{"id":5596,"date":"2020-12-22T15:31:09","date_gmt":"2020-12-22T15:31:09","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5596"},"modified":"2021-07-15T19:54:29","modified_gmt":"2021-07-15T19:54:29","slug":"arthrotec","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/arthrotec\/","title":{"rendered":"Arthrotec &#8211; Diclofenac sodium \/ Misoprostol uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n50 mg \/ 0.2 mg&nbsp;modified-&nbsp;release&nbsp;tablets&nbsp;<br>diclofenac sodium \/ <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/topogyne\/\">misoprostol<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Arthrotec is and what it is used for<\/h2>\n\n\n\n<p>Arthrotec relieves pain and swelling in&nbsp;rheumatoid arthritis&nbsp;(&nbsp;rheumatoid arthritis&nbsp;) and joint wear and tear (&nbsp;osteoarthritis&nbsp;) and can also provide protection in patients who are at increased risk of irritation or ulcers in the stomach or intestines.<br><\/p>\n\n\n\n<p>Arthrotec contains&nbsp;diclofenac&nbsp;and misoprostol.&nbsp;Diclofenac&nbsp;belongs to a group of medicines called non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;).<\/p>\n\n\n\n<p>NSAIDs&nbsp;relieve pain, but can also reduce the amount of naturally occurring substances, called&nbsp;prostaglandins, in the&nbsp;lining of the&nbsp;stomach&nbsp;.<\/p>\n\n\n\n<p>This means that&nbsp;NSAIDs&nbsp;can cause stomach irritation or&nbsp;stomach ulcers.&nbsp;Arthrotec also contains misoprostol, which is very similar to these&nbsp;prostaglandins&nbsp;and can therefore help protect the stomach.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Arthrotec<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Arthrotec<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you think you may be allergic to diclofenac sodium,&nbsp;acetylsalicylic acid,&nbsp;ibuprofen&nbsp;or any other&nbsp;NSAID, misoprostol or other prostaglandin-type medicines, or any of the other ingredients of Arthrotec (listed in section 6).&nbsp;Signs of a&nbsp;hypersensitivity reaction&nbsp;may include skin rash, swelling or&nbsp;itching&nbsp;of the skin, swelling of the face and mouth (&nbsp;angioedema&nbsp;), severe nasal congestion,&nbsp;asthma(difficulty breathing), chest pain, wheezing, or any other type of&nbsp;allergic reaction.<\/li><li>if you currently have a&nbsp;stomach ulcer&nbsp;or&nbsp;perforation&nbsp;(hole) in your stomach or intestines<\/li><li>if you currently have bleeding in your stomach, intestines, or brain<\/li><li>if you are undergoing or have recently had a&nbsp;bypass&nbsp;operation on your coronary arteries<\/li><li>if you have severe kidney or liver failure<\/li><li>if you have known heart disease and\/or disease of the blood vessels of the brain, e.g.&nbsp;heart attack,&nbsp;stroke, &#8220;mini-stroke&#8221; (&nbsp;transient&nbsp;ischemic attack,&nbsp;TIA&nbsp;).&nbsp;You may also have had constrictions in the blood vessels of the heart or brain, or have had surgery for such constrictions by clearing&nbsp;vessels&nbsp;one&nbsp;by&nbsp;one or via a&nbsp;bypass operation<\/li><li>if you have or have had problems with blood circulation (&nbsp;peripheral&nbsp;vascular disease)<\/li><li>if you are pregnant or trying to conceive, as Arthrotec may cause miscarriage.&nbsp;Women of&nbsp;childbearing potential&nbsp;should have adequate contraception during treatment with Arthrotec<\/li><li>if you are a woman of&nbsp;childbearing potential&nbsp;and do not use effective contraception to avoid pregnancy (read more in the section \u201cPregnancy\u201d).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Arthrotec:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have other health problems, such as liver or kidney disease.<\/li><li>if you have previously had ulcers or bleeding in the stomach or intestines.