{"id":5527,"date":"2020-12-21T15:16:50","date_gmt":"2020-12-21T15:16:50","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5527"},"modified":"2021-07-24T08:29:51","modified_gmt":"2021-07-24T08:29:51","slug":"apresolin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/apresolin\/","title":{"rendered":"Apresolin &#8211; Hydralazine hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n25 mg&nbsp;coated&nbsp;tablets&nbsp;<br>hydralazine hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Apresolin is and what it is used for<\/h2>\n\n\n\n<p>Apresolin contains the active substance hydralazine hydrochloride.<br><\/p>\n\n\n\n<p>Apresolin is used in patients who have not had a satisfactory effect on the standard treatment of high&nbsp;blood pressure&nbsp;and&nbsp;heart failure.&nbsp;Apresolin lowers high&nbsp;blood pressure&nbsp;by dilating certain blood vessels (&nbsp;arterioles&nbsp;).<\/p>\n\n\n\n<p>In&nbsp;heart failure, the dilation of blood vessels means that the work of the heart is facilitated and the pumping capacity of the heart increases.<br><\/p>\n\n\n\n<p>Hydralazine contained&nbsp;in Apresolin may also be approved for the treatment of other conditions not mentioned in this leaflet.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you take Apresolin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Apresolin<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;hydralazine, dihydralazine, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have connective tissue disease&nbsp;lupus erythematosus disseminatus&nbsp;(&nbsp;SLE&nbsp;) or similar diseases.&nbsp;A condition in which the body&#8217;s immune system attacks healthy&nbsp;tissue.&nbsp;It can affect the skin, joints, kidneys, brain, and other organs.<\/li><li>if you have problems caused by a fast&nbsp;pulse<\/li><li>if your&nbsp;hernia&nbsp;of the great carotid artery (dissecting aortic aneurysm).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Apresolin.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have severe renal impairment<\/li><li>if you have&nbsp;heart failure&nbsp;with low&nbsp;blood pressure<\/li><li>if you have any heart disease<\/li><li>if you have angina<\/li><li>if you have cerebrovascular&nbsp;disease (diseases that affect the blood vessels that supply the brain with blood)<\/li><li>if you know you are a slow or fast acetylator (this may affect the conversion and&nbsp;elimination&nbsp;one of Apresolin), which may require adjustment of&nbsp;dose&nbsp;one<\/li><\/ul>\n\n\n\n<p>Treatment with Apresolin may cause an&nbsp;SLE&nbsp;-like condition.&nbsp;Therefore, contact a doctor immediately if you experience symptoms such as joint pain, fever, rash, pale skin, weakness, shortness of breath, and easier bleeding and bruising, see also section 4.<br><\/p>\n\n\n\n<p>Treatment with Apresolin can cause&nbsp;inflammation&nbsp;of the walls of blood vessels (&nbsp;vasculitis&nbsp;) which can lead to&nbsp;a pulmonary&nbsp;renal&nbsp;syndrome which can be serious and life-threatening.&nbsp;Contact a doctor immediately if you get a fever, loss of appetite, weight loss, fatigue, general pain in the body, coughing up blood, swollen feet, and ankles, blood in the urine during treatment with Apresolin (see section 4).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Apresolin is not recommended for children.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use of other medicines<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>The effect of the treatment can be affected if the drug is taken together with certain other drugs such as.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>indomethacin (medicine for rheumatic and inflammatory diseases).<\/li><li>other medicine for high&nbsp;blood pressure&nbsp;e.g.