{"id":5636,"date":"2020-12-23T14:48:33","date_gmt":"2020-12-23T14:48:33","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5636"},"modified":"2023-01-01T09:30:13","modified_gmt":"2023-01-01T09:30:13","slug":"atenative","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/atenative\/","title":{"rendered":"Atenative &#8211; Antithrombin Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>Atenative  50 IU \/ ml&nbsp;Antithrombin powder for solution for&nbsp;infusion&nbsp;solution&nbsp;<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Atenative Is And What Atenative Used For<\/h2>\n\n\n\n<p>Atenativ is a so-called antithrombotic drug containing antithrombin isolated from\u00a0human\u00a0blood plasma.\u00a0Antithrombin is a normal component of blood plasma and an important inhibitor of blood\u00a0coagulation\u00a0(clotting).<\/p>\n\n\n\n<p>Atenatives treat and prevent blood clots in blood vessels in people with congenital or certain forms of\u00a0acute\u00a0antithrombin deficiency.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. Before You Use Atenativ<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Options<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to\u00a0human\u00a0plasma\u00a0antithrombin\u00a0or other ingredients of <strong>Atenative <\/strong>(listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Atenatives contain very small amounts of other human&nbsp;proteins.&nbsp;All medicines that contain&nbsp;proteins&nbsp;injected into a vein (&nbsp;intravenous&nbsp;administration&nbsp;) can cause allergic reactions.<\/p>\n\n\n\n<p>Early signs of\u00a0hypersensitivity reaction\u00a0are <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hives (\u00a0urticaria\u00a0)<\/li><li>Feeling of pressure in the chest<\/li><li>Difficulty breathing<\/li><li>Dizziness<\/li><li>Fainting<\/li><\/ul>\n\n\n\n<p>If such symptoms occur after receiving Atenativ, contact a doctor immediately.<\/p>\n\n\n\n<p><strong>Virus safety<\/strong>\u00a0<br>When medicines are made from\u00a0human\u00a0plasma\u00a0or blood, special measures are taken to prevent the\u00a0transmission of\u00a0infection\u00a0to patients.\u00a0This includes:<br>A careful selection of blood and plasma donors to ensure that people at risk of being carriers are excluded, testing individual donations and plasma pools for signs of virus\/infection and introducing steps in the processing of blood and\u00a0plasma that can inactivate different\u00a0viruses.<\/p>\n\n\n\n<p>Nevertheless, the risk of transmission of\u00a0infection\u00a0can not be completely ruled out when drugs made from human blood or\u00a0plasma\u00a0are given.\u00a0This also applies to new, unknown\u00a0viruses\u00a0and other types of\u00a0infections.<\/p>\n\n\n\n<p>The measures taken are effective against enveloped\u00a0viruses, such as\u00a0HIV,\u00a0hepatitis\u00a0B, and\u00a0hepatitis\u00a0C\u00a0virus,\u00a0and for non-enveloped\u00a0viruses,\u00a0hepatitis\u00a0A\u00a0virus.\u00a0The measures may be of limited value against unencapsulated\u00a0viruses\u00a0such as parvovirus B19.\u00a0Infection\u00a0of parvovirus B19 can be serious for pregnant women and individuals with a weakened immune system or condition nedbrystning of\u00a0red blood cells\u00a0(e.g.,\u00a0hemolytic anaemia).<br>When given Atenativ, it is recommended that the product name and batch number be registered to trace the medicine used.<\/p>\n\n\n\n<p>Your doctor may suggest vaccination against\u00a0Hepatitis\u00a0A and B if you are regularly \/ repeatedly treated with plasma-derived medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Alternatives<\/h2>\n\n\n\n<p>Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p>Co-administration\u00a0of\u00a0heparin\u00a0with antithrombin increases the risk of bleeding.\u00a0Concomitant heparin treatment must be carefully considered if you have an increased risk of bleeding.\u00a0If your doctor finds that you need\u00a0heparin, you will be closely monitored using laboratory tests.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or healthcare professional for advice before taking <strong>Atenative<\/strong>.\u00a0Your doctor will decide if you can use Atenativ during pregnancy or breastfeeding.\u00a0Pregnancy in itself means an increased risk of blood clots.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>No effects have been observed on the ability to drive and use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How To Use Atenative<\/h2>\n\n\n\n<p>Your doctor will decide if you need Atenativ and in what&nbsp;dose.&nbsp;Healthcare professionals will give you Atenativ as an&nbsp;infusion&nbsp;directly into the bloodstream.&nbsp;You will be checked with the necessary laboratory tests during the treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Use Too Much Atenativ\u00a0<\/h2>\n\n\n\n<p>No overdose symptoms have been reported.&nbsp;Your doctor will treat you appropriately if you experience any adverse effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Stop Using Options<\/h2>\n\n\n\n<p>Your doctor will decide when to stop the treatment, depending on laboratory values \u200b\u200band your state of health.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible Atenative Side Effects<\/h2>\n\n\n\n<p>Like all medicines, Atenativ can cause\u00a0side effects,\u00a0although not everybody gets them.