{"id":5588,"date":"2020-12-22T15:13:40","date_gmt":"2020-12-22T15:13:40","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5588"},"modified":"2021-07-15T19:54:09","modified_gmt":"2021-07-15T19:54:09","slug":"armisarte","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/armisarte\/","title":{"rendered":"Armisarte &#8211; Pemetrexed uses, dose and side effects"},"content":{"rendered":"\n<p> 25 mg \/ mL&nbsp;concentrate for&nbsp;infusion&nbsp;solution&nbsp;<br>pemetrexed (pemetrexed)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Armisarte is and what it is used for<\/h2>\n\n\n\n<p>Armisarte is a medicine used to treat cancer.&nbsp;It contains the active substance pemetrexed.&nbsp;Pemetrexed belongs to a group of medicines called <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triobe\/\">folic acid<\/a> analogs and disrupts processes that are necessary for the cells to divide.<\/p>\n\n\n\n<p>Armisarte is given together with cisplatin, another anti-cancer drug, for the treatment of malignant pleural mesothelioma, a form of lung sac cancer, in patients who have not previously received anti-cancer drug therapy.<br><\/p>\n\n\n\n<p>Armisarte is also used with cisplatin in the initial treatment of advanced lung cancer.<br><\/p>\n\n\n\n<p>Armisarte can be prescribed to you if you have advanced lung cancer and your disease has responded to treatment or if it is largely unchanged after initial drug treatment.<br><\/p>\n\n\n\n<p>In addition, Armisarte is used to treat advanced lung cancer whose disease has progressed, after other previous drug treatments have been used.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Armisarte<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Armisarte<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to pemetrexed or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are breast-feeding.&nbsp;You should stop breast-feeding during treatment with Armisarte.<\/li><li>if you have recently been vaccinated or are just about to be vaccinated against yellow fever.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>Talk to your doctor or pharmacist before receiving Armisarte.<\/strong><\/p>\n\n\n\n<p>Talk to your doctor or pharmacist if you have or have had kidney problems, as you may not be able to get Armisarte.<\/p>\n\n\n\n<p>Before each&nbsp;infusion, blood samples will be taken to determine if the function of the kidneys and liver is sufficient and to check that the amount of&nbsp;blood cells&nbsp;is sufficient to obtain Armisarte.&nbsp;Your doctor may choose to change the&nbsp;dose&nbsp;or postpone your treatment depending on your general condition and if your blood levels are too low.<\/p>\n\n\n\n<p>If you are also taking cisplatin, your doctor will make sure that you have been given enough fluids and that you will receive appropriate treatment before and after the cisplatin treatment to prevent vomiting.<br><\/p>\n\n\n\n<p>If you have received radiation therapy or if such treatment is planned, tell your doctor, like radiation therapy and Armisarte may cause immediate or late&nbsp;side effects.<br><\/p>\n\n\n\n<p>If you have recently been vaccinated, you should tell your doctor, as Armisarte may cause unwanted reactions in connection with the vaccination.<br><\/p>\n\n\n\n<p>Tell your doctor if you have, or have previously had, heart disease.<br><\/p>\n\n\n\n<p>If you have fluid accumulation around your lungs, your doctor may decide to remove the fluid before treatment with Armisarte.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>There is no relevant use of Armisarte in the pediatric population.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Armisarte<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take other medicines for pain or&nbsp;inflammation&nbsp;(swelling), such as so-called non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;), including over-the-counter medicines (such as&nbsp;ibuprofen&nbsp;).&nbsp;There are many different types of these drugs with varying duration of action.&nbsp;Knowing the date of the planned&nbsp;infusion&nbsp;of Armisarte and\/or renal function status, your doctor must advise you on which medicines you can take and when you can take them.