<\/li><li>if you easily get bleeding or bruising<\/li><li>if you have intestinal inflammation (ulcerative colitis or&nbsp;Crohn&#8217;s disease&nbsp;)<\/li><li>if you have or have had&nbsp;asthma&nbsp;or any allergic disease<\/li><li>if you have an&nbsp;infection, as Arthrotec may mask a fever or other signs of&nbsp;infection<\/li><li>if you are dehydrated<\/li><li>if you are over 65 years old because doctors will want to check you regularly<\/li><li>if you smoke<\/li><li>if you have&nbsp;diabetes<\/li><li>if you have angina, blood clots, high&nbsp;blood pressure, high cholesterol, or high&nbsp;triglycerides&nbsp;(blood fats)<\/li><li>if you are pregnant or planning to become pregnant (see section \u201cPregnancy\u201d).&nbsp;Due to the risk to the fetus, your treatment with Arthrotec must be stopped immediately.<\/li><li>if you are a woman of&nbsp;childbearing potential&nbsp;(see also section \u201cPregnancy\u201d).&nbsp;It is important that you use effective contraception while taking this medicine.<\/li><li>if you have recently had surgery or are about to have surgery on your stomach or intestinal tract, as Arthrotec can sometimes impair wound healing in the intestines after surgery.<\/li><\/ul>\n\n\n\n<p>NSAIDs&nbsp;such as Arthrotec can cause bleeding or&nbsp;stomach ulcers.&nbsp;Treatment should be discontinued if this occurs.&nbsp;You have a particularly high risk of serious&nbsp;side effects in the stomach and intestines if you:<\/p>\n\n\n\n<p>&#8211; while taking a&nbsp;corticosteroid&nbsp;(eg prednisone)<\/p>\n\n\n\n<p>&#8211; at the same time taking a blood-thinning medicine orally,<\/p>\n\n\n\n<p>&#8211; at the same time taking a&nbsp;selective&nbsp;serotonin reuptake inhibitor (eg&nbsp;sertraline&nbsp;)<\/p>\n\n\n\n<p>&#8211; drink alcohol.<\/p>\n\n\n\n<p>&#8211; use Arthrotec with&nbsp;acetylsalicylic acid&nbsp;or any other&nbsp;NSAID&nbsp;(eg&nbsp;ibuprofen&nbsp;).&nbsp;You can then more easily get sores or bleeding in the stomach and intestines.<\/p>\n\n\n\n<p>&#8211; is older<\/p>\n\n\n\n<p>&#8211; have any cardiovascular disease<\/p>\n\n\n\n<p>&#8211; if you have previously had or have ulcers or bleeding in the stomach or intestines<\/p>\n\n\n\n<p>&#8211; be treated with higher&nbsp;doses&nbsp;of&nbsp;NSAIDs.<br><\/p>\n\n\n\n<p>Medicines such as Arthrotec may have a small increased risk of heart attack or&nbsp;stroke.&nbsp;Such an increase in risk is more likely with the use of high&nbsp;doses&nbsp;and with long-term treatment.&nbsp;Do not exceed the recommended&nbsp;dose&nbsp;or treatment time.<br><\/p>\n\n\n\n<p>Side effects&nbsp;can be minimized by treating with the lowest effective&nbsp;dose&nbsp;for the shortest possible time.<br><\/p>\n\n\n\n<p>Like other&nbsp;NSAIDs&nbsp;(eg&nbsp;ibuprofen&nbsp;), Arthrotec can cause high&nbsp;blood pressure, so your doctor may want to measure your&nbsp;blood pressure&nbsp;regularly.<br><\/p>\n\n\n\n<p>Your doctor will want to examine you regularly if you have heart, liver, or kidney problems.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Arthrotec<\/h2>\n\n\n\n<p>Some medicines may affect the way some other medicines work.&nbsp;Tell your doctor or pharmacist if you are taking, have recently taken,<strong> or might take any other medicines, such as:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Acetylsalicylic acid&nbsp;or other&nbsp;NSAIDs&nbsp;(eg&nbsp;ibuprofen&nbsp;)<\/li><li>Medicines for&nbsp;osteoarthritis&nbsp;or&nbsp;rheumatoid arthritis&nbsp;belonging to the group cyclooxygenase-2 (&nbsp;COX-2&nbsp;) inhibitors<\/li><li>Diuretics&nbsp;(used for fluid retention in the body)<\/li><li>Ciclosporin or tacrolimus (used to suppress the immune system, eg after transplants)<\/li><li>Lithium (used to treat certain types of depression)<\/li><li>Digoxin&nbsp;(a medicine for irregular