{"id":5473,"date":"2020-12-18T14:55:21","date_gmt":"2020-12-18T14:55:21","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5473"},"modified":"2023-02-14T03:49:02","modified_gmt":"2023-02-14T03:49:02","slug":"angusta","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/angusta\/","title":{"rendered":"Angusta &#8211; Misoprostol Uses, Dose, And Side Effects"},"content":{"rendered":"\n<p><strong>Angusta 25 micrograms&nbsp;Misoprostol Tablets<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Angusta Is And What Is It Used For<\/h2>\n\n\n\n<p>This medicine contains the active substance misoprostol. <strong>Angusta is used to help start a birth.<\/strong> Misoprostol belongs to a group of medicines called&nbsp;prostaglandins.&nbsp;Prostaglandins have two functions during labor.<\/p>\n\n\n\n<p>One function is to soften the cervix so the baby can be born more easily through the vagina.&nbsp;The second function is that they trigger the <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pains<\/a>, which help to push the baby out of the uterus (&nbsp;uterus&nbsp;).&nbsp;There can be several different reasons why you need help starting labor.&nbsp;Ask your midwife or doctor for more information.<\/p>\n\n\n\n<p>Misoprostol in this medicine may also be approved for treating other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What You Need To Know Before Taking Angusta<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Take:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to misoprostol or any of the other ingredients of this medicine (listed in section 6).<\/li><li>If the <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a> has started<\/li><li>If the midwife or doctor thinks that your baby is not in good shape and is stressed<\/li><li>If&nbsp;you are given&nbsp;other medicines that facilitate childbirth (eg&nbsp;oxytocin&nbsp;) (see &#8220;Warning and precautions,&#8221; &#8220;Other medicines and Angusta&#8221; and &#8220;How to take Angusta&#8221; below)<\/li><li>If you have previously operated on the cervix (other than conization) or the uterus, including the cesarean section in the delivery of previous children<\/li><li>If you have an abnormal uterus, such as a heart-shaped uterus (&nbsp;uterus&nbsp;bicornis), which prevents&nbsp;vaginal&nbsp;delivery<\/li><li>If the midwife or doctor considers that the placenta covers the birth canal (&nbsp;placenta&nbsp;praevia) or if you have had unexplained&nbsp;vaginal&nbsp;bleeding after the 24th week of pregnancy<\/li><li>If the position of the baby in the womb prevents it from being born the natural way (position anomalies)<\/li><li>If you have&nbsp;renal failure&nbsp;(&nbsp;glomerular filtration rate&nbsp;&lt;15 ml\/min \/ 1.73 m&nbsp;<sup>2<\/sup>&nbsp;)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Talk to your midwife, doctor, or nurse before taking this medicine. This medicine should only be given by trained staff in hospitals where equipment is available to monitor you and your baby.&nbsp;The cervix will be examined carefully before you receive this medicine.<br>This medicine can cause severe stimulation of the uterus. If the pain is too long or too strong and the doctor or midwife is worried about you and your baby, you will not receive any more tablets, and the midwife or doctor will decide if you need to take medicine to reduce the pain or slow it down the frequency.<\/p>\n\n\n\n<p>The effect of Angusta has not been studied in women with severe preeclampsia (a condition in which pregnant women have high&nbsp;blood pressure,&nbsp;protein&nbsp;in the urine, and sometimes other complications).<\/p>\n\n\n\n<p>In case of&nbsp;infection&nbsp;of the amniotic membranes surrounding the baby (chorioamnionitis), rapid delivery may be necessary.&nbsp;The doctor makes all the necessary decisions regarding treatment with&nbsp;antibiotics, initiation of labor, or cesarean section.<\/p>\n\n\n\n<p>There is no or limited experience with the use of this medicine in women whose placenta has ruptured more than 48 hours before the use of this medicine.<\/p>\n\n\n\n<p>Suppose your doctor concludes that you need treatment with oxytocin(medicines used to facilitate childbirth). In that case, it will be carefully considered as\u00a0oxytocin may work in the same way as this medicine.<\/p>\n\n\n\n<p>It is recommended to wait 4 hours after the last\u00a0dose\u00a0of this medicine before\u00a0starting\u00a0oxytocin\u00a0(see &#8216;Do not take Angusta&#8217; above and &#8216;Other medicines and Angusta&#8217; and &#8216;How to take Angusta&#8217; below).<\/p>\n\n\n\n<p>There is no experience of using this medicine to initiate labor in pregnant women with more than one child. There is no experience using this medicine in women who have previously given birth to 5 or more children vaginally.<\/p>\n\n\n\n<p>There is limited experience using this medicine to initiate labor in women before week 37 of pregnancy (see \u201cPregnancy, breast-feeding, and fertility\u201d below).<\/p>\n\n\n\n<p>You should only take this medicine if the midwife or doctor considers that there is a medical need to initiate labor.<\/p>\n\n\n\n<p>There is no or limited information on the use of Angusta in pregnant women with Bishop scores higher than 6 (Bishop scores are the most common method of measuring cervical maturity).