{"id":5463,"date":"2020-12-18T14:48:40","date_gmt":"2020-12-18T14:48:40","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5463"},"modified":"2021-07-26T07:05:36","modified_gmt":"2021-07-26T07:05:36","slug":"ancotil","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ancotil\/","title":{"rendered":"Ancotil &#8211; Flucytosine uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n10 mg \/ mL&nbsp;infusion&nbsp;solution&nbsp;<br>flucytosine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Ancotil is and what it is used for<\/h2>\n\n\n\n<p>Ancotil contains flucytosine.&nbsp;Ancotil is used to treat fungal infections in children, adolescents, and adults.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Ancotil<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Ancotil<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to flucytosine or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you know that the&nbsp;enzyme&nbsp;a dihydropyridine dehydrogenase (DPD) is completely inactive in you (total DPD deficiency).<\/li><li>if you are already being treated with certain medicines for viral infections.<\/li><li>if you are breastfeeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before receiving Ancotil:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have impaired liver or kidney function<\/li><li>if you have a blood problem<\/li><li>if you are being treated with a medicine that weakens your immune system<\/li><li>if you are deficient in the&nbsp;enzyme&nbsp;a DPD (dihydropyridine dehydrogenase).&nbsp;This is determined by your doctor based on blood test results.<\/li><\/ul>\n\n\n\n<p>You may need to submit blood samples before and during treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Ancotil<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Ancotil may affect or be affected by treatment with other medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ganciclovir, valganciclovir, brivudine, sorivudine or similar medicines (against certain&nbsp;viruses&nbsp;)<\/li><li>Phenytoin&nbsp;(for&nbsp;epilepsy&nbsp;)<\/li><li>Cytarabine (cytotoxic&nbsp;drug&nbsp;)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, you must tell your doctor before using this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will decide if you should be treated with Ancotil when you are pregnant.&nbsp;If Ancotil is given during pregnancy, there is a risk of birth defects.&nbsp;Close monitoring before and after delivery must therefore be ensured.<\/li><li>Ancotil should not be used if you are breast-feeding.<\/li><\/ul>\n\n\n\n<p><strong>Contraceptive methods for men and women<\/strong><\/p>\n\n\n\n<p>Women of&nbsp;childbearing potential&nbsp;treated with Ancotil should use effective contraception during treatment and one month thereafter.&nbsp;Men treated with Ancotil and their female partners of&nbsp;childbearing potential&nbsp;should use effective contraception during treatment and for three months thereafter.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>During treatment with Ancotil you may experience confusion, hallucinations, and fatigue.&nbsp;This should be taken into account when sharper attention is required, e.g.&nbsp;while driving.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ancotil contains sodium<\/h2>\n\n\n\n<p>This medicine contains 792 mg&nbsp;sodium&nbsp;(the main ingredient in table salt\/table salt) per bottle (250 ml).&nbsp;This corresponds to 40% of the maximum recommended daily intake of&nbsp;sodium&nbsp;for adults.<br><\/p>\n\n\n\n<p>The sodium content per&nbsp;dose&nbsp;depends on the estimated amount of Ancotil infusion solution you are receiving.&nbsp;Talk to your doctor or pharmacist if you need Ancotil daily for a long period of time, especially if you have been prescribed a low-salt (sodium-poor) diet.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Ancotil<\/h2>\n\n\n\n<p>Ancotil is given in hospitals by healthcare professionals.&nbsp;Your doctor will decide how long the treatment should last and how much Ancotil you should receive per day.<br><\/p>\n\n\n\n<p>Ancotil is given as an&nbsp;infusion&nbsp;into a friend.&nbsp;The&nbsp;infusion is&nbsp;usually given&nbsp;four times a day at 6-hour intervals.&nbsp;Each&nbsp;infusion&nbsp;lasts 20-40 minutes.&nbsp;The length of treatment varies from a few weeks to several months.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children<\/h2>\n\n\n\n<p>Although some data are available for use in children, they are not sufficient to provide accurate dose recommendations for this age group.&nbsp;If this medicine is prescribed for your child, your doctor will decide on the most appropriate&nbsp;dose.<\/p>\n\n\n\n<p>Due to delayed secretion of flucytosine in children, especially in very young children, the use of flucytosine may cause the amount of drug in the blood to become too high.&nbsp;Therefore, the concentrations of flucytosine in your baby&#8217;s blood will be measured regularly throughout the treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Ancotil than you should&nbsp;<\/h2>\n\n\n\n<p>Your doctor will decide how much Ancotil to get and for how long.&nbsp;If you are concerned that you have received too much Ancotil, talk to your doctor or nurse.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, nurse, or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Altered blood count (eg decreased red or&nbsp;white blood cell count&nbsp;or decreased&nbsp;platelet count&nbsp;)<\/li><li>Nausea, vomiting, diarrhea<\/li><li>Hepatic impairment, altered liver values<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Confusion<\/li><li>Rash<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bone marrow changes<\/li><li>Severe skin damage (skin detachment of the epidermis and superficial mucous membranes).<\/li><li>Hallucinations<\/li><li>Cramps<\/li><li>Tingling and numbness<\/li><li>Fatigue<\/li><li>Damage to the heart<\/li><li>Intestinal injuries<\/li><li>Severe liver disease<\/li><\/ul>\n\n\n\n<p>Most&nbsp;side effects&nbsp;occur during the first two to three weeks of treatment.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Ancotil<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Ancotil should only be stored at 18\u00baC &#8211; 25\u00baC.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is flucytosine 10 mg\/ml.<\/li><li>The other ingredients are sodium chloride, tromethamine,&nbsp;hydrochloric acid, water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Ancotil is supplied in 250 ml glass infusion bottles in packs of 5 bottles.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Meda AB<\/p>\n\n\n\n<p>Box 906<\/p>\n\n\n\n<p>170 09 Solna<\/p>\n\n\n\n<p>08-630 19 00<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ancotil contains flucytosine. Ancotil is used to treat fungal infections in children, adolescents, and adults.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10379,10383,10374,10377,2212,10382,10378,10381,10376,10380,10375],"class_list":["post-5463","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-ancotil","tag-ancotil-injection","tag-flucytosine","tag-flucytosine-powder","tag-medicine","tag-side-effects-of-ancotil","tag-side-effects-of-flucytosine","tag-what-ancotil-is-used-for","tag-what-flucytosine-is-used-for","tag-what-is-ancotil","tag-what-is-flucytosine"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5463","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5463"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5463\/revisions"}],"predecessor-version":[{"id":12619,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5463\/revisions\/12619"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}