{"id":6036,"date":"2020-12-30T14:37:32","date_gmt":"2020-12-30T14:37:32","guid":{"rendered":"https:\/\/zeepedia.com\/?p=6036"},"modified":"2021-07-03T06:40:13","modified_gmt":"2021-07-03T06:40:13","slug":"bevespi-aerosphere","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/bevespi-aerosphere\/","title":{"rendered":"Bevespi Aerosphere &#8211; Formoterol \/ Glycopyrronium uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n7.2 micrograms \/ 5 micrograms&nbsp;inhalation&nbsp;spray&nbsp;,&nbsp;suspension&nbsp;glycopyrronium \/ formoterol fumarate dihydrate&nbsp;<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Bevespi Aerosphere is and what it is used for<\/h2>\n\n\n\n<p>Bevespi Aerosphere contains two active substances called glycopyrronium and formoterol fumarate dihydrate.&nbsp;These belong to a group of drugs called long-acting bronchodilators.<\/p>\n\n\n\n<p>Bevespi Aerosphere is used to make it easier for adults to have a lung disease called COPD (chronic&nbsp;obstructive pulmonary disease&nbsp;).&nbsp;COPD is a long-term disease of the lungs&#8217; airways, which is often caused by smoking.&nbsp;If you have COPD, the muscles in the trachea become tense, which makes it difficult to breathe.<\/p>\n\n\n\n<p>This medicine prevents the muscles in the trachea from becoming tense, making it easier for air to get in and out of the lungs.<\/p>\n\n\n\n<p>Bevespi Aerosphere delivers the active ingredients directly to the lungs&#8217; airways when you inhale.&nbsp;This will help reduce the effects of COPD in your daily life<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Bevespi Aerosphere<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Bevespi Aerosphere<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to glycopyrronium, formoterol fumarate dihydrate, or any of the other ingredients of this medicine (listed in section 6).&nbsp;If you are not sure, talk to your doctor or pharmacist before using Bevespi Aerosphere.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Bevespi Aerosphere is regularly used as a long-term treatment for COPD.&nbsp;Do not use this medicine to treat sudden attacks of shortness of breath or wheezing.<br><\/p>\n\n\n\n<p><strong>Sudden difficulty breathing<\/strong><\/p>\n\n\n\n<p>If you get pressure over your chest, cough, wheeze or shortness of breath immediately after using Bevespi Aerosphere:<\/p>\n\n\n\n<p><strong>Stop using this medicine and seek immediate medical attention<\/strong>&nbsp;as this may be a serious condition called parodoxal&nbsp;bronchospasm.<br><\/p>\n\n\n\n<p><strong>Talk to your doctor or pharmacist before using Bevespi Aerosphere<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have&nbsp;asthma.&nbsp;Do not use this medicine to treat&nbsp;asthma<\/li><li>you have heart problems<\/li><li>you have&nbsp;diabetes<\/li><li>you have low potassium levels in your blood<\/li><li>you have thyroid problems (called &#8220;thyrotoxicosis&#8221;)<\/li><li>you have an eye&nbsp;problem&nbsp;called&nbsp;narrow-angle glaucoma<\/li><li>you have prostate problems or difficulty urinating<\/li><li>you have impaired kidney or liver function.<\/li><\/ul>\n\n\n\n<p>Always tell your doctor about other health problems.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Bevespi Aerosphere should not be used by children and adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Bevespi Aerosphere<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n<p>Some medicines may affect the way this medicine works or make you more likely to experience&nbsp;side effects.&nbsp;These medicines include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines that work in the same way as Bevespi Aerosphere, for example, medicines that contain active substances such as <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiogiva\/\">tiotropium<\/a>, ipratropium, aclidinium, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/trilegy-ellipta\/\">umeclidinium<\/a>,&nbsp;salmeterol, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/trilegy-ellipta\/\">vilanterol<\/a>, olodaterol, or indacaterol.&nbsp;If you are not sure, ask your doctor or pharmacist.&nbsp;It is not recommended to use Bevespi Aerosphere with these medicines.<\/li><li>drugs that can reduce&nbsp;potassium&nbsp;in the blood.&nbsp;These medicines include:<ul><li>cortisone&nbsp;that is swallowed (such as&nbsp;prednisolone&nbsp;),<\/li><li>diuretics (such as&nbsp;furosemide&nbsp;or&nbsp;hydrochlorothiazide&nbsp;) used for high&nbsp;blood pressure&nbsp;,<\/li><li>certain drugs used to treat respiratory problems, so-called methylxanthines (such as theophylline).<\/li><\/ul><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines called&nbsp;beta-blockers&nbsp;that can be used to treat high&nbsp;blood pressure&nbsp;or other heart problems (such as atenolol or propranolol) or to treat&nbsp;glaucoma&nbsp;(such as&nbsp;timolol&nbsp;)<\/li><li>drugs that can cause so-called&nbsp;QT&nbsp;prolongation (a change in the electrical activity of the heart).