{"id":5773,"date":"2020-12-25T15:45:51","date_gmt":"2020-12-25T15:45:51","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5773"},"modified":"2021-07-12T07:09:02","modified_gmt":"2021-07-12T07:09:02","slug":"avelox","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/avelox\/","title":{"rendered":"Avelox &#8211; Moxifloxacin uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n400 mg&nbsp;film-coated tablets.&nbsp;For use by adults.&nbsp;<br>moxifloxacin<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Avelox is and what it is used for<\/h2>\n\n\n\n<p>Avelox contains the active substance moxifloxacin, which belongs to a group of&nbsp;antibiotics&nbsp;called&nbsp;fluoroquinolones.&nbsp;Avelox works by killing bacteria that cause&nbsp;infection.<br><\/p>\n\n\n\n<p>Avelox is used in patients aged 18 years and older to treat the following bacterial&nbsp;infections&nbsp;caused by bacteria that moxifloxacin is effective against.&nbsp;Avelox should only be used to treat these&nbsp;infections&nbsp;when standard&nbsp;antibiotics&nbsp;cannot be used or have not worked:<br><\/p>\n\n\n\n<p>Sinus infection, sudden worsening of long-term&nbsp;inflammation&nbsp;of the airways (&nbsp;chronic&nbsp;bronchitis&nbsp;), or&nbsp;pneumonia&nbsp;(&nbsp;pneumonia&nbsp;) that has been received outside of the hospital (does not apply to serious cases).<br><\/p>\n\n\n\n<p>Mild to moderate&nbsp;infection&nbsp;in the upper parts of the woman&#8217;s abdomen (&nbsp;inflammation&nbsp;of the small pelvis), including&nbsp;infection&nbsp;in the fallopian tubes and&nbsp;infection&nbsp;in the lining of the uterus.&nbsp;It is not enough to treat these types of&nbsp;infections with Avelox tablets alone, but your doctor will prescribe an additional&nbsp;antibiotic&nbsp;in addition to Avelox tablets to treat&nbsp;infections&nbsp;in the upper parts of the woman&#8217;s genitals (see section 2:&nbsp;<em>What you need to know before you are taking Avelox, Warnings, and Precautions, Talk to your doctor before taking Avelox).<\/em><br><\/p>\n\n\n\n<p>If the following bacterial&nbsp;infection&nbsp;you have improved in initial treatment with Avelox&nbsp;solution for infusion&nbsp;solution can Avelox tablets prescribed by your doctor to complete the treatment:&nbsp;pneumonia&nbsp;(&nbsp;pneumonia&nbsp;) acquired outside the hospital, skin and soft tissue infections.&nbsp;Avelox tablets should not be used for the initial treatment of any type of skin or soft tissue infection or&nbsp;pneumonia.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Avelox<\/h2>\n\n\n\n<p>Contact your doctor if you are not sure if you belong to any of the patient groups described below.<br><\/p>\n\n\n\n<p><strong>Do not take Avelox<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to the active substance moxifloxacin, any other quinolone antibiotic,s or any of the other ingredients of this medicine (listed in section 6).<\/li><li>If you are pregnant or breastfeeding.<\/li><li>If you are younger than 18 years.<\/li><li>If you have a history of tendon disease or disorder that was related to treatment with quinolone antibiotics (see sections&nbsp;<em>warnings and precautions, and&nbsp;Possible&nbsp;side effect&nbsp;s&nbsp;).<\/em><\/li><li><em>If you were born with or have ever experienced abnormal heart rhythms (visible on&nbsp;ECG<\/em>, heart examination using electrodes), have an imbalance in the blood salts (especially low levels of&nbsp;potassium&nbsp;or&nbsp;magnesium&nbsp;in the blood), have a very slow heart rhythm (called&nbsp;bradycardia&nbsp;), have a weak heart (&nbsp;heart failure&nbsp;), have previously had an abnormal heart rhythm or if you are being treated with other medicines that may cause abnormal&nbsp;ECG&nbsp;changes (see section&nbsp;<em>Other medicines and Avelox<\/em>&nbsp;).&nbsp;<br>This is because Avelox can cause&nbsp;ECG&nbsp;changes&nbsp;that are an extension of the&nbsp;QT interval and e.g.&nbsp;delayed transmission of electrical signals.<\/li><li>If you have severe liver disease (elevated liver enzymes (&nbsp;transaminases&nbsp;) higher than 5 times the upper limit of normal).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><em>Before taking this medicine<\/em><\/p>\n\n\n\n<p>You should not take&nbsp;antibacterial&nbsp;fluoroquinolone\/quinolone medicines, including Avelox if you have previously had any serious&nbsp;side effects&nbsp;from taking any&nbsp;quinolone or fluoroquinolone medicines.&nbsp;If this is the case, contact your doctor as soon as possible.