{"id":5351,"date":"2020-12-16T10:12:21","date_gmt":"2020-12-16T10:12:21","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5351"},"modified":"2021-07-28T08:13:20","modified_gmt":"2021-07-28T08:13:20","slug":"amitriptyline-abcur","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/amitriptyline-abcur\/","title":{"rendered":"Amitriptyline Abcur &#8211; Amitriptyline uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n10 mg, 25 mg, 50 mg&nbsp;film-coated tablets&nbsp;<br>amitriptyline<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Amitriptyline Abcur is and what it is used for<\/h2>\n\n\n\n<p>Amitriptyline Abcur belongs to the group of&nbsp;tricyclic antidepressants.<br><\/p>\n\n\n\n<p>This medicine is used for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>treatment of depression in adults (actual depression)<\/li><li>treatment of&nbsp;neuropathic pain&nbsp;in adults<\/li><li>preventive treatment of&nbsp;chronic&nbsp;tension-type headache in adults<\/li><li>preventive treatment of&nbsp;migraine&nbsp;in adults<\/li><li>nocturnal bedwetting in children from 6 years.&nbsp;Before treatment, physical (anatomical) causes of nocturnal bedwetting, such as&nbsp;spina bifida and related diseases have been excluded.&nbsp;All other treatments, with and without drugs, including muscle relaxants and desmopressin, should also have been without effect.&nbsp;This medicine should only be prescribed by a doctor who has experience in the treatment of patients with persistent bedwetting.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Amitriptyline Abcur<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Amitriptyline Abcur:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to amitriptyline or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have recently had a heart attack (heart attack)<\/li><li>if you have heart problems e.g.&nbsp;heart rhythm disorders as seen with&nbsp;ECG, cardiac arrhythmia (&nbsp;AV block&nbsp;), or coronary heart disease<\/li><li>if you are taking medicines called&nbsp;monoamine oxidase inhibitors&nbsp;(&nbsp;MAOIs&nbsp;)<\/li><li>if you have been taking&nbsp;MAOIs&nbsp;for the last 14 days<\/li><li>if you have taken moclobemide the day before<\/li><li>if you have severe liver disease<\/li><\/ul>\n\n\n\n<p>If you are being treated with Amitriptyline Abcur, you must stop taking this medicine and wait 14 days before you can start treatment with an&nbsp;MAOI.<\/p>\n\n\n\n<p>This medicine should not be used to treat children younger than 6 years.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Amitriptyline Abcur.<br><\/p>\n\n\n\n<p>Heart rhythm disturbances and low&nbsp;blood pressure&nbsp;may occur if you receive high&nbsp;dose of&nbsp;amitriptyline.&nbsp;This can also happen with regular&nbsp;doses&nbsp;if you already have pre-existing heart disease.<br><\/p>\n\n\n\n<p>Extended&nbsp;QT interval<\/p>\n\n\n\n<p>A heart problem called &#8220;prolonged&nbsp;QT&nbsp;interval&#8221; (which can be seen on your&nbsp;ECG&nbsp;) and heart rhythm disturbances (rapid or irregular heartbeat) have been reported with Amitriptyline Abcur. Tell your doctor if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>has a slow heart rate,<\/li><li>have or have had problems with your heart not being able to pump blood around the body as well as it should (a condition called&nbsp;heart failure&nbsp;),<\/li><li>taking any other medicine that may cause heart problems<\/li><li>have problems that cause low levels of&nbsp;potassium&nbsp;or&nbsp;magnesium&nbsp;or high levels of&nbsp;potassium&nbsp;in the blood<\/li><li>have an operation booked, as treatment with amitriptyline may need to be stopped before you receive anesthesia.