Do not use BeneFIX<\/h2>\n\n\n\n- if you are allergic to nonacog alfa or any of the other ingredients of this medicine (listed in section 6).<\/li>
- if you are allergic to hamster protein.<\/li><\/ul>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n- Talk to your doctor or pharmacist before using BeneFIX.<\/li>
- Contact your doctor immediately if the bleeding does not stop as expected.<\/li><\/ul>\n\n\n\n
- Allergic reactions are possible. The product may contain traces of hamster proteins (see “Do not use BeneFIX”). Potentially life-threatening anaphylactic reactions (severe allergic reaction ) have occurred with factor IX products, including BeneFIX. Early signs of allergic reactions include difficulty breathing, shortness of breath, swelling, hives that may be widespread throughout the body, itching , chest tightness, wheezing, low blood pressure , blurred vision and anaphylaxis (severe allergic reaction that may cause difficulty swallowing and \/ or or breathing, redness or swelling of the face and \/ or hands).<\/li>
- If allergic or anaphylactic reactions occur, discontinue injection of BeneFIX immediately and consult a physician<\/strong> , or seek emergency medical attention immediately . If severe allergic reactions occur, alternative therapy should be considered.<\/li>
- It is less common for previously treated patients receiving factor IX products to develop neutralizing antibodies (inhibitors). However, during treatment with BeneFIX, you should be closely monitored to check if factor IX inhibitors have been developed. The same applies to treatment with all products containing factor IX.<\/li>
- In the literature, it has been reported that there is an association between the presence of factor IX inhibitors and allergic reactions. Therefore, if you get allergic reactions such as those described above, you should be investigated for the presence of inhibitors. It should be noted that patients taking factor IX inhibitors may be at higher risk of anaphylaxis during additional BeneFIX treatment sessions.<\/li>
- The body’s production of factor IX is regulated by the factor IX gene. Patients who have specific mutations on the factor IX gene, such as larger deletion mutations, may be more likely to develop factor IX inhibitors and \/ or have allergic reactions. If you are known to have such a mutation, your doctor may monitor you extra closely for signs of an allergic reaction, especially when you start treatment with BeneFIX for the first time.<\/li>
- Due to the risk of allergic reactions to factor IX, your first injections of BeneFIX should be given under medical supervision so that appropriate medical treatment for allergic reactions is available.<\/li>
- Even in the absence of inhibitors, a higher dose of BeneFIX may be needed compared to other plasma IX products that you may have taken before. Careful monitoring of factor IX plasma activity (which measures your blood’s ability to coagulate) must therefore be performed to adjust dose one. If the bleeding is not under control after the recommended dose , consult your doctor.<\/li>
- If you have liver or heart disease or if you have recently undergone surgical treatment, there is an increased risk of clot formation (coagulation complications).<\/li>
- Renal impairment ( nephrotic syndrome ) has been reported at high doses of factor IX produced by blood plasma in haemophilia B patients with factor IX inhibitors who have previously experienced allergic reactions.<\/li>
- Sufficient data have not been obtained from clinical trials regarding BeneFIX treatment in patients who have not previously received any treatment (patients who have never received a factor IX infusion before ).<\/li>
- It is recommended that you note the name and batch number of the product each time you use BeneFIX. You can use one of the removable labels on the bottle to document the batch number in your diary or to report side effects .<\/li><\/ul>\n\n\n\n
Other medicines and BeneFIX<\/h2>\n\n\n\n
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n
Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, you should only take BeneFIX as prescribed by your doctor. It is not known whether BeneFIX can cause harm to an unborn baby when taken by pregnant women. Your doctor may advise you to stop taking BeneFIX if you are breast-feeding or pregnant.
<\/p>\n\n\n\n
Ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
BeneFIX has no effect on the ability to drive or use machines.<\/p>\n\n\n\n
BeneFIX contains sodium<\/h2>\n\n\n\n
After preparation BeneFIX contains 0.2 mmol (4.6 mg) of sodium per vial , ie essentially “sodium-free”. However, depending on your body weight and your dose ofBeneFIX, you may receive several vials. This should be considered if you have been prescribed a low-salt diet.
<\/p>\n\n\n\n
3. How to use BeneFIX<\/h2>\n\n\n\n
Always use this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure.
<\/p>\n\n\n\n
Your doctor will decide on the dose of one of BeneFIX that you should take. The doseand duration of treatment depends on your individual need for factor IX replacement therapy and how quickly your body uses up factor IX, which will be checked regularly. You may notice a difference in the dose you receive if you switch from a plasma factor IX product to BeneFIX.