<br><\/p>\n\n\n\n<p><strong>Talk to your doctor before taking Avelox<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Avelox can&nbsp;<strong>change your&nbsp;ECG<\/strong>, especially if you are a woman or if you are older.&nbsp;If you are currently taking any medicine that lowers the levels of&nbsp;potassium&nbsp;in your blood, consult your doctor before taking Avelox (see also&nbsp;Do not take Avelox&nbsp;and&nbsp;Other medicines and Avelox&nbsp;).<\/li><li>If you have ever developed&nbsp;a severe rash or scaly skin, blisters, and\/or sores in your mouth&nbsp;after taking moxifloxacin.<\/li><li>If you have&nbsp;epilepsy&nbsp;or any other condition that can cause&nbsp;seizures, talk to your doctor before taking Avelox.<\/li><li>If you have or have had&nbsp;problems with your mental health, talk to your doctor before taking Avelox.<\/li><li>If you have&nbsp;myasthenia gravis, Avelox may make your symptoms worse.&nbsp;Contact a doctor immediately if you think this applies to you.<\/li><li>If you have been diagnosed with an&nbsp;<strong>enlargement or &#8220;bulge&#8221;<\/strong>&nbsp;of a large blood vessel (aortic aneurysm or peripheral&nbsp;aneurysm&nbsp;in a large blood vessel).<\/li><li>If you have had an&nbsp;<strong>aortic dissection<\/strong>&nbsp;(a rupture in the aortic wall).<\/li><li>If someone in your family has or has had an&nbsp;<strong>aortic aneurysm or aortic dissection<\/strong>&nbsp;or has other risk factors or conditions that increase the risk of this (eg connective tissue diseases such as Marfan&#8217;s syndrome, or vascular&nbsp;Ehlers-Danlos syndrome&nbsp;, or vascular diseases such as Takayasu&#8217;s arteritis, giant cell arteritis, Beh\u00e7et&#8217;s disease, high&nbsp;blood pressure, or known atherosclerosis).<\/li><li>If you are&nbsp;<strong>diabetic<\/strong>&nbsp;because there is a risk of you getting&nbsp;<strong>altered blood sugar levels<\/strong>&nbsp;of moxifloxacin.<\/li><li>If you or someone in your family has&nbsp;<strong>glucose&nbsp;-6-phosphate dehydrogenase deficiency<\/strong>&nbsp;(an uncommon inherited disease), tell your doctor, who will tell you if Avelox is suitable for you.<\/li><li>If you as a woman have a&nbsp;<strong>complicated&nbsp;infection&nbsp;in the abdomen<\/strong>&nbsp;(eg at the same time as varicose veins in the fallopian tubes and ovaries or in the pelvis), for which your doctor considers an&nbsp;intravenous&nbsp;treatment is necessary, treatment with Avelox tablets is not suitable.<\/li><li>For the treatment of&nbsp;mild to moderate&nbsp;infections&nbsp;in the woman&#8217;s abdomen, your doctor may also prescribe another&nbsp;antibiotic&nbsp;in addition to Avelox.&nbsp;If no improvement in symptoms is seen after 3 days of treatment, consult your doctor.<\/li><\/ul>\n\n\n\n<p><strong>During treatment with Avelox<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you experience&nbsp;<strong>palpitations or irregular heartbeats<\/strong>&nbsp;during the treatment period, tell your doctor immediately.&nbsp;He\/she may want to do an&nbsp;ECG&nbsp;to measure your heart rate.<\/li><li><strong>The risk of heart problems<\/strong>&nbsp;may increase if the&nbsp;dose is&nbsp;increased.&nbsp;Therefore, the recommended dosing instructions must be followed.<\/li><li>There is a small risk that you may have a&nbsp;<strong>severe, sudden&nbsp;allergic reaction<\/strong>&nbsp;(an anaphylactic reaction\/shock), already at the first&nbsp;dose&nbsp;one, with the following symptoms: pressure over the chest, that you feel dizzy, feel unwell, feel faint or dizzy when you get up.&nbsp;<strong>If this happens, stop taking Avelox and seek medical attention immediately.<\/strong><\/li><li>Avelox may cause&nbsp;<strong>a rapid and severe&nbsp;inflammation&nbsp;of the liver<\/strong>&nbsp;which can lead to life-threatening liver failure (including fatal cases, see section&nbsp;<em>4. Possible&nbsp;side effects&nbsp;s<\/em>&nbsp;).&nbsp;Contact your doctor before continuing treatment if you develop signs such as sudden malaise and\/or nausea in combination with yellowing of the whites of the eyes, dark urine,&nbsp;itchy&nbsp;skin, bleeding tendencies, or brain disease caused by the liver (symptoms of hepatic impairment or a sudden and severe&nbsp;inflammation&nbsp;of the liver ).<\/li><li><strong>Severe skin reactions<\/strong>Severe skin reactions including Stevens-Johnson syndrome,&nbsp;toxic epidermal necrolysis,&nbsp;and&nbsp;acute&nbsp;generalized exanthematous&nbsp;pustulosis&nbsp;(AGEP) have been reported with moxifloxacin.