{"id":5786,"date":"2020-12-25T16:10:51","date_gmt":"2020-12-25T16:10:51","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5786"},"modified":"2021-07-12T06:41:11","modified_gmt":"2021-07-12T06:41:11","slug":"azactam","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/azactam\/","title":{"rendered":"Azactam &#8211; Aztreonam uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n1 g and 2 g&nbsp;powder for injection and&nbsp;infusion&nbsp;solution&nbsp;<br>aztreonam<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Azactam is and what it is used for<\/h2>\n\n\n\n<p>Azactam is an&nbsp;antibiotic&nbsp;belonging to the group of beta-lactams.&nbsp;Azactam is used to treat severe&nbsp;infections&nbsp;caused by gram-negative bacteria (eg&nbsp;pneumonia, urinary tract infections, and urogenital&nbsp;infections&nbsp;).&nbsp;<br><br>Aztreonam contained in Azactam may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Azactam<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Azactam<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to aztreonam or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before using Azactam:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to certain&nbsp;antibiotics&nbsp;such as&nbsp;penicillin&nbsp;or&nbsp;cephalosporins.<\/li><li>if you have impaired liver or kidney function, transient or persistent&nbsp;kidney failure.&nbsp;Liver and kidney function should be checked by taking regular blood tests.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor if you experience any of the following after starting treatment with Azactam:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you get symptoms of severe changes in blood levels.<\/li><li>if you get severe skin changes.<\/li><li>if you have seizures.<\/li><li>if you have diarrhea.&nbsp;This can be diarrhea associated with&nbsp;<em>Clostridium difficile<\/em>(CDAD) and has been reported with the use of almost all&nbsp;antibiotics, including aztreonam.&nbsp;CDAD can vary in severity from mild diarrhea to fatal&nbsp;colitis&nbsp;and must be considered in all patients who develop diarrhea after using&nbsp;antibiotics.&nbsp;It is important to follow this as CDAD has been reported to occur several weeks after treatment with&nbsp;antibiotics&nbsp;.<\/li><\/ul>\n\n\n\n<p>The use of&nbsp;antibiotics&nbsp;can promote the growth of resistant&nbsp;microorganisms, including certain bacteria and fungi.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>There are limited data on safety and efficacy in newborns younger than one week.&nbsp;Use in this group must be carefully evaluated.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Azactam<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<br><\/p>\n\n\n\n<p>If an&nbsp;aminoglycoside&nbsp;is used concurrently as aztreonam, renal function should be monitored because the&nbsp;antibiotics&nbsp;of the type&nbsp;aminoglycoside&nbsp;can damage the kidneys and the inner ear.<br><\/p>\n\n\n\n<p>When Azactam is used at the same time as other medicines, it may be necessary to adjust the&nbsp;dose&nbsp;of Azactam.&nbsp;It is especially important to consult your doctor if you use the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs that increase the excretion of&nbsp;uric acid&nbsp;(eg probenecid)<\/li><li>drugs that promote the excretion of urine (eg&nbsp;furosemide&nbsp;)<\/li><li>medicines that prevent the blood from clotting (eg oral&nbsp;anticoagulants&nbsp;)<\/li><li>other&nbsp;antibiotics&nbsp;(eg&nbsp;aminoglycosides, cefoxitin, and <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tenam\/\">imipenem<\/a>).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p>There is little experience with the use of Azactam during pregnancy.&nbsp;Aztreonam passes through the placenta and enters the fetal bloodstream.&nbsp;Azactam passes into breast milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>No studies on the ability to drive and use machines have been performed.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Azactam contains arginine<\/h2>\n\n\n\n<p>Studies in children with low birth weight have shown that the amino acid&nbsp;arginine contained&nbsp;in this medicine can increase the amount of&nbsp;arginine,&nbsp;insulin,&nbsp;and&nbsp;bilirubin in the blood.&nbsp;The consequences of exposure to&nbsp;arginine&nbsp;during the treatment of newborns have not been fully established.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Azactam<\/h2>\n\n\n\n<p>This medicine will be given in a hospital by a healthcare professional.<br><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for adult patients is 1 g or 2 g every 8 to 12 hours.&nbsp;Sometimes the doctor may&nbsp;prescribe&nbsp;a lower or higher&nbsp;dose&nbsp;to adjust the&nbsp;dose&nbsp;one after&nbsp;infection&nbsp;one.&nbsp;In some&nbsp;infections, Azactam is combined with other&nbsp;antibiotics.<br><\/p>\n\n\n\n<p>The maximum recommended&nbsp;dose&nbsp;is 8 g per day.