{"id":5777,"date":"2020-12-25T15:52:36","date_gmt":"2020-12-25T15:52:36","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5777"},"modified":"2021-07-12T06:41:42","modified_gmt":"2021-07-12T06:41:42","slug":"avonex","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/avonex\/","title":{"rendered":"Avonex &#8211; Interferon Beta-1a uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n30 micrograms \/ 0.5 ml solution for injection&nbsp;in a pre-filled pen&nbsp;<br>(&nbsp;Interferon&nbsp;beta-1a).&nbsp;Pre-filled pen<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. WHAT AVONEX IS AND WHAT IT IS USED FOR<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Avonex works best when you use it:<\/strong><strong>at the same time<\/strong><strong>once a week<\/strong><strong>regularly<\/strong>Do not stop taking Avonex without talking to your neurologist first<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>What AVONEX is<\/strong><br><\/p>\n\n\n\n<p><strong>The Avonex Pen is used to inject Avonex.&nbsp;<\/strong>The active substance in Avonex is a&nbsp;protein&nbsp;called&nbsp;<em>interferon&nbsp;-beta-1a<\/em>.&nbsp;Interferons&nbsp;are natural body substances that protect you from&nbsp;infections&nbsp;and diseases.&nbsp;The protein&nbsp;in Avonex is made from exactly the same substances as the&nbsp;interferon&nbsp;beta found in the body.<br><\/p>\n\n\n\n<p><strong>What AVONEX is used for<\/strong><br><\/p>\n\n\n\n<p><strong>Avonex is used to treat&nbsp;multiple sclerosis&nbsp;(MS).&nbsp;<\/strong>Avonex treatment can protect you from getting worse but does not cure MS.<br><\/p>\n\n\n\n<p><strong>The symptoms of MS are different between different people<\/strong>.&nbsp;These can be, for example:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Feeling of instability or dizziness, difficulty walking, stiffness and muscle twitching, fatigue, numbness of the face, arms, or legs.<\/li><li>Acute&nbsp;or&nbsp;chronic&nbsp;pain, bladder and bowel problems, sexual problems, and visual difficulties<\/li><li>Difficulty thinking and concentrating on depression.<\/li><\/ul>\n\n\n\n<p>MS also tends to flare up from time to time: this is called a&nbsp;relapse.<br><\/p>\n\n\n\n<p><strong>Avonex can reduce the number of&nbsp;relapses&nbsp;and slow down the disabling effects of MS.&nbsp;<\/strong>Your doctor will tell you how long you can use Avonex or when to stop treatment.<br><\/p>\n\n\n\n<p><strong>How AVONEX works<\/strong><br><\/p>\n\n\n\n<p>Multiple sclerosis&nbsp;is associated with nerve damage (in the brain or spinal cord).&nbsp;In MS, the body&#8217;s immune system reacts to the body&#8217;s own myelin, ie.&nbsp;the &#8220;insulation&#8221; that surrounds the nerve fibers.&nbsp;When myelin is damaged, communication between the brain and other parts of the body is disrupted.&nbsp;This is what causes MS symptoms.&nbsp;Avonex seems to be able to prevent the body&#8217;s immune system from attacking myelin.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using AVONEX<\/h2>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Avonex and allergic reactions<\/strong>Because Avonex is based on a&nbsp;protein&nbsp;, there is a small risk of an&nbsp;allergic reaction&nbsp;.<br><strong>More on depression.<\/strong>If you have severe depression or suicidal ideation, do not use Avonex.&nbsp;If you have depression, your doctor may still prescribe Avonex to you, but it is important that you tell your doctor if you have had depression or similar problems that affect your mood.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Do not use AVONEX<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are allergic<\/strong>&nbsp;to&nbsp;interferon&nbsp;beta or any of the other ingredients of this medicine (listed in section 6).<\/li><li><strong>If you have severe depression<\/strong>&nbsp;or have suicidal thoughts.