<ul><li>Stevens-Johnson syndrome and&nbsp;toxic epidermal necrolysis&nbsp;may first appear as red, target-like spots or round spots, often with blisters in the center, on the torso.&nbsp;In addition, sores in the mouth, throat, nose, genitals, and eyes (red and swollen eyes) may occur.&nbsp;These severe skin rashes are often preceded by fever and\/or&nbsp;flu-like symptoms.&nbsp;The rash can develop into widespread peeling and complications that can be life-threatening or fatal.<\/li><li>Acute&nbsp;generalized exanthematous&nbsp;pustulosis&nbsp;(AGEP) occurs at the beginning of treatment as a red, widespread, and flaky rash with lumps under the skin and blisters along with fever.&nbsp;Most often located in skin folds, on the upper body, and on the arms. If you develop a severe skin rash or any of these other skin symptoms, stop taking moxifloxacin and consult a doctor or seek medical attention immediately.<br><\/li><\/ul><\/li><li>Antibiotics&nbsp;of the&nbsp;quinolone&nbsp;type, including Avelox, may cause&nbsp;<strong>convulsions<\/strong>.&nbsp;If this happens, stop taking Avelox and contact your doctor immediately.<\/li><li><strong>Long-term, debilitating,<\/strong> and potentially lasting serious&nbsp;side effects<strong>&nbsp;antibacterial<\/strong> fluoroquinolone\/quinolone drugs, including Avelox have been linked to very rare but serious&nbsp;side effects.&nbsp;Some of these have been long-lasting (up to months or years), disabling, and possibly permanent.&nbsp;This includes pain in tendons, muscles, and joints in arms and legs, difficulty walking, abnormal sensations such as ant crawling, tingling, tingling, numbness or a burning sensation (&nbsp;paresthesia&nbsp;), sensory disturbances in the form of impaired vision, taste, smell, and hearing, depression, impaired memory, extreme fatigue, and severe sleep problems. If you get any of these&nbsp;side effects&nbsp;after taking Avelox, talk to a doctor immediately before continuing treatment.&nbsp;You and your doctor will decide if you should continue treatment or consider using another type of&nbsp;antibiotic.<\/li><li>In rare cases, you may experience&nbsp;symptoms of nerve damage (&nbsp;neuropathy&nbsp;)such as pain, a burning sensation, tingling, numbness, and\/or weakness, especially in the feet and legs or in the hands and arms.&nbsp;If this happens, stop taking Avelox and contact your doctor immediately to prevent the development of a possible permanent condition.<\/li><li>You may experience&nbsp;<strong>problems with your mental health&nbsp;when taking&nbsp;antibiotics for <\/strong>the&nbsp;quinolone&nbsp;type, including Avelox, for the first time.&nbsp;In very rare cases, depression and problems with mental health led to suicidal thoughts and self-injurious behavior such as suicide attempts (see section&nbsp;<em>4. Possible&nbsp;side effects&nbsp;s<\/em>&nbsp;).&nbsp;If you develop such reactions, stop taking Avelox and tell your doctor immediately.<\/li><li>You may experience&nbsp;<strong>diarrhea<\/strong>&nbsp;during or after taking&nbsp;antibiotics, including Avelox.&nbsp;If this becomes severe or long-lasting or if you notice that the stool contains blood or mucus, stop Avelox treatment immediately and contact your doctor.&nbsp;In this situation, do not take any medicine that stops or reduces bowel motility.<\/li><li>In rare cases,&nbsp;<strong>pain and swelling in the joints and&nbsp;inflammation, or rupture of tendons<\/strong>&nbsp;occur (see sections&nbsp;<em>Do not take Avelox<\/em>&nbsp;and&nbsp;<em>4. Possible&nbsp;side effects&nbsp;s<\/em>&nbsp;).&nbsp;The risk is greater if you are older (over 60 years), have undergone an organ transplant, have kidney problems, or if you are being treated with&nbsp;cortisone&nbsp;(&nbsp;corticosteroids&nbsp;).&nbsp;Inflammation&nbsp;and tendon rupture can occur within the first 48 hours after starting treatment but also up to several months after stopping treatment with Avelox.&nbsp;At the first sign of pain or&nbsp;inflammation in a tendon (eg in the ankle, wrist, elbow, shoulder, or knee), stop taking Avelox, consult a doctor, and rest the painful area.&nbsp;Avoid unnecessary effort as it may increase the risk of a tendon rupture.<\/li><li>If you feel a&nbsp;<strong>sudden, severe pain in your stomach, chest,<\/strong> or back, you should immediately go to an emergency room.<\/li><li>If you are older and have&nbsp;kidney problems, be sure to drink enough as dehydration can increase the risk of&nbsp;kidney failure.