{"id":5761,"date":"2020-12-25T15:31:38","date_gmt":"2020-12-25T15:31:38","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5761"},"modified":"2021-07-13T07:39:19","modified_gmt":"2021-07-13T07:39:19","slug":"aubagio","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/aubagio\/","title":{"rendered":"Aubagio &#8211; Teriflunomide uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n14 mg&nbsp;film-coated tablets&nbsp;<br>teriflunomide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What AUBAGIO is and what it is used for<\/h2>\n\n\n\n<p>AUBAGIO contains the active substance teriflunomide, which is an immunomodulatory agent and regulates the immune system to limit its attack on the nervous system.<br><\/p>\n\n\n\n<p><strong>What AUBAGIO is used for<br><\/strong>AUBAGIO is used in adults for the treatment of relapsing&nbsp;multiple sclerosis&nbsp;(MS).<br><\/p>\n\n\n\n<p><strong>What&nbsp;multiple sclerosis&nbsp;is<br><\/strong>MS is a long-term disease that affects the&nbsp;central nervous system&nbsp;(&nbsp;CNS&nbsp;).&nbsp;The CNS is made&nbsp;up of the brain and spinal cord.&nbsp;In MS, an&nbsp;inflammation&nbsp;destroys&nbsp;the protective sheath (called myelin), which surrounds the nerves in the&nbsp;CNS&nbsp;.&nbsp;This loss of myelin is called demyelination.&nbsp;It prevents the nerves from functioning normally.<br><\/p>\n\n\n\n<p>People with relapsing&nbsp;multiple sclerosis&nbsp;have repeated attacks (&nbsp;relapses&nbsp;) of physical symptoms caused by their nerves not functioning properly.&nbsp;Symptoms vary between patients, but usually include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty walking<\/li><li>vision problems<\/li><li>balance problem.<\/li><\/ul>\n\n\n\n<p>The symptoms may disappear completely when the&nbsp;relapse&nbsp;is over, but over time, some problems may persist between&nbsp;relapses&nbsp;.&nbsp;This can cause physical disability that can interfere with daily activities.<br><\/p>\n\n\n\n<p><strong>How&nbsp;<\/strong><strong>AUBAGIO&nbsp;<\/strong><strong>works<br><\/strong>AUBAGIO helps protect the&nbsp;central nervous system&nbsp;from attack by the immune system, by limiting the growth of certain&nbsp;white blood cells&nbsp;(&nbsp;lymphocytes&nbsp;).&nbsp;This limits&nbsp;inflammation&nbsp;which leads to nerve damage in MS.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking AUBAGIO<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take AUBAGIO:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to teriflunomide or any of the other ingredients of this medicine (listed in section 6),<\/li><li>if you have severe liver disease,<\/li><li>if you are&nbsp;<strong>pregnant<\/strong>, think you may be pregnant or breast-feeding,<\/li><li>if you suffer from a serious problem affecting your immune system (eg Acquired Immune Deficiency Syndrome (&nbsp;AIDS&nbsp;),<\/li><li>if the function of your&nbsp;bone marrow&nbsp;is severely impaired or if you have a low number of red or&nbsp;white blood cells&nbsp;or a reduced number of&nbsp;platelets,<\/li><li>if you have a serious&nbsp;infection,<\/li><li>if you have a kidney disease that requires&nbsp;dialysis,<\/li><li>if you have very low levels of&nbsp;protein in&nbsp;your blood (hypoproteinemia).<\/li><\/ul>\n\n\n\n<p>If you are not sure, talk to your doctor or pharmacist before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking AUBAGIO if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have liver problems and\/or if you drink large amounts of alcohol.&nbsp;Your doctor will take blood samples before and during treatment to check how well your liver is working.&nbsp;If your test results show problems with your liver, your doctor may discontinue treatment with AUBAGIO.&nbsp;Read section 4.<\/li><li>you have high&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;), whether this is controlled with medication or not.&nbsp;AUBAGIO may cause a slight increase in&nbsp;blood pressure.&nbsp;Your doctor will check your&nbsp;blood pressure&nbsp;before starting treatment and regularly during treatment.