<\/li><\/ul>\n\n\n\n<p><strong>Contact a doctor immediately if any of these apply to you.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>Talk to your doctor before using Avonex if you have or have had:<\/strong><br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Depression<\/strong>&nbsp;or problems affecting mood<\/li><li><strong>Suicidal thoughts.<\/strong><\/li><\/ul>\n\n\n\n<p>If you experience a change in mood, suicidal ideation, or feel unusually sad, anxious, or worthless, consult a physician immediately.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Epilepsy<\/strong>&nbsp;or other seizures that cannot be controlled with medication<\/li><li><strong>Severe kidney or liver problems<\/strong><\/li><li><strong>A low number of&nbsp;white blood cells&nbsp;or&nbsp;platelets<\/strong>, which may increase the risk of&nbsp;infection, bleeding, or&nbsp;anemia<\/li><li>Heart problems&nbsp;can cause symptoms such as chest pain (&nbsp;angina&nbsp;), especially after physical activity, swollen ankles, shortness of breath (&nbsp;heart failure), or irregular heartbeat (&nbsp;<em>arrhythmia<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor if you have any of these conditions<\/strong>&nbsp;or if they have worsened while you are taking Avonex.<br><\/p>\n\n\n\n<p>During treatment, blood clots may form in the small blood vessels.&nbsp;Blood clots can affect your kidneys.&nbsp;This can happen several weeks or up to&nbsp;<strong>several years<\/strong>&nbsp;after you start taking Avonex.<br><\/p>\n\n\n\n<p>Your doctor may want to check your&nbsp;blood pressure, blood&nbsp;count&nbsp;(&nbsp;platelet count&nbsp;), and kidney function.<br><\/p>\n\n\n\n<p><strong>Tell your doctor that you are using Avonex:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are going to take a blood sample.&nbsp;<\/strong>Avonex may affect test results<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Sometimes you need to remind other healthcare professionals that you are being treated with Avonex.&nbsp;<\/strong>If you e.g.&nbsp;Using other medicines or taking a blood test Avonex may affect the other medicines or the blood test result.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and AVONEX&nbsp;<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines, especially medicines for&nbsp;epilepsy&nbsp;or depression.&nbsp;Avonex can affect or be affected by other medicines.&nbsp;This also applies to over-the-counter medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p>No adverse effects are expected on the breast-fed infant\/infant.&nbsp;Avonex can be used during breast-feeding.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p><strong>Do not drive if you feel dizzy.&nbsp;<\/strong>Avonex may make some people feel dizzy.&nbsp;If this affects you or you get other&nbsp;side effects&nbsp;that affect your ability to drive, avoid driving, and using machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about some of the ingredients of Avonex<\/h2>\n\n\n\n<p>This medicine is almost &#8216;sodium-free&#8217; and contains less than 23 mg (1 mmol)&nbsp;sodium per week.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use AVONEX PEN<\/h2>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>There is more information on how to inject Avonex Pen in the expandable part at the back of the package leaflet.<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Recommended weekly dose<\/strong><br><\/p>\n\n\n\n<p><strong>An&nbsp;injection&nbsp;of Avonex Pen, once a week.&nbsp;<\/strong>If possible, take Avonex at the same time and on the same day of the week each week.<br><\/p>\n\n\n\n<p><strong>Do not use on children<\/strong><\/p>\n\n\n\n<p>Children under 12 years of age&nbsp;<strong>should not use Avonex.