<\/p>\n\n\n\n<p>An increased risk of blood clot formation in small blood vessels around the body (disseminated intravascular\u00a0coagulation\u00a0) has been seen after delivery in patients whose labor has been initiated, regardless of method.<\/p>\n\n\n\n<p>Dose adjustments may be needed in pregnant women with renal or hepatic impairment (see &#8220;How to take Angusta&#8221; below).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Angusta<\/h2>\n\n\n\n<p>Tell your midwife or doctor if you are taking, have recently taken, or might take any other medicines. You must not take this medicine simultaneously as other medicines used to facilitate childbirth or start labor (see &#8220;Do not take Angusta&#8221;).<\/p>\n\n\n\n<p>It is recommended that you wait 4 hours after the last\u00a0dose\u00a0of this medicine before\u00a0oxytocin\u00a0can be given (see \u201cWarnings and Precautions\u201d above and \u201cHow to take Angusta\u201d below).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, Breastfeeding, And Fertility<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>This medicine is used to help start childbirth from week 37 of pregnancy. When used at that stage of pregnancy, there is no risk of harm to your baby.\u00a0You should not use this medicine during any other period of pregnancy as misoprostol may cause malformations in the unborn baby.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Misoprostol can be excreted in breast milk, but the amount and for how long it remains is expected to be very limited and should not prevent breastfeeding.\u00a0Breastfeeding can be started 4 hours after the last\u00a0dose\u00a0of this medicine.<\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>The use of this medicine to initiate labor from week 37 does not affect\u00a0fertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How To Take Angusta<\/h2>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">Angusta tablet uses<\/span><\/strong><\/p>\n\n\n\n<p>Always take this medicine exactly as your midwife, doctor or nurse has told you.\u00a0Consult a doctor if you are unsure.\u00a0This medicine will be provided to you by trained staff at hospitals where equipment is available to monitor you and your baby.<\/p>\n\n\n\n<p>The uterus will be examined carefully before you receive this medicine. The recommended\u00a0dose\u00a0is 25 micrograms every two hours or 50 micrograms every four hours.\u00a0Angusta should be taken orally with a glass of water.\u00a0The tablet should not be shared.<\/p>\n\n\n\n<p>The midwife or doctor will decide when to stop treatment with Angusta.&nbsp;The midwife or doctor will discontinue treatment with this medicine:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have taken 200 micrograms over 24 hours<\/li><li>When labor begins<\/li><li>If the pain is too strong or too prolonged<\/li><li>If your child becomes stressed<\/li><li>If treatment with\u00a0oxytocin\u00a0or other medicines to facilitate childbirth is needed (see &#8220;Do not take Angusta&#8221;, &#8220;Warnings and precautions&#8221;, and &#8220;Other medicines and Angusta&#8221; above).<\/li><\/ul>\n\n\n\n<p><strong>Use in patients with renal or hepatic impairment<\/strong><\/p>\n\n\n\n<p>Dose adjustments (lower&nbsp;dose&nbsp;and\/or less frequently) may be required in pregnant women with renal or hepatic impairment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use For Children And Adolescents<\/h2>\n\n\n\n<p>The use of this medicine has not been studied in pregnant women under 18 years of age. Taking too much this medicine may cause too much or too long pain, or the baby may become stressed.\u00a0The treatment must then be stopped.<\/p>\n\n\n\n<p>The midwife or doctor decides if you need to receive medication that reduces the intensity of the pain or slows down the frequency or if the baby needs to be delivered by cesarean section.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible Angusta Side Effetcs<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;The following&nbsp;side effects&nbsp;may occur when using this medicine:<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 user in 10<\/strong>&nbsp;)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea<\/li><li>Vomiting\u00a0<\/li><li>Meconium splashes (feces from the unborn baby in the amniotic fluid)<\/li><li>Bleeding after childbirth\u00a0<sup>2)<\/sup>\u00a0(loss of more than 500 ml of blood after childbirth)<\/li><li>Reported as very common for Angusta 50 varg every four hours<\/li><li>Reported as very common for Angusta 25 \u00b5g every two hours<\/li><\/ul>\n\n\n\n<p><strong>Common side effects<\/strong> <strong>(may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low Apgar score&nbsp;<sup>* 1)<\/sup>&nbsp;(test performed on the baby 1 and 5 minutes after birth, where the score in the test indicates how well the baby is feeling after birth)<\/li><li>Abnormal&nbsp;pulse&nbsp;in the fetus&nbsp;<sup>* 1)<\/sup><\/li><li>Hyperstimulated uterus&nbsp;<sup>2)<\/sup>&nbsp;(when the pains are too strong, too often, or too long)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diarrhea-in-children\/\">Diarrhea<\/a><\/li><li>Nausea&nbsp;<sup>3)<\/sup><\/li><li>Vomiting&nbsp;<sup>3)<\/sup><\/li><li>Bleeding after childbirth&nbsp;<sup>2)<\/sup>&nbsp;(loss of more than 500 ml of blood after childbirth)<\/li><li>Overindulge<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">Fever<\/a><\/li><\/ul>\n\n\n\n<p><strong>* Side effect in the child.