<\/p>\n\n\n\n
Your doctor may change the dose of BeneFIX you receive during treatment.
<\/p>\n\n\n\n
Preparation and administration<\/strong><\/p>\n\n\n\nThe instructions below are advice for the preparation and administration of BeneFIX. Follow your doctor’s instructions for venipuncture.
<\/p>\n\n\n\n
BeneFIX is given by intravenous (IV) infusion after reconstitution of the powder for solution for injection with the supplied diluent (sodium chloride (saline) solution) in the pre-filled syringe.
<\/p>\n\n\n\n
Always wash your hands before doing the following. Aseptic technique (meaning clean and germ-free) should be used during reconstitution .
<\/p>\n\n\n\n
Preparation<\/strong> :<\/p>\n\n\n\nBeneFIX is given by intravenous (IV) infusion after reconstitution with sterile diluent .
<\/p>\n\n\n\n
1. Allow the bottle of freeze-dried BeneFIX and the pre-filled syringe to reach room temperature.
<\/p>\n\n\n\n
2. Remove the plastic cap from the BeneFIX bottle so that the middle part of the rubber stopper is visible.
<\/p>\n\n\n\n![\"The](\"https:\/\/www.fass.se\/res\/RootMedia\/Wyeth\/Media\/BeneFIX\/Bild1.jpg\")
<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
3. Clean the stopper with the supplied compress one with alcohol or use another antiseptic solution and let it dry. Do not touch the rubber stopper with your hand after cleaning and do not allow the stopper to come into contact with any surface.
<\/p>\n\n\n\n
4. Remove the cap from the bottle adapter’s clear plastic package. Do not remove the adapter from the package.
<\/p>\n\n\n\n
5. Place the bottle on a flat surface. While holding the adapter package, place the adapter over the bottle. Press firmly down on the package until the adapter clicks into place at the top of the bottle and the adapter needle passes through the rubber stopper of the bottle.
<\/p>\n\n\n\n![\"The](\"https:\/\/www.fass.se\/res\/RootMedia\/Wyeth\/Media\/BeneFIX\/Bild2.jpg\")
<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
6. Lift the package off the adapter and discard the package.
<\/p>\n\n\n\n![\"The](\"https:\/\/www.fass.se\/res\/RootMedia\/Wyeth\/Media\/BeneFIX\/Bild3.jpg\")
<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
7. Attach the piston rod to the syringe with diluent by pressing and screwing firmly.
<\/p>\n\n\n\n
8. Break the plastic cap from the syringe with diluent by breaking the perforation on the cap. This is done by bending up and down until the perforation is broken. Do not touch the inside of the cap or the top of the syringe. The lid may need to be used again (unless the reconstituted BeneFIX is administered immediately), so set it aside by placing it on top.
<\/p>\n\n\n\n![\"The](\"https:\/\/www.fass.se\/res\/RootMedia\/Wyeth\/Media\/BeneFIX\/Bild4.jpg\")
<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
9. Place the bottle on a flat surface. Attach the diluent with the diluent to the bottle adapter by placing the top of the syringe in the adapter opening while pressing firmly and screwing the syringe clockwise until it has stabilized in place.
<\/p>\n\n\n\n![\"The](\"https:\/\/www.fass.se\/res\/RootMedia\/Wyeth\/Media\/BeneFIX\/Bild5.jpg\")
<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
10. Slowly push in the plunger to transfer all the liquid to the bottle of BeneFIX.
<\/p>\n\n\n\n![\"The](\"https:\/\/www.fass.se\/res\/RootMedia\/Wyeth\/Media\/BeneFIX\/Bild6.jpg\")