&nbsp;In&nbsp;acute&nbsp;surgery, the anesthetist should be informed about the treatment with amitriptyline.<\/li><li>have an overactive&nbsp;thyroid gland&nbsp;or receive treatment with thyroid hormone.<\/li><\/ul>\n\n\n\n<p>Suicidal thoughts and worsening depression<\/p>\n\n\n\n<p>You who are depressed can sometimes have thoughts of harming yourself or committing suicide.&nbsp;These thoughts can get worse when you start using antidepressants, as it takes time for drugs of this type to take effect,&nbsp;<em>usually about 2 weeks, sometimes longer<\/em>.<\/p>\n\n\n\n<p>These thoughts may be more common:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have previously had thoughts of harming yourself or committing suicide<\/li><li>if you are a young adult.&nbsp;Data from&nbsp;clinical trials&nbsp;have shown an increased risk of suicidal behavior in young adults (younger than 25 years) with mental illness who were treated with antidepressant drugs.<\/li><\/ul>\n\n\n\n<p>Contact a doctor as soon as possible or see the nearest hospital&nbsp;if you have thoughts of injuring yourself or committing suicide.<br><\/p>\n\n\n\n<p>It can be helpful to tell a relative or close friend that you are depressed.&nbsp;Feel free to ask them to read this leaflet.&nbsp;You can also ask them to tell you if they think you are feeling worse or if they think your behavior is changing.<br><\/p>\n\n\n\n<p>Manic episodes<\/p>\n\n\n\n<p>Some patients with&nbsp;bipolar disorder&nbsp;may end up in a manic phase.&nbsp;This is characterized by intense and rapidly changing thinking activity, strong elation, and excessive physical activity.&nbsp;If this happens, it is important that you contact your doctor who is likely to change your medication.<br><\/p>\n\n\n\n<p>Tell your doctor if you have, or have had any medical problems in the past, especially if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>glaucoma&nbsp;with narrow&nbsp;ventricular angle&nbsp;(visual impairment due to increased pressure in the eye)<\/li><li>epilepsy, previous seizures<\/li><li>difficulty urinating<\/li><li>enlarged&nbsp;prostate<\/li><li>thyroid disease<\/li><li>bipolar disease<\/li><li>schizophrenia<\/li><li>severe liver disease<\/li><li>severe heart disease<\/li><li>pyloric stenosis (narrowing of the lower gastrointestinal tract) and paralytic&nbsp;ileus(blocked intestine)<\/li><li>diabetes, as your diabetes treatment may need to be adjusted.<\/li><\/ul>\n\n\n\n<p>If you use antidepressant drugs such as&nbsp;SSRIs, your doctor may consider changing the&nbsp;dose of&nbsp;one of your medicines (see also section 2, Other medicines and Amitriptyline Abcur and section 3)<\/p>\n\n\n\n<p>The elderly have an increased risk of certain&nbsp;side effects&nbsp;such as&nbsp;dizziness when getting up which is caused by a drop in blood pressure (see also section 4 Possible&nbsp;side effects&nbsp;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p><em>Depression,&nbsp;neuropathic pain,&nbsp;chronic&nbsp;tension-type headaches, and preventive treatment of&nbsp;migraines<\/em><\/p>\n\n\n\n<p>Do not give this medicine to children and adolescents under 18 years of age for these diseases as safety and efficacy have not been established for this age group.<\/p>\n\n\n\n<p><em>Nocturnal bedwetting<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>An&nbsp;ECG&nbsp;should be&nbsp;performed before starting&nbsp;treatment with amitriptyline to rule out long&nbsp;QT&nbsp;syndrome (prolonged&nbsp;QT interval&nbsp;)<\/li><li>This medicine should not be taken with anticholinergic medicines (see also section 2, Other medicines and Amitriptyline Abcur)<\/li><li>Suicidal ideation and suicidal ideation may also occur in the early stages of treatment with antidepressants for diseases other than depression.