&nbsp;Read section 4.<\/li><li>you have an&nbsp;infection.&nbsp;Before taking AUBAGIO, your doctor will check that you have enough&nbsp;white blood cells&nbsp;and&nbsp;platelets.&nbsp;Because AUBAGIO reduces the number of&nbsp;white blood cells, it can affect your ability to fight&nbsp;infection&nbsp;.&nbsp;Your doctor may take blood samples to check your&nbsp;white blood cells&nbsp;if you think you have an&nbsp;infection.&nbsp;Read section 4.<\/li><li>you get severe skin reactions.<\/li><li>you have or get respiratory symptoms.<\/li><li>you feel weakness, numbness, and pain in your hands and feet.<\/li><li>you should be vaccinated.<\/li><li>you are taking leflunomide with AUBAGIO.<\/li><li>you switch to or from AUBAGIO.<\/li><li>you are lactose intolerant.<\/li><li>you should take a specific blood test (calcium level).&nbsp;Measurements can show falsely low calcium levels.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>AUBAGIO should not be used by children and adolescents under 18 years of age.&nbsp;This is because the effects of the drug in this age group are not known.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and AUBAGIO<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.&nbsp;This also applies to over-the-counter medicines.&nbsp;<br>In particular, tell your doctor or pharmacist if you are taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>leflunomide, methotrexate, and other medicines that affect the immune system (often called immunosuppressants or&nbsp;immunomodulators&nbsp;)<\/li><li>rifampicin (a medicine used to treat&nbsp;tuberculosis&nbsp;and other&nbsp;infections&nbsp;)<\/li><li>carbamazepine, phenobarbital, or&nbsp;phenytoin&nbsp;in&nbsp;epilepsy<\/li><li>St. John&#8217;s wort&nbsp;(herbal remedy for depression)<\/li><li>repaglinide, pioglitazone, nateglinide, or rosiglitazone in&nbsp;diabetes<\/li><li>daunorubicin, doxorubicin, paclitaxel, or <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/topotecan-ebewe\/\">topotecan<\/a> in cancer<\/li><li>duloxetine in depression, urinary incontinence, or kidney disease in&nbsp;diabetes<\/li><li>alosetron in severe diarrhea<\/li><li>theophylline in&nbsp;asthma<\/li><li>tizanidine, a muscle relaxant<\/li><li>warfarin, an&nbsp;anticoagulant&nbsp;used to make the blood thinner to avoid blood clots<\/li><li>oral contraceptives (containing Ethinyl estradiol and levonorgestrel)<\/li><li>cefaclor, benzylpenicillin,&nbsp;ciprofloxacin&nbsp;at&nbsp;infection&nbsp;s<\/li><li>indomethacin,&nbsp;ketoprofen&nbsp;for pain or&nbsp;inflammation<\/li><li>furosemide&nbsp;in heart disease<\/li><li>cimetidine to reduce stomach acid<\/li><li>zidovudine,&nbsp;HIV&nbsp;&#8211;&nbsp;infection<\/li><li>rosuvastatin,&nbsp;simvastatin, atorvastatin, pravastatin for&nbsp;hypercholesterolemia(high&nbsp;cholesterol&nbsp;)<\/li><li>sulfasalazine in&nbsp;inflammatory&nbsp;bowel disease or&nbsp;rheumatoid arthritis<\/li><li>cholestyramine in high&nbsp;cholesterol&nbsp;or as an antipruritic agent in liver disease<\/li><li>activated carbon to reduce the&nbsp;absorption&nbsp;of drugs or other substances<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p><strong>Do not<\/strong>&nbsp;take AUBAGIO if you are pregnant or think you may be&nbsp;<strong>pregnant<\/strong>.&nbsp;If you are pregnant or become pregnant while taking AUBAGIO, the risk of birth defects is increased.&nbsp;Women of&nbsp;childbearing potential&nbsp;must not take this medicine without using a reliable contraceptive.<br><\/p>\n\n\n\n<p>Tell your doctor if you are planning to become pregnant after stopping treatment with AUBAGIO, as most of this medicine must have disappeared from your body before trying to conceive.&nbsp;The excretion of the active substance can take up to 2 years naturally.&nbsp;The time can be shortened to a few weeks by taking special drugs that speed up the excretion of AUBAGIO from your body.<\/p>\n\n\n\n<p>In both cases, a blood test must check whether the active substance has been excreted sufficiently from your body and the doctor must determine that the amount of AUBAGIO is low enough in the blood for you to become pregnant.