{"id":5420,"date":"2020-12-17T15:16:26","date_gmt":"2020-12-17T15:16:26","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5420"},"modified":"2021-07-27T07:22:41","modified_gmt":"2021-07-27T07:22:41","slug":"anagrelide-bluefish","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/anagrelide-bluefish\/","title":{"rendered":"Anagrelide Bluefish &#8211; Anagrelide uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n0.5 mg hard capsules&nbsp;<br>anagrelide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Anagrelide Bluefish is and what it is used for<\/h2>\n\n\n\n<p>Anagrelide Bluefish contains the active substance anagrelide.&nbsp;Anagrelide Bluefish is a drug that affects the development of&nbsp;platelets.&nbsp;It reduces the number of&nbsp;plateletsproduced by the&nbsp;bone marrow&nbsp;and thus the number of&nbsp;platelets&nbsp;in the blood&nbsp;becomes&nbsp;more normal.&nbsp;Therefore, it is used to treat patients with&nbsp;essential thrombocythemia.<\/p>\n\n\n\n<p>Essential&nbsp;thrombocythaemia&nbsp;is a condition that occurs when the&nbsp;bone marrow produces too many of the blood cells called&nbsp;platelets.&nbsp;A large number of&nbsp;platelets&nbsp;in the blood can cause serious problems with blood circulation and blood clotting.<\/p>\n\n\n\n<p>Anagrelide contained in Anagrelide Bluefish may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Anagrelide Bluefish<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Anagrelide Bluefish<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to anagrelide or any of the other ingredients of this medicine (listed in section 6).&nbsp;An&nbsp;allergic reaction&nbsp;may manifest as a rash,&nbsp;itching, swollen face or swollen lips, or shortness of breath;<\/li><li>if you have moderate or severe liver problems;<\/li><li>if you have moderate or severe kidney problems.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Anagrelide Bluefish:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or think you may have heart problems;<\/li><li>if you were born with a prolonged&nbsp;QT interval&nbsp;(seen on&nbsp;ECG, electrical recording of the heart) or if it is present in your family, or if you are taking other medicines that lead to abnormal&nbsp;ECG&nbsp;changes, or if you have low levels of&nbsp;electrolytes, for example,&nbsp;potassium,&nbsp;magnesium&nbsp;or&nbsp;calcium&nbsp;(see section \u201cOther medicines and Anagrelide Bluefish\u201d);<\/li><li>if you have any problems with your liver or kidneys.<\/li><\/ul>\n\n\n\n<p>Concomitant use of&nbsp;acetylsalicylic acid&nbsp;(a substance also known as <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/treo-comp\/\">aspirin<\/a> and found in many medicines used to relieve pain and lower fever and also to prevent blood clots) increases the risk of major bleeding (see section &#8220;Other medicines and Anagrelide Bluefish&#8221;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Data on the use of Anagrelide Bluefish in children and adolescents are limited and this medicine should therefore be used with caution.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Anagrelide Bluefish<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tell your doctor if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs that can change the heart rhythm, e.g.&nbsp;sotalol and&nbsp;amiodarone<\/li><li>Fluvoxamine used to treat depression<\/li><li>Some types of&nbsp;antibiotics, such as enoxacin which are used to treat the&nbsp;infection your<\/li><li>Theophylline used to treat severe&nbsp;asthma&nbsp;and respiratory problems<\/li><li>Drugs used to treat heart disease, e.g.&nbsp;milrinone, enoximone, amrinone, olprinone, and cilostazol<\/li><li>Acetylsalicylic acid&nbsp;(a substance also called aspirin and found in many medicines used to relieve pain and lower fever and also to prevent blood clots)<\/li><li>Other drugs used to treat conditions that affect the platelets in the blood, e.g.&nbsp;clopidogrel<\/li><li>Omeprazole used to reduce the amount of acid produced in the stomach<\/li><li>Oral contraceptives: If you get severe diarrhea while taking this medicine, it may affect how well the oral contraceptive works, and the use of another method of contraception is recommended (eg condoms).&nbsp;See the instructions in the package leaflet for the&nbsp;contraceptive pill&nbsp;you are taking.<\/li><\/ul>\n\n\n\n<p>Anagrelide Bluefish or these medicines may not work properly if taken together.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Tell your doctor if you are pregnant or planning to become pregnant.&nbsp;Anagrelide Bluefish should not be taken by pregnant women.&nbsp;Women who are at risk of becoming pregnant should make sure that they use effective contraception while taking Anagrelide Bluefish.&nbsp;Talk to your doctor if you need advice on contraception.<\/p>\n\n\n\n<p>Tell your doctor if you are breast-feeding or if you are planning to breast-feed your baby.