<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
11. Without removing the syringe from the adapter, gently rotate the bottle until the powder has dissolved.
<\/p>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n- Talk to your doctor or pharmacist before using BeneFIX.<\/li>
- Contact your doctor immediately if the bleeding does not stop as expected.<\/li><\/ul>\n\n\n\n
- Allergic reactions are possible. The product may contain traces of hamster proteins (see “Do not use BeneFIX”). Potentially life-threatening anaphylactic reactions (severe allergic reaction ) have occurred with factor IX products, including BeneFIX. Early signs of allergic reactions include difficulty breathing, shortness of breath, swelling, hives that may be widespread throughout the body, itching , chest tightness, wheezing, low blood pressure , blurred vision and anaphylaxis (severe allergic reaction that may cause difficulty swallowing and \/ or or breathing, redness or swelling of the face and \/ or hands).<\/li>
- If allergic or anaphylactic reactions occur, discontinue injection of BeneFIX immediately and consult a physician<\/strong> , or seek emergency medical attention immediately . If severe allergic reactions occur, alternative therapy should be considered.<\/li>
- It is less common for previously treated patients receiving factor IX products to develop neutralizing antibodies (inhibitors). However, during treatment with BeneFIX, you should be closely monitored to check if factor IX inhibitors have been developed. The same applies to treatment with all products containing factor IX.<\/li>
- In the literature, it has been reported that there is an association between the presence of factor IX inhibitors and allergic reactions. Therefore, if you get allergic reactions such as those described above, you should be investigated for the presence of inhibitors. It should be noted that patients taking factor IX inhibitors may be at higher risk of anaphylaxis during additional BeneFIX treatment sessions.<\/li>
- The body’s production of factor IX is regulated by the factor IX gene. Patients who have specific mutations on the factor IX gene, such as larger deletion mutations, may be more likely to develop factor IX inhibitors and \/ or have allergic reactions. If you are known to have such a mutation, your doctor may monitor you extra closely for signs of an allergic reaction, especially when you start treatment with BeneFIX for the first time.<\/li>
- Due to the risk of allergic reactions to factor IX, your first injections of BeneFIX should be given under medical supervision so that appropriate medical treatment for allergic reactions is available.<\/li>
- Even in the absence of inhibitors, a higher dose of BeneFIX may be needed compared to other plasma IX products that you may have taken before. Careful monitoring of factor IX plasma activity (which measures your blood’s ability to coagulate) must therefore be performed to adjust dose one. If the bleeding is not under control after the recommended dose , consult your doctor.<\/li>
- If you have liver or heart disease or if you have recently undergone surgical treatment, there is an increased risk of clot formation (coagulation complications).<\/li>
- Renal impairment ( nephrotic syndrome ) has been reported at high doses of factor IX produced by blood plasma in haemophilia B patients with factor IX inhibitors who have previously experienced allergic reactions.<\/li>
- Sufficient data have not been obtained from clinical trials regarding BeneFIX treatment in patients who have not previously received any treatment (patients who have never received a factor IX infusion before ).<\/li>
- It is recommended that you note the name and batch number of the product each time you use BeneFIX. You can use one of the removable labels on the bottle to document the batch number in your diary or to report side effects .<\/li><\/ul>\n\n\n\n
Other medicines and BeneFIX<\/h2>\n\n\n\n
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n
Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, you should only take BeneFIX as prescribed by your doctor. It is not known whether BeneFIX can cause harm to an unborn baby when taken by pregnant women. Your doctor may advise you to stop taking BeneFIX if you are breast-feeding or pregnant.
<\/p>\n\n\n\n
Ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
BeneFIX has no effect on the ability to drive or use machines.<\/p>\n\n\n\n
BeneFIX contains sodium<\/h2>\n\n\n\n
After preparation BeneFIX contains 0.2 mmol (4.6 mg) of sodium per vial , ie essentially “sodium-free”. However, depending on your body weight and your dose ofBeneFIX, you may receive several vials. This should be considered if you have been prescribed a low-salt diet.
<\/p>\n\n\n\n
3. How to use BeneFIX<\/h2>\n\n\n\n
Always use this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure.
<\/p>\n\n\n\n
Your doctor will decide on the dose of one of BeneFIX that you should take. The doseand duration of treatment depends on your individual need for factor IX replacement therapy and how quickly your body uses up factor IX, which will be checked regularly. You may notice a difference in the dose you receive if you switch from a plasma factor IX product to BeneFIX.
<\/p>\n\n\n\n
Your doctor may change the dose of BeneFIX you receive during treatment.
<\/p>\n\n\n\n
Preparation and administration<\/strong><\/p>\n\n\n\nThe instructions below are advice for the preparation and administration of BeneFIX. Follow your doctor’s instructions for venipuncture.
<\/p>\n\n\n\n
BeneFIX is given by intravenous (IV) infusion after reconstitution of the powder for solution for injection with the supplied diluent (sodium chloride (saline) solution) in the pre-filled syringe.
<\/p>\n\n\n\n
Always wash your hands before doing the following. Aseptic technique (meaning clean and germ-free) should be used during reconstitution .
<\/p>\n\n\n\n
Preparation<\/strong> :<\/p>\n\n\n\nBeneFIX is given by intravenous (IV) infusion after reconstitution with sterile diluent .
