{"id":5428,"date":"2020-12-17T15:20:17","date_gmt":"2020-12-17T15:20:17","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5428"},"modified":"2021-07-27T07:21:39","modified_gmt":"2021-07-27T07:21:39","slug":"anagrelide-stada","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/anagrelide-stada\/","title":{"rendered":"Anagrelide STADA &#8211; Anagrelide uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n0.5 mg&nbsp;hard&nbsp;anagrelide&nbsp;capsules<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Anagrelide STADA is and what it is used for<\/h2>\n\n\n\n<p>Anagrelide Stada contains the active substance anagrelide.<\/p>\n\n\n\n<p>Anagrelide is a drug that affects the development of&nbsp;platelets.&nbsp;It reduces the number of&nbsp;platelets&nbsp;produced by the&nbsp;bone marrow&nbsp;and thus the number of&nbsp;platelets&nbsp;in the blood&nbsp;becomes&nbsp;more normal.&nbsp;Therefore, it is used to treat patients with&nbsp;essential thrombocythemia.<\/p>\n\n\n\n<p>Essential&nbsp;thrombocythaemia&nbsp;is a condition that occurs when the&nbsp;bone marrow produces too many of the blood cells called&nbsp;platelets.&nbsp;A large number of&nbsp;platelets&nbsp;in the blood can cause serious problems with blood circulation and blood clotting.<\/p>\n\n\n\n<p>Anagrelide contained in Anagrelide Stada may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Anagrelide STADA<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Anagrelide STADA<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic to anagrelide or any of the other ingredients<\/strong>&nbsp;of this medicine (listed in section 6).&nbsp;An&nbsp;allergic reaction&nbsp;may manifest as rash,&nbsp;itching, swollen face or swollen lips, or shortness of breath<\/li><li>if you have moderate or severe&nbsp;<strong>liver problems<\/strong><\/li><li><strong>if you have moderate or severe&nbsp;kidney problems<\/strong>.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking anagrelide:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or think you may have&nbsp;<strong>heart problems<\/strong>&nbsp;;<\/li><li>if you were born with&nbsp;<strong>prolonged&nbsp;QT interval<\/strong>&nbsp;(seen on&nbsp;ECG, electrical recording of the heart) or if there are in your family, or if you are taking other medicines that result in&nbsp;<strong>abnormal&nbsp;ECG&nbsp;changes<\/strong>, or if you have&nbsp;<strong>low levels of&nbsp;electrolyte you<\/strong>, to for example&nbsp;potassium,&nbsp;magnesium&nbsp;or&nbsp;calcium&nbsp;(see section \u201cOther medicines and Anagrelide Stada\u201d);<\/li><li>if you have any&nbsp;<strong>problems with<\/strong>&nbsp;your&nbsp;<strong>liver or kidneys<\/strong>.<\/li><\/ul>\n\n\n\n<p>Concomitant use of&nbsp;<strong><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiplo-citrus\/\">acetylsalicylic acid<\/a><\/strong>&nbsp;(a substance also known as <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/treo-comp\/\">aspirin<\/a> and found in many medicines used to relieve pain and lower fever and also to prevent blood clots) increases the risk of major bleeding (see section &#8220;Other medicines and Anagrelide Stada&#8221;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Data on the use of Anagrelide Stada in children and adolescents are limited and this medicine should therefore be used with caution.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Anagrelide STADA<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tell your doctor if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs that can change the heart rhythm, e.g.&nbsp;<strong>sotalol and&nbsp;amiodarone<\/strong><\/li><li><strong>fluvoxamine<\/strong>&nbsp;used to treat depression<\/li><li><strong>some types of&nbsp;antibiotics<\/strong>, such as enoxacin which are used to treat the&nbsp;infection&nbsp;your<\/li><li><strong>theophylline<\/strong>&nbsp;used to treat severe&nbsp;asthma&nbsp;and respiratory problems<\/li><li>drugs used to treat heart disease, e.g.