{"id":5418,"date":"2020-12-17T15:15:26","date_gmt":"2020-12-17T15:15:26","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5418"},"modified":"2021-07-27T07:22:51","modified_gmt":"2021-07-27T07:22:51","slug":"anagrelide-aop","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/anagrelide-aop\/","title":{"rendered":"Anagrelide AOP &#8211; Anagrelide uses, dose and side effects"},"content":{"rendered":"\n<p> 0.5 mg\u00a0hard\u00a0anagrelide\u00a0capsules<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Anagrelide AOP is and what it is used for<\/h2>\n\n\n\n<p>Anagrelide AOP contains the active substance anagrelide.&nbsp;Anagrelide AOP is a drug that inhibits the development of&nbsp;platelets&nbsp;in the&nbsp;bone marrow.<\/p>\n\n\n\n<p>Anagrelide AOP is used to reduce the number of&nbsp;platelets&nbsp;in patients with&nbsp;essential thrombocythemia&nbsp;(which is a disease in which the&nbsp;bone marrow&nbsp;forms too many&nbsp;platelets&nbsp;).&nbsp;Too high a&nbsp;platelet count&nbsp;can cause problems with blood circulation and the blood&#8217;s ability to coagulate.&nbsp;By lowering the number of&nbsp;platelets,&nbsp;the risk of serious health problems is reduced.<\/p>\n\n\n\n<p>Anagrelide contained in Anagrelide AOP may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Anagrelide AOP<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Anagrelide AOP<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to anagrelide or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have a serious heart condition<\/li><li>if you have severe kidney problems<\/li><li>if you have moderate to severe liver problems.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Anagrelide AOP:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or think you have heart disease<\/li><li>if you were born with a prolonged&nbsp;QT interval&nbsp;(seen on&nbsp;ECG, electrical recording of the heart) or if it is present in your family, or if you are taking other medicines that lead to abnormal&nbsp;ECG&nbsp;changes, or if you have low levels of&nbsp;electrolytes, for example,&nbsp;potassium,&nbsp;magnesium&nbsp;or&nbsp;calcium&nbsp;(see section \u201cOther medicines and Anagrelide AOP\u201d)<\/li><li>if you have kidney or liver disease.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>There is only limited experience in the use of anagrelide in children and adolescents.&nbsp;Your doctor will decide if treatment with Anagrelide AOP is right for you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Anagrelide AOP<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tell your doctor if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs that can change the heart rhythm<\/li><li>Certain types of&nbsp;antibiotics&nbsp;used to treat&nbsp;infections, e.g.&nbsp;enoxacin<\/li><li>Fluvoxamine used to treat depression<\/li><li>Certain types of drugs used to reduce the amount of acid produced in the stomach, e.g.&nbsp;omeprazole<\/li><li>Theophylline used to treat lung diseases such as&nbsp;asthma<\/li><li>Drugs used to treat heart disease, e.g.&nbsp;milrinone, enoximone, amrinone, olprinone, and cilostazol<\/li><li>Drugs that affect the platelets, e.g.&nbsp;acetylsalicylic acid&nbsp;(concomitant use of&nbsp;acetylsalicylic acid&nbsp;and Anagrelide AOP may increase bleeding tendency)<\/li><li>In some patients, this medicine may cause indigestion (eg diarrhea) and may make&nbsp;birth control pills&nbsp;less effective.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Anagrelide AOP with food and drink<\/h2>\n\n\n\n<p>Grapefruit juice can prolong the time it takes for this medicine to leave the body.&nbsp;It is recommended that you do not drink grapefruit juice while taking Anagrelide AOP.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p>Anagrelide AOP should not be taken during pregnancy.<\/p>\n\n\n\n<p>During treatment with Anagrelide AOP, fertile women should use an effective contraceptive.<\/p>\n\n\n\n<p>Anagrelide AOP should not be used during breast-feeding.