/td><td>84.0 micrograms<\/td><\/tr><tr><td><strong>40,000 IU \/ ml:<\/strong><\/td><\/tr><tr><td>20,000 IU \/ 0.5 ml<\/td><td>168.0 micrograms<\/td><\/tr><tr><td>30,000 IU \/ 0.75 ml<\/td><td>252.0 micrograms<\/td><\/tr><tr><td>40,000 IU \/ 1 ml<\/td><td>336.0 micrograms<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>Packs of 1, 4, or 6 pre-filled syringes with or without needle guard.<\/li><li>Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p>Sandoz GmbH<\/p>\n\n\n\n<p>Biochemiestr.&nbsp;10<\/p>\n\n\n\n<p>A-6250 Kundl<\/p>\n\n\n\n<p>Austria<\/p>\n\n\n\n<p>L\u00e4kemedelsverket, Box 26, 751 03 Uppsala<\/p>\n\n\n\n<p>www.lakemedelsverket.se<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\">The representative of the marketing authorization holder:<\/th><\/tr><\/thead><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Sandoz nv-saTel: +32 2 722 97 97<\/td><td><strong>Lithuania<\/strong>Sandoz Pharmaceuticals dd branchesTel: +370 5 2636 037<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>The Targovsky presidential agency &#8220;Sandoz d.d.&#8221;Tel .: +359 2 970 47 47<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Sandoz GmbHTel: +43 5338 2000<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Sandoz sroTel: +420 221 421 611<\/td><td><strong>Hungary<\/strong>Sandoz Hungary Kft.Tel .: +36 1 430 2890<\/td><\/tr><tr><td><\/td><td><strong>Malta<\/strong>Sandoz GmbHTel: +43 5338 2000<\/td><\/tr><tr><td><strong>Germany<\/strong>Hexal AGTel: +49 8024 908 0<\/td><td><strong>The Netherlands<\/strong>Sandoz BVTel: +31 36 52 41 600<\/td><\/tr><tr><td><strong>Eesti<\/strong>Sandoz dd Eesti subsidiaryTel: +372 6652 400<\/td><td><strong>Austria<\/strong>Sandoz GmbHTel: +43 5338 2000<\/td><\/tr><tr><td><strong>Greece<\/strong>Novartis (Hellas) AEBE:\u0397\u03bb: +30 210 281 17 12\u03aeSandoz Pharmaceuticals dd,:\u0397\u03bb: +30 216 600 5000\u03aeDEMO Unified Chemicals in the Humorous State:\u0397\u03bb: +30 210 816 18 02<br><\/td><td><strong>Poland<\/strong>Sandoz Polska Sp.&nbsp;z ooTel .: +48 22 209 70 00<br><\/td><\/tr><tr><td><strong>Spain<\/strong>Sandoz Pharmac\u00e9utica, SATel: +34 900 456 856<\/td><td><strong>Portugal<\/strong>Sandoz Pharmaceuticals Lda.Tel: +351 21 924 19 11<\/td><\/tr><tr><td><strong>France<\/strong>Sandoz SASTel: + 33 1 49 64 48 00<\/td><td><strong>Romania<\/strong>SC Sandoz SRLTel: +40 265 208 120<\/td><\/tr><tr><td><strong>Croatia<\/strong>Sandoz dooTel: +385 1 23 53 111<\/td><td><strong>Slovenia<\/strong>Lek farmacevtska dru\u017eba ddTel: +386 1 580 21 11<\/td><\/tr><tr><td><strong>Ireland<\/strong>Novartis Ireland LimitedTel: + 353 1 260 12 55<\/td><td><strong>Slovak Republic<\/strong>Sandoz dd &#8211; organizational serviceTel: +421 2 48 200 600<\/td><\/tr><tr><td><strong>Italy<\/strong>Sandoz SpATel: +39 02 96541<\/td><td><strong>Finland \/ Finland<\/strong>Sandoz A \/ SPuh \/ Tel: +358 10 6133 415<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>PTHadjigeorgiou co ltd:\u0397\u03bb: +357 25372425<\/td><td><strong>United Kingdom<\/strong>Sandoz LtdTel: + 44 1276 69 8020<\/td><\/tr><tr><td><strong>Latvia<\/strong>Sandoz dd P\u0101rst\u0101vniec\u012bba Latvij\u0101Tel: +371 67 892 006<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Binocrit is a medication used to treat anaemia in individuals with myelodysplastic syndromes (conditions in which the production of healthy blood cells is defective).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2202,2200],"tags":[8819,8821,8823,3968,8816,8818,8822,8817,8820,3969],"class_list":["post-6085","post","type-post","status-publish","format-standard","hentry","category-b","category-medicines","tag-binocrit","tag-binocrit-injection","tag-binocrit-side-effects","tag-epoetin-alfa","tag-epoetin-alfa-injection","tag-side-effects-of-epoetin-alfa","tag-what-binocrit-is-used-for","tag-what-epoetin-alfa-is-used-for","tag-what-is-binocrit","tag-what-is-epoetin-alfa"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6085"}],"version-history":[{"count":88,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6085\/revisions"}],"predecessor-version":[{"id":47511,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6085\/revisions\/47511"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}