<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Reported as usual for Angusta 50 varg every four hours.<\/li><li>Hyperstimulated uterus was reported both with and without effect on fetal\u00a0heart rate.<\/li><li>Reported as usual for Angusta 25 \u00b5g every two hours.<\/li><\/ol>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low Apgar score&nbsp;<sup>* 1)<\/sup>&nbsp;(test performed on the baby 1 and 5 minutes after birth, where the score in the test indicates how well the baby is feeling after birth)<\/li><li>Abnormal&nbsp;pulse&nbsp;in the fetus&nbsp;<sup>* 1)<\/sup><\/li><\/ul>\n\n\n\n<p>* Side effect in the child.<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Reported as less common for Angusta 50 \u00b5g every four hours.<\/li><\/ol>\n\n\n\n<p><strong>Has been reported (occurs in an unknown number of users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/dizziness\/\">Dizziness<\/a><\/li><li>Cramps<\/li><li>Lack of oxygen in the baby&#8217;s brain and organs during childbirth<\/li><li>Lack of oxygen in the blood of the newborn baby\u00a0<sup>*<\/sup>\u00a0(also called &#8220;blue baby syndrome&#8221; and means blue staining of the skin and mucous membranes of the newborn baby)<\/li><li>Itchy rash<\/li><li>Acidosis\u00a0fetal\u00a0<sup>*<\/sup>\u00a0(high acid content in the unborn baby&#8217;s blood)<\/li><li>Premature placental abruption (the placenta detaches from the uterine wall before birth)<\/li><li>Uterine rupture<\/li><\/ul>\n\n\n\n<p>* Side effect in the child.<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How To Store Angusta<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Store in the original package.\u00a0Moisture sensitive.<\/li><li>Do not use this medicine after the expiry date which is stated on the blister and the carton after EXP.\u00a0The expiration date is the last day of the specified month.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater.&nbsp;Ask your midwife, doctor, or pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents Of The Packaging And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is misoprostol.<\/li><li>The other ingredients are hypromellose, microcrystalline cellulose, maize starch, crospovidone, croscarmellose sodium, anhydrous silica.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And The Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Angusta tablet is a white, uncoated oval tablet with dimensions 7.5 x 4.5 with a notch on one side and smooth on the other side.<\/li><li>The notch is not intended for splitting the tablet.<\/li><li>Angusta tablets are packaged in blisters in cartons of 8 tablets each.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Azanta Danmark A \/ S<\/p>\n\n\n\n<p>Gearhalsvej 1<\/p>\n\n\n\n<p>2500 Valby<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Piramal Healthcare (UK) Limited<\/p>\n\n\n\n<p>Whalton Road,<\/p>\n\n\n\n<p>Morpeth,<\/p>\n\n\n\n<p>Northumberland,<\/p>\n\n\n\n<p>NE61 3YA, UK<\/p>\n\n\n\n<p>Azanta Danmark A \/ S<\/p>\n\n\n\n<p>Gearhalsvej 1<\/p>\n\n\n\n<p>2500 Valby<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>Bulgaria: Angusta 25 micrograms tablets<\/p>\n\n\n\n<p>Denmark: Angusta<\/p>\n\n\n\n<p>Estonia: Angusta<\/p>\n\n\n\n<p>Finland: Angusta 25 microg tabletit<\/p>\n\n\n\n<p>France: Angusta 25 micrograms, compressed<\/p>\n\n\n\n<p>Iceland: Angusta 25 microgram tablets<\/p>\n\n\n\n<p>Croatia: Angusta 25 micrograms tablet<\/p>\n\n\n\n<p>Latvia: Angusta 25 micrograms tablets<\/p>\n\n\n\n<p>Norway: Angusta<\/p>\n\n\n\n<p>Slovakia: Angusta 25 micrograms tablets<\/p>\n\n\n\n<p>Slovenia: Angusta 25 microgram tablet<\/p>\n\n\n\n<p>Poland: Angusta<\/p>\n\n\n\n<p>Romania: Angusta 25 micrograme comprimate<\/p>\n\n\n\n<p>Czech Republic: Angusta 25 micrograms tablets<\/p>\n\n\n\n<p>Hungary: Angusta 25 micrograms tablet<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Angusta is used for a short period at the end of pregnancy to induce labor with a low misoprostol dosage. There is no chance of fetal abnormalities when utilized during that stage of pregnancy.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10333,10336,6222,6225,10337,6226,10335,10334,6223,9982],"class_list":["post-5473","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-angusta","tag-angusta-tablet","tag-misoprostol","tag-misoprostol-tablet","tag-side-effects-of-angusta","tag-side-effects-of-misoprostol","tag-what-angusta-is-used-for","tag-what-is-angusta","tag-what-is-misoprostol","tag-what-misoprostol-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5473","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5473"}],"version-history":[{"count":66,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5473\/revisions"}],"predecessor-version":[{"id":48512,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5473\/revisions\/48512"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5473"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5473"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5473"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}