&nbsp;so-called calcium&nbsp;channel blockers,&nbsp;beta-blockers&nbsp;(eg propranolol),&nbsp;diuretics&nbsp;(&nbsp;diuretics&nbsp;), or&nbsp;ACE inhibitors, as the antihypertensive effect may be enhanced.<\/li><li>sedatives,<\/li><li>certain&nbsp;antidepressants&nbsp;(&nbsp;tricyclic antidepressants&nbsp;or&nbsp;MAO inhibitors&nbsp;)<\/li><\/ul>\n\n\n\n<p>If you get low&nbsp;blood pressure&nbsp;during treatment with Apresolin, you should not be treated with&nbsp;sympathomimetics&nbsp;(eg&nbsp;epinephrine&nbsp;)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Apresolin with food, drink, and alcohol<\/h2>\n\n\n\n<p>Alcohol may potentiate the antihypertensive effect of Apresolin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>No adverse effects on the fetus have been demonstrated.&nbsp;However, consult your doctor if you are pregnant or may become pregnant during treatment with Apresolin.<br><\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Apresolin passes into breast milk but is unlikely to affect breastfed infants.&nbsp;Mothers taking Apresolin can breast-feed their infant, provided that the baby is observed for any unexpected&nbsp;side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Some patients may experience dizziness or low&nbsp;blood pressure&nbsp;during treatment with Apresolin.&nbsp;This can affect the ability to drive and use machines.&nbsp;Be observant of how you react.&nbsp;<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Apresolin contains sucrose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Apresolin<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>Dose&nbsp;one is determined by your doctor who adjusts it individually for you.<br><\/p>\n\n\n\n<p><strong><em>The recommended&nbsp;dose&nbsp;is:<\/em><\/strong><\/p>\n\n\n\n<p><em>High&nbsp;blood pressure<\/em><\/p>\n\n\n\n<p>The usual starting dose is 1 tablet 1-2 times daily for a week, after which the&nbsp;dose is increased to 1 tablet 3 times daily or 2 tablets twice daily during the second week.&nbsp;Dose&nbsp;one can then be increased as needed to 2-8 tablets daily.&nbsp;With a satisfactory reduction in blood pressure, the&nbsp;dose is&nbsp;reduced&nbsp;to the lowest possible maintenance&nbsp;dose.<\/p>\n\n\n\n<p>In the case of high&nbsp;blood pressure, Apresolin should be combined with other antihypertensive agents, especially&nbsp;beta-blockers&nbsp;or&nbsp;diuretics.<br><\/p>\n\n\n\n<p><em>Heart failure<\/em><\/p>\n\n\n\n<p>The usual starting dose is 1 tablet 3 times daily.&nbsp;If necessary, the&nbsp;dose&nbsp;can be increased gradually at weekly intervals up to 3 tablets 3 times daily<\/p>\n\n\n\n<p>Apresolin should be taken as an adjunct to&nbsp;digitalis&nbsp;and&nbsp;diuretics.<\/p>\n\n\n\n<p>In case of overdose, you can get low&nbsp;blood pressure&nbsp;and fast&nbsp;heart rate&nbsp;which can cause nausea, dizziness, and sweating.&nbsp;You may also experience severe chest pain, irregular heartbeat, headaches, vomiting, tremors, cramps, decreased urine output, or decreased body temperature.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Apresolin<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Apresolin<\/h2>\n\n\n\n<p>Do not stop taking Apresolin without consulting your doctor.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse<strong>.<\/strong><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<br><\/p>\n\n\n\n<p>Stop taking Apresolin and contact&nbsp;<strong>a<\/strong>&nbsp;doctor&nbsp;<strong>immediately<\/strong>&nbsp;or see your nearest emergency department if you experience the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>an&nbsp;infection&nbsp;with symptoms such as fever with severely deteriorating general condition or fever with local infection symptoms such as sore throat\/throat\/mouth or difficulty urinating, you should see a doctor as soon as possible so that blood tests can rule out a lack of&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis&nbsp;) as is a very rare side effect (may affect up to 1 in 10,000 people).