&nbsp;These include drugs for the treatment of:<ul><li>depression (such as&nbsp;monoamine oxidase inhibitors&nbsp;or&nbsp;tricyclic antidepressants)<\/li><li>bacterial&nbsp;infections&nbsp;(such as erythromycin, clarithromycin, telithromycin)<\/li><li>allergic reactions (&nbsp;antihistamines&nbsp;)<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>If any of the above apply to you, or if you are not sure, talk to your doctor or pharmacist before using Bevespi Aerosphere.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using Bevespi Aerosphere.<br><\/p>\n\n\n\n<p>Do not use Bevespi Aerosphere if you are pregnant unless your doctor tells you to.<br><\/p>\n\n\n\n<p>Do not use Bevespi Aerosphere if you are breast-feeding unless your doctor tells you to<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>It is unlikely that this medicine will affect your ability to drive or use machines.&nbsp;However, dizziness and nausea are common&nbsp;side effects&nbsp;that can occur.&nbsp;If this occurs, do not drive or use machines.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Bevespi Aerosphere<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p><strong>How much to use<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is two puffs twice daily.<\/p>\n\n\n\n<p>It is important that you use Bevespi Aerosphere every day, even if you do not have any symptoms of COPD at that time.<br><\/p>\n\n\n\n<p><strong>How to use Bevespi Aerosphere<\/strong><\/p>\n\n\n\n<p>Bevespi Aerosphere is intended for&nbsp;inhalation&nbsp;.<\/p>\n\n\n\n<p>Read the instructions for use at the end of this leaflet.&nbsp;If you are not sure how to use Bevespi Aerosphere, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<p><strong>Use of Bevespi Aerosphere with a respirator<\/strong><\/p>\n\n\n\n<p>If you have problems breathing in and pressing the inhaler at the same time, talk to your doctor or pharmacist.&nbsp;It is possible that you can use a &#8220;breathing container&#8221; together with your&nbsp;inhaler.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Bevespi Aerosphere than you should &nbsp;<\/h2>\n\n\n\n<p>If you have used more Bevespi Aerosphere than you should contact a doctor or pharmacist immediately.&nbsp;You may need medical attention.&nbsp;You may feel your heartbeat faster than normal, feel shaky, have visual disturbances, have a dry mouth, have a headache, or feel nauseous.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Bevespi Aerosphere<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose&nbsp;.&nbsp;Take it as soon as you remember.&nbsp;However, if it is soon time to take the next&nbsp;dose, skip the missed&nbsp;dose.&nbsp;Do not take more than two puffs twice daily.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Bevespi Aerosphere<\/h2>\n\n\n\n<p>This medicine is for long-term use.&nbsp;It will only take effect while you use it.&nbsp;Do not stop taking this medicine unless your doctor tells you to, even if you feel better, as your symptoms may get worse.&nbsp;If you want to stop treatment, talk to your doctor first.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Stop using Bevespi Aerosphere and contact a doctor immediately if you experience any of the following symptoms:<br><\/p>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, especially around the mouth (swelling of the tongue or throat, which may make it difficult to swallow)<\/li><li>rash or hives in combination with difficulty breathing<\/li><li>sudden feeling of fainting.<\/li><\/ul>\n\n\n\n<p>These symptoms may be a sign of a severe&nbsp;allergic reaction&nbsp;.<br><\/p>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are<\/strong><br><\/p>\n\n\n\n<p><strong>Common<\/strong>: may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>dry mouth<\/li><li>nausea<\/li><li>painful and frequent urination (may be a sign of urinary tract infection)<\/li><li>muscle cramps<\/li><li>chest pain<\/li><li>concern<\/li><li>dizziness<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;: may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>shaking or trembling<\/li><li>high blood sugar<\/li><li>agitation (&nbsp;agitation&nbsp;)<\/li><li>restlessness<\/li><li>difficulty sleeping<\/li><li>fast or irregular heartbeat<\/li><li>difficulty urinating (&nbsp;urinary retention&nbsp;).<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Bevespi Aerosphere<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton, bag, or pressure container after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Once opened, the inhaler can be used for up to 3 months.&nbsp;Write down the date the bag was opened in the designated place on the inhaler label.<br><\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<br><\/p>\n\n\n\n<p><strong>Warning:<\/strong>&nbsp;Do not destroy, puncture, or burn the pressure vessel, even if it appears empty.&nbsp;Do not expose the container to temperatures above 50 \u00b0 C.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are glycopyrronium and formoterol fumarate dihydrate.<\/li><\/ul>\n\n\n\n<p>Each individual puff provides an added&nbsp;dose&nbsp;of 9 micrograms glycopyrronium bromide (equivalent to 7.2 micrograms glycopyrronium) and 5 micrograms formoterol fumarate dihydrate.