&nbsp;The same precautions to be taken when treating patients with depression should therefore be taken when treating patients with bedwetting<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Amitriptyline Abcur<\/h2>\n\n\n\n<p>Some medicines can affect the way some other medicines work and this can sometimes cause serious&nbsp;side effects.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>valproic acid&nbsp;(&nbsp;valproate&nbsp;)MAO inhibitors, e.g.&nbsp;phenelzine, iproniazid, isocarboxazid, nialamide, or <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tranylcypromine-glenmark\/\">tranylcypromine<\/a> (used to treat depression) or&nbsp;selegiline&nbsp;(used to treat&nbsp;Parkinson&#8217;s disease&nbsp;).&nbsp;These should not be taken concomitantly with Amitriptyline Abcur (see section 2 Do not take Amitriptyline Abcur)<\/li><li>adrenaline,&nbsp;ephedrine,&nbsp;isoprenaline,&nbsp;noradrenaline,&nbsp;phenylephrine,&nbsp;and phenylpropanolamine (these can be found in cough medicines, certain cold medicines, and certain anesthetics)<\/li><li>medicines for high&nbsp;blood pressure&nbsp;such as calcium channel blockers (eg&nbsp;diltiazem and verapamil), guanethidine, betanidine,&nbsp;clonidine, reserpine, and methyldopa<\/li><li>anticholinergic drugs such as certain drugs for&nbsp;Parkinson&#8217;s disease&nbsp;and gastrointestinal diseases (eg atropine, hyoscyamine)<\/li><li>thioridazine (used to treat schizophrenia)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tramadol-retard-krka\/\">tramadol<\/a> (painkiller)<\/li><li>medicines for fungal infections (eg&nbsp;fluconazole, terbinafine,&nbsp;ketoconazole,&nbsp;and itraconazole)<\/li><li>sedatives (eg&nbsp;barbiturates&nbsp;)<\/li><li>antidepressants (eg&nbsp;SSRIs&nbsp;(&nbsp;fluoxetine,&nbsp;paroxetine, fluvoxamine) and bupropion)<\/li><li>medicines for certain heart diseases (eg&nbsp;beta-blockers&nbsp;and&nbsp;antiarrhythmics&nbsp;)<\/li><li>cimetidine (used to treat&nbsp;stomach ulcers&nbsp;)<\/li><li>methylphenidate (used to treat&nbsp;ADHD&nbsp;)<\/li><li>ritonavir (used to treat&nbsp;HIV&nbsp;)<\/li><li>birth control pills<\/li><li>rifampicin (used to treat&nbsp;infections&nbsp;)<\/li><li>phenytoin&nbsp;and carbamazepine (used to&nbsp;treat epilepsy&nbsp;)<\/li><li>St. John&#8217;s wort&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;) &#8211; a herbal remedy used for depression<\/li><li>thyroid hormone.<\/li><\/ul>\n\n\n\n<p>You should also tell your doctor if you are taking or have recently taken medicines that may affect your heart rhythm, for example:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines for irregular heartbeats (eg&nbsp;quinidine&nbsp;and sotalol)<\/li><li>astemizole and terfenadine (used to treat&nbsp;allergies&nbsp;and hay fever)<\/li><li>medicines used to treat mental illness (eg pimozide and sertindole)<\/li><li>cisapride (used to treat certain types of indigestion)<\/li><li>halofantrine (used against&nbsp;malaria&nbsp;)<\/li><li>methadone&nbsp;(used for pain and detoxification)<\/li><li>diuretics&nbsp;(&nbsp;diuretics&nbsp;such as&nbsp;furosemide&nbsp;).<\/li><\/ul>\n\n\n\n<p>If you are going to have an operation and receive general or local anesthesia, tell your doctor that you are taking this medicine.<br><\/p>\n\n\n\n<p>In the same way, you should tell your dentist that you are taking this medicine if you are to receive&nbsp;local anesthesia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Amitriptyline Abcur with alcohol<\/h2>\n\n\n\n<p>You should not drink alcohol during treatment with this medicine as the&nbsp;sedative effect (such as drowsiness and lethargy) may worsen.