&nbsp;If you are not sure, ask your doctor or&nbsp;pharmacist&nbsp;if any of your medicines are&nbsp;NSAIDs.<br><\/p>\n\n\n\n<p>Like other chemotherapeutic drugs, Armisarte is not recommended in combination with live attenuated vaccines.&nbsp;Inactive vaccines should be used where possible.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby,&nbsp;tell your doctor&nbsp;and ask for advice before taking this medicine<strong>.&nbsp;<\/strong>Treatment with Armisarte should be avoided during pregnancy.&nbsp;Your doctor will discuss any possible risks when Armisarte is given during pregnancy.&nbsp;Women should use effective contraception during treatment with Armisarte.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you are breast-feeding.<\/p>\n\n\n\n<p>Breast-feeding should be discontinued during treatment with Armisarte.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>Men are advised not to have children during and up to 6 months after Armisarte treatment and should therefore use an effective method of contraception during Armisarte treatment and up to 6 months after the end of treatment.&nbsp;If you plan to have children during treatment or the following 6 months after treatment, consult your doctor or&nbsp;pharmacist.&nbsp;You may want to seek advice on sperm preservation before starting treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Treatment with Armisarte may make you feel tired.&nbsp;Be careful when driving or using machines.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Armisarte<\/h2>\n\n\n\n<p>Armisarte 25 mg\/ml concentrate for&nbsp;solution&nbsp;for&nbsp;infusion&nbsp;will always be given to you by a healthcare professional.&nbsp;Dose&nbsp;one of Armisarte is 500 mg per square meter of body surface area.&nbsp;Your height and weight are used to calculate the body surface area.&nbsp;Your doctor will use the measurement of your body surface area to calculate the right&nbsp;dose&nbsp;for you.&nbsp;This&nbsp;dose&nbsp;can be adjusted or the treatment can be postponed depending on blood levels and your general condition.&nbsp;A hospital pharmacist, nurse, or doctor will have mixed Armisarte concentrate with 5% glucose solution for&nbsp;injection&nbsp;before giving it to you.<br><\/p>\n\n\n\n<p>Armisarte is always given as&nbsp;an infusion&nbsp;into a friend.&nbsp;Infusion&nbsp;one lasts for about 10 minutes.<br><\/p>\n\n\n\n<p>When Armisarte is given in combination with cisplatin:<\/p>\n\n\n\n<p>Your doctor or hospital pharmacist will have calculated the&nbsp;required&nbsp;dose&nbsp;using your height and weight.&nbsp;Cisplatin is also given as&nbsp;an infusion&nbsp;into a vein and is given about 30 minutes after the end of the Armisarte infusion.&nbsp;Infusion&nbsp;one of cisplatin lasts for about 2 hours.<br><\/p>\n\n\n\n<p>You usually receive&nbsp;an infusion&nbsp;once every three weeks.<br><\/p>\n\n\n\n<p>Other medicines:<\/p>\n\n\n\n<p>Corticosteroids: Your doctor will prescribe steroid tablets (equivalent to 4 milligrams of <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a> twice daily).&nbsp;You should take these tablets the day before, on the day of treatment, and the day after treatment with Armisarte.&nbsp;The tablets are given to reduce the frequency and severity of the skin reactions that may occur during treatment for cancer.<br><\/p>\n\n\n\n<p>Vitamin supplement: Your doctor will prescribe a&nbsp;preparation&nbsp;of&nbsp;folic acid&nbsp;(&nbsp;vitamin&nbsp;) to be taken by mouth or a multivitamin preparation containing&nbsp;folic acid&nbsp;(350 to 1000 micrograms) that you should take once a day during treatment with Armisarte.&nbsp;You should take at least 5&nbsp;doses&nbsp;during the seven days preceding the first&nbsp;dose of&nbsp;one of Armisarte.&nbsp;You should continue to take&nbsp;folic acid&nbsp;for 21 days after the last Armisarte&nbsp;dose.&nbsp;You will also receive a&nbsp;vitamin&nbsp;B&nbsp;<sub>12<\/sub>&nbsp;&#8211;&nbsp;Injection&nbsp;(1000 micrograms) in the week before Armisarte &#8211;&nbsp;infusion done and then approximately every 9 weeks (equivalent to 3 treatment regimens with Armisarte).