&nbsp;You should stop breast-feeding if you are taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p>Do not drive or use machines if you feel dizzy after taking Anagrelide AOP.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Anagrelide AOP contains lactose<\/h2>\n\n\n\n<p>This medicine contains&nbsp;lactose.&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Anagrelide AOP<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p>Your doctor will prescribe the&nbsp;dose&nbsp;that is best for you.&nbsp;The usual starting dose of Anagrelide AOP is 1 capsule to 2 capsules per day for at least one week.&nbsp;Then your doctor can either increase or decrease the number of capsules you take to find the&nbsp;dose&nbsp;that is best for you and that treats your condition most effectively.&nbsp;The maximum&nbsp;dose&nbsp;is 10 capsules per day.<\/p>\n\n\n\n<p>If you have liver or kidney disease, your doctor will decide if you will be treated with Anagrelide AOP.<br><\/p>\n\n\n\n<p>Anagrelide AOP capsules should be swallowed whole with some water.&nbsp;The capsules should not be crushed or dissolved in any liquid.&nbsp;You can take the capsules with food, after a meal, or on an empty stomach.&nbsp;You should preferably take the capsules at the same time each day.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Anagrelide AOP<\/h2>\n\n\n\n<p>If you forget to take your capsules at the prescribed time, take them as soon as you remember.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Anagrelide AOP<\/h2>\n\n\n\n<p>Do not stop taking this medicine without first consulting your doctor.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Stop taking Anagrelide AOP and contact a doctor or see your nearest emergency department immediately if you experience any of the following symptoms:<\/strong><br><\/p>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>signs that include severe chest pain and shortness of breath (&nbsp;heart failure&nbsp;)<\/li><li>signs that include very rapid heartbeat, and severe chest pain associated with shortness of breath (&nbsp;ventricular arrhythmia&nbsp;)<\/li><li>Signs include shortness of breath, swelling of the legs and ankles, and bluish discoloration of the skin and lips (pulmonary hypertension).<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>signs that include severe chest pain and shortness of breath (heart attack)<\/li><li>signs that include very rapid heartbeat and severe chest pain associated with shortness of breath (&nbsp;atrial fibrillation&nbsp;)<\/li><li>signs that include severe chest pain due to insufficient blood flow to the heart (angina).<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;that may occur:<\/strong><\/p>\n\n\n\n<p><em>Very common&nbsp;side effects&nbsp;(may affect more than 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<br><\/li><\/ul>\n\n\n\n<p><em>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;), local bleeding in the skin<\/li><li>fluid retention (&nbsp;edema&nbsp;)<\/li><li>dizziness (&nbsp;vertigo&nbsp;), tingling and ant crawling, insomnia<\/li><li>irregular heartbeat (palpitations), rapid heartbeat (&nbsp;tachycardia&nbsp;), high&nbsp;blood pressure<\/li><li>nosebleeds<\/li><li>nausea, diarrhea, indigestion<\/li><li>itchy and\/or reddening skin<\/li><li>back pain<\/li><li>weakness or fatigue<\/li><\/ul>\n\n\n\n<p><em>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased&nbsp;platelet count, bleeding, bruising<\/li><li>weight gain<\/li><li>depression, nervousness,&nbsp;dry mouth,&nbsp;migraine<\/li><li>visual disturbances,&nbsp;eye infection<\/li><li>ringing in the ears (&nbsp;tinnitus&nbsp;)<\/li><li>cardiac arrhythmia,&nbsp;circulatory failure<\/li><li>shortness of breath, respiratory infection<\/li><li>vomiting, gas (&nbsp;flatulence&nbsp;), constipation, abdominal pain<\/li><li>hair loss,&nbsp;itching<\/li><li>muscle and joint pain<\/li><li>renal impairment, urinary tract