heartbeat and\/or&nbsp;heart failure&nbsp;)<\/li><li>Warfarin&nbsp;or other blood-thinning medicines taken by mouth (reduces blood clotting, eg&nbsp;acetylsalicylic acid&nbsp;)<\/li><li>Drugs for anxiety and depression belonging to the group of selective serotonin reuptake inhibitors (&nbsp;SSRIs&nbsp;)<\/li><li>Blood glucose control drugs are taken orally (for&nbsp;diabetes&nbsp;)<\/li><li>Methotrexate (used to treat&nbsp;rheumatoid arthritis,&nbsp;psoriasis,&nbsp;and&nbsp;leukemia&nbsp;)<\/li><li>Treatment with&nbsp;steroids&nbsp;(eg&nbsp;corticosteroids&nbsp;which are often used as anti-inflammatory drugs)<\/li><li>Medicines for high&nbsp;blood pressure<\/li><li>Antacids containing&nbsp;magnesium&nbsp;(used for heartburn, indigestion)<\/li><li>Antibiotics&nbsp;quinolone (used against certain&nbsp;infectious&nbsp;s)<\/li><li>Ketoconazole&nbsp;,&nbsp;fluconazole&nbsp;,&nbsp;miconazole&nbsp;and voriconazole (used against certain types of fungal infections)<\/li><li>Amiodarone&nbsp;(used to treat abnormal heart rhythms)<\/li><li>Sulfinpyrazone (used to&nbsp;treat gout&nbsp;)<\/li><\/ul>\n\n\n\n<p>If you have been taking mifepristone (to terminate a pregnancy) for the last 12 days.&nbsp;Arthrotec should not be used within 8-12 days after taking mifepristone.<br><\/p>\n\n\n\n<p>Concomitant use of&nbsp;anti-inflammatory&nbsp;and analgesic drugs of the&nbsp;NSAID&nbsp;type&nbsp;can in rare cases cause an increase in certain blood levels, as well as fluid accumulation in the body (swelling in the ankles, legs, and\/or hands).&nbsp;Concomitant use of other&nbsp;NSAIDs&nbsp;should be avoided as the risk of&nbsp;side effects&nbsp;increases.<br><\/p>\n\n\n\n<p>Blood pressure-lowering drugs containing propranolol may, after repeated&nbsp;dosing&nbsp;of Arthrotec, lead to a moderate increase in the concentration of propranolol in the blood.&nbsp;Therefore, consult your doctor before concomitant use.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Pregnancy<\/p>\n\n\n\n<p>Do not take Arthrotec if you are pregnant, think you may be pregnant, or are trying to become pregnant.&nbsp;Tell your doctor if you are planning to have a baby.&nbsp;Due to the possible risk of birth defects, you must make sure that you are not pregnant before starting treatment.&nbsp;Women who have not reached menopause must use a reliable contraceptive during treatment with Arthrotec.<br><\/p>\n\n\n\n<p>Your doctor will inform you about the risks if you become pregnant while taking Arthrotec, as the medicine may cause miscarriage, premature birth, or abnormal fetal development (malformations).&nbsp;You should NEVER take this medicine if you are pregnant, as it can also have serious consequences for your baby, especially on the heart, lungs, and\/or kidneys, including death.&nbsp;If you have been treated with this medicine during pregnancy, talk to your doctor.&nbsp;If you decide to complete the pregnancy, it should be followed up closely with ultrasound examinations with a special focus on the baby&#8217;s legs, arms, and head.<br><\/p>\n\n\n\n<p>Breast-feeding<\/p>\n\n\n\n<p>If you are breast-feeding, talk to your doctor or pharmacist before taking this medicine.&nbsp;Do not use Arthrotec if you are breast-feeding.<br><\/p>\n\n\n\n<p>Fertility<\/p>\n\n\n\n<p>Arthrotec can cause temporary&nbsp;infertility.&nbsp;In women who are having difficulty conceiving or undergoing fertility testing, discontinuation of Arthrotec treatment should be considered.<br><\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Arthrotec can cause dizziness, fatigue, and visual disturbances.<\/p>\n\n\n\n<p>If you feel dizzy or drowsy after taking Arthrotec, do not drive or use machines until these symptoms have subsided.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Arthrotec contains lactose<\/h2>\n\n\n\n<p>Arthrotec contains&nbsp;<strong>lactose<\/strong>&nbsp;(a&nbsp;<strong>sugar<\/strong>&nbsp;).