<\/li><li>If your&nbsp;vision is impaired&nbsp;or if your eyes are affected in other ways, contact an eye specialist immediately (see sections&nbsp;Driving and using machines&nbsp;and&nbsp;4. Possible&nbsp;side effects&nbsp;s&nbsp;).<\/li><li>Fluoroquinolone&nbsp;-type antibiotics may cause&nbsp;your blood sugar level&nbsp;to&nbsp;rise above normal (hyperglycemia) or&nbsp;<strong>decrease your blood sugar level<\/strong>&nbsp;below normal (hypoglycemia), which may lead to loss of consciousness (hypoglycaemic&nbsp;coma&nbsp;) in severe cases (see section 4. Possible&nbsp;side effects&nbsp;). If you have&nbsp;diabetes, your blood sugar should be monitored carefully.<\/li><li>Quinolone&nbsp;can make your&nbsp;<strong>skin<\/strong>&nbsp;more&nbsp;<strong>sensitive to sunlight or UV rays<\/strong>.&nbsp;You should avoid prolonged exposure to sunlight or strong sunlight and do not sunbathe in a solarium or use any other UV light lamp during Avelox treatment.<\/li><li>The effect of Avelox&nbsp;infusion&nbsp;has not been established in the treatment of serious burns,&nbsp;infection&nbsp;s deep in&nbsp;tissue&nbsp;one or foot infections with osteomyelitis (&nbsp;infection&nbsp;s in the&nbsp;bone marrow&nbsp;a) in diabetics.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children and adolescents under 18 years of age as efficacy and safety have not been established for this age group (see section&nbsp;<em>Do not use Avelox<\/em>&nbsp;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Avelox<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines other than Avelox.<br><\/p>\n\n\n\n<p>For Avelox, you should know the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are taking Avelox and other&nbsp;<strong><em>medicines that may affect your heart,<\/em><\/strong>&nbsp;there is an increased risk of heart rhythm changes.&nbsp;Therefore, do not take Avelox with the following medicines:&nbsp;<br>Medicines belonging to the&nbsp;antiarrhythmic&nbsp;group&nbsp;(eg&nbsp;quinidine, hydroquinone,&nbsp;disopyramide,&nbsp;amiodarone, sotalol, dofetilide, ibutilide), antipsychotics (eg phenothiazines, pimozide, sertindole,&nbsp;haloperidol, sultoprid),&nbsp;tricyclic antidepressants, certain antimicrobials (eg saquinavir, sparfloxacin,&nbsp;intravenous erythromycin, pentamidine, antimalarials, especially halofantrine), certain&nbsp;antihistamines(eg terfenadine, astemizole, mizolastine) and other medicines (eg cisapride,&nbsp;intravenous&nbsp;vincamine, bepridil, difemanil).<\/li><li>You must tell your doctor if you are taking other medicines that may lower your blood potassium levels (eg certain&nbsp;diuretics, certain&nbsp;laxatives&nbsp;and enemas (in high&nbsp;doses&nbsp;) or&nbsp;corticosteroids&nbsp;(anti-inflammatory drugs), amphotericin B) or cause slower heartbeats as this may increase the risk of severe heart rhythm disturbances while you are taking Avelox.<\/li><li><span style=\"background-color: rgb(255, 255, 255);\">Drug-containing<\/span><em>&nbsp;magnesium&nbsp;or aluminum<\/em>&nbsp;such as antacids for indigestion, or any other&nbsp;<em>medicine containing iron or zinc,&nbsp;a medicine containing didanosine,<\/em>&nbsp;or&nbsp;<em>medicine containing sucralfate for the treatment of gastrointestinal problems<\/em>&nbsp;may reduce the effect of Avelox.&nbsp;Therefore, take Avelox 6 hours before or after taking these other medicines.<\/li><li>Taking&nbsp;<em>medical carbon orally<\/em>&nbsp;at the same time as Avelox reduces the effect of Avelox.&nbsp;Therefore, it is recommended that these medications not be taken at the same time.<\/li><li>If you are being treated with&nbsp;<em>oral&nbsp;anticoagulants<\/em>&nbsp;(eg&nbsp;warfarin&nbsp;)&nbsp;at the same time,&nbsp;your doctor may need to check your coagulation time.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Avelox with food and drink<\/h2>\n\n\n\n<p>The effect of Avelox is not affected by food or dairy products.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Do not take Avelox if you are pregnant or breast-feeding.&nbsp;<br>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Animal studies do not suggest that your&nbsp;fertility&nbsp;will be impaired when using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Avelox may make you feel dizzy and faint, you may experience a sudden transient loss of vision or you may faint for a short time.&nbsp;If you feel this, do not drive or operate machinery.&nbsp;<br>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Avelox contains lactose and sodium<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking Avelox.