&nbsp;Anagrelide Bluefish should not be taken while breast-feeding.&nbsp;You must stop breast-feeding if you are taking Anagrelide Bluefish.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Dizziness has been reported in some patients taking Anagrelide Bluefish.&nbsp;Avoid driving or using machines if you feel dizzy.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Anagrelide Bluefish contains lactose<\/h2>\n\n\n\n<p>Lactose&nbsp;is an ingredient in this medicine.&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Anagrelide Bluefish<\/h2>\n\n\n\n<p>Always take Anagrelide Bluefish exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>Different people may take different amounts of Anagrelide Bluefish depending on the disease state.&nbsp;Your doctor will prescribe the&nbsp;dose&nbsp;that is best for you.<br><\/p>\n\n\n\n<p>The usual starting dose of Anagrelide Bluefish is 1 mg.&nbsp;You take this&nbsp;dose&nbsp;as a 0.5 mg capsule twice a day for at least one week.&nbsp;Then your doctor can either increase or decrease the number of capsules you take to find the&nbsp;dose&nbsp;that is best for you and that treats your condition most effectively.<br><\/p>\n\n\n\n<p>The capsules should be swallowed whole and rinsed with water.&nbsp;They must not be crushed and the contents must not be dissolved in liquid.&nbsp;You can take the capsules with a meal or after a meal or on an empty stomach.&nbsp;You should preferably take the capsules at the same time each day.<br><\/p>\n\n\n\n<p><strong>Do not take<\/strong>&nbsp;more capsules than your doctor has recommended.<br><\/p>\n\n\n\n<p>Your doctor will take blood samples at regular intervals to check that the medicine is working effectively and that your liver and kidneys are working well.<\/p>\n\n\n\n<p>Show them the Anagrelide Bluefish package.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Anagrelide Bluefish<\/h2>\n\n\n\n<p>Take your capsules as soon as you remember.&nbsp;Take the next&nbsp;dose&nbsp;at the usual time.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Anagrelide Bluefish can cause&nbsp;side effects, although not everybody gets them.&nbsp;Talk to your doctor if you are worried.<\/p>\n\n\n\n<p><strong><em>Serious side effects:<\/em><\/strong><\/p>\n\n\n\n<p>Uncommon:&nbsp;Heart failure&nbsp;(signs of shortness of breath, chest pain, and leg swelling due to fluid retention), severe heart rate or heart rhythm&nbsp;problems&nbsp;(&nbsp;ventricular tachycardia,&nbsp;supraventricular&nbsp;tachycardia,&nbsp;or&nbsp;atrial fibrillation&nbsp;),&nbsp;inflammation&nbsp;of the&nbsp;pancreas causing&nbsp;severe pain in the stomach and back (&nbsp;pancreas&nbsp;) vomiting blood or black or bloody stool, severe reduction of the amount of&nbsp;blood&nbsp;s that can cause weakness, bruising, bleeding or&nbsp;infection&nbsp;s (pancytopenia), increased pressure in the&nbsp;artery&nbsp;are the lungs (&nbsp;pulmonary&nbsp;hypertension, signs that include shortness of breath, swollen legs or ankles and that the lips and skin get a bluish tint).<\/p>\n\n\n\n<p>Rare:&nbsp;Kidney failure&nbsp;(little or no urination) or heart attack.<br><\/p>\n\n\n\n<p><strong>If you notice any of these&nbsp;side effects,&nbsp;talk to your doctor immediately.<\/strong><br><\/p>\n\n\n\n<p><strong><em>Very common side effects: may affect more than 1 in 10 people<\/em><\/strong><\/p>\n\n\n\n<p>Headache.<br><\/p>\n\n\n\n<p><strong><em>Common side effects: may affect up to 1 in 10 people<\/em><\/strong>&nbsp;<\/p>\n\n\n\n<p>Dizziness, fatigue, rapid heartbeat, irregular or heavy heartbeat (&nbsp;palpitation&nbsp;), nausea, diarrhea, stomach pain, gas, vomiting, reduction in&nbsp;red blood cell count&nbsp;(&nbsp;anemia&nbsp;), fluid retention, or rash.<\/p>\n\n\n\n<p><strong><em>Uncommon side effects: may affect up to 1 in 100 people<\/em><\/strong>&nbsp;<\/p>\n\n\n\n<p>Feeling weak or sick, high&nbsp;blood pressure, irregular heartbeat, fainting, chills or fever, indigestion, loss of appetite, constipation, bruising, bleeding, swelling (&nbsp;edema), weight loss, muscle aches, joint pain, back pain, decreased or lost sensation, especially sensation or loss of sensation abnormal sensation, or tingling and prickling, insomnia, depression, confusion, nervousness,&nbsp;dry mouth, memory loss, shortness of breath, nose bleeds, severe lung infection with fever, shortness of breath, cough, sputum production, hair loss, skin itching or discoloration,&nbsp;impotence, chest pain, decreased number of&nbsp;blood platelets&nbsp;which increases the risk of bleeding or bruising (&nbsp;thrombocytopenia), fluid accumulation around the lungs or an increase in&nbsp;enzymes&nbsp;in the liver.&nbsp;Your doctor may do a blood test that may show an increase in the&nbsp;enzyme&nbsp;in your liver.