<br><\/p>\n\n\n\n<p>Other ingredients are norflurane, 1,2-distearoyl-sn-glycero-3-phosphocholine, and calcium chloride.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Bevespi Aerosphere is an&nbsp;inhalation spray&nbsp;,&nbsp;suspension&nbsp;.<\/p>\n\n\n\n<p>Bevespi Aerosphere consists of a pressure container with a dose indicator, equipped with a white plastic adapter and a nozzle (see figure 1 in the operating instructions at the end of this leaflet).&nbsp;The nozzle has an orange protective cover.&nbsp;Bevespi Aerosphere comes in a foil bag that contains a desiccant and is packed in a carton.<br><\/p>\n\n\n\n<p>The active ingredients are&nbsp;contained&nbsp;in a&nbsp;suspension&nbsp;inside the pressure vessel.<br><\/p>\n\n\n\n<p>Bevespi Aerosphere in packs containing an&nbsp;inhaler&nbsp;with 120 puffs and in multipacks containing three&nbsp;inhalers&nbsp;s each with 120 puffs.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder:<\/strong><\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>AstraZeneca Dunkirk Production<\/p>\n\n\n\n<p>224 Avenue de la Dordogne<\/p>\n\n\n\n<p>Dunkirk<\/p>\n\n\n\n<p>59640<\/p>\n\n\n\n<p>France<br><\/p>\n\n\n\n<p>AstraZeneca GmbH<\/p>\n\n\n\n<p>Tinsdaler Weg 183<\/p>\n\n\n\n<p>22880 Wedel<\/p>\n\n\n\n<p>Germany<br><\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>AstraZeneca SA \/ NVTel: +32 2 370 48 11<\/td><td><strong>Lithuania<\/strong>UAB AstraZeneca LietuvaTel: +370 5 2660550<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Astrology Bulgaria BODYTel: +359 24455000<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>AstraZeneca SA \/ NVTel: +32 2 370 48 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>AstraZeneca Czech Republic sroTel: +420 222 807 111<\/td><td><strong>Hungary<\/strong>AstraZeneca Kft.Tel .: +36 1 883 6500<\/td><\/tr><tr><td><strong>Denmark<\/strong>AstraZeneca A \/ STel: +45 43 66 64 62<\/td><td><strong>Malta<\/strong>Associated Drug Co.&nbsp;Ltd.Tel: +356 2277 8000<\/td><\/tr><tr><td><strong>Germany<\/strong>AstraZeneca GmbHTel: +49 41 03 7080<\/td><td><strong>The Netherlands<\/strong>AstraZeneca BVTel: +31 79 363 2222<\/td><\/tr><tr><td><strong>Eesti<\/strong>AstraZenecaTel: +372 6549 600<\/td><td><strong>Norway<\/strong>AstraZeneca ASTel: +47 21 00 64 00<\/td><\/tr><tr><td><strong>Greece<\/strong>AstraZeneca AE:\u0397\u03bb: +30 210 6871500<\/td><td><strong>Austria<\/strong>AstraZeneca \u00d6sterreich GmbHTel: +43 1 711 31 0<\/td><\/tr><tr><td><strong>Spain<\/strong>AstraZeneca Pharmac\u00e9utica Spain, SATel: +34 91 301 91 00<\/td><td><strong>Poland<\/strong>AstraZeneca Pharma Poland Sp.&nbsp;z ooTel .: +48 22 245 73 00<\/td><\/tr><tr><td><strong>France<\/strong>AstraZenecaTel: +33 1 41 29 40 00<\/td><td><strong>Portugal<\/strong>AstraZeneca Pharmaceutical Products, Lda.Tel: +351 21 434 61 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>AstraZeneca dooTel: +385 1 4628 000<\/td><td><strong>Romania<\/strong>AstraZeneca Pharma SRLTel: +40 21 317 60 41<\/td><\/tr><tr><td><strong>Ireland<\/strong>AstraZeneca Pharmaceuticals (Ireland) LtdTel: +353 1609 7100<\/td><td><strong>Slovenia<\/strong>AstraZeneca UK LimitedTel: +386 1 51 35 600<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>AstraZeneca AB, ozTel: +421 2 5737 7777<\/td><\/tr><tr><td><strong>Italy<\/strong>AstraZeneca SpATel: +39 02 9801 1<\/td><td><strong>Finland \/ Finland<\/strong>AstraZeneca OyPuh \/ Tel: +358 10 23 010<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>Alexander the Great:\u0397\u03bb: +357 22490305<\/td><td><\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA AstraZeneca LatvijaTel: +371 67377100<\/td><td><strong>United Kingdom<\/strong>AstraZeneca UK LtdTel: +44 1582 836 836<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Bevespi Aerosphere contains two active substances called glycopyrronium and formoterol fumarate dihydrate. These belong to a group of drugs called long-acting bronchodilators.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2202,2200],"tags":[8910,8914,8918,8921,8913,8917,8912,8916,8920,8911,8915,8919],"class_list":["post-6036","post","type-post","status-publish","format-standard","hentry","category-b","category-medicines","tag-bevespi-aerosphere","tag-formoterol","tag-glycopyrronium","tag-glycopyrronium-side-effects","tag-side-effects-of-bevespi-aerosphere","tag-side-effects-of-formoterol","tag-what-bevespi-aerosphere-is-used-for","tag-what-formoterol-is-used-for","tag-what-glycopyrronium-is-used-for","tag-what-is-bevespi-aerosphere","tag-what-is-formoterol","tag-what-is-glycopyrronium"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=6036"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6036\/revisions"}],"predecessor-version":[{"id":12030,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/6036\/revisions\/12030"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=6036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=6036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=6036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}