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per film-coated tablet, ie&nbsp;essentially&nbsp;&#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Avelox<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for adults is one 400 mg tablet once a day.<\/p>\n\n\n\n<p>Avelox tablets should be taken orally.&nbsp;Swallow the tablet whole (so as not to feel the bitter taste) and together with plenty of liquid.&nbsp;You can take Avelox with or without food.&nbsp;It is recommended to take the tablet at about the same time each day.<\/p>\n\n\n\n<p>There is no need to change the&nbsp;dose&nbsp;to elderly patients, patients with low body weight, or patients with kidney problems.<\/p>\n\n\n\n<p>The duration of treatment with Avelox film-coated tablets depends on the type of&nbsp;infection.&nbsp;Unless your doctor prescribes otherwise, the following treatment times are recommended:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211; Sudden exacerbation of&nbsp;chronic&nbsp;bronchitis&nbsp;(&nbsp;acuteexacerbation&nbsp;of&nbsp;chronic obstructive pulmonary diseaseincluding&nbsp;bronchitis&nbsp;)<\/td><td>5-10 days<\/td><\/tr><tr><td>&#8211;&nbsp;Pneumonia&nbsp;(&nbsp;pneumonia&nbsp;) that has been received outside of a hospital, does not apply to serious cases<\/td><td>Ten days<\/td><\/tr><tr><td>&#8211;&nbsp;Acute&nbsp;sinus&nbsp;infection&nbsp;(&nbsp;acute&nbsp;bacterial&nbsp;sinusitis&nbsp;)<\/td><td>7 days<\/td><\/tr><tr><td>Mild to moderate&nbsp;infection&nbsp;in the upper parts of the woman&#8217;s abdomen (&nbsp;inflammation&nbsp;of the small pelvis), including&nbsp;infection&nbsp;in the fallopian tubes and&nbsp;infection&nbsp;in the lining of the uterus).<\/td><td>14 days<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>When Avelox film-coated tablets are used to terminate a treatment started with Avelox&nbsp;solution&nbsp;for&nbsp;infusion, the recommended treatment time is: <\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><td>&#8211;&nbsp;Pneumonia&nbsp;(&nbsp;pneumonia&nbsp;) that has been received outside of hospital most patients with&nbsp;pneumonia&nbsp;switched to&nbsp;oral&nbsp;treatment with Avelox film-coated tablets within 4 days.<\/td><td>7-14 days<\/td><\/tr><\/thead><tbody><tr><td>&#8211;&nbsp;Infection&nbsp;in the skin and soft tissuesMost patients with&nbsp;infection&nbsp;you in the skin and soft tissue switched to&nbsp;oral&nbsp;treatment with Avelox film-coated tablets within 6 days.<\/td><td>7-21 days<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>It is important that you complete the entire course, even if you feel better after a few days.&nbsp;If you stop taking this medicine too soon, the&nbsp;infection&nbsp;may&nbsp;not be adequately treated, the&nbsp;infection&nbsp;may return or your general condition may worsen and you may even develop bacterial&nbsp;resistance&nbsp;to&nbsp;antibiotics.<br><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;and duration of treatment should not be exceeded (see&nbsp;<em>2.&nbsp;What you need to know before taking Avelox,&nbsp;Warnings, and Precautions<\/em>&nbsp;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Avelox than you should<\/h2>\n\n\n\n<p>If you take more than one prescribed&nbsp;dose&nbsp;(1 tablet per day), seek medical advice immediately and, if possible, take any remaining tablet or package or this leaflet and show your doctor or pharmacist which medicine you have taken.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Avelox<\/h2>\n\n\n\n<p>If you forget to take your tablet, take it as soon as you remember on the same day.&nbsp;If you do not take a tablet for one day, take your normal&nbsp;dose&nbsp;(one tablet) the next day.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Avelox<\/h2>\n\n\n\n<p>If you stop taking this medicine too soon,&nbsp;your infection&nbsp;may&nbsp;not be adequately treated.&nbsp;Contact your doctor if you wish to stop taking your tablets before the end of the treatment period.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>The&nbsp;<strong>most serious adverse reactions&nbsp;were<\/strong>&nbsp;observed in connection with Aveloxbehandling are listed below.<br><\/p>\n\n\n\n<p>If you experience:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>an abnormally fast heartbeat (rare side effect)<\/li><li>if you suddenly start to feel unwell or discover yellowing whites of the eyes, dark urine,&nbsp;itching&nbsp;of the skin, bleeding tendencies or thought disorders, and altered alertness (these may be signs or symptoms of a sudden&nbsp;inflammation&nbsp;of the liver which can lead to life-threatening liver failure (very rare side effect, death has been observed ))<\/li><li>severe skin rash including Steven-Johnson syndrome and&nbsp;toxic epidermal necrolysis.