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children<\/h2>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for patients older than one week is 30 mg\/kg every 6 or 8 hours.&nbsp;Your doctor may prescribe a lower or higher&nbsp;dose&nbsp;depending on the&nbsp;infection.<br><\/p>\n\n\n\n<p>The maximum daily&nbsp;dose&nbsp;for children must not exceed the maximum recommended&nbsp;dose&nbsp;for adults.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>If you get any of the following serious&nbsp;side effects, contact your doctor or nurse immediately:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, lips, mouth, tongue, or throat [has been reported (affects an unknown number of users)]<\/li><li>skin reactions (eg&nbsp;redness, scaling, red spots, blisters) [has been reported (occurs in an unknown number of users)]<\/li><li>allergic reactions [reported (occurs in an unknown number of users)].<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;ar<\/strong><br><\/p>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased tendency to bleed, elevated renal values.<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;<\/strong><strong>(may affect up to 1 in 1,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart rhythm changes<\/li><li>altered blood levels (shown at blood tests)<\/li><li>anemia<\/li><li>cramps<\/li><li>knitting<\/li><li>dizziness<\/li><li>headache<\/li><li>double vision<\/li><li>instability<\/li><li>\u00f6ronsus<\/li><li>difficulty breathing (wheezing, shortness of breath)<\/li><li>sneezing<\/li><li>stuffy nose<\/li><li>colitis, bleeding in the gastrointestinal tract<\/li><li>bad breath<\/li><li>muscle pain<\/li><li>gynecological&nbsp;infection&nbsp;(vaginitis)<\/li><li>low&nbsp;blood pressure<\/li><li>bleeding<\/li><li>chest pain<\/li><li>fever<\/li><li>impotence<\/li><li>feeling sick<\/li><li>hepatitis&nbsp;(&nbsp;inflammation&nbsp;of the liver)<\/li><li>yellowing of the skin and eyes<\/li><li>sore breasts<\/li><li>confusion<\/li><li>insomnia.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurs in an unknown number of users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>taste changes<\/li><li>respiratory cramps<\/li><li>abdominal pain<\/li><li>cold sores<\/li><li>nausea<\/li><li>vomiting<\/li><li>diarrhea<\/li><li>infection&nbsp;of the skin<\/li><li>rash<\/li><li>itching<\/li><li>extreme sweating<\/li><li>inflammation&nbsp;of veins<\/li><li>discomfort at the injection site<\/li><li>elevated liver values \u200b\u200b(shown during a blood test).<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Azactam<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.&nbsp;<br><br>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.&nbsp;<br><br>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is aztreonam.&nbsp;<\/li><li>The other ingredient is L-&nbsp;arginine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Azactam is a white powder that gives a colorless or light yellow solution, depending on the&nbsp;diluent&nbsp;and concentration.<\/p>\n\n\n\n<p>The pack contains one&nbsp;vial of&nbsp;1 g or 2 g of powder.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Bristol-Myers Squibb AB<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><br><\/p>\n\n\n\n<p>Swords Laboratories T \/ A Bristol-Myers Squibb Pharmaceutical Operations, External Manufacturing<\/p>\n\n\n\n<p>Plaza 254<\/p>\n\n\n\n<p>Blanchardstown Corporate Park 2<\/p>\n\n\n\n<p>Dublin 15, D15 T867<\/p>\n\n\n\n<p>Ireland<br><\/p>\n\n\n\n<p>CATALENT ANAGNI SRL<\/p>\n\n\n\n<p>Loc.&nbsp;Fontana del Ceraso snc<\/p>\n\n\n\n<p>Provincial Street 12 Casilina, 41<\/p>\n\n\n\n<p>03012 ANAGNI (FR)<\/p>\n\n\n\n<p>Italy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Azactam is an antibiotic belonging to the group of beta-lactams. Azactam is used to treat severe infections caused by gram-negative bacteria (eg pneumonia, urinary tract infections, and urogenital infections ). <\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[9579,9583,7644,9577,9582,9578,9581,9576,9580,7645],"class_list":["post-5786","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-azactam","tag-azactam-injection","tag-aztreonam","tag-aztreonam-injection","tag-side-effects-of-azactam","tag-side-effects-of-aztreonam","tag-what-azactam-is-used-for","tag-what-aztreonam-is-used-for","tag-what-is-azactam","tag-what-is-aztreonam"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5786","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5786"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5786\/revisions"}],"predecessor-version":[{"id":12269,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5786\/revisions\/12269"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5786"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5786"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5786"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}