<\/p>\n\n\n\n
1. Allow the bottle of freeze-dried BeneFIX and the pre-filled syringe to reach room temperature.
<\/p>\n\n\n\n
2. Remove the plastic cap from the BeneFIX bottle so that the middle part of the rubber stopper is visible.
<\/p>\n\n\n\n<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
3. Clean the stopper with the supplied compress one with alcohol or use another antiseptic solution and let it dry. Do not touch the rubber stopper with your hand after cleaning and do not allow the stopper to come into contact with any surface.
<\/p>\n\n\n\n
4. Remove the cap from the bottle adapter’s clear plastic package. Do not remove the adapter from the package.
<\/p>\n\n\n\n
5. Place the bottle on a flat surface. While holding the adapter package, place the adapter over the bottle. Press firmly down on the package until the adapter clicks into place at the top of the bottle and the adapter needle passes through the rubber stopper of the bottle.
<\/p>\n\n\n\n<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
6. Lift the package off the adapter and discard the package.
<\/p>\n\n\n\n<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
7. Attach the piston rod to the syringe with diluent by pressing and screwing firmly.
<\/p>\n\n\n\n
8. Break the plastic cap from the syringe with diluent by breaking the perforation on the cap. This is done by bending up and down until the perforation is broken. Do not touch the inside of the cap or the top of the syringe. The lid may need to be used again (unless the reconstituted BeneFIX is administered immediately), so set it aside by placing it on top.
<\/p>\n\n\n\n<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
9. Place the bottle on a flat surface. Attach the diluent with the diluent to the bottle adapter by placing the top of the syringe in the adapter opening while pressing firmly and screwing the syringe clockwise until it has stabilized in place.
<\/p>\n\n\n\n<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
10. Slowly push in the plunger to transfer all the liquid to the bottle of BeneFIX.
<\/p>\n\n\n\n<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
11. Without removing the syringe from the adapter, gently rotate the bottle until the powder has dissolved.
<\/p>\n\n\n\n
- Allergic reactions are possible. The product may contain traces of hamster proteins (see “Do not use BeneFIX”). Potentially life-threatening anaphylactic reactions (severe allergic reaction ) have occurred with factor IX products, including BeneFIX. Early signs of allergic reactions include difficulty breathing, shortness of breath, swelling, hives that may be widespread throughout the body, itching , chest tightness, wheezing, low blood pressure , blurred vision and anaphylaxis (severe allergic reaction that may cause difficulty swallowing and \/ or or breathing, redness or swelling of the face and \/ or hands).<\/li>
- If allergic or anaphylactic reactions occur, discontinue injection of BeneFIX immediately and consult a physician<\/strong> , or seek emergency medical attention immediately . If severe allergic reactions occur, alternative therapy should be considered.<\/li>
- It is less common for previously treated patients receiving factor IX products to develop neutralizing antibodies (inhibitors). However, during treatment with BeneFIX, you should be closely monitored to check if factor IX inhibitors have been developed. The same applies to treatment with all products containing factor IX.<\/li>
- In the literature, it has been reported that there is an association between the presence of factor IX inhibitors and allergic reactions. Therefore, if you get allergic reactions such as those described above, you should be investigated for the presence of inhibitors. It should be noted that patients taking factor IX inhibitors may be at higher risk of anaphylaxis during additional BeneFIX treatment sessions.<\/li>
- The body’s production of factor IX is regulated by the factor IX gene. Patients who have specific mutations on the factor IX gene, such as larger deletion mutations, may be more likely to develop factor IX inhibitors and \/ or have allergic reactions. If you are known to have such a mutation, your doctor may monitor you extra closely for signs of an allergic reaction, especially when you start treatment with BeneFIX for the first time.<\/li>
- Due to the risk of allergic reactions to factor IX, your first injections of BeneFIX should be given under medical supervision so that appropriate medical treatment for allergic reactions is available.<\/li>
- Even in the absence of inhibitors, a higher dose of BeneFIX may be needed compared to other plasma IX products that you may have taken before. Careful monitoring of factor IX plasma activity (which measures your blood’s ability to coagulate) must therefore be performed to adjust dose one. If the bleeding is not under control after the recommended dose , consult your doctor.<\/li>
- If you have liver or heart disease or if you have recently undergone surgical treatment, there is an increased risk of clot formation (coagulation complications).<\/li>
- Renal impairment ( nephrotic syndrome ) has been reported at high doses of factor IX produced by blood plasma in haemophilia B patients with factor IX inhibitors who have previously experienced allergic reactions.<\/li>
- Sufficient data have not been obtained from clinical trials regarding BeneFIX treatment in patients who have not previously received any treatment (patients who have never received a factor IX infusion before ).<\/li>
- It is recommended that you note the name and batch number of the product each time you use BeneFIX. You can use one of the removable labels on the bottle to document the batch number in your diary or to report side effects .<\/li><\/ul>\n\n\n\n
Other medicines and BeneFIX<\/h2>\n\n\n\n
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n
Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, you should only take BeneFIX as prescribed by your doctor. It is not known whether BeneFIX can cause harm to an unborn baby when taken by pregnant women. Your doctor may advise you to stop taking BeneFIX if you are breast-feeding or pregnant.
