\n\n250 mg soft capsules
tipranavir<\/p>\n\n\n\n
Aptivus contains the active substance tipranavir. It belongs to a group of medicines called protease inhibitors and is used in the treatment of infections caused by the Human Immunodeficiency Virus ( HIV ). It inhibits an enzyme called protease that is involved in the multiplication of HIV. When the enzyme is inhibited, the virus does not multiply as normal, which slows down the infection. You must take Aptivus with:<\/p>\n\n\n\n
– low dose ritonavir (this helps Aptivus to reach a sufficiently high level in the blood)<\/p>\n\n\n\n
– other HIV medicines. Your doctor, together with you, will decide which medicines to use. This depends on, for example:<\/p>\n\n\n\n
– what other medicines you are already taking for HIV<\/p>\n\n\n\n
– which drugs your HIV is resistant to. If your HIV is resistant to any HIV drugs, it means that those drugs will not work so well, or will not work at all.
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Aptivus is especially used for the treatment of HIV which is resistant to most other protease inhibitors. Before starting treatment, your doctor will take a blood test to check the resistance of your HIV. These tests will have confirmed that HIV in your blood is resistant to most other protease inhibitors. Aptivus treatment is, therefore, suitable for you. You should not use Aptivus if you have never received antiretroviral therapy or have other treatment options.
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Aptivus soft capsules are intended for:<\/p>\n\n\n\n
– young people 12 years or older<\/p>\n\n\n\n
– adults
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<\/p>\n\n\n\n Do not take Aptivus<\/strong> :<\/p>\n\n\n\n – if you are allergic to tipranavir or any of the other ingredients of this medicine (listed in section 6).<\/p>\n\n\n\n – if you have moderate to severe liver disease. Your doctor will take blood samples to examine your liver function. Depending on your liver function, you may need to wait or discontinue treatment with Aptivus.<\/p>\n\n\n\n – if you are currently taking medicines containing:<\/p>\n\n\n\n Do not use products that contain St. John’s wort (a natural remedy for mild depression and mild anxiety). This may prevent Aptivus from working properly.<\/p>\n\n\n\n Talk to your doctor or pharmacist before taking Aptivus. Tell your doctor if you have:<\/p>\n\n\n\n type A or B hemophilia<\/p>\n\n\n\n – diabetes<\/p>\n\n\n\n – liver disease If you have:<\/p>\n\n\n\n you have an increased risk of serious and potentially fatal liver damage when using Aptivus. Your doctor will monitor your liver function through blood tests before and during treatment with Aptivus. If you have liver disease or hepatitis, your doctor will decide if you need extended sampling. You should tell your doctor as soon as possible if you notice any signs or symptoms of hepatitis:<\/p>\n\n\n\n Aptivus does not lead to HIV – infection, a cure:<\/strong><\/p>\n\n\n\n You should know that you can constantly develop new infections or other diseases related to HIV. You should therefore keep in regular contact with your doctor. You can still transmit HIV infection when you take this medicine, even though the risk of effective antiviral therapy is reduced. Discuss with your doctor the necessary steps to avoid infecting others. Skin rash<\/em> :<\/p>\n\n\n\n Mild to moderate skin rashes, including:<\/p>\n\n\n\n has been reported in approximately 1 patient in 10 treated with Aptivus. Some patients who developed rash also had:<\/p>\n\n\n\n In some patients with advanced HIV – infection ( AIDS ) and a history of HIV -related infection, may be symptoms of inflammation occur soon after anti- HIV has begun. It is believed that these symptoms are due to the improvement of the body’s immune response, which allows the body to fight infection, which may have previously been hidden without obvious symptoms. Tell your doctor immediately if you notice any symptoms of infection (such as fever, enlarged lymph nodes ). In addition to opportunistic infections, autoimmune disorders (conditions in which the immune system attacks healthy body tissue) can also occur after you start taking medicines to treat your HIV infection. Autoimmune disorders can occur several months after starting treatment. If you notice any symptoms of infection or other symptoms such as muscle weakness, the weakness that starts in the hands or feet and moves to the torso, palpitations, tremors, or hyperactivity, informs your doctor immediately for the necessary treatment. Tell your doctor if you have fainted or experienced abnormal heartbeats. Aptivus with low dose ritonavir can cause changes in your heart rhythm and the electrical activity of your heart. These changes can be seen on an ECG ( electrocardiogram ). Bone problems<\/em>: Some patients receiving combination antiretroviral therapy may develop a bone disease called osteonecrosis (bone tissue dies due to lost blood supply to the bone). Some of the many risk factors for developing the disease are long-term antiretroviral combination therapy, use of corticosteroids, alcohol consumption, a severe weakening of the immune system, and higher body mass index. Signs of osteonecrosis are stiffness in the joints and pain (especially in the hip, knee, and shoulders) and difficulty moving. Tell your doctor if you experience any of these symptoms. Elderly:<\/em> If you are older than 65 years, your doctor will exercise caution when prescribing Aptivus soft capsules to you and will closely monitor your treatment. Tipranavir has been used in a limited number of patients aged 65 years or older. Aptivus soft capsules should not be used by children under 12 years of age.<\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n This is very important. If you are taking other medicines at the same time as Aptivus and ritonavir, this may increase or decrease the effectiveness of the treatment. These effects are called interactions and can lead to serious side effects or prevent adequate control of other conditions you may have.You must take Aptivus with low dose ritonavir and other antiviral medicines. It is therefore important to also know about these drugs. You should therefore carefully read the package leaflet for ritonavir and other antiviral medicines. Ask your doctor or pharmacist if you have any questions about ritonavir or the other medicines you have been prescribed.<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n Warnings and cautions<\/h2>\n\n\n\n
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<\/p>\n\n\n\nChildren and young people<\/h2>\n\n\n\n
Other medicines and Aptivus<\/h2>\n\n\n\n
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