{"id":5545,"date":"2020-12-21T15:30:55","date_gmt":"2020-12-21T15:30:55","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5545"},"modified":"2021-07-18T17:06:21","modified_gmt":"2021-07-18T17:06:21","slug":"aricept","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/aricept\/","title":{"rendered":"Aricept &#8211; Donepezil hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n5 mg and 10 mg&nbsp;film-coated tablets&nbsp;<br>Donepezil hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Aricept is and what it is used for<\/h2>\n\n\n\n<p>Aricept contains the active substance donepezil hydrochloride.&nbsp;Aricept (donepezil hydrochloride) belongs to a group of medicines called acetylcholinesterase inhibitors.<\/p>\n\n\n\n<p>Donepezil increases the levels of a substance in the brain (&nbsp;acetylcholine&nbsp;), which is involved in memory function, by delaying the breakdown of&nbsp;acetylcholine.<\/p>\n\n\n\n<p>Aricept is used to treat the symptoms of dementia in mild to moderate<\/p>\n\n\n\n<p>Alzheimer&#8217;s disease.&nbsp;These symptoms include increasing memory loss, confusion, and behavioral changes.&nbsp;As a consequence of these symptoms, those suffering from&nbsp;Alzheimer&#8217;s disease&nbsp;find&nbsp;it more and more difficult to perform normal daily activities.<br><\/p>\n\n\n\n<p>Aricept should only be used by adults.<br><\/p>\n\n\n\n<p>Donepezil hydrochloride contained in Aricept may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Aricept<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Aricept<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to donepezil hydrochloride, piperidine derivatives, or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Aricept if you have or have had:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>gastric ulcer<\/li><li>seizures or convulsions<\/li><li>any heart disease (irregular or very slow heart rate)<\/li><li>asthma&nbsp;or other so-called chronic lung diseases<\/li><li>any liver disease or&nbsp;hepatitis&nbsp;(hepatitis)<\/li><li>difficulty trying to urinate or mild kidney disease<\/li><\/ul>\n\n\n\n<p>Also, tell your doctor if you are pregnant or think you may be pregnant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Aricept is not recommended for use in children and adolescents (younger than 18 years).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Aricept<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.&nbsp;This includes other medicines that you may take at some point in the future if you continue to use Aricept.&nbsp;This information is important as some other medicines may reduce or increase the effect of Aricept.<br><\/p>\n\n\n\n<p>You should be extra careful to tell your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other drugs used in&nbsp;Alzheimer&#8217;s disease, e.g.&nbsp;galantamine<\/li><li>medicines for pain or&nbsp;arthritis, e.g.&nbsp;acetylsalicylic acid, so-called&nbsp;NSAIDs&nbsp;such as&nbsp;ibuprofen&nbsp;or&nbsp;diclofenac<\/li><li>anticholinergic drugs, e.g.&nbsp;tolterodine<\/li><li>certain&nbsp;antibiotics, e.g.&nbsp;erythromycin, rifampicin<\/li><li>drugs against fungal infections, e.g.&nbsp;ketoconazole<\/li><li>antidepressant drugs, e.g.&nbsp;fluoxetine<\/li><li>medicines for seizures, e.g.&nbsp;phenytoin, carbamazepine<\/li><li>drugs for cardiovascular disease, e.g.&nbsp;quinidine,&nbsp;beta-blockers&nbsp;(propranolol, atenolol)<\/li><li>muscle relaxants, such as diazepam, succinylcholine<\/li><li>anesthetics<\/li><li>over-the-counter medicines and herbal medicines.<br>If you are planning to be hospitalized for an operation that requires you to be put to sleep, tell your doctor and the doctor performing the operation that you are using Aricept.&nbsp;This is because Aricept can affect the amount of anesthetic needed.<br>Aricept can be used by people with impaired kidney function or with mild to moderate hepatic impairment.&nbsp;Tell your doctor if you have any kidney or liver disease.&nbsp;Patients with severe hepatic impairment should not use Aricept.<br>Tell your doctor who your guardian is.&nbsp;Your guardian can help you use your medicine according to the doctor&#8217;s prescription.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Aricept with food, drink, and alcohol<\/h2>\n\n\n\n<p>Food intake does not affect the effect of Aricept<\/p>\n\n\n\n<p>You should avoid alcohol as it may affect the effect of Aricept.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Breastfeeding women should not use Aricept.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Alzheimer&#8217;s disease&nbsp;can impair your ability to drive or operate machinery.&nbsp;You must therefore first discuss with your doctor if you intend to drive or operate machinery.<\/p>\n\n\n\n<p>It may be that the medicine makes you feel tired and dizzy and that you may have muscle cramps.&nbsp;If you experience any of these symptoms, do not drive or use machines.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;The description of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Aricept contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking Aricept.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Aricept<\/h2>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.&nbsp;The recommended&nbsp;dose&nbsp;to start with is 5 mg (one white tablet) in the evening before going to bed.&nbsp;After one month, your doctor may ask you to take 10 mg (one yellow tablet) in the evening before going to bed.<\/p>\n\n\n\n<p>The tablet strength you should take may change depending on how long you have been taking the medicine and what your doctor recommends.&nbsp;The maximum recommended&nbsp;dose&nbsp;is 10 mg in the evening.<br><\/p>\n\n\n\n<p>Always follow the advice of your doctor or pharmacist on how and when to take your medicine.&nbsp;Do not change the&nbsp;dose&nbsp;without the advice of a doctor.<br><\/p>\n\n\n\n<p><strong>How to use your medicine<\/strong><\/p>\n\n\n\n<p>Aricept tablets should be swallowed whole with a glass of water in the evening before going to bed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Aricept is not recommended for use in children and adolescents (younger than 18 years).