{"id":5582,"date":"2020-12-22T15:08:39","date_gmt":"2020-12-22T15:08:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5582"},"modified":"2021-07-16T19:51:17","modified_gmt":"2021-07-16T19:51:17","slug":"arixtra","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/arixtra\/","title":{"rendered":"Arixtra &#8211; Fondaparinux sodium uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n1.5 mg \/ 0.3 ml solution for injection&nbsp;<br>fondaparinux sodium<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Arixtra is and what it is used for<\/h2>\n\n\n\n<p><strong>Arixtra is a medicine that helps prevent blood clots from forming in the blood vessels<\/strong>&nbsp;(&nbsp;<em>an&nbsp;<\/em><em>antithrombotic agent<\/em>&nbsp;).<br><\/p>\n\n\n\n<p>Arixtra contains a synthetically produced substance called fondaparinux sodium.&nbsp;It prevents&nbsp;coagulation factor&nbsp;Xa &#8220;to-A&#8221; from acting in the blood and thus prevents unwanted blood clots&nbsp;<em>(&nbsp;thrombosis&nbsp;)<\/em>&nbsp;from forming in the blood vessels.<br><\/p>\n\n\n\n<p><strong>Arixtra is used to:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>prevent the formation of blood clots in the veins of the legs or lungs after orthopedic surgery (such as hip and knee joint surgery) or after abdominal surgery<\/li><li>prevent the formation of blood clots during and shortly after a period of reduced mobility due to&nbsp;acute&nbsp;illness<\/li><li>treat blood clots in the superficial veins of the legs (&nbsp;<em>superficial&nbsp;venous thrombosis<\/em>).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Arixtra<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Arixtra<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic<\/strong>&nbsp;to fondaparinux sodium or any of the other ingredients of this medicine (listed in section 6)<\/li><li><strong>if you bleed heavily<\/strong><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you have a bacterial&nbsp;infection&nbsp;in the heart<\/strong><\/li><li><strong>if you have very serious kidney disease.<\/strong><\/li><\/ul>\n\n\n\n<p>\u2192&nbsp;<strong>Tell your doctor<\/strong>&nbsp;if any of these apply to you.&nbsp;If it does, do&nbsp;<strong>not<\/strong>&nbsp;use Arixtra.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Arixtra:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you have a history of complications during treatment with&nbsp;heparin&nbsp;or&nbsp;heparin-like medicines that have caused a decrease in&nbsp;platelet count(heparin-induced&nbsp;thrombocytopenia&nbsp;)<\/strong><\/li><li><strong>if you are at risk of uncontrolled bleeding<\/strong>&nbsp;that includes:<ul><li><strong>gastric ulcer<\/strong><\/li><li><strong>bleeding disorder<\/strong><\/li><li>recent&nbsp;<strong>cerebral hemorrhage <\/strong><em>(&nbsp;intracranial&nbsp;hemorrhage)<\/em><\/li><li><strong>recently undergone surgery<\/strong>&nbsp;in the brain, spine or<\/li><\/ul><\/li><li><strong>if you have severe liver disease<\/strong><\/li><li><strong>if you have kidney disease<\/strong><\/li><li><strong>if you are 75 years or older<\/strong><\/li><li><strong>if you weigh less than 50 kg.<\/strong>\u2192&nbsp;<strong>Tell your doctor<\/strong>&nbsp;if any of these apply to you.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>The use of Arixtra has not been studied in children and adolescents under 17 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Arixtra<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.&nbsp;This also includes over-the-counter medications.&nbsp;Some other medicines may affect the effect of Arixtra or be affected by Arixtra.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Arixtra should not be prescribed to pregnant women unless clearly necessary.&nbsp;Breastfeeding is not recommended during treatment with Arixtra.&nbsp;If you are&nbsp;<strong>pregnant<\/strong>, or&nbsp;<strong>breast-feeding<\/strong>, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Arixtra contains excipients<\/h2>\n\n\n\n<p><strong>Arixtra contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 23 mg&nbsp;sodium&nbsp;per&nbsp;dose&nbsp;and is therefore considered&nbsp;sodium-free&nbsp;.<br><\/p>\n\n\n\n<p><strong>The syringe for Arixtra contains latex<\/strong><\/p>\n\n\n\n<p>The needle cover of the syringe contains latex which can cause allergic reactions in people sensitive to latex.<\/p>\n\n\n\n<p>\u2192&nbsp;<strong>Tell your doctor<\/strong>&nbsp;if you are allergic to latex before you are treated with Arixtra.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Arixtra<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist if you are unsure.&nbsp;<\/p>\n\n\n\n<p>If you have kidney disease, the&nbsp;dose&nbsp;can be reduced to 1.5 mg once a day.<br><\/p>\n\n\n\n<p><strong>How Arixtra is given<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Arixtra is given as an&nbsp;injection&nbsp;under the skin&nbsp;<em>(&nbsp;subcutaneously&nbsp;)<\/em>&nbsp;into a fold of skin in the lower abdomen. The syringe is pre-filled with exactly the&nbsp;dose&nbsp;you need.