<\/strong><br><\/p>\n\n\n\n<p><strong>Inject yourself<\/strong><br><\/p>\n\n\n\n<p>You can inject Avonex yourself with the Avonex Pen without the help of your doctor if you have been trained to do so.&nbsp;Instructions on how to inject yourself can be found at the end of this leaflet (see section 7,&nbsp;<em>How to inject with Avonex Pen<\/em>&nbsp;).<br><\/p>\n\n\n\n<p><strong>If you have difficulty<\/strong>&nbsp;handling the Avonex Pen, ask your doctor for help.<br><\/p>\n\n\n\n<p><strong>How long to use Avonex<\/strong><br><\/p>\n\n\n\n<p>Your doctor will tell you how long to continue using Avonex.&nbsp;It is important that you continue to use Avonex regularly.&nbsp;Do not change the medication unless your doctor tells you to.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you inject too much<\/h2>\n\n\n\n<p>You should inject with only one Avonex Pen, once a week.&nbsp;If you have used more than one Avonex Pen for a three-day period, consult a&nbsp;<strong>doctor or pharmacist<\/strong>&nbsp;immediately&nbsp;<strong>for advice.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget an injection<\/h2>\n\n\n\n<p><strong>If you miss your usual weekly dose<\/strong>, do the&nbsp;injection&nbsp;one as soon as you can.&nbsp;Then wait a week before using Avonex Pen again.&nbsp;Continue to inject on the new day of the week each week.&nbsp;If you prefer a particular day of the week to do the Avonex injection, you should talk to your doctor about how to handle the&nbsp;dosage&nbsp;one so that you can return to that day of the week.&nbsp;Do not take double&nbsp;injections&nbsp;to compensate for missed&nbsp;injections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Although the list of possible&nbsp;side effects&nbsp;may seem worrying, you may not experience any&nbsp;side effects&nbsp;at all.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Serious side effects: seek medical attention<\/strong><br><\/p>\n\n\n\n<p><strong>Severe allergic reactions<\/strong><\/p>\n\n\n\n<p>If you experience any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling of the face, lips, or tongue<\/li><li>Breathing difficulties<\/li><li>Rash<\/li><\/ul>\n\n\n\n<p><strong>Contact a doctor immediately.&nbsp;<\/strong>Do not take Avonex again until you have talked to a doctor.<br><\/p>\n\n\n\n<p><strong>Depression<\/strong><\/p>\n\n\n\n<p>If you get symptoms of depression:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Feeling unusually sad, anxious, or useless.<\/li><\/ul>\n\n\n\n<p><strong>Contact a doctor immediately.<\/strong><br><\/p>\n\n\n\n<p><strong>Liver problem<\/strong><\/p>\n\n\n\n<p>If you experience any of the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The skin or whites of the eyes turn yellow (&nbsp;<em>jaundice<\/em>&nbsp;)<\/li><li>Itching&nbsp;all over the body<\/li><li>Nausea (&nbsp;<em>nausea and vomiting<\/em>&nbsp;)<\/li><li>Easily get bruises.<\/li><\/ul>\n\n\n\n<p><strong>Contact a doctor immediately<\/strong>&nbsp;as these symptoms may be signs of liver problems.<br><\/p>\n\n\n\n<p><strong>Side effects have&nbsp;been demonstrated in&nbsp;clinical trials<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Side effects have&nbsp;been demonstrated in&nbsp;clinical trials&nbsp;.&nbsp;<\/strong>These&nbsp;side effects&nbsp;have been reported when Avonex was tested.&nbsp;The figures are based on how many people stated that they had the&nbsp;side effects&nbsp;.&nbsp;It gives an indication of how great the risk is that you will have similar&nbsp;side effects&nbsp;.