<br><\/p>\n\n\n\n<p><strong><em>Rare side effects: may affect up to 1 in 1,000 people<\/em><\/strong>&nbsp;<\/p>\n\n\n\n<p>Bleeding gums, weight gain, severe chest pain (angina), heart muscle disease (signs of this are fatigue, chest pain, and&nbsp;palpitations&nbsp;), heart enlargement, fluid accumulation around the heart, loss of coordination, speech difficulties, dry skin,&nbsp;migraine, visual or double vision, ringing in the ears, dizziness when getting up from sitting or lying down, increased need to urinate at night, pain,&nbsp;flu-like symptoms, drowsiness, dilated blood vessels,&nbsp;inflammation&nbsp;of the colon (signs of this are pain, nausea, and vomiting), area with abnormal density in the lung or elevated creatinine levels in the blood which may be a sign of kidney problems.<br><\/p>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;have been reported but it is not known exactly how often they occur:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>potentially life-threatening, irregular heartbeat (&nbsp;torsade de points&nbsp;);<\/li><li>hepatitis.&nbsp;Signs of this are nausea, vomiting,&nbsp;itching, yellowing of the skin and eyes, and discoloration of feces and urine (&nbsp;hepatitis&nbsp;);<\/li><li>pneumonia&nbsp;(signs of this are fever, cough, difficulty breathing, and wheezing that causes scarring of the lungs), (allergic alveolitis, including interstitial lung disease and&nbsp;pneumonitis&nbsp;);<\/li><li>renal inflammation (tubulointerstitial nephritis).<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Anagrelide Bluefish<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and can label after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>No special storage instructions.<br><\/p>\n\n\n\n<p>If your doctor interrupts your treatment with the medicine, you should not keep any capsules left unless your doctor tells you to.&nbsp;Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is anagrelide.&nbsp;Each capsule contains 0.5 mg of anagrelide (as anagrelide hydrochloride).<br><\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p>Capsule contents: povidone, crospovidone, anhydrous&nbsp;lactose,&nbsp;lactose&nbsp;monohydrate, microcrystalline cellulose, and magnesium stearate.<\/p>\n\n\n\n<p>Capsule shell: gelatin, titanium dioxide, sodium lauryl sulfate, and water.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Anagrelide Bluefish is supplied as a white to off-white granular powder filled in white opaque hard gelatin capsules that are 14.3 mm long and 5.2 mm wide.<br><\/p>\n\n\n\n<p>Anagrelide Bluefish 0.5 mg hard capsules are packaged in cans of high-density polyethylene (HDPE) with a child-resistant polypropylene closure containing a desiccant.<\/p>\n\n\n\n<p>Pack sizes: 42 or 100 capsules.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Bluefish Pharmaceuticals AB<\/p>\n\n\n\n<p>Box 49013<\/p>\n\n\n\n<p>100 28 Stockholm<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Bluefish Pharmaceuticals AB<\/p>\n\n\n\n<p>G\u00e4vlegatan 22<\/p>\n\n\n\n<p>113 30 Stockholm<br><\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Denmark<\/td><td>Anagrelide Bluefish 0.5 mg hard capsules.<\/td><\/tr><tr><td>Norway<\/td><td>Anagrelide Bluefish 0.5 mg hard capsules<\/td><td><br><\/td><\/tr><tr><td>Portugal<\/td><td>Anagrelida Bluefish 0.5 mg capsules<\/td><td><br><\/td><\/tr><tr><td>Spain<\/td><td>Anagrelide Bluefish 0.5 mg capsules Duras.<\/td><td><br><\/td><\/tr><tr><td>UK<\/td><td>Anagrelide 0.5 mg hard capsules<\/td><td><br><\/td><\/tr><tr><td><\/td><td><\/td><td><br><\/td><\/tr><tr><td>Germany<\/td><td>Anagrelide Bluefish 0.5 mg Heart Capsules<\/td><td><br><\/td><\/tr><tr><td>Austria<\/td><td>Anagrelide Bluefish 0.5 mg Heart Capsules<\/td><td><br><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>This leaflet was last modified on 25 May 2018<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Anagrelide Bluefish contains the active substance anagrelide. Anagrelide Bluefish is a drug that affects the development of platelets. It reduces the number of plateletsproduced by the bone marrow and thus the number of platelets in the blood becomes more normal. Therefore, it is used to treat patients with essential thrombocythemia.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10420,10452,10455,10423,10424,10456,10454,10422,10430,10453],"class_list":["post-5420","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-anagrelide","tag-anagrelide-bluefish","tag-anagrelide-bluefish-capsule","tag-anagrelide-capsule","tag-side-effects-of-anagrelide","tag-side-effects-of-anagrelide-bluefish","tag-what-anagrelide-bluefish-is-used-for","tag-what-anagrelide-is-used-for","tag-what-is-anagrelide","tag-what-is-anagrelide-bluefish"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5420","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5420"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5420\/revisions"}],"predecessor-version":[{"id":12653,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5420\/revisions\/12653"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5420"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}