&nbsp;There are different syringes for&nbsp;doses&nbsp;are 2.5 mg and 1.5 mg.&nbsp;<strong>Step-by-step instruction is included in the package leaflet<\/strong>.<\/li><li>Inject&nbsp;<strong>not<\/strong>&nbsp;Arixtra into muscle.<br><\/li><\/ul>\n\n\n\n<p><strong>How long to use Arixtra<\/strong><\/p>\n\n\n\n<p>You should continue treatment with Arixtra for as long as your doctor prescribes as Arixtra prevents the development of serious medical conditions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you inject too much Arixtra<\/h2>\n\n\n\n<p>Contact your doctor or pharmacist for advice as soon as possible, as there is an increased risk of bleeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Arixtra<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Take the missed&nbsp;dose&nbsp;as soon as you remember.&nbsp;Do not inject a double&nbsp;dose to make up for&nbsp;the&nbsp;dose&nbsp;you forgot.<\/strong><\/li><li><strong>If you are not sure what to do<\/strong>, ask your doctor or pharmacist.<br><\/li><\/ul>\n\n\n\n<p><strong>Do not stop using Arixtra without the advice<\/strong><\/p>\n\n\n\n<p>If you stop treatment earlier than your doctor has told you, there is a risk of a blood clot forming in a vein in your leg or lung.&nbsp;<strong>Contact your doctor or pharmacist before stopping treatment.<\/strong><br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Conditions that you need to watch out for<\/strong><br><\/p>\n\n\n\n<p><strong>Severe allergic reactions (&nbsp;anaphylaxis&nbsp;):<\/strong>&nbsp;These are very rare in people (up to one in 10,000) treated with Arixtra.&nbsp;Signs of this include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling, sometimes on the face or mouth&nbsp;<em>(&nbsp;angioedema&nbsp;),<\/em>&nbsp;which may make it difficult to swallow or breathe<\/li><li>fainting.<\/li><li><strong>Contact a doctor immediately<\/strong>&nbsp;if you get these symptoms.&nbsp;<strong>Stop using Arixtra<\/strong>.<br><\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>more than 1 in 100 people<\/strong>&nbsp;treated with Arixtra<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>bleeding<\/strong>&nbsp;(eg at the surgical site, an existing&nbsp;stomach ulcer,&nbsp;or nosebleeds)<\/li><li><strong>anemia<\/strong>&nbsp;(decreased number of&nbsp;red blood cells&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 100 people<\/strong>&nbsp;treated with Arixtra<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>bruising or swelling&nbsp;<em>(&nbsp;edema&nbsp;)<\/em>&nbsp;<\/li><li>nausea, vomiting<\/li><li>chest pain<\/li><li>respiratory distress<\/li><li>skin rash or&nbsp;itching<\/li><li>exuding wounds at the surgical site<\/li><li>fever<\/li><li>decreased or increased&nbsp;platelet count&nbsp;(ie&nbsp;blood cells&nbsp;needed for blood clotting)<\/li><li>elevated liver enzyme values.<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 1,000 people<\/strong>&nbsp;treated with Arixtra<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions (including&nbsp;itching, swelling, and rash)<\/li><li>bleeding inside the brain or abdomen<\/li><li>anxiety or confusion<\/li><li>headache<\/li><li>fainting or dizziness, low&nbsp;blood pressure<\/li><li>drowsiness or fatigue<\/li><li>redness<\/li><li>cough<\/li><li>leg pain or abdominal pain<\/li><li>diarrhea or constipation<\/li><li>indigestion<\/li><li>wound infection<\/li><li>elevated bilirubin levels in the blood (a substance produced in the liver)<\/li><li>the decrease in&nbsp;potassium&nbsp;in the blood.<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Arixtra<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children<\/li><li>Store below 25 \u00b0 C.&nbsp;Do not freeze<\/li><li>Arixtra does not need to be stored in the refrigerator.<br><strong>Do not use this medicine:<\/strong><\/li><li>after the expiry date which is stated on the label and carton<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>if you see any particles in the solution or if the solution is discolored<\/li><li>if you see that the syringe is damaged<\/li><li>if you have opened a&nbsp;syringe&nbsp;but do not intend to use it immediately.<br><\/li><\/ul>\n\n\n\n<p><strong>Disposal of syringes:<\/strong><\/p>\n\n\n\n<p>Medicines and syringes should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is 1.5 mg fondaparinux sodium in 0.3 ml&nbsp;solution for injection.<\/li><li>The other ingredients are sodium chloride, water for injections, and&nbsp;hydrochloric acid&nbsp;and\/or sodium hydroxide for&nbsp;pH&nbsp;adjustment&nbsp;(see section 2).<br><\/li><\/ul>\n\n\n\n<p>Arixtra does not contain any animal products.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Arixtra is a clear and colorless&nbsp;solution for injection&nbsp;that comes in pre-filled syringes equipped with a safety system that helps prevent needle stick injuries after use.&nbsp;Arixtra is available in packs of 2, 7, 10, and 20 pre-filled syringes (not all pack sizes may be marketed).