&nbsp;<strong>milrinone, enoximone, amrinone, olprinone, and cilostazol<\/strong><\/li><li><strong>acetylsalicylic acid<\/strong>&nbsp;(a substance also called aspirin and found in many medicines used to relieve pain and lower fever and also to prevent blood clots)<\/li><li>other drugs used to&nbsp;<strong>treat conditions that affect platelets in the blood, e.g.&nbsp;clopidogrel<\/strong><\/li><li><strong>omeprazole<\/strong>&nbsp;used to reduce the amount of acid produced in the stomach<\/li><li><strong>oral contraceptives<\/strong>: If you get severe diarrhea while taking this medicine, it may affect how well the oral contraceptive works, and the use of another method of contraception is recommended (eg condoms).&nbsp;See the instructions in the package leaflet for the&nbsp;contraceptive pill&nbsp;you are taking.<\/li><\/ul>\n\n\n\n<p>Anagrelide Stada or these medicines may not work properly if taken together.<br><\/p>\n\n\n\n<p>Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Tell your doctor if you are pregnant or planning to become pregnant.&nbsp;Anagrelide Stada should not be taken by pregnant women.&nbsp;Women who are at risk of becoming pregnant should ensure that they use effective contraception while taking Anagrelide Stada.&nbsp;Talk to your doctor if you need advice on contraception.<\/p>\n\n\n\n<p>Tell your doctor if you are breast-feeding or if you are planning to breast-feed your baby.&nbsp;Anagrelide Stada should not be taken while breast-feeding.&nbsp;You must stop breast-feeding if you are taking Anagrelide Stada.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Dizziness has been reported in some patients taking Anagrelide Stada.&nbsp;Avoid driving or using machines if you feel dizzy.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and \/ or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Anagrelide STADA contains lactose and sodium<\/h2>\n\n\n\n<p>Lactose&nbsp;is an ingredient in this medicine.&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per capsule, ie&nbsp;essentially &#8216;sodium-free&#8217;.&nbsp;is next to &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Anagrelide STADA<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>Different people may take different amounts of Anagrelide Stada depending on the disease state.&nbsp;Your doctor will prescribe the&nbsp;dose&nbsp;that is best for you.<br><\/p>\n\n\n\n<p>The usual starting dose of Anagrelide Stada is 1 mg.&nbsp;You take this&nbsp;dose&nbsp;as a 0.5 mg capsule twice daily for at least one week.&nbsp;Then your doctor can either increase or decrease the number of capsules you take to find the&nbsp;dose&nbsp;that is best for you and that treats your condition most effectively.<br><\/p>\n\n\n\n<p>The capsules should be swallowed whole and rinsed with water;&nbsp;They must not be crushed and the contents must not be dissolved in liquid.&nbsp;You can take the capsules with a meal or after a meal or on an empty stomach.&nbsp;You should preferably take the capsules at the same time each day.<br><\/p>\n\n\n\n<p><strong>Do not take<\/strong>&nbsp;more capsules than your doctor has recommended.<br><\/p>\n\n\n\n<p>Your doctor will take blood samples at regular intervals to check that the medicine is working effectively and that your liver and kidneys are working well.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Anagrelide STADA<\/h2>\n\n\n\n<p>Take your capsules as soon as you remember.&nbsp;Take the next&nbsp;dose&nbsp;at the usual time.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;Talk to your doctor if you are worried.