<\/p>\n\n\n\n<p>Symptoms of overdose may include nausea and vomiting, involuntary drooling, sweating, slow heart rate, low&nbsp;blood pressure&nbsp;(intoxication or dizziness when standing), difficulty breathing, loss of consciousness, and seizures or convulsions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Aricept<\/h2>\n\n\n\n<p>If you forget to take your medicine, take the next&nbsp;dose&nbsp;at the usual time.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Aricept<\/h2>\n\n\n\n<p>Do not stop taking the tablets unless your doctor tells you to.&nbsp;If you stop taking Aricept, the benefits of treatment will gradually diminish.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<br><\/p>\n\n\n\n<p><strong>How long to use Aricept<\/strong><\/p>\n\n\n\n<p>Your doctor or pharmacist will tell you how long to use the tablets.&nbsp;You need to see your doctor regularly to evaluate your treatment and assess your symptoms.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine&nbsp;can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported during treatment with Aricept.<\/p>\n\n\n\n<p><strong>Tell your doctor if you get any of these&nbsp;side effects&nbsp;while using Aricept.<\/strong><br><\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Contact a doctor immediately if you get these serious&nbsp;side effects.&nbsp;You may need immediate medical attention.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver damage, e.g.&nbsp;liver inflammation (&nbsp;hepatitis&nbsp;).&nbsp;Symptoms of&nbsp;hepatitis include nausea or vomiting, loss of appetite, general malaise, fever,&nbsp;itching, yellowing of the skin and whites of the eyes, and dark-colored urine (may affect up to 1 in 1,000 people)<\/li><li>stomach ulcer.&nbsp;Symptoms of&nbsp;stomach ulcers&nbsp;can be stomach pain and stomach problems that are felt between the navel and the sternum (may occur in up to 1 in 100 users)<\/li><li>bleeding and ulcers in the gastrointestinal tract.&nbsp;Maybe manifested by carbon black feces or by clearly visible bleeding from the rectum during toilet visits (may occur in up to 1 in 100 users)<\/li><li>seizures or convulsions (may affect up to 1 in 100 people)<\/li><li>fever with muscle stiffness, sweating, or decreased consciousness (this is a condition called &#8216;malignant neuroleptic syndrome&#8217; or &#8216;neuroleptic malignant syndrome&#8217;) (may affect up to 1 in 10,000 users)<\/li><li>muscle weakness, soreness, or pain, especially if you feel sick, have a high fever, or dark urine at the same time.&nbsp;The symptoms can be caused by an abnormal breakdown of the muscles which can be life-threatening and lead to kidney problems (a condition called&nbsp;rhabdomyolysis&nbsp;) (can occur in up to 1 in 10,000 users)<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Very common&nbsp;side effects&nbsp;(may affect more than 1 user in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea<\/li><li>headache<\/li><\/ul>\n\n\n\n<p>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>muscle cramps<\/li><li>fatigue<\/li><li>insomnia (insomnia)<\/li><li>cold symptoms<\/li><li>hallucinations (seeing or hearing things that do not exist)<\/li><li>unusual dreams including nightmares<\/li><li>restlessness<\/li><li>aggressive behavior<\/li><li>fainting<\/li><li>dizziness<\/li><li>a feeling of discomfort in the stomach<\/li><li>rash<\/li><li>difficulty keeping tight (urinary incontinence)<\/li><li>pain<\/li><li>accident (due to risk of falling)<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>slow heart rate<\/li><li>overproduction of saliva<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>stiffness, tremors or uncontrolled movements especially of the face and tongue but also in the hands and legs<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Aricept<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister or jar after \u201cEXP\u201d or \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is donepezil hydrochloride.&nbsp;There are two different strengths available.&nbsp;Each film-coated tablet contains 5 mg and 10 mg donepezil hydrochloride, respectively.<\/li><li>The other ingredients are&nbsp;lactose monohydrate, corn starch, microcrystalline cellulose, hydroxypropyl cellulose, magnesium stearate, hypromellose, talc, macrogol, titanium dioxide (E171).<\/li><li>In addition, 10 mg film-coated tablet contains yellow iron oxide (E172).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Aricept 5 mg film-coated tablets are white, round, biconvex, and marked \u201cARICEPT\u201d on one side and \u201c5\u201d on the other side.<\/li><li>Aricept 10 mg film-coated tablets are yellow, round, biconvex, and marked \u201cARICEPT\u201d on one side and \u201c10\u201d on the other side.<\/li><\/ul>\n\n\n\n<p>Aricept is available in packs of:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>7, 14, 28, 30, 50, 56, 60, 84, 98, 112 and 120 film-coated tablets in blister packs<\/li><li>28, 30, and 100 film-coated tablets in HDPE jars<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Fareva Amboise<\/p>\n\n\n\n<p>Industrial Zone<\/p>\n\n\n\n<p>29route des Industries<\/p>\n\n\n\n<p>37530 Poc\u00e9-sur-Cisse<\/p>\n\n\n\n<p>France<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aricept contains the active substance donepezil hydrochloride. Aricept (donepezil hydrochloride) belongs to a group of medicines called acetylcholinesterase inhibitors.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10103,10105,5265,5268,10107,10102,10106,10101,10104,5266],"class_list":["post-5545","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-aricept","tag-aricept-tablet","tag-donepezil-hydrochloride","tag-donepezil-hydrochloride-tablet","tag-side-effects-of-aricept","tag-side-effects-of-donepezil-hydrochloride","tag-what-aricept-is-used-for","tag-what-donepezil-hydrochloride-is-used-for","tag-what-is-aricept","tag-what-is-donepezil-hydrochloride"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5545"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5545\/revisions"}],"predecessor-version":[{"id":12524,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5545\/revisions\/12524"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}