&nbsp;It is important that you then information about your medication.&nbsp;Apresolin can in rare cases affect the white&nbsp;blood cells&nbsp;so that the&nbsp;defense against&nbsp;infection deteriorates.<\/li><li>excess&nbsp;protein&nbsp;in the urine (cloudy\/frothy urine &#8211;&nbsp;proteinuria&nbsp;), less common side effect (may affect up to 1 in 100 people).&nbsp;Swelling in the ankles and high&nbsp;blood pressure&nbsp;can be symptoms of&nbsp;acute&nbsp;kidney inflammation which is a very rare&nbsp;side effect&nbsp;(may occur in up to 1 in 10,000 users).&nbsp;Nausea, vomiting, worsening of the general condition, and decreased urine output may be symptoms of&nbsp;acute renal failure, as has been reported for Apresolin (may occur in an unknown number of users).<\/li><li>joint pain, fever, rash, pale skin, weakness, shortness of breath, and easier bleeding and bruising.&nbsp;This can be a symptom of&nbsp;SLE-&nbsp;like syndrome that can occur in up to 1 in 10 users (common side effect) when treated with Apresolin.<\/li><li>chest pain, possibly radiating to the arm or neck, and shortness of breath.&nbsp;These symptoms can be signs of&nbsp;angina pectoris&nbsp;which is a common side effect (may affect up to 1 in 10 people).<\/li><li>abdominal pain with abdominal pain, vomiting, and swollen abdomen.&nbsp;This can be a symptom of intestinal upset (paralytic&nbsp;ileus&nbsp;) that can occur in up to 1 in 10,000 users (very rare side effect).&nbsp;<\/li><li>fever, loss of appetite, weight loss, fatigue, general pain in the body, coughing up blood, swollen feet, and ankles, blood in the urine (&nbsp;hematuria&nbsp;) during treatment with Apresolin.&nbsp;This can be a symptom of&nbsp;inflammation&nbsp;in the walls of the blood vessels (&nbsp;vasculitis&nbsp;) which can lead to a medical syndrome with bleeding in the lungs and kidney damage (&nbsp;Pulmonary&nbsp;renal&nbsp;syndrome) which is a less common side effect (may occur in up to 1 in 100 users).<\/li><li>yellowed skin and\/or eyes, pale stools with dark urine.&nbsp;This can be a symptom of hepatitis and jaundice, which is a less common&nbsp;side effect&nbsp;(may affect up to 1 in 100 people)<\/li><li>shortness of breath or swollen ankles.&nbsp;This may be a symptom of&nbsp;heart failure which is a less common&nbsp;side effect&nbsp;(may affect up to 1 in 100 people)<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;may occur<\/strong><br><\/p>\n\n\n\n<p><em>Very common<\/em>&nbsp;(may affect more than 1 user in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>a faster or irregular heartbeat that you can feel (palpitations).&nbsp;These symptoms may occur at the beginning of treatment and if the&nbsp;dose is&nbsp;increased rapidly, but are usually transient with continued treatment).<\/li><\/ul>\n\n\n\n<p><em>Common<\/em>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>positive blood test for ANF (Anti Nuclear Factor);&nbsp;which may indicate an&nbsp;autoimmune&nbsp;disease (where the body&#8217;s own immune system attacks and destroys healthy&nbsp;tissue&nbsp;)<\/li><li>low&nbsp;blood pressure<\/li><li>redness<\/li><li>nausea<\/li><li>vomiting<\/li><li>diarrhea<\/li><li>gastrointestinal upset<\/li><li>joint pain, joint swelling, and muscle pain.<\/li><\/ul>\n\n\n\n<p><em>Uncommon<\/em>&nbsp;(may affect up to 1 in 100 people):&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hypersensitivity reaction&nbsp;you like&nbsp;hives,&nbsp;itching&nbsp;)<\/li><li>dizziness<\/li><li>fluid accumulation in the&nbsp;tissues&nbsp;(&nbsp;edema&nbsp;)<\/li><li>loss of appetite<\/li><li>anxiety<\/li><li>nasal congestion<\/li><li>respiratory distress<\/li><li>pain in the alveoli<\/li><li>fever<\/li><li>feeling sick<\/li><li>increased tear flow<\/li><li>inflammation&nbsp;of the eye (&nbsp;conjunctivitis&nbsp;)<\/li><li>anemia&nbsp;(&nbsp;anemia&nbsp;)<\/li><li>blood effects such as low&nbsp;platelet counts&nbsp;(which increases the risk of bleeding and bruising).