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p>Amitriptyline is not recommended during pregnancy, unless your doctor considers it absolutely necessary, and only after careful analysis of the risks and benefits of treatment.&nbsp;If you have taken the medicine during the latter part of the pregnancy, the newborn baby may experience withdrawal symptoms (withdrawal symptoms) such as&nbsp;anxiety\/irritability, muscle tension, tremors, irregular breathing, difficulty eating, loud crying, difficulty urinating, and constipation.<\/p>\n\n\n\n<p>Your doctor will tell you if you should start, continue or stop breast-feeding or if you should stop using the medicine.&nbsp;This is after the doctor has assessed the benefit of breastfeeding for the baby and the benefit of treatment for you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>This medicine may cause drowsiness and dizziness, especially at the beginning of treatment.&nbsp;Do not drive or use tools if this occurs.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Amitriptyline Abcur contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Amitriptyline Abcur<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.&nbsp;<br><br><strong><em>Depression<\/em><\/strong><\/p>\n\n\n\n<p><em>Adults<\/em><\/p>\n\n\n\n<p>The recommended starting dose is 25 mg twice daily.<\/p>\n\n\n\n<p>Depending on the effect you get from the medicine, your doctor may gradually increase the&nbsp;dose to&nbsp;one to 150 mg per day, divided into two&nbsp;doses.<\/p>\n\n\n\n<p><em>Elderly (over 65 years) and patients with cardiovascular disease<\/em><\/p>\n\n\n\n<p>The recommended starting dose is 10-25 mg daily.<\/p>\n\n\n\n<p>Depending on the effect of the medicine, your doctor may gradually increase your&nbsp;dose&nbsp;to a total daily&nbsp;dose&nbsp;of 100 mg, divided into two&nbsp;doses.&nbsp;If you are given a&nbsp;dose in the range of 100-150 mg, your doctor may need to follow up your treatment more often.<\/p>\n\n\n\n<p><strong>Use for children and adolescents<\/strong><\/p>\n\n\n\n<p>This medicine should not be given to children or adolescents for the treatment of depression.&nbsp;For more information, see section 2.<br><\/p>\n\n\n\n<p><strong><em>Neuropathic pain,&nbsp;chronic&nbsp;tension-type headache, and preventive treatment of&nbsp;migraine<\/em><\/strong><\/p>\n\n\n\n<p>Your doctor will adjust the treatment according to your symptoms and your treatment response.<br><\/p>\n\n\n\n<p><em>Adults<\/em><\/p>\n\n\n\n<p>The recommended starting dose is 10-25 mg in the evening.<br><\/p>\n\n\n\n<p>The recommended daily&nbsp;dose&nbsp;is 25-75 mg.<br><\/p>\n\n\n\n<p>Depending on the effect you get from the medicine, your doctor may gradually increase the&nbsp;dose.&nbsp;If you are given a&nbsp;dose&nbsp;of more than 100 mg daily, your doctor may need to monitor your treatment more often.&nbsp;Your doctor will tell you if you should take a&nbsp;dose&nbsp;once a day or divided it into two doses.<\/p>\n\n\n\n<p><em>Elderly&nbsp;<\/em><em>(over 65 years) and patients with cardiovascular disease<\/em><\/p>\n\n\n\n<p>The recommended&nbsp;initial&nbsp;dose&nbsp;is 10-25 mg in the evening.<br><\/p>\n\n\n\n<p>Depending on the effect of the medicine, your doctor may increase the&nbsp;dose gradually.&nbsp;If you are given a&nbsp;dose of&nbsp;more than 75 mg daily, your doctor may need to monitor your treatment more often.<\/p>\n\n\n\n<p><strong>Use for children and adolescents<\/strong><\/p>\n\n\n\n<p>It should not be given to children and adolescents for the treatment of&nbsp;neuropathic pain, for the treatment of&nbsp;chronic headache, or for the treatment of&nbsp;migraine.&nbsp;For more information, see section 2.