&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Arthrotec<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p><em>The usual&nbsp;dose&nbsp;for adults<\/em>&nbsp;is 1 tablet 2-3 times daily.<br><\/p>\n\n\n\n<p>Arthrotec should be swallowed whole with water (not chewed) with, or immediately after, a meal.<br><\/p>\n\n\n\n<p><strong>Elderly patients and patients with liver or kidney disease<\/strong><\/p>\n\n\n\n<p>Your doctor may want to check you more closely<strong>.&nbsp;<\/strong>No dose adjustment is necessary.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children<\/h2>\n\n\n\n<p>Arthrotec is for adults only and should not be used by children (under 18 years of age).<br><\/p>\n\n\n\n<p>In case of overdose, the following symptoms may occur drowsiness, tremors, cramps, shortness of breath, abdominal pain, diarrhea, fever, palpitations, low&nbsp;blood pressure,&nbsp;or slow heartbeat.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Arthrotec<\/h2>\n\n\n\n<p>If you forget to take a tablet, take it as soon as you remember.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Arthrotec<\/h2>\n\n\n\n<p>Do not stop taking Arthrotec unless your doctor tells you to.&nbsp;If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Arthrotec can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Stop taking Arthrotec and contact a doctor immediately if any of the following occur:<\/strong><br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>weakness or inability to move one side of the body, slurred speech (&nbsp;stroke&nbsp;), chest pain (heart attack),&nbsp;heart failure&nbsp;or palpitations (you feel your heartbeat) &#8211;&nbsp;<strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/li><li>shortness of breath &#8211;&nbsp;<strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Arthrotec can cause a decrease in a type of&nbsp;white blood cell&nbsp;(which helps defend the body against&nbsp;infection&nbsp;and disease) which can lead to&nbsp;infection&nbsp;with symptoms such as chills, sudden fever, sore throat or&nbsp;flu-like symptoms&nbsp;&#8211;&nbsp;<strong>Uncommon<\/strong>&nbsp;(may occur in up to 1 in 100 users)<\/li><li>severe abdominal pain or see any signs of bleeding or ulceration in the stomach or intestines, such as black or bloody stools &#8211;&nbsp;<strong>Uncommon<\/strong>&nbsp;&nbsp;(may affect up to 1 in 100 people), or bloody vomiting &#8211;&nbsp;<strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people) )&nbsp;<\/li><li>a severe&nbsp;allergic reaction&nbsp;with symptoms such as swelling of the face, tongue or throat, difficulty swallowing, wheezing or difficulty breathing,&nbsp;hives, drop in blood pressure (&nbsp;angioedema, anaphylactic&nbsp;shock&nbsp;) &#8211;&nbsp;<strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people)<\/li><li>jaundice (your skin or whites of the eyes look yellowish) &#8211;&nbsp;<strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people)<\/li><li>reduction in&nbsp;platelet count&nbsp;(increased risk of bleeding or bruising) &#8211;&nbsp;<strong>Uncommon<\/strong>(may affect up to 1 in 100 people)<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>symptoms of&nbsp;meningitis&nbsp;(stiff neck, headache, nausea, vomiting, fever, or loss of consciousness) &#8211; occurs in an&nbsp;<strong>unknown<\/strong>&nbsp;number of users<br><\/li><li>chest pain, which may be a sign of a potentially serious&nbsp;allergic reaction&nbsp;known as Kuoni&#8217;s syndrome &#8211; occurs in an&nbsp;<strong>unknown<\/strong>&nbsp;number of users<br><\/li><li>a severe skin reaction such as rash, blistering, or peeling of the skin (DRESS,&nbsp;Stevens-Johnson syndrome, exfoliative&nbsp;dermatitis,&nbsp;and&nbsp;toxic epidermal necrolysis&nbsp;) &#8211; occurs in an&nbsp;<strong>unknown<\/strong>&nbsp;number of users.