<br><\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart failure&nbsp;(signs of this are shortness of breath, chest pain, and swelling of the legs due to fluid retention)<\/li><li>severe problems with heart rate or heart rate (&nbsp;ventricular tachycardia,&nbsp;supraventricular&nbsp;tachycardia,&nbsp;or&nbsp;atrial fibrillation&nbsp;)<\/li><li>inflammation&nbsp;of the&nbsp;pancreas&nbsp;that causes severe pain in the abdomen and back (&nbsp;pancreatitis&nbsp;)<\/li><li>vomiting or bloody or black stools<\/li><li>a sharp decrease in the number of&nbsp;blood cells&nbsp;that can cause weakness<\/li><li>bruises<\/li><li>bleeding or&nbsp;infection&nbsp;(pancytopenia)<\/li><li>increased pressure in the&nbsp;artery&nbsp;are the lungs (&nbsp;pulmonary&nbsp;hypertension, characters which include shortness of breath, swollen ankles or legs, and that the lips and skin, a bluish color tone).<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>renal failure&nbsp;(little or no urination)<\/li><li>myocardial infarction.<\/li><\/ul>\n\n\n\n<p><strong>If you notice any of these&nbsp;side effects,&nbsp;talk to your doctor immediately.<\/strong><br><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache.<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>fatigue<\/li><li>fast heartbeat<\/li><li>irregular or severe heartbeat (&nbsp;palpitation&nbsp;)<\/li><li>nausea<\/li><li>diarrhea<\/li><li>magnet<\/li><li>gases<\/li><li>vomiting<\/li><li>reduction in&nbsp;red blood cell count&nbsp;(&nbsp;anemia&nbsp;)<\/li><li>fluid retention or rash.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the feeling of weakness or feeling of illness<\/li><li>high&nbsp;blood pressure<\/li><li>irregular heartbeats<\/li><li>fainting<\/li><li>chills or fever<\/li><li>indigestion<\/li><li>loss of appetite<\/li><li>constipation<\/li><li>bruises<\/li><li>bleeding<\/li><li>swelling (&nbsp;edema&nbsp;)<\/li><li>weight loss<\/li><li>muscle aches<\/li><li>joint pain<\/li><li>back pain<\/li><li>decreased or lost sensation or numbness, especially in the skin<\/li><li>an abnormal feeling or crawling and tingling<\/li><li>insomnia&nbsp;<\/li><li>Depression<\/li><li>confusion<\/li><li>nervousness<\/li><li>dry mouth<\/li><li>memory loss<\/li><li>shortness of breath<\/li><li>nosebleeds<\/li><li>severe lung infection with fever<\/li><li>respiratory distress<\/li><li>cough<\/li><li>mucus formation<\/li><li>hair loss<\/li><li>itchy skin or skin discoloration<\/li><li>impotence<\/li><li>chest pain<\/li><li>a decreased&nbsp;platelet count&nbsp;that increases the risk of bleeding or bruising (&nbsp;thrombocytopenia&nbsp;)<\/li><li>fluid accumulation around the lungs or an increase in&nbsp;enzymes&nbsp;in the liver.<\/li><\/ul>\n\n\n\n<p>Your doctor may do a blood test that may show an increase in the&nbsp;enzyme&nbsp;in your liver.<br><\/p>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>bleeding gums<\/li><li>weight gain<\/li><li>severe chest pain (angina)<\/li><li>heart muscle disease (signs of this are fatigue, chest pain, and&nbsp;palpitations&nbsp;)<\/li><li>heart enlargement<\/li><li>fluid accumulation around the heart<\/li><li>loss of coordination<\/li><li>speech difficulties<\/li><li>dry skin<\/li><li>migraine<\/li><li>visual disturbances or double vision<\/li><li>ringing in the ears<\/li><li>dizziness when getting up from sitting or lying down<\/li><li>increased need to urinate at night<\/li><li>pain<\/li><li>flu-like symptoms<\/li><li>somnolence<\/li><li>dilated blood vessels<\/li><li>inflammation&nbsp;of the colon (signs of this are diarrhea, usually with blood and mucus, abdominal pain, fever)<\/li><li>gastritis (signs of this are pain, nausea, and vomiting)<\/li><li>an area with abnormal density in the lung<\/li><li>elevated creatinine levels in the blood which may be a sign of kidney problems.