<br><\/p>\n\n\n\n<p>Contact your doctor for more information about the laboratory samples.<br><\/p>\n\n\n\n<p>If you suspect you are pregnant while taking AUBAGIO, or within two years of stopping treatment, you must&nbsp;contact a doctor&nbsp;<strong>immediately<\/strong>&nbsp;for a pregnancy test.&nbsp;If the test confirms that you are pregnant, your doctor may suggest treatment with special medicines, so that AUBAGIO is removed more quickly and sufficiently from your body, as this may reduce the risks to your baby.<br><\/p>\n\n\n\n<p><strong>Contraceptives<\/strong>&nbsp;<br>You must use an effective contraceptive during and after treatment with AUBAGIO.&nbsp;Teriflunomide remains in your blood long after you stop taking it.&nbsp;Continue to use an effective contraceptive after stopping treatment.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Continue doing this until the amount of AUBAGIO in your blood is low enough &#8211; your doctor will check this.<\/li><li>Talk to your doctor about the best method of contraception for you and when changing contraceptives.<\/li><\/ul>\n\n\n\n<p>Do not take AUBAGIO while breast-feeding, as teriflunomide passes into breast milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>AUBAGIO can make you dizzy, and it can impair your ability to concentrate and react.&nbsp;If this happens, do not drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">AUBAGIO contains lactose<\/h2>\n\n\n\n<p>AUBAGIO contains&nbsp;lactose&nbsp;(a type of sugar).&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<p><strong>AUBAGIO contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per tablet, ie essentially &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take AUBAGIO<\/h2>\n\n\n\n<p>Treatment with AUBAGIO will be supervised by a doctor who has experience in the treatment of MS.<br><\/p>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Consult your doctor if you are unsure.<br><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 14 mg daily.<br><\/p>\n\n\n\n<p>AUBAGIO is taken daily as a single dose at any time of the day.&nbsp;<br>The tablet should be swallowed whole with a little water.&nbsp;<br>AUBAGIO can be taken with or without food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more AUBAGIO than you should&nbsp;<\/h2>\n\n\n\n<p>Contact a doctor immediately if you have taken too much AUBAGIO.&nbsp;You may experience&nbsp;side effects&nbsp;similar to those mentioned in section 4 below.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take AUBAGIO<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.&nbsp;Take the next&nbsp;dose&nbsp;when you normally take it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking AUBAGIO<\/h2>\n\n\n\n<p>Do not stop taking AUBAGIO or change your&nbsp;dose&nbsp;without first talking to your doctor.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;<br>The following&nbsp;side effects&nbsp;may occur with this medicine.<br><\/p>\n\n\n\n<p><strong>Serious&nbsp;adverse events&nbsp;are&nbsp;<\/strong><br><strong>Talk immediately to your doctor if you notice any of the following serious side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions that may include symptoms such as rash, hives, swollen lips, tongue or face, or sudden difficulty breathing<\/li><li>severe skin reactions that may include symptoms such as rash, blisters, or sores in the mouth<\/li><li>severe&nbsp;infection&nbsp;or&nbsp;sepsis&nbsp;(a potentially life-threatening type of infection) that may include symptoms such as high fever, tremors, chills, decreased urine flow, or confusion<\/li><li>severe liver disease that may include symptoms such as yellowing of the skin or whites of the eyes, darker-than-normal urine, unexplained nausea or vomiting, or abdominal pain<\/li><li>inflammation&nbsp;of the lungs which may include symptoms such as shortness of breath or persistent cough<\/li><li>inflammation&nbsp;of the pancreas which may include symptoms such as severe pain in the upper