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;may occur<\/strong><br><\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 user in 10):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stomach pain, diarrhea, nausea, indigestion<\/li><\/ul>\n\n\n\n<p>Diarrhea is most common and in exceptional cases is of a serious nature.&nbsp;Taking Arthrotec with food reduces the risk of diarrhea.&nbsp;If you are taking antacids (for the acid stomach), you should avoid antacids that contain&nbsp;magnesium&nbsp;as they can worsen diarrhea.<\/p>\n\n\n\n<p>The pharmacy staff can help you choose the appropriate antacid.&nbsp;If diarrhea continues and becomes severe, you should contact your doctor.<br><\/p>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Skin rash,&nbsp;itching<\/li><li>Vomiting, flatulence, constipation, regurgitation, gastritis (indigestion, abdominal pain, vomiting)<\/li><li>Inflammation&nbsp;of the esophagus<\/li><li>Stomach or intestinal ulcers<\/li><li>Headache, dizziness<\/li><li>Difficulty sleeping<\/li><li>Altered blood test results associated with liver function<\/li><li>Inflammation&nbsp;of the gastrointestinal tract such as nausea, diarrhea, and abdominal pain<\/li><li>Abnormal fetal development<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling and&nbsp;inflammation&nbsp;in the mouth<\/li><li>Fluid retention in the body can cause swollen ankles and bones<\/li><li>Abnormal or unexpected abdominal bleeding<\/li><li>Decreased&nbsp;platelet count&nbsp;(may lead to increased risk of bleeding or bruising)<\/li><li>Purple (purple skin spots)<\/li><li>Hives&nbsp;(raised, itchy rash)<\/li><li>Infection&nbsp;in&nbsp;the vagina&nbsp;(&nbsp;itching, burning, soreness, pain particularly during intercourse and\/or urination)<\/li><li>Dimsyn<\/li><li>High&nbsp;blood pressure<\/li><li>Reduced appetite<\/li><li>Menstrual disorders, such as heavy or minor bleeding or delayed menstruation<\/li><li>Chills or fever<\/li><li>Drowsiness, fatigue, tremors<\/li><li>Ringing in the ears (&nbsp;tinnitus&nbsp;)<\/li><li>Bleeding from the stomach and intestines (gastrointestinal&nbsp;bleeding)<\/li><li>Depression and anxiety<\/li><li>Tingling or tingling<\/li><li>Cold sores and&nbsp;dry mouth<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hepatitis (may lead to yellowing of the skin, headache, fever, chills, a general feeling of weakness)<\/li><li>Inflammation&nbsp;of the pancreas, leading to severe pain in the abdomen and back<\/li><li>Pain in the breasts<\/li><li>Painful menstruation<\/li><li>Vomiting containing blood<\/li><li>Exacerbation of&nbsp;ulcerative colitis&nbsp;(&nbsp;inflammation&nbsp;of the colon)<\/li><li>Damage to the esophagus<\/li><li>Swelling of the tongue<\/li><li>Low&nbsp;blood pressure<\/li><li>Hair loss<\/li><li>The skin rash in the form of blisters (bullous skin rash)<\/li><li>Increased light sensitivity<\/li><li>Nightmares<\/li><\/ul>\n\n\n\n<p><strong>Very rare (may affect up to 1 in 10,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe liver disease including liver failure<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurs in an unknown number of users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Exacerbation of&nbsp;Crohn&#8217;s disease&nbsp;(intestinal inflammation)<\/li><li>Kidney problems<\/li><li>Inflammation&nbsp;of the lungs such as cough increased mucus formation<\/li><li>Seizures<\/li><li>Tingling or numbness<\/li><li>Inflamed blood vessels (may cause fever, aches, purple rash))<\/li><li>Psychosis&nbsp;(a mental illness characterized by a lack of perception of reality)<\/li><li>Mood swings<\/li><li>, irritation, memory disorders, confusion<\/li><li>Visual disturbances, taste