<\/p>\n\n\n\n<p>Contact a doctor immediately if you get any of the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling of the tongue, face, or throat<\/li><li>Difficulty swallowing<\/li><li>Hives\u00a0and difficulty breathing<\/li><li>The feeling of pressure in the chest<\/li><li>Drop in blood pressure<\/li><\/ul>\n\n\n\n<p>This may be a sign of&nbsp;angioedema, hypersensitivity, or allergic reactions.<\/p>\n\n\n\n<p>The following symptoms have been observed when using Atenativ, but the frequency can not be calculated from the available data:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anxiety<\/li><li>Seizures<\/li><li>Headaches<\/li><li>Dizziness<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/fatigue-syndrome\/\">Fatigue<\/a><\/li><li>Lack of energy<\/li><li>Tingling<\/li><li>Restlessness<\/li><li>Nausea<\/li><li>Vomiting<\/li><li>Abdominal <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a><\/li><li>Diarrhoea<\/li><li>High\u00a0blood pressure<\/li><li>Low\u00a0blood pressure<\/li><li>Palpitations<\/li><li>Cardiac arrest<\/li><li>Bleeding<\/li><li>Blood clots<\/li><li>Wheezing<\/li><li>Dermatitis<\/li><li>Arthritis<\/li><li>Arthritis or <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/back-hurts\/\">back pain<\/a><\/li><li>Chest pain<\/li><li>Injection site reactions<\/li><li>Chills<\/li><li>Redness<\/li><li>Sweating<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">Fever<\/a><\/li><\/ul>\n\n\n\n<p><strong>Reporting of\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse if you get any<strong> Atenative side effects.<\/strong>\u00a0This also applies to any side effects not mentioned in this information.\u00a0You can also report\u00a0side effects\u00a0directly. By reporting\u00a0side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How To Store Atenativ<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep <strong>Atenative <\/strong>out of sight and reach of children.<\/li><li>Store at 2-8 \u00b0 C (in a refrigerator).\u00a0However, storage at room temperature for one month does not affect the product&#8217;s shelf life.\u00a0After this period, the medicine should not be put back in the safe and thrown away.<\/li><li>The reconstituted solution should be used within 12 hours.<\/li><li>From a\u00a0microbiological\u00a0point of view, the drug should be used immediately.\u00a0If not used immediately, in-use storage times and conditions before use is the user&#8217;s responsibility.\u00a0The storage time should not exceed 12 hours at 2-8 \u00b0 C unless reconstitution has occurred under controlled and validated aseptic conditions.<\/li><li>Do not use <strong>Atenative <\/strong>after the expiry date stated on the carton EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>Any new solution will be discarded according to local regulations.<\/li><li>Do not use <strong>Atenative <\/strong>if the solution is cloudy or contains particles.<\/li><\/ul>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.\u00a0Ask your pharmacist how to dispose of medicines that are no longer required.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents Of The Packaging And Other Information<\/h2>\n\n\n\n<p><strong>Content Declaration<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active ingredient is human antithrombin, 50 International Units (IU) \/ ml<\/li><li>The other ingredients are:<ul><li><em>Powder<\/em>: Sodium chloride, human albumin, stabilized with acetyltryptophan and caprylic acid<\/li><li><em>Liquid<\/em>: Water for injections<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And The Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The pack contains powder and solvent for\u00a0solution\u00a0for\u00a0injection.<\/li><li>The powder for\u00a0solution\u00a0for\u00a0injection\u00a0contains 500 IU or 1000 IU antithrombin.<\/li><li>The reconstituted solution should be clear or slightly opalescent.\u00a0<\/li><li>Not all pack sizes may be marketed.\u00a0<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p>Octapharma AB<\/p>\n\n\n\n<p>Lars Forssells gata 23<\/p>\n\n\n\n<p>112 75 Stockholm<\/p>\n\n\n\n<p>Tel 08-566 430 00<\/p>\n\n\n\n<p>Customer support: 020-31 10 20\u00a0<br>fraga@octapharma.se<\/p>\n\n\n\n<p><strong>Medical Products Agency<\/strong><\/p>\n\n\n\n<p>Box 26<\/p>\n\n\n\n<p>751 03 Uppsala<\/p>\n\n\n\n<p>Website:\u00a0www.lakemedelsverket.se\u00a0<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Atenativ is a so-called antithrombotic drug containing antithrombin isolated from human blood plasma. Antithrombin is a normal component of blood plasma and an important inhibitor of blood coagulation (clotting).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[9901,9905,2215,9904,2212,9908,9903,9907,9902,9906],"class_list":["post-5636","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-antithrombin","tag-atenative","tag-injection","tag-iside-effects-of-antithrombin","tag-medicine","tag-side-effects-of-atenative","tag-what-antithrombin-is-used-for","tag-what-atenative-is-used-for","tag-what-is-antithrombin","tag-what-is-atenative"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5636","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5636"}],"version-history":[{"count":42,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5636\/revisions"}],"predecessor-version":[{"id":42348,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5636\/revisions\/42348"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5636"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5636"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5636"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}