<\/li><\/ul>\n\n\n\n<p><em>Rare<\/em>&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Depression<\/li><li>hallucinations<\/li><li>glossy eyes (protruding eyes).<\/li><\/ul>\n\n\n\n<p><em>Very rare<\/em>&nbsp;(may affect up to 1 in 10,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>numbness and crawling in the arms and legs<\/li><li>abnormal sensations (paracentesis)<\/li><li>shaking (&nbsp;tremor&nbsp;)<\/li><li>increase in&nbsp;blood pressure&nbsp;(paradoxical&nbsp;compressor effect&nbsp;)<\/li><li>disorders of nerve function that may cause numbness, tingling, or weakness (&nbsp;peripheral&nbsp;neuropathy&nbsp;)<\/li><li>inability to empty the bladder (&nbsp;urinary retention&nbsp;)<\/li><li>lymph node disease<\/li><li>enlargement of the spleen<\/li><\/ul>\n\n\n\n<p><em>Has&nbsp;<\/em><em>been reported<\/em>&nbsp;(may occur in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>weight loss<\/li><li>enlargement of both liver and&nbsp;spleen&nbsp;(more common in connection with&nbsp;SLE-&nbsp;like symptoms)<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Apresolin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.&nbsp;Moisture sensitive.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is hydralazine hydrochloride 25 mg\/tablet.<\/li><li>Other ingredients are&nbsp;:&nbsp;<\/li><li>Corn starch<\/li><li>microcrystalline cellulose<\/li><li>anhydrous&nbsp;colloidal&nbsp;silica<\/li><li>povidone<\/li><li>magnesium stearate<\/li><li>povidone<\/li><li>hypromellose<\/li><li>macrogol<\/li><li>talcum powder<\/li><li>sucrose<\/li><li>propylene glycol<\/li><li>dispersed yellow,<\/li><li>shellac<\/li><li>iron oxide (E 172)<\/li><li>titanium dioxide (E 171)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>The tablets are pale yellow, round, biconvex, marked\/printed with \u201cGF\u201d in brown on one side.<\/p>\n\n\n\n<p>The tablets are delivered in HDPE jars containing 100 tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Amdipharm Limited<\/p>\n\n\n\n<p>Temple Chambers<\/p>\n\n\n\n<p>3 Burlington Road<\/p>\n\n\n\n<p>Dublin 4<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Tel.&nbsp;+44 1268 82 3049<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Manufacturer<\/h2>\n\n\n\n<p>Amdipharm UK Limited<\/p>\n\n\n\n<p>Capital House, 85 King William Street,<\/p>\n\n\n\n<p>London EC4N 7BL,<\/p>\n\n\n\n<p>UK<br><\/p>\n\n\n\n<p>Or<br><\/p>\n\n\n\n<p>Rottendorf Pharma GmbH<\/p>\n\n\n\n<p>Ostenfelder Strasse 51-61<\/p>\n\n\n\n<p>59320 Ennigerloh<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Apresolin contains the active substance hydralazine hydrochloride.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10193,10196,10188,10190,10197,10192,10195,10191,10194,10189],"class_list":["post-5527","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-apresolin","tag-apresolin-tablet","tag-hydralazine-hydrochloride","tag-hydralazine-hydrochloride-tablet","tag-side-effects-of-apresolin","tag-side-effects-of-hydralazine-hydrochloride","tag-what-apresolin-is-used-for","tag-what-hydralazine-hydrochloride-is-used-for","tag-what-is-apresolin","tag-what-is-hydralazine-hydrochloride"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5527","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5527"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5527\/revisions"}],"predecessor-version":[{"id":12568,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5527\/revisions\/12568"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5527"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}