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder:<\/strong><\/p>\n\n\n\n<p>Aspen Pharma Trading Limited, 3016 Lake Drive, Citywest Business Campus, Dublin 24, Ireland<br><\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Aspen Notre Dame de Bondeville, 1 rue de l&#8217;Abbaye, F-76960 Notre Dame de Bondeville, France.<br><\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Aspen Pharma Trading LimitedTel: 0032 24009864aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Aspen Pharma Trading LimitedTel: 0035 227861279aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Aspen Pharma Trading LimitedTel: 00359 24917582aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>Hungary<\/strong>Aspen Pharma Trading LimitedTel .: 003 618480681aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Aspen Pharma Trading LimitedTel: 00420 228880774aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>Malta<\/strong>Aspen Pharma Trading LimitedTel: 00356 21497982aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Denmark<\/strong>Aspen Pharma Trading LimitedTel: 0045 78772887 aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>The Netherlands<\/strong>Aspen Pharma Trading LimitedTel: 0031 207095007aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Germany<\/strong>Aspen Germany GmbHTel .: 0049 3056796862aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>Norway<\/strong>Aspen Pharma Trading LimitedTel: 0047 21984376aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Eesti<\/strong>Aspen Pharma Trading LimitedTel: 003531 6308400aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>Austria<\/strong>Aspen Pharma Trading LimitedTel: 0043 19284015aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Greece<\/strong>Aspen Pharma Trading Limited.:\u0397\u03bb: 0030 2111768477aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>Poland<\/strong>Aspen Pharma Trading LimitedTel .: 0048 221253376aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Spain<\/strong>Aspen Pharmacare Espa\u00f1a SLAvenida Diagonal, 512Planta Interior 1, Office 408006 BarcelonaTel: 0034 952010137aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>Portugal<\/strong>Aspen Pharma Trading LimitedTel: 00351 300501243aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>France<\/strong>Aspen FranceTel .: + 33 (0) 1 39177000aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>Romania<\/strong>Aspen Pharma Trading Limited.Tel: 0040 316301169aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Croatia<\/strong>Aspen Pharma Trading LimitedTel: 00385 17776395aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>Slovenia<\/strong>Aspen Pharma Trading LimitedTel: 003861 18888201aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Ireland<\/strong>Aspen Pharma Trading LimitedTel: 003531 6308400aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>Slovak Republic<\/strong>Aspen Pharma Trading LimitedTel: 00421 233329930aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Iceland<\/strong>Aspen Pharma Trading Limited.Phone: 003531 6308400aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>Finland \/ Finland<\/strong>Aspen Pharma Trading LimitedPuh \/ Tel: 00358 974 790 156aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Italy<\/strong>Aspen Pharma Trading LimitedTel: 0039 0687502429aspenmedinfo@professionalinformation.co.uk<\/td><td><\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>Aspen Pharma Trading Limited:\u0397\u03bb: 00357 25030922aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>United Kingdom<\/strong>Aspen Pharma Trading LimitedTel: +44 (0) 1748 828 391aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Latvia<\/strong>Aspen Pharma Trading LimitedTel: 00371 66163124aspenmedinfo@professionalinformation.co.uk<\/td><td><strong>Liechtenstein<\/strong>Aspen Pharma Trading LimitedTel: 0049 3056796862aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><tr><td><strong>Lithuania<\/strong>Aspen Pharma Trading LimitedTel: 00370 5 214 0291aspenmedinfo@professionalinformation.co.uk<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Arixtra is a medicine that helps prevent blood clots from forming in the blood vessels ( an antithrombotic agent ).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10049,10052,10044,10047,10053,10048,10051,10046,10050,10045],"class_list":["post-5582","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-arixtra","tag-arixtra-tablet","tag-fondaparinux-sodium","tag-fondaparinux-sodium-tablet","tag-side-effects-of-arixtra","tag-side-effects-of-fondaparinux-sodium","tag-what-arixtra-is-used-for","tag-what-fondaparinux-sodium-is-used-for","tag-what-is-arixtra","tag-what-is-fondaparinux-sodium"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5582","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5582"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5582\/revisions"}],"predecessor-version":[{"id":12490,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5582\/revisions\/12490"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5582"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5582"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5582"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}