&nbsp;These rashes can appear as red, target-like spots or round spots, often with blisters in the middle, trunk, skin rash, sores in the mouth, throat, nose, genitals, and eyes and may be preceded by fever and&nbsp;flu-like symptoms&nbsp;(very rare&nbsp;side effects, maybe life-threatening).<\/li><li>a red, widespread, flaky rash with bumps under the skin and blisters together with fever at the beginning of treatment (&nbsp;acute&nbsp;generalized exanthematous&nbsp;pustulosis) (the frequency of this&nbsp;side effect&nbsp;is &#8220;unknown&#8221;)<\/li><li>syndrome associated with decreased water excretion and low sodium levels (SIADH) (very rare&nbsp;side effect&nbsp;)<\/li><li>loss of consciousness due to severe hypoglycemia (hypoglycaemic&nbsp;coma&nbsp;) (very rare&nbsp;side effect&nbsp;)<\/li><li>inflammation&nbsp;of blood vessels (signs may be red marks on the skin, usually on the shins, or symptoms such as joint pain) (very rare side effect)<\/li><li>severe, sudden generalized&nbsp;allergic reaction&nbsp;incl.&nbsp;very rarely life-threatening shock&nbsp;(eg difficulty breathing, drop in blood pressure and fast&nbsp;pulse&nbsp;) (rare side effect)<\/li><li>swelling (rare side effect, including potentially life-threatening airway swelling)<\/li><li>seizures (rare side effect)<\/li><li>disorders related to the nervous system such as pain, burning sensation, tingling, numbness, and\/or weakness in the arms and legs (rare side effect)<\/li><li>depression (can in very rare cases lead to self-harming behavior, such as suicidal ideation \/ thoughts or suicide attempts) (rare side effect)<\/li><li>mental illness (may lead to self-harming behavior, such as suicidal ideation\/thoughts or suicide attempts) (very rare side effect)<\/li><li>severe diarrhea containing blood and \/ or mucus (&nbsp;colitis&nbsp;caused by&nbsp;antibiotics, including pseudomembranous&nbsp;colitis&nbsp;), which in some very rare cases can lead to life-threatening complications (rare side effect)<\/li><li>tendon pain and swelling (tendinitis) (rare side effect), muscle cramps, muscle twitching, muscle weakness (very rare side effect)<\/li><li>muscle weakness, tenderness, or pain, and especially if you also feel sick, have a high body temperature or have dark urine.&nbsp;This can be caused by abnormal muscle breakdown which can be life-threatening and lead to kidney problems (a condition called&nbsp;rhabdomyolysis&nbsp;) (the frequency of this&nbsp;side effect&nbsp;is &#8220;unknown&#8221;)<\/li><\/ul>\n\n\n\n<p><strong>stop taking Avelox and contact a doctor immediately&nbsp;as you may need&nbsp;urgent medical<\/strong> attention.<br><\/p>\n\n\n\n<p>In addition, if you experience:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>transient vision loss (very rare side effect)<\/li><li>discomfort or pain in the eyes, especially when exposed to light (very rare to rare side effect)<\/li><\/ul>\n\n\n\n<p><strong>contact an ophthalmologist immediately<\/strong>.<br><\/p>\n\n\n\n<p>If you have experienced life-threatening, irregular heartbeats (&nbsp;torsade de pointes&nbsp;) or&nbsp;your&nbsp;heart has stopped beating during treatment with Avelox (a very rare side effect),&nbsp;<strong>tell your treating doctor immediately that you have taken Avelox and do not resume treatment.<\/strong><br><\/p>\n\n\n\n<p>Deterioration of&nbsp;myasthenia gravis&nbsp;symptoms&nbsp;has been observed in very rare cases.&nbsp;If this happens,&nbsp;<strong>consult a doctor immediately.<\/strong><\/p>\n\n\n\n<p>If you have&nbsp;diabetes&nbsp;and notice that your blood sugar level increases or decreases (rare or very rare side effect),&nbsp;<strong>tell your doctor immediately<\/strong>.<br><\/p>\n\n\n\n<p>If you are elderly, have kidney problems and notice a decrease in urine levels, swelling in the legs, ankles, fatigue, nausea, drowsiness, difficulty breathing, or confusion (these may be signs and symptoms of&nbsp;kidney failure, a rare side effect),&nbsp;<strong>contact your doctor immediately.<\/strong><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong>&nbsp;observed during treatment with Avelox are listed below according to how common they are:<br><\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea<\/li><li>diarrhea<\/li><li>dizziness<\/li><li>abdominal and abdominal pain<\/li><li>vomiting<\/li><li>headache<\/li><li>increase in special liver enzymes (&nbsp;transaminases&nbsp;) in the blood<\/li><li>infection&nbsp;is caused by resistant bacteria or fungi e.g.