<br><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Very common&nbsp;side effect&nbsp;is&nbsp;<\/strong><em>(can occur in more than 1 in 10)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Flu-like symptoms&nbsp;&#8211; headache, muscle aches, chills or fever: see&nbsp;<em>Flu-like symptoms,<\/em>&nbsp;below<\/li><li>Headache<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are&nbsp;<\/strong><em>(may affect up to 1 in 10)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Loss of appetite<\/li><li>Feeling weak and tired<\/li><li>Difficulty sleeping<\/li><li>Depression<\/li><li>Redness<\/li><li>Runny nose<\/li><li>Diarrhea (&nbsp;<em>loose in the stomach<\/em>&nbsp;)<\/li><li>Nausea (&nbsp;<em>nausea or vomiting<\/em>&nbsp;)<\/li><li>Numbness or tingling in the skin<\/li><li>Skin rash, bruising<\/li><li>Increased sweating, night sweats<\/li><li>Pain in muscles, joints, arms, legs, or neck<\/li><li>Muscle cramps, stiffness in joints and muscles<\/li><li>Pain, bruising, and&nbsp;redness&nbsp;at the injection site<\/li><li>Changes in blood tests.&nbsp;Symptoms that you may notice are fatigue, repeated&nbsp;infections, unexplained bruising, or bleeding.<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;are&nbsp;<\/strong><em>(may affect up to 1 in 100)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hair loss<\/li><li>Altered menstrual bleeding<\/li><li>Burning at the injection site.<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;are&nbsp;<\/strong><em>(may affect up to 1 in 1000 patients)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Breathing difficulties<\/li><li>Kidney problems including scarring that can impair kidney function if you get any or all of these symptoms:<ul><li>Frothy urine<\/li><li>Fatigue<\/li><li>Swelling, especially in the ankles and eyelids, as well as weight gain.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor as they may be a sign of a possible kidney problem.<\/strong><\/p>\n\n\n\n<p>Blood clots in the small blood vessels, which can affect the kidneys (thrombotic thrombocytopenic purpura or&nbsp;hemolytic uremic syndrome&nbsp;).&nbsp;Symptoms may include increased bruising, bleeding, fever, extreme weakness, headache, dizziness, or fainting.&nbsp;Your doctor may notice changes in your blood and kidney function.<br><\/p>\n\n\n\n<p><strong>Talk to your doctor if&nbsp;you experience&nbsp;any&nbsp;side effects.<\/strong><br><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>The following&nbsp;side effects&nbsp;have been reported in people using Avonex but the risk of getting them is unknown.<\/strong><br><strong>If you feel dizzy, do not drive.<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>Less or more active&nbsp;thyroid&nbsp;than normal<\/li><li>Nervousness or anxiety, emotional instability, irrational thoughts or hallucinations (seeing or hearing things that do not exist), confusion or suicide<\/li><li>Numbness, dizziness, seizures, and&nbsp;migraines<\/li><li>Awareness of heartbeats (&nbsp;<em>palpitations&nbsp;s<\/em>&nbsp;), rapid or irregular heartbeat, or heart problems with the following symptoms: reduced ability to exercise, inability to lie flat in the bed, shortness of breath, or swollen ankles<\/li><li>Liver problems as described above<\/li><li>Hives or bladder-like rash,&nbsp;itching, worsening of any&nbsp;psoriasis<\/li><li>Swelling or bleeding at the injection site or chest pain after&nbsp;injection<\/li><li>Weight loss or gain<\/li><li>Changed test results, eg changed liver function values.<\/li><li>Pulmonary&nbsp;arterial&nbsp;hypertension: A disease with severe narrowing of the blood vessels of the lungs that leads to high&nbsp;blood pressure&nbsp;in the blood vessels that carry blood from the heart to the lungs.&nbsp;Pulmonary&nbsp;arterial&nbsp;hypertension&nbsp;has been observed at various times during treatment, even up to several years after&nbsp;initiating&nbsp;interferon-&nbsp;beta treatment.<br><\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor if&nbsp;you experience&nbsp;any&nbsp;side effects.<\/strong><br><\/p>\n\n\n\n<p><strong>Effects of&nbsp;injection&nbsp;a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Feeling tired: You get your first Avonex injection from your doctor.