&nbsp;Vitamin&nbsp;B&nbsp;<sub>12<\/sub>&nbsp;and&nbsp;folic acid&nbsp;are given to reduce the possible harmful effects of cancer treatment.<br><\/p>\n\n\n\n<p>Your condition will be closely monitored during treatment.&nbsp;This involves routine blood tests, including checks on your liver and kidney function.&nbsp;Your&nbsp;dose&nbsp;may change or treatment may be delayed depending on the results of these tests.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>You should contact your doctor immediately if you notice any of the following side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fever or&nbsp;infection&nbsp;(common): if you have a temperature of 38\u00ba C or more, sweating, or other signs of an&nbsp;infection&nbsp;(because you may have a lower&nbsp;than normal&nbsp;white blood cell count, which is very common).&nbsp;Infection&nbsp;one (blood poisoning) can be serious and lead to death.<\/li><li>If you start to feel chest pain (common) or have a fast heart rate (less common).<\/li><li>If you feel pain,&nbsp;redness, swelling, or soreness in your mouth (very common).<\/li><li>Allergic reaction: if you get a rash (very common) \/ burning or stinging sensation (common) or fever (common).&nbsp;Skin reactions can be severe and lead to death (rare).&nbsp;Contact your doctor if you get a lot of rash,&nbsp;itching,&nbsp;or blisters (&nbsp;Stevens-Johnson&nbsp;syndrome or&nbsp;toxic epidermal necrolysis&nbsp;).<\/li><li>If you get tired, feel weak, get short of breath easily, or if you look pale (because you may have less&nbsp;hemoglobin&nbsp;than normal, which is very common).<\/li><li>If it bleeds from the gums, nose, or mouth or you get any non-stop bleeding, reddish or pinkish urine, unexpected bruising (because you may have fewer&nbsp;platelets&nbsp;than normal, which is very common).<\/li><li>If you experience sudden shortness of breath, intense chest pain, or cough with bloody cough (less common) (may indicate a blockage in the blood vessels of the lungs)<br><\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;of Armisarte that may occur:<\/strong><br><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10)<\/em>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased&nbsp;white blood cell count<\/li><li>Low hemoglobin (&nbsp;anemia&nbsp;)<\/li><li>Reduced&nbsp;platelet count<\/li><li>Diarrhea<\/li><li>Vomiting<\/li><li>Pain,&nbsp;redness, swelling, or soreness in the mouth<\/li><li>Nausea<\/li><li>Decreased appetite<\/li><li>Fatigue (fatigue)<\/li><li>Skin rash, scaly skin<\/li><li>Hair loss<\/li><li>Constipation<\/li><li>Loss of feeling<\/li><li>Kidneys: abnormal blood counts<br><\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reaction: skin rash\/burning or stinging sensation<\/li><li>Infection&nbsp;(including sepsis)<\/li><li>Fever<\/li><li>Dehydration<\/li><li>Kidney failure<\/li><li>Skin irritation and&nbsp;itching<\/li><li>Hives<\/li><li>Chest pain<\/li><li>Muscle weakness<\/li><li>Conjunctivitis&nbsp;(inflamed eye)<\/li><li>Troubled stomach<\/li><li>Abdominal pain<\/li><li>Taste changes<\/li><li>Liver: abnormal blood counts<\/li><li>Tear-filled eyes<\/li><li>Dizziness<br><\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Acute&nbsp;renal failure<\/li><li>Fast or irregular heart rate<\/li><li>Inflammation&nbsp;of the esophageal&nbsp;mucosa&nbsp;(esophagus) has occurred with pemetrexed and radiation therapy<\/li><li>Colitis&nbsp;(&nbsp;inflammation&nbsp;of the colon wall, which may be accompanied by bleeding from the intestines)<\/li><li>Interstitial&nbsp;pneumonitis&nbsp;(scarring of the lungs)<\/li><li>Edema&nbsp;(accumulation of fluid in any body tissue that causes swelling)<\/li><li>Some patients have had a heart attack,&nbsp;stroke,&nbsp;or &#8216;mini-stroke&#8217; during treatment with pemetrexed, usually in combination with other cancer treatments.<\/li><li>Pancytopenia &#8211; combined low number of&nbsp;white blood cells,&nbsp;red blood cells,&nbsp;and&nbsp;platelets<\/li><li>Radiation pneumonitis (scarring of the air bubbles in connection with radiation therapy) may occur in patients who have also received radiation therapy either before, during, or after treatment with pemetrexed.