&nbsp;Oral or vaginal&nbsp;infection&nbsp;is caused by&nbsp;Candida<\/li><li>change in heart rate (&nbsp;ECG&nbsp;) in patients with low potassium levels in the blood<br><\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>upset stomach (indigestion \/ heartburn)<\/li><li>sleep disorders (mainly insomnia)<\/li><li>increase in specific liver enzymes (gamma-glutamyltransferase and\/or&nbsp;alkaline phosphatase) in the blood<\/li><li>the low number of special&nbsp;white blood cells&nbsp;(&nbsp;leukocytes,&nbsp;neutrophils&nbsp;)<\/li><li>constipation<\/li><li>itching<\/li><li>a feeling of dizziness (instability or risk of falling)<\/li><li>somnolence<\/li><li>gas in the stomach<\/li><li>change in heart rate (&nbsp;ECG&nbsp;)<\/li><li>Impaired liver function (including an increase in specific liver enzymes (LDH) in the blood)<\/li><li>decreased appetite and decreased food intake<\/li><li>low&nbsp;white blood cell count<\/li><li>aches and pains in e.g.&nbsp;back, chest, pelvic and&nbsp;extremity&nbsp;are<\/li><li>increase of special&nbsp;blood cell is&nbsp;necessary for&nbsp;coagulation&nbsp;one<\/li><li>sweating<\/li><li>increased number of special&nbsp;white blood cells&nbsp;(&nbsp;eosinophils&nbsp;)<\/li><li>anxiety<\/li><li>feeling sick (mainly feeling weak or tired)<\/li><li>shaking<\/li><li>joint pain<\/li><li>palpitation<\/li><li>irregular and rapid heartbeat<\/li><li>difficulty breathing including asthmatic conditions<\/li><li>increase in special digestive enzymes (amylase) in the blood &nbsp;<\/li><li>restlessness \/ agitation<\/li><li>creeping sensation (tingling) and\/or numbness<\/li><li>hives<\/li><li>dilation of blood vessels<\/li><li>confusion and disorientation<\/li><li>reduction of special&nbsp;blood cells&nbsp;are necessary for&nbsp;coagulation&nbsp;one<\/li><li>visual disturbances including double vision and blurred vision<\/li><li>decreased blood coagulation<\/li><li>the increased amount of&nbsp;lipids&nbsp;(fats) in the blood<\/li><li>low&nbsp;red blood cell count<\/li><li>muscle pain<\/li><li>allergic reaction<\/li><li>increase in&nbsp;bilirubin&nbsp;in the blood<\/li><li>inflammation&nbsp;of the stomach<\/li><li>dehydration<\/li><li>severe abnormal heart rhythm<\/li><li>dry skin<\/li><li>angina<br><\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;&nbsp;(may affect up to 1 in 1,000 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>muscle twitching<\/li><li>muscle cramps<\/li><li>hallucination<\/li><li>high&nbsp;blood pressure<\/li><li>swelling (hands, feet, ankles, lips, mouth, throat)<\/li><li>low&nbsp;blood pressure<\/li><li>renal impairment (including elevated laboratory values \u200b\u200bwith respect to the kidneys, such as&nbsp;urea&nbsp;and&nbsp;creatinine&nbsp;)<\/li><li>inflammation&nbsp;of the liver<\/li><li>inflammation&nbsp;of the oral mucosa<\/li><li>ringing\/noise in the ears<\/li><li>jaundice (whites of the eyes or skin yellowing)<\/li><li>decreased sensitivity of the skin<\/li><li>abnormal dreams<\/li><li>impaired concentration<\/li><li>difficulty swallowing<\/li><li>changes in the sense of smell (including the lost sense of smell)<\/li><li>imbalance and poor coordination (due to fraud)<\/li><li>partially or completely lost memory<\/li><li>hearing loss incl.&nbsp;deafness (usually transient)<\/li><li>elevated uric acid levels in the blood<\/li><li>emotional instability<\/li><li>impaired speech<\/li><li>fainting<\/li><li>muscle weakness<br><\/li><\/ul>\n\n\n\n<p><strong>Very rare<\/strong>&nbsp;(may affect up to 1 in 10,000 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of red and&nbsp;white blood cells&nbsp;and&nbsp;platelets&nbsp;(pancytopenia)<\/li><li>inflammation&nbsp;in the joints<\/li><li>abnormal heart rhythm<\/li><li>increased sensitivity of the skin<\/li><li>the feeling of seclusion (not being yourself)<\/li><li>increased blood coagulation<\/li><li>muscle stiffness<\/li><li>clear reduction in the number of special&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis&nbsp;)<br><\/li><\/ul>\n\n\n\n<p>In very rare cases, long-term (up to several months or years) or lasting&nbsp;side effects, such as tendinitis, tendonitis, joint pain, pain in arms and legs, difficulty walking, abnormal sensations such as ant crawling, tingling, tingling, a burning sensation, numbness or pain (&nbsp;neuropathy&nbsp;), depression, fatigue, sleep disturbances, impaired memory and impaired hearing, vision and taste and odor associated with treatment with&nbsp;quinolone&nbsp;and fluoroquinolone antibiotics, in some cases regardless of existing risk factors.