changes<\/li><li>Inflammation<\/li><li>Swelling of the face<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Abnormal contractions of the uterus, rupture of the uterine wall, retention of placenta after childbirth, a life-threatening reaction caused by amniotic fluid or other&nbsp;tissues&nbsp;passing from the pregnancy to the mother&#8217;s blood circulation, uterine bleeding, miscarriage, fetal death, premature birth<\/li><li>Anemia&nbsp;(decreased number of&nbsp;red blood cells&nbsp;) can lead to pale skin, feeling weak, and short of breath<\/li><li>Decreased&nbsp;fertility&nbsp;in women<\/li><li>Skin rash (Erythema multiforme, Henoch-Sch\u00f6nlein purpura, mucosal rash, vesicular rash)<\/li><li>Altered blood test results associated with liver function (increased&nbsp;bilirubin&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Arthrotec<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;Store in the original package.&nbsp;Moisture sensitive.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;date.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substances are diclofenac sodium and misoprostol.<\/p>\n\n\n\n<p>One tablet contains 50 mg of diclofenac sodium and 0.2 mg of misoprostol.<br><\/p>\n\n\n\n<p>The other ingredients are&nbsp;lactose monohydrate, microcrystalline cellulose, corn starch, povidone, magnesium stearate, methacrylic acid ethyl acrylate copolymer, sodium hydroxide, triethyl citrate hypromellose, crospovidone,&nbsp;colloidal&nbsp;anhydrous silica, hydrogenated talc castor oil.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product;jsessionid=oL-K71JmOL1bpx7Z45NSNpVB3kTLU6RPYD1ZPLSderD1ONEJ_KWE!1291279176?userType=2&amp;nplId=19921023000144#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Pfizer20AB\/Media\/Arthrotec\/untitled.jpg\" alt=\"marking\"\/><\/a><\/figure>\n\n\n\n<p>Arthrotec tablets are white to off-white, round, biconvex and marked with&nbsp;on one side and &#8220;SEARLE 1411&#8221; on the other side.<br><\/p>\n\n\n\n<p>Pack sizes:<\/p>\n\n\n\n<p>Blister: 20 and 100 tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Pfizer AB<\/p>\n\n\n\n<p>191 90 Sollentuna<\/p>\n\n\n\n<p>Tel: 08-550 520 00<\/p>\n\n\n\n<p>Email: eumedinfo@pfizer.com<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><br><\/p>\n\n\n\n<p>Piramal Healthcare UK Limited<\/p>\n\n\n\n<p>Morpeth<\/p>\n\n\n\n<p>Northumberland<\/p>\n\n\n\n<p>NE61 3YA<\/p>\n\n\n\n<p>UK<br><\/p>\n\n\n\n<p>or<br><\/p>\n\n\n\n<p>Piramal Pharma Solutions (Dutch) BV<\/p>\n\n\n\n<p>Level, 7th floor<\/p>\n\n\n\n<p>Bargelaan 200<\/p>\n\n\n\n<p>2333 CW<\/p>\n\n\n\n<p>Leiden<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Arthrotec relieves pain and swelling in rheumatoid arthritis ( rheumatoid arthritis ) and joint wear and tear ( osteoarthritis ) and can also provide protection in patients who are at increased risk of irritation or ulcers in the stomach or intestines.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[9983,9986,2897,5574,6222,6225,6226,9985,9980,9984,6223,9982],"class_list":["post-5596","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-arthrotec","tag-arthrotec-tablet","tag-diclofenac-sodium","tag-diclofenac-sodium-tablet","tag-misoprostol","tag-misoprostol-tablet","tag-side-effects-of-misoprostol","tag-what-arthrotec-is-used-for","tag-what-diclofenac-sodium-is-used-for","tag-what-is-arthrotec","tag-what-is-misoprostol","tag-what-misoprostol-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5596"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5596\/revisions"}],"predecessor-version":[{"id":12466,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5596\/revisions\/12466"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5596"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5596"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}