<\/li><li>Pain and low temperature in arms or legs with discoloration have been reported.<\/li><li>Blood clots in the&nbsp;pulmonary&nbsp;blood vessels (&nbsp;pulmonary embolism&nbsp;)<br><\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Skin rash, which looks like severe sun damage, can occur on skin that has previously (several days or years ago) been exposed to radiation treatment.<\/li><li>Bullous conditions (skin diseases with blistering) including&nbsp;Stevens-Johnson syndrome and&nbsp;toxic epidermal necrolysis<\/li><li>Immune-mediated&nbsp;hemolytic anemia&nbsp;(destruction of&nbsp;red blood cells&nbsp;caused by&nbsp;antibodies&nbsp;)<\/li><li>Hepatitis&nbsp;(inflammation of the liver)<\/li><li>Anaphylactic&nbsp;shock&nbsp;(severe&nbsp;allergic reaction&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling of the legs with pain and&nbsp;redness<\/li><li>Increased urine output<\/li><li>Thirst and increased water intake<\/li><li>Hypernatremia&nbsp;&#8211; increased sodium content in the blood<\/li><\/ul>\n\n\n\n<p>You may get any of these symptoms and\/or ailments.&nbsp;If you start to experience any of these&nbsp;side effects,&nbsp;talk to your doctor as soon as possible.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Armisarte<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Store and transport cold (2 \u00b0 C &#8211; 8 \u00b0 C).<br><\/p>\n\n\n\n<p>Do not freeze.<br><\/p>\n\n\n\n<p>Keep the vial in the outer carton.&nbsp;Sensitive to light.<br><\/p>\n\n\n\n<p><em>Infusion solution:<\/em>&nbsp;Chemical and physical shelf life at room temperature for 3 days and in a refrigerator for 21 days has been demonstrated for pemetrexed infusion solution.&nbsp;From a microbiological perspective, the product should be used directly.&nbsp;If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user.&nbsp;This storage should not be longer than 24 hours at 2 \u00baC &#8211; 8 \u00baC unless dilution has been performed under controlled and validated aseptic conditions.<br><\/p>\n\n\n\n<p>Armisarte should not be used if particles are observed.<br><\/p>\n\n\n\n<p>This medicine is for single use only.&nbsp;Any unused solution should be disposed of in accordance with local requirements.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is pemetrexed.<br><\/p>\n\n\n\n<p>1 ml of the concentrate contains 25 mg of pemetrexed (as pemetrexed diacid).&nbsp;Further dilution of healthcare professionals is required before&nbsp;injection.<br><\/p>\n\n\n\n<p>One&nbsp;vial&nbsp;of 4 ml concentrate contains 100 mg pemetrexed (as pemetrexed diacid).<\/p>\n\n\n\n<p>One&nbsp;vial&nbsp;of 20 ml concentrate contains 500 mg pemetrexed (as pemetrexed diacid).<\/p>\n\n\n\n<p>One&nbsp;vial&nbsp;of 34 ml concentrate contains 850 mg of pemetrexed (as pemetrexed diacid).<\/p>\n\n\n\n<p>One&nbsp;vial&nbsp;of 40 ml concentrate contains 1000 mg pemetrexed (as pemetrexed diacid).<br><\/p>\n\n\n\n<p>The other ingredients are <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tribonate\/\">trometamol<\/a> (for&nbsp;pH&nbsp;adjustment), citric acid, anhydrous, methionine, water for injections<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Armisarte concentrate for&nbsp;solution&nbsp;for&nbsp;infusion&nbsp;(sterile concentrate) is a clear, colorless to the slightly yellowish solution or yellow-green solution.<br><\/p>\n\n\n\n<p>Armisarte is supplied in a colorless&nbsp;vial&nbsp;with a rubber stopper and an aluminum seal with a polypropylene sheet.&nbsp;The vials may be enclosed in a protective sleeve.<br><\/p>\n\n\n\n<p>Each pack of Armisarte contains one&nbsp;vial.<br><\/p>\n\n\n\n<p>Pack sizes:<\/p>\n\n\n\n<p>1 x 4 ml&nbsp;vial&nbsp;(100 mg \/ 4ml)<\/p>\n\n\n\n<p>1 x 20 ml&nbsp;vial&nbsp;(500 mg \/ 20 ml)<\/p>\n\n\n\n<p>1 x 34 ml&nbsp;vial&nbsp;(850 mg \/ 34 ml)<\/p>\n\n\n\n<p>1 x 40 ml&nbsp;vial&nbsp;(1000 mg \/ 40 ml)<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder:<\/h2>\n\n\n\n<p>Actavis Group PTC ehf.