<br><\/p>\n\n\n\n<p><strong><em>Nocturnal bedwetting<\/em><\/strong><\/p>\n\n\n\n<p><em>Use for children and adolescents<\/em><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for children:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>for 6 years: see section 2 Do not take Amitriptyline Abcur<\/li><li>aged 6 to 10 years: 10 \u00e5r20 mg daily.&nbsp;A suitable dosage form should be used for this age group.<\/li><li>from 11 years: 25\u201150 mg.<\/li><\/ul>\n\n\n\n<p>The dose&nbsp;should be increased gradually according to the doctor&#8217;s&nbsp;prescription.<br><\/p>\n\n\n\n<p>Take this medicine 1\u20131\u00bd hours before bedtime.<br><\/p>\n\n\n\n<p>Before starting treatment, your doctor will examine your heart with an&nbsp;ECG&nbsp;to see if there are any signs of an unusual heartbeat.<br><\/p>\n\n\n\n<p>Your doctor will re-evaluate the treatment after 3 months and if necessary take a new&nbsp;ECG.<\/p>\n\n\n\n<p>Do not stop treatment without first consulting your doctor.<\/p>\n\n\n\n<p><em>Patients at particular risk<\/em><\/p>\n\n\n\n<p>Patients with liver disease or people who are known to be &#8220;slow metabolizers&#8221; of certain drugs usually receive lower&nbsp;doses.&nbsp;Your doctor may take blood samples to check the concentration of amitriptyline in your blood (see also section 2).<br><\/p>\n\n\n\n<p><strong>How and when to take Amitriptyline Abcur<\/strong><\/p>\n\n\n\n<p>This medicine can be taken with or without food.<\/p>\n\n\n\n<p>Swallow the tablets with a little water.&nbsp;Do not chew them.<br><\/p>\n\n\n\n<p><strong>Treatment time<\/strong><\/p>\n\n\n\n<p>Do not change the dose of the medicine and do not stop taking the medicine without first consulting your doctor.<br><\/p>\n\n\n\n<p><strong><em>Depression<\/em><\/strong><\/p>\n\n\n\n<p>As with other antidepressants, it may take a few weeks before you feel any improvement.<br><\/p>\n\n\n\n<p>In the treatment of depression, the treatment period is individually adapted and is usually at least 6 months.&nbsp;The treatment time is determined by your doctor.<br><\/p>\n\n\n\n<p>Continue to take this medicine for the time your doctor recommends it.<br><\/p>\n\n\n\n<p>The underlying disease can persist for a long time.&nbsp;If you stop your treatment too soon, your symptoms may return.<br><\/p>\n\n\n\n<p><strong><em>Neuropathic pain,&nbsp;chronic&nbsp;tension-type headache, and preventive treatment of&nbsp;migraine<\/em><\/strong><\/p>\n\n\n\n<p>It may take a few weeks before you feel any improvement in your pain.<br><\/p>\n\n\n\n<p>Talk to your doctor about the duration of treatment and continue to take the medicine for the time your doctor recommends.<br><\/p>\n\n\n\n<p><strong><em>Nocturnal bedwetting<\/em><\/strong><\/p>\n\n\n\n<p>The doctor will evaluate whether the treatment should continue after 3 months.<\/p>\n\n\n\n<p>Symptoms of overdose include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>large&nbsp;pupils&nbsp;are<\/li><li>fast or irregular heartbeat<\/li><li>difficulty urinating<\/li><li>dry mouth&nbsp;and dry tongue<\/li><li>intestinal obstruction (constipation)<\/li><li>seizures<\/li><li>fever<\/li><li>anxiety or physical restlessness<\/li><li>confusion<\/li><li>hallucinations<\/li><li>uncontrolled movements<\/li><li>low&nbsp;blood pressure, weak&nbsp;pulse, pallor<\/li><li>breathing difficulties&nbsp;<\/li><li>bluish discoloration of the skin<\/li><li>decreased heart rate<\/li><li>somnolence<\/li><li>unconsciousness that can turn into&nbsp;a coma<\/li><li>various heart symptoms such as&nbsp;cardiac arrhythmia (&nbsp;AV block&nbsp;),&nbsp;heart failure, low&nbsp;blood pressure,&nbsp;cardiogenic&nbsp;shock&nbsp;(the heart does not pump around enough blood), metabolic&nbsp;acidosis&nbsp;(too low&nbsp;pH&nbsp;in the blood), too low levels of&nbsp;potassium&nbsp;in the blood.