<br><\/p>\n\n\n\n<p>Furthermore, in very rare cases, the following&nbsp;side effects have&nbsp;been reported during treatment with other&nbsp;quinolones, which may also occur during treatment with Avelox: increased pressure in the skull (symptoms include headache, vision problems including blurred vision, blind spots, double vision, loss of vision), increased sodium levels in the blood, increased calcium levels in the blood, decreased level of a special type of&nbsp;red blood cells&nbsp;(&nbsp;hemolytic anemia&nbsp;), the skin becomes more sensitive to sunlight or UV light.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Avelox<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the blister and carton after EXP and EXP respectively.&nbsp;date.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is moxifloxacin.&nbsp;Each film-coated tablet contains 400 milligrams of moxifloxacin as moxifloxacin hydrochloride.<\/li><li>The other ingredients are: The&nbsp;<br>core: Microcrystalline cellulose, croscarmellose sodium,&nbsp;lactose monohydrate&nbsp;(see section 2:&nbsp;<em>Avelox contains&nbsp;lactose<\/em>&nbsp;), magnesium stearate.&nbsp;<br>Coating: Hypromellose, Macrogol 4000, iron oxide (E 172), and titanium dioxide (E 171).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Each film-coated, pale red, oblong, slightly rounded tablet, measuring 17 x 7 mm, is marked \u201cM400\u201d on one side and \u201cBAYER\u201d on the other side.<br><\/p>\n\n\n\n<p>Avelox is packaged in cartons containing colorless, transparent, or white opaque polypropylene\/aluminum blisters or colorless transparent polyvinyl chloride\/polyvinylidene chloride\/aluminum blisters.<br><\/p>\n\n\n\n<p>Avelox is available in packs containing 5, 7, and 10 film-coated tablets, in<\/p>\n\n\n\n<p>hospital packs containing 25, 50, or 70 film-coated tablets and in multipacks for hospitals consisting of 5 cartons, each carton containing 16 film-coated tablets, or 10 cartons, each carton containing 10 film-coated tablets.<br><\/p>\n\n\n\n<p>Avelox is also available in drug test packs of 1 film-coated tablet in a carton containing aluminum\/aluminum blisters.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Bayer AB&nbsp;<br>Box 606<\/p>\n\n\n\n<p>SE-169 26 Solna<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>The manufacturer can be identified by the batch number printed on the side flap of the carton and on each blister:<\/p>\n\n\n\n<p><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If the first and second characters are BX, the manufacturer<\/strong><\/li><\/ul>\n\n\n\n<p>Bayer AG<\/p>\n\n\n\n<p>Kaiser-Wilhelm-Allee<\/p>\n\n\n\n<p>51368 Leverkusen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If the first and second signs are IT, it is the manufacturer<\/strong><\/li><\/ul>\n\n\n\n<p>Bayer HealthCare Manufacturing Srl&nbsp;<br>Via Delle Groaned, 126&nbsp;<br>20024 Garbagnate Milanese&nbsp;<br>Italien<br><\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Belgium, Cyprus, Denmark, Estonia, Finland, Greece, Ireland, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Czech Republic, Portugal, Slovenia, United Kingdom, , Hungary, Austria:<\/td><td>Avelox<\/td><\/tr><tr><td>France:<\/td><td>Izilox<\/td><\/tr><tr><td>Italy, Germany:<\/td><td>Avalox<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Avelox contains the active substance moxifloxacin, which belongs to a group of antibiotics called fluoroquinolones. Avelox works by killing bacteria that cause infection.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[9589,9592,9584,9587,9593,9588,9591,9590,9585,9586],"class_list":["post-5773","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-avelox","tag-avelox-tablet","tag-moxifloxacin","tag-moxifloxacin-tablet","tag-side-effects-of-avelox","tag-side-effects-of-moxifloxacin","tag-what-avelox-is-used-for","tag-what-is-avelox","tag-what-is-moxifloxacin","tag-what-moxifloxacin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5773","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5773"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5773\/revisions"}],"predecessor-version":[{"id":12289,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5773\/revisions\/12289"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5773"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5773"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5773"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}