&nbsp;You may then feel dull and you may faint.&nbsp;This is unlikely to happen again.<\/strong><\/li><li><strong>Just after injection, the muscles may feel tense or very weak&nbsp;&#8211; as if you are having a&nbsp;relapse.&nbsp;These symptoms rarely occur.&nbsp;They only occur when you inject and the effects then quickly disappear.&nbsp;This can happen at any time after you start treatment with Avonex.<\/strong><\/li><li><strong>If you notice any irritation or skin problem&nbsp;after an&nbsp;injection<\/strong>, talk to your doctor.<\/li><\/ul>\n\n\n\n<p><strong>Flu-like symptoms<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Three simple ways to relieve flu-like symptoms:<\/strong><strong>Use the Avonex Pen just before bedtime.&nbsp;<\/strong>Then you can sleep through the symptoms.<strong>Take&nbsp;paracetamol&nbsp;or&nbsp;ibuprofen&nbsp;half an hour before using Avonex Pen and continue<\/strong>&nbsp;to take it for up to a day.&nbsp;Ask your doctor or pharmacist what&nbsp;dose&nbsp;is appropriate.<strong>Drink plenty of water if you get a fever<\/strong>&nbsp;so that you do not become dehydrated.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Some people feel like they have the&nbsp;flu&nbsp;after using Avonex Pen.&nbsp;<\/strong>The symptoms are as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Muscle aches<\/li><li>Chills or fever<\/li><\/ul>\n\n\n\n<p><strong>These symptoms are not signs of the&nbsp;flu.&nbsp;<\/strong><br>You can not infect anyone else.&nbsp;Symptoms are more common at the beginning of Avonex treatment.&nbsp;When you continue with the&nbsp;injections, the&nbsp;flu-like symptoms gradually&nbsp;decrease.<br><\/p>\n\n\n\n<p>To facilitate the traceability of this medicine, your doctor or pharmacist should document the product name and batch number in your patient record.&nbsp;Note these details in case you are asked about this information in the future.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store AVONEX PEN<\/h2>\n\n\n\n<p><strong>Keep this medicine out of the sight and reach of children.<\/strong><br><\/p>\n\n\n\n<p><strong>Do not use this medicine after the expiry date which is stated on the label.<\/strong><br><\/p>\n\n\n\n<p>The Avonex Pen contains a pre-filled&nbsp;syringe&nbsp;of Avonex.&nbsp;Store in the original package.&nbsp;Sensitive to light.<br><\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).&nbsp;Do not freeze.<br><\/p>\n\n\n\n<p>Avonex Pen can also be stored at room temperature (between 15 \u00b0 C and 30 \u00b0 C) for up to one week.<br><\/p>\n\n\n\n<p><strong>Do not use Avonex Pen if you see:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>that the pen is broken<\/li><li>that the solution is colored or contains particles<\/li><li>that the tamper-proof protective hat has been broken.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p><strong>The active substance is:&nbsp;<\/strong>Interferon-beta 1a 30 micrograms \/ 0.5 ml<\/p>\n\n\n\n<p><strong>The other ingredients are<\/strong>&nbsp;Sodium acetate trihydrate;&nbsp;concentrated acetic acid, arginine hydrochloride, polysorbate, and water for injections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Each individual pack contains an Avonex Pen, a needle, and a pen cap.&nbsp;Avonex Pen contains a pre-filled&nbsp;syringe&nbsp;of Avonex and should only be used after&nbsp;adequate training.&nbsp;Avonex Pen comes in packs of four or twelve for one or three months of&nbsp;injections&nbsp;you<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>The marketing authorization holder is:<\/strong><br><\/p>\n\n\n\n<p>Biogen Netherlands BV<\/p>\n\n\n\n<p>Prins Mauritslaan 13<\/p>\n\n\n\n<p>1171 LP Badhoevedorp<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>Avonex is manufactured by:<\/strong><br><\/p>\n\n\n\n<p>Biogen Denmark Manufacturing ApS,<\/p>\n\n\n\n<p>Biogen All\u00e9 1,<\/p>\n\n\n\n<p>DK-3400 Hiller\u00f8d,<\/p>\n\n\n\n<p>Denmark.