abdominal area which may also be felt in the back, nausea or vomiting<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are&nbsp;<\/strong><strong>can occur with the following frequencies:<\/strong><\/p>\n\n\n\n<p><strong><br>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Diarrhea, malaise<\/li><li>Elevated&nbsp;ALT&nbsp;(elevated blood levels of certain liver enzymes) as shown by tests<\/li><li>Hair thinning<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Influenza, upper respiratory infection, urinary tract infections,&nbsp;bronchitis&nbsp;(&nbsp;bronchitis&nbsp;), sinusitis (&nbsp;sinusitis&nbsp;), sore throat and pain on swallowing,&nbsp;bladder infection&nbsp;(&nbsp;cystitis&nbsp;) caused viral gastrointestinal infection, cold sores, tooth infection, st\u00e4mbandskatarr (&nbsp;laryngitis&nbsp;),&nbsp;athlete&#8217;s foot<\/li><li>Laboratory values: Decreased&nbsp;red blood cell count&nbsp;(&nbsp;anemia&nbsp;), altered liver and white blood cell test results (see section 2), as well as elevated muscle enzyme levels (creatinine phosphokinase), have been observed<\/li><li>Mild allergic reactions<\/li><li>Feeling anxious<\/li><li>Tingling, feeling of weakness, numbness, tingling or pain in the lower back or leg (sciatica), numbness, burning or tingling sensation, pain in hands and fingers (&nbsp;carpal tunnel syndrome&nbsp;)<\/li><li>Palpitation<\/li><li>High&nbsp;blood pressure<\/li><li>Nausea (vomiting), toothache, pain in the upper abdomen.<\/li><li>Skin rash,&nbsp;acne<\/li><li>Pain in tendons, joints, legs, muscle aches (musculoskeletal pain),<\/li><li>Need to throw water more often than normal<\/li><li>Abundant menstruation<\/li><li>Pain<\/li><li>Lack of energy or feeling of weakness (&nbsp;asthenia&nbsp;)<\/li><li>Weight loss<\/li><\/ol>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased&nbsp;platelet count&nbsp;(mild&nbsp;thrombocytopenia&nbsp;)<\/li><li>Increased sensitivity, especially in the skin, stabbing or throbbing pain along one or more nerves, problems with the nerves in the arms or legs (&nbsp;peripheral neuropathy&nbsp;)<\/li><li>Nail diseases<\/li><li>Post-traumatic&nbsp;pain<\/li><\/ul>\n\n\n\n<p><strong>No known frequency<\/strong>&nbsp;(cannot be calculated from the available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe&nbsp;infection&nbsp;(including&nbsp;sepsis&nbsp;(blood poisoning))<\/li><li>Severe allergic reactions (including anaphylaxis)<\/li><li>Lung reaction (interstitial lung disease, ILD)<\/li><li>Inflammation&nbsp;of the liver,&nbsp;pancreas,&nbsp;or mouth\/lips<\/li><li>Severe skin reactions<\/li><li>Abnormal levels of fat (&nbsp;lipid&nbsp;s) in the blood<\/li><li>Psoriasis<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store AUBAGIO<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton, cap, or blister after \u201cEXP.\u201d The expiry date will be the last day of that month.<br><\/p>\n\n\n\n<p>No special storage instructions.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is teriflunomide.&nbsp;Each tablet contains 14 mg of teriflunomide.<\/li><li>The other ingredients are&nbsp;lactose monohydrate,&nbsp;maize&nbsp;starch, microcrystalline cellulose, sodium starch&nbsp;glycolate&nbsp;(type A), hydroxypropyl cellulose, magnesium stearate, hypromellose, titanium dioxide (E171), talc, macrogol 8000, indigotin\/indigo carmine (E132).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>AUBAGIO 14 mg film-coated tablets (tablets) are pale blue to pastel blue, five-sided film-coated tablets debossed on one side (&#8220;14&#8221;) and engraved with the company logo on the other side.<br><\/p>\n\n\n\n<p>AUBAGIO is available in cartons containing:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>14, 28, 84, and 98 tablets in folding packs with integrated aluminum blisters;<\/li><li>10 x 1 tablets in aluminum single-dose blisters.