infection<\/li><li>pain, weakness<\/li><\/ul>\n\n\n\n<p><em>Rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;blood pressure<\/li><li>fluid accumulation around or in the lungs, lung infection,&nbsp;asthma<\/li><li>inflammation&nbsp;of the stomach, eating disorders<\/li><li>rash<\/li><li>increased need to urinate at night<\/li><li>elevated liver enzymes<\/li><li>flu-like symptoms, chills, general discomfort<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>torsades de pointes&nbsp;(potentially life-threatening, irregular heartbeat)<\/li><li>pulmonary fibrosis&nbsp;(inflammation&nbsp;of the lungs that can cause scarring of the lungs)<\/li><li>renal inflammation (tubulointerstitial nephritis)<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Anagrelide AOP<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.&nbsp;Store in the original package.&nbsp;Sensitive to light.<br><\/p>\n\n\n\n<p>The medicine should be used within 100 days after opening the jar.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and can label after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is anagrelide.<\/p>\n\n\n\n<p>One hard capsule contains anagrelide hydrochloride monohydrate equivalent to 0.5 mg anagrelide.<br><\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p>Capsule content:&nbsp;lactose monohydrate, povidone K30, crospovidone type A, microcrystalline cellulose (E460), magnesium stearate (E470b)<\/p>\n\n\n\n<p>Capsule shell: titanium dioxide (E171), indigo carmine (E132), gelatin, water<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Anagrelide AOP is supplied as blue hard capsules approximately 14.3 mm long, filled with a white powder.<br><\/p>\n\n\n\n<p>Anagrelide AOP is supplied in polyethylene cans with child-resistant, safety-sealed polypropylene lids with desiccant.&nbsp;The jar contains 100 blue capsules.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>AOP Orphan Pharmaceuticals AG<\/p>\n\n\n\n<p>Wilhelminenstra\u00dfe 91 \/ II f<\/p>\n\n\n\n<p>1160 Vienna<\/p>\n\n\n\n<p>Austria<br><\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Austria<\/td><td>Anagrelide AOP 0.5 mg Heart Capsules<\/td><\/tr><tr><td>Bulgaria<\/td><td>anagrelide AOP 0.5 mg Capsules, Verdi<\/td><\/tr><tr><td>Czech Republic<\/td><td>Anagrelid AOP<\/td><\/tr><tr><td>Germany<\/td><td>Anagrelide AOP 0.5 mg Heart Capsules<\/td><\/tr><tr><td>Denmark<\/td><td>Anagrelid AOP<\/td><\/tr><tr><td>Estonia<\/td><td>Anagrelide AOP<\/td><\/tr><tr><td>Finland<\/td><td>Anagrelide AOP 0.5 mg covate capsule<\/td><\/tr><tr><td>France<\/td><td>ANAGRELIDE AOP<\/td><\/tr><tr><td>Latvia<\/td><td>Anagrelide AOP 0.5 mg is a capsule<\/td><\/tr><tr><td>Norway<\/td><td>Anagrelide AOP<\/td><\/tr><tr><td>Poland<\/td><td>Anagrelidum AOP<\/td><\/tr><tr><td>Romania<\/td><td>Anagrelid\u0103 AOP 0.5mg capsule<\/td><\/tr><tr><td><\/td><td><\/td><\/tr><tr><td>Slovenia<\/td><td>Anagrelide AOP Orphan 0.5 mg third capsule<\/td><\/tr><tr><td>Slovakia<\/td><td>Anagrelide AOP 0.5 mg tvrd\u00e9 capsule<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Anagrelide AOP contains the active substance anagrelide. Anagrelide AOP is a drug that inhibits the development of platelets in the bone marrow.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10420,10457,10460,10423,10424,10461,10459,10422,10430,10458],"class_list":["post-5418","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-anagrelide","tag-anagrelide-aop","tag-anagrelide-aop-capsule","tag-anagrelide-capsule","tag-side-effects-of-anagrelide","tag-side-effects-of-anagrelide-aop","tag-what-anagrelide-aop-is-used-for","tag-what-anagrelide-is-used-for","tag-what-is-anagrelide","tag-what-is-anagrelide-aop"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5418"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5418\/revisions"}],"predecessor-version":[{"id":12654,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5418\/revisions\/12654"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5418"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}