<\/p>\n\n\n\n<p>Reykjav\u00edkurvegur 76\u201178<\/p>\n\n\n\n<p>220 Hafnarfj\u00f6r\u00f0ur<\/p>\n\n\n\n<p>Iceland<br><\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>PLIVA CROATIA Ltd.<\/p>\n\n\n\n<p>10000 Zagreb<\/p>\n\n\n\n<p>Prilaz baruna Filipovi\u0107a 25<\/p>\n\n\n\n<p>Croatia<br><\/p>\n\n\n\n<p>Actavis Italy SpA<\/p>\n\n\n\n<p>Viale Pasteur 10<\/p>\n\n\n\n<p>20014 Nerviano (Milan)<\/p>\n\n\n\n<p>Italy<br><\/p>\n\n\n\n<p>SC Sindan-Pharma SRL<\/p>\n\n\n\n<p>11 Ion Mihalache Blvd.<\/p>\n\n\n\n<p>011171 Bucharest<\/p>\n\n\n\n<p>Romania<br><\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Teva Pharma Belgium NV \/ SA \/ AGTel \/ Tel: + 32 (0) 38 20 73 73<\/td><td><strong>Lithuania<\/strong>UAB &#8220;Sicor Biotech&#8221;Tel: +370 5 266 0203<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Octavis FADTel: +359 2 489 95 85<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Teva Pharma Belgium NV \/ SA \/ AGTel \/ Tel: + 32 (0) 38 20 73 73<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Teva Pharmaceuticals CR, sroTel: +420 251 007 111<\/td><td><strong>Hungary<\/strong>Teva Gy\u00f3gyszergy\u00e1r Zrt.Tel .: +36 1 288 6400<\/td><\/tr><tr><td><strong>Denmark<\/strong>Teva Denmark A \/ STel: +45 44 98 55 11<\/td><td><strong>Malta<\/strong>Actavis Ltd.Tel: +35621693533<\/td><\/tr><tr><td><strong>Germany<\/strong>ratiopharm GmbHTel: +49 731 402 02<\/td><td><strong>The Netherlands<\/strong>Teva Nederland BVTel: +31 (0) 800 0228 400<\/td><\/tr><tr><td><strong>Eesti<\/strong>UAB &#8220;Sicor Biotech&#8221; Eesti subsidiaryTel: +372 661 0801<\/td><td><strong>Norway<\/strong>Teva Norway ASTel: +47 66 77 55 90<\/td><\/tr><tr><td><strong>Greece<\/strong>Specify ABEE:\u0397\u03bb: +30 210 5401500<\/td><td><strong>Austria<\/strong>ratiopharm Arzneimittel Vertriebs-GmbHTel: +43 (0) 1 97007 0<\/td><\/tr><tr><td><strong>Spain<\/strong>Teva Pharma, SLUTel: + (34) 91 387 32 80<\/td><td><strong>Poland<\/strong>Teva Pharmaceuticals Polska Sp.&nbsp;z ooTel: +48 22 345 93 00<\/td><\/tr><tr><td><strong>France<\/strong>Teva HealthTel: + (33) 1 55 91 78 00<\/td><td><strong>Portugal<\/strong>Teva Pharma &#8211; Pharmaceutical Products LdaTel: +351 21 476 75 50<\/td><\/tr><tr><td><strong>Croatia<\/strong>Pliva Hrvatska dooTel: +385 1 37 20 000<\/td><td><strong>Romania<\/strong>Teva Pharmaceuticals SRLTel: +4021 230 65 24<\/td><\/tr><tr><td><strong>Ireland<\/strong>Actavis Ireland LimitedTel: +353 (0) 21 4619040<\/td><td><strong>Slovenia<\/strong>Pliva Ljubljana dooTel: +386 1 58 90 390<\/td><\/tr><tr><td><strong>Iceland<\/strong>Actavis Group PTC ehf.Phone: +354 550 3300<\/td><td><strong>Slovak Republic<\/strong>TEVA Pharmaceuticals Slovakia sroTel: +421 2 57 26 79 11<\/td><\/tr><tr><td><strong>Italy<\/strong>Teva Italia SrlTel: + (39) 028917981<\/td><td><strong>Finland \/ Finland<\/strong>ratiopharm OyPuh \/ Tel: +358 (0) 20 180 5900<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>Specify ABEE:\u0397\u03bb: +30 210 5401500Greece<\/td><td><\/td><\/tr><tr><td><strong>Latvia<\/strong>UAB &#8220;Sicor Biotech&#8221; branch of LatviaTel: +371 673 23 666<\/td><td><strong>United Kingdom<\/strong>Actavis UK LimitedTel: +44 1271 385257<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Armisarte is a medicine used to treat cancer. It contains the active substance pemetrexed. Pemetrexed belongs to a group of medicines called folic acid analogs and disrupts processes that are necessary for the cells to divide.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10017,10021,10012,10015,10020,10016,10019,10018,10013,10014],"class_list":["post-5588","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-armisarte","tag-armisarte-side-effects","tag-pemetrexed","tag-pemetrexed-side-effects","tag-side-effects-of-armisarte","tag-side-effects-of-pemetrexed","tag-what-armisarteis-used-for","tag-what-is-armisarte","tag-what-is-pemetrexed","tag-what-pemetrexed-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5588"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5588\/revisions"}],"predecessor-version":[{"id":12465,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5588\/revisions\/12465"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}