<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder:<\/h2>\n\n\n\n<p>sanofi-aventis groupe&nbsp;<br>54, rue La Bo\u00e9tie&nbsp;<br>F-75008 Paris&nbsp;<br>France<br><\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong>&nbsp;<br>Sanofi Winthrop Industrie&nbsp;<br>56, route de Choisy au Bac&nbsp;<br>60205 Compi\u00e8gne&nbsp;<br>France<br><\/p>\n\n\n\n<p>Sanofi Winthrop Industry<\/p>\n\n\n\n<p>30-36, Gustave Eiffel Avenue<\/p>\n\n\n\n<p>37100 Tours<\/p>\n\n\n\n<p>France<br><\/p>\n\n\n\n<p>Contact the&nbsp;<strong>representative of the marketing authorization holder<\/strong>&nbsp;to find out more about this medicine<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Sanofi BelgiumTel \/ Tel \/ Tel: +32 (0) 2 710 54 00<\/td><td><strong>Lithuania<\/strong>UAB SANOFI-AVENTIS LIETUVATel: +370 5 2755224<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>SANOFI BULGARIA EOODPhone: +359 2 9705300<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Sanofi BelgiumPhone: +32 (0) 2 710 54 00 (Belgium \/ Belgium)<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>sanofi-aventis, sroTel: +420 233 086 111<\/td><td><strong>Hungary<\/strong>SANOFI-AVENTIS Zrt.Tel: +36 1 505 0050<\/td><\/tr><tr><td><strong>Denmark<\/strong>Sanofi A \/ STel: +45 45 16 70 00<\/td><td><strong>Malta<\/strong>Sanofi SpA&nbsp;<br>Tel: +39 02 39394275<\/td><\/tr><tr><td><strong>Germany<\/strong>Sanofi-Aventis Deutschland GmbHTel .: 0800 04 36 996Tel.&nbsp;from abroad: +49 69 305 70 13<\/td><td><strong>The Netherlands<\/strong>Genzyme Europe BVTel: +31 20 245 4000<\/td><\/tr><tr><td><strong>Eesti<\/strong>sanofi-aventis Estonia O\u00dcTel: +372 627 34 88<\/td><td><strong>Norway<\/strong>sanofi-aventis Norge ASTel: +47 67 10 71 00<\/td><\/tr><tr><td><strong>Greece<\/strong>sanofi-aventis AEBE:\u0397\u03bb: +30 210 900 16 00<\/td><td><strong>Austria<\/strong>sanofi-aventis GmbHTel: +43 1 80 185 &#8211; 0<\/td><\/tr><tr><td><strong>Spain<\/strong>sanofi-aventis SATel: +34 93 485 94 00<\/td><td><strong>Poland<\/strong>sanofi-aventis Sp.&nbsp;z oo&nbsp;Tel: +48 22 280 00 00<\/td><\/tr><tr><td><strong>France<\/strong>sanofi-aventis FranceTel: 0 800 222 555Call from abroad: +33 1 57 63 23 23<\/td><td><strong>Portugal<\/strong>Sanofi &#8211; Pharmaceutical Products, LdaTel: +351 21 35 89 400<\/td><\/tr><tr><td><strong>Croatia<\/strong>sanofi-aventis Croatia dooTel: +385 1 600 34 00<\/td><td><strong>Romania<\/strong>Sanofi Romania SRLTel: +40 (0) 21 317 31 36<\/td><\/tr><tr><td><strong>Ireland<\/strong>sanofi-aventis Ireland Ltd.&nbsp;T \/ A SANOFITel: +353 (0)1 403 56 00<\/td><td><strong>Slovenia<\/strong>sanofi-aventis dooTel: +386 1 560 48 00<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>sanofi-aventis Pharma Slovakia sroTel: +421 2 33 100 100<\/td><\/tr><tr><td><strong>Italy<\/strong>Sanofi SpATel: 800536389<br><\/td><td><strong>Finland \/ Finland<\/strong>Sanofi OyPuh \/ Tel: +358 (0) 201 200 300<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>sanofi-aventis Cyprus Ltd.:\u0397\u03bb: +357 22 871600<\/td><td><\/td><\/tr><tr><td><strong>Latvia<\/strong>sanofi-aventis Latvia SIATel: +371 67 33 24 51<\/td><td><strong>United Kingdom<\/strong>SanofiPhone +44 (0)845 372 7101<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>AUBAGIO contains the active substance teriflunomide, which is an immunomodulatory agent and regulates the immune system to limit its attack on the nervous system.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[9651,9654,9655,9650,9646,9649,9653,9652,9647,9648],"class_list":["post-5761","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-aubagio","tag-aubagio-tablet","tag-side-effects-of-aubagio","tag-side-effects-of-teriflunomide","tag-teriflunomide","tag-teriflunomide-tablet","tag-what-aubagio-is-used-for","tag-what-is-aubagio","tag-what-is-teriflunomide","tag-what-teriflunomide-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5761"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5761\/revisions"}],"predecessor-version":[{"id":12325,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5761\/revisions\/12325"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5761"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5761"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}