<\/li><\/ul>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;have been reported but it is not known exactly how often they occur (&nbsp;<\/strong><strong>occurs in an unknown number of users)&nbsp;<\/strong><strong>:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>potentially life-threatening, irregular heartbeat (&nbsp;<em>torsade de points<\/em>&nbsp;)<\/li><li>hepatitis.&nbsp;Signs of this are nausea, vomiting,&nbsp;itching, yellowing of the skin and eyes, and discoloration of stools and urine (&nbsp;hepatitis&nbsp;)<\/li><li>pneumonia&nbsp;(signs of this are fever, cough, difficulty breathing and wheezing causing scarring of the lungs), (allergic alveolitis, including interstitial lung disease and&nbsp;pneumonitis&nbsp;)<\/li><li>renal inflammation (tubulointerstitial nephritis).<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Anagrelide STADA<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The first two digits indicate the month and the last four digits indicate the year.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Sensitive to light.&nbsp;Moisture sensitive.<br><\/p>\n\n\n\n<p>If your doctor interrupts your treatment with the medicine, you should not keep any capsules left unless your doctor tells you to.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is anagrelide.&nbsp;Each capsule contains anagrelide hydrochloride monohydrate equivalent to 0.5 mg anagrelide.<br><\/p>\n\n\n\n<p><strong>Other ingredients are<\/strong><\/p>\n\n\n\n<p><strong>Capsule content<\/strong>:&nbsp;lactose monohydrate, croscarmellose sodium, povidone (K29 \/ 32),&nbsp;lactose, cellulose microcrystalline, magnesium stearate.<\/p>\n\n\n\n<p><strong>Capsule shell<\/strong>: gelatin, titanium dioxide (E171).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Anagrelide Stada is supplied as hard capsules (size 4) with an opaque white body and lid.&nbsp;The capsule is filled with white to off-white powder.<br><\/p>\n\n\n\n<p>The capsules are supplied in jars with childproof closures and desiccants containing 42 or 100 hard capsules.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>STADA Arzneimittel AG<\/p>\n\n\n\n<p>Stadastrasse 2-18<\/p>\n\n\n\n<p>61118 Bad Vilbel<\/p>\n\n\n\n<p>Germany<br><\/p>\n\n\n\n<p><strong>Other manufacturers<\/strong><\/p>\n\n\n\n<p>Synthon Hispania, SL<\/p>\n\n\n\n<p>C \/ Castell\u00f3 no1, Pol.&nbsp;Las Salinas, Sant Boi de Llobregat<\/p>\n\n\n\n<p>08830 Barcelona<\/p>\n\n\n\n<p>Spain<br><\/p>\n\n\n\n<p>Synthon BV<\/p>\n\n\n\n<p>Microweg 22<\/p>\n\n\n\n<p>6545 CM Nijmegen<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n\n\n\n<p>Centrafarm Services BV<\/p>\n\n\n\n<p>New Donk 9<\/p>\n\n\n\n<p>4879 AC Etten-Leur<\/p>\n\n\n\n<p>Netherlands<br><\/p>\n\n\n\n<p><strong>Local representative<\/strong><\/p>\n\n\n\n<p>STADA Nordic ApS<\/p>\n\n\n\n<p>Marielundvej 46A<\/p>\n\n\n\n<p>2730 Herlev<\/p>\n\n\n\n<p>Denmark<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Anagrelide Stada contains the active substance anagrelide.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10420,10423,10432,10435,10424,10436,10434,10431,10430,10433],"class_list":["post-5428","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-anagrelide","tag-anagrelide-capsule","tag-anagrelide-stada","tag-anagrelide-stada-capsule","tag-side-effects-of-anagrelide","tag-side-effects-of-anagrelide-stada","tag-what-anagrelide-stada-is-used-for","tag-what-anagrelideis-used-for","tag-what-is-anagrelide","tag-what-is-anagrelide-stada"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5428"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5428\/revisions"}],"predecessor-version":[{"id":12649,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5428\/revisions\/12649"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}