<br><\/p>\n\n\n\n<p>If you contact your local representative, you can get this leaflet with larger text.<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><br><strong>Belgium \/ Belgique \/ Belgien<\/strong>Biogen Belgium NV \/ SA(+32 2 2191218<\/td><td><strong>Lithuania<\/strong>UAB &#8220;JOHNSON &amp; JOHNSON&#8221;(+370 5 278 68 88<\/td><\/tr><tr><td><br><strong>Bulgaria<\/strong>TP WATERMARMA(+359 2 962 12 00<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Biogen Belgium NV \/ SA(+32 2 2191218<\/td><\/tr><tr><td><br><strong>Czech Republic<\/strong>Biogen (Czech Republic) sro(+420 255 706 200<\/td><td><strong>Hungary<\/strong>Biogen Hungary Kft.(+36 1 899 9883<\/td><\/tr><tr><td><br><strong>Denmark<\/strong>Biogen Denmark A \/ S(+45 77 41 57 57<\/td><td><strong>Malta<\/strong>Pharma.&nbsp;MT Ltd ..(+356 21337008<\/td><\/tr><tr><td><br><strong>Germany<\/strong>Biogen GmbH(+49 (0) 89 99 6170<\/td><td><strong>The Netherlands<\/strong>Biogen Netherlands BV(+31 20 542 2000<\/td><\/tr><tr><td><br><strong>Eesti<\/strong>UAB &#8220;JOHNSON &amp; JOHNSON&#8221; Eesti subsidiary(+372 617 7410<\/td><td><strong>Norway<\/strong>Biogen Norway AS(+47 23 40 01 00<\/td><\/tr><tr><td><br><strong>Greece<\/strong>Genesis Pharma SA(+30 210 8771500<\/td><td><strong>Austria<\/strong>Biogen Austria GmbH(+43 1 484 46 13<\/td><\/tr><tr><td><strong>Spain<\/strong>Biogen Spain SL(+34 91 310 7110<\/td><td><strong>Poland<\/strong>Biogen Poland Sp.&nbsp;z oo(+48 22 351 51 00<\/td><\/tr><tr><td><strong>France<\/strong>Biogen France SAS(+33 (0) 1 41 37 9595<\/td><td><strong>Portugal<\/strong>Biogen PortugalPharmaceutical Society, Unipessoal Lda.(+351 21 318 8450<\/td><\/tr><tr><td><strong>Croatia<\/strong>Medis Adria doo(+385 1 230 34 46<\/td><td><strong>Romania<\/strong>Johnson &amp; Johnson Romania SRL(+40 21 207 18 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Biogen Idec (Ireland) Ltd.(+353 (0) 1 463 7799<\/td><td><strong>Slovenia<\/strong>Biogen Pharma doo(+386 1 511 02 90<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hf(+354 540 8000<\/td><td><strong>Slovak Republic<\/strong>Biogen Slovakia sro(+421 2 323 34008<\/td><\/tr><tr><td><strong>Italy<\/strong>Biogen Italia srl(+39 02 584 9901<\/td><td><strong>Finland \/ Finland<\/strong>Biogen Finland Oy(+358 207 401 200<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>Genesis Pharma Cyprus Ltd(+3572 2 769946<\/td><td><\/td><\/tr><tr><td><strong>Latvia<\/strong>UAB &#8220;JOHNSON &amp; JOHNSON&#8221; subsidiary Latvij\u0101(+371 678 93561<\/td><td><strong>United Kingdom<\/strong>Biogen Idec Limited(+44 (0) 1628 50 1000<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Avonex Pen is used to inject Avonex. The active substance in Avonex is a protein called interferon -beta-1a. Interferons are natural body substances that protect you from infections and diseases. The protein in Avonex is made from exactly the same substances as the interferon beta found in the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[9560,9562,9555,9557,9564,9559,9563,9558,9556,9561],"class_list":["post-5777","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-avonex","tag-avonex-injection","tag-interferon-beta-1a","tag-interferon-beta-1a-injection","tag-side-effects-of-avonex","tag-side-effects-of-interferon-beta-1a","tag-what-avonex-is-used-for","tag-what-interferon-beta-1a-is-used-for","tag-what-is-interferon-beta-1a","tag-whati-is-avonex"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5777"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5777\/revisions"}],"predecessor-version":[{"id":12273,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5777\/revisions\/12273"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}