<\/p>\n\n\n\nAsk your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
BeneFIX has no effect on the ability to drive or use machines.<\/p>\n\n\n\n
BeneFIX contains sodium<\/h2>\n\n\n\n
After preparation BeneFIX contains 0.2 mmol (4.6 mg) of sodium per vial , ie essentially “sodium-free”. However, depending on your body weight and your dose ofBeneFIX, you may receive several vials. This should be considered if you have been prescribed a low-salt diet.
<\/p>\n\n\n\n3. How to use BeneFIX<\/h2>\n\n\n\n
Always use this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure.
<\/p>\n\n\n\nYour doctor will decide on the dose of one of BeneFIX that you should take. The doseand duration of treatment depends on your individual need for factor IX replacement therapy and how quickly your body uses up factor IX, which will be checked regularly. You may notice a difference in the dose you receive if you switch from a plasma factor IX product to BeneFIX.
<\/p>\n\n\n\nYour doctor may change the dose of BeneFIX you receive during treatment.
<\/p>\n\n\n\nPreparation and administration<\/strong><\/p>\n\n\n\n
The instructions below are advice for the preparation and administration of BeneFIX. Follow your doctor’s instructions for venipuncture.
<\/p>\n\n\n\nBeneFIX is given by intravenous (IV) infusion after reconstitution of the powder for solution for injection with the supplied diluent (sodium chloride (saline) solution) in the pre-filled syringe.
<\/p>\n\n\n\nAlways wash your hands before doing the following. Aseptic technique (meaning clean and germ-free) should be used during reconstitution .
<\/p>\n\n\n\nPreparation<\/strong> :<\/p>\n\n\n\n
BeneFIX is given by intravenous (IV) infusion after reconstitution with sterile diluent .
<\/p>\n\n\n\n1. Allow the bottle of freeze-dried BeneFIX and the pre-filled syringe to reach room temperature.
<\/p>\n\n\n\n2. Remove the plastic cap from the BeneFIX bottle so that the middle part of the rubber stopper is visible.
<\/p>\n\n\n\n<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
3. Clean the stopper with the supplied compress one with alcohol or use another antiseptic solution and let it dry. Do not touch the rubber stopper with your hand after cleaning and do not allow the stopper to come into contact with any surface.
<\/p>\n\n\n\n4. Remove the cap from the bottle adapter’s clear plastic package. Do not remove the adapter from the package.
<\/p>\n\n\n\n5. Place the bottle on a flat surface. While holding the adapter package, place the adapter over the bottle. Press firmly down on the package until the adapter clicks into place at the top of the bottle and the adapter needle passes through the rubber stopper of the bottle.
<\/p>\n\n\n\n<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
6. Lift the package off the adapter and discard the package.
<\/p>\n\n\n\n<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
7. Attach the piston rod to the syringe with diluent by pressing and screwing firmly.
<\/p>\n\n\n\n8. Break the plastic cap from the syringe with diluent by breaking the perforation on the cap. This is done by bending up and down until the perforation is broken. Do not touch the inside of the cap or the top of the syringe. The lid may need to be used again (unless the reconstituted BeneFIX is administered immediately), so set it aside by placing it on top.
<\/p>\n\n\n\n<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
9. Place the bottle on a flat surface. Attach the diluent with the diluent to the bottle adapter by placing the top of the syringe in the adapter opening while pressing firmly and screwing the syringe clockwise until it has stabilized in place.
<\/p>\n\n\n\n<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
10. Slowly push in the plunger to transfer all the liquid to the bottle of BeneFIX.
<\/p>\n\n\n\n<\/a><\/figure>\n\n\n\n<\/p>\n\n\n\n
11. Without removing the syringe from the adapter, gently rotate the bottle until the powder has dissolved.
<\/p>\n\n\n\n
![\"The](\"https:\/\/www.fass.se\/res\/RootMedia\/Wyeth\/Media\/BeneFIX\/Bild7.jpg\")
<\/a><\/figure>\n\n\n\n![\"The](\"https:\/\/www.fass.se\/res\/RootMedia\/Wyeth\/Media\/BeneFIX\/Bild8.jpg\")
<\/a><\/figure>\n\n\n\n