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Amitriptyline Abcur<\/h2>\n\n\n\n<p>Take the next&nbsp;dose&nbsp;as usual.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Amitriptyline Abcur<\/h2>\n\n\n\n<p>Your doctor will decide when and how to stop your treatment to avoid unpleasant symptoms that may occur during a sudden interruption (eg headache, malaise, insomnia, and irritability).<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If you get any of the following symptoms, consult a doctor immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Recurrent blurred vision, rainbow vision, and eye pain.&nbsp;Your eyes should be examined immediately before treatment with this medicine can continue.&nbsp;This may be a sign of&nbsp;acute&nbsp;glaucoma.&nbsp;The very rare&nbsp;side effect&nbsp;may affect up to 1 in 10,000 people.<\/li><li>A heart problem called &#8221;&nbsp;QT&nbsp;prolongation&#8221; (which can be seen on your&nbsp;electrocardiogram&nbsp;(&nbsp;ECG&nbsp;). The common&nbsp;side effect&nbsp;may affect up to 1 in 10 people.<\/li><li>Severe constipation, bloated stomach, fever, and vomiting.&nbsp;These symptoms may be due to parts of the intestinal muscles stopping functioning.&nbsp;Rare&nbsp;side effects&nbsp;may affect up to 1 in 1,000 people.<\/li><li>Yellow skin or yellow whites of the eyes (jaundice).&nbsp;Your liver may be affected.&nbsp;Rare&nbsp;side effects&nbsp;may affect up to 1 in 1,000 people.<\/li><li>Bruising, bleeding, pallor, or persistent sore throat and fever.&nbsp;These symptoms may be the first signs of an effect on the blood or&nbsp;bone marrow.&nbsp;Effects on the blood can be a reduced number of&nbsp;red blood cells&nbsp;(which carry oxygen in the body),&nbsp;white blood cells&nbsp;(which fight&nbsp;infections&nbsp;), and&nbsp;platelets&nbsp;(which help the blood to clot).&nbsp;Rare&nbsp;side effects&nbsp;may affect up to 1 in 1,000 people.<\/li><li>Suicidal ideation or suicidal ideation.&nbsp;Rare&nbsp;side effects&nbsp;may affect up to 1 in 1,000 people.<\/li><\/ul>\n\n\n\n<p>Adverse reactions&nbsp;listed below have been reported with the following frequencies:<br><\/p>\n\n\n\n<p>Very common: may affect more than 1 user in 10<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drowsiness\/drowsiness<\/li><li>tremors in the hands or other parts of the body<\/li><li>dizziness<\/li><li>headache<\/li><li>irregular, strong, or rapid heartbeat<\/li><li>dizziness due to a drop in blood pressure when you get up (&nbsp;orthostatic hypotension&nbsp;)<\/li><li>dry mouth<\/li><li>constipation<\/li><li>nausea<\/li><li>heavy sweating<\/li><li>weight gain<\/li><li>slurred or slow speech<\/li><li>aggression<\/li><li>nasal congestion.<\/li><\/ul>\n\n\n\n<p>Common: may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>confusion<\/li><li>sexual changes (decreased sexual drive,&nbsp;erection&nbsp;problems&nbsp;)<\/li><li>attention deficit disorder<\/li><li>taste changes<\/li><li>numbness and tingling in the arms and legs<\/li><li>coordination difficulties<\/li><li>large&nbsp;pupils&nbsp;are<\/li><li>heart rhythm disorder (&nbsp;AV block&nbsp;)<\/li><li>fatigue<\/li><li>low sodium content in the blood<\/li><li>anxiety, physical restlessness<\/li><li>various problems with the urinary tract<\/li><li>thirst.<\/li><\/ul>\n\n\n\n<p>Uncommon: may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>arousal, anxiety, difficulty sleeping, nightmares<\/li><li>cramps<\/li><li>tinnitus&nbsp;(ringing in the ears)<\/li><li>high&nbsp;blood pressure<\/li><li>diarrhea, vomiting<\/li><li>skin rash,&nbsp;hives&nbsp;(hives), swelling of the face and tongue<\/li><li>difficulty urinating<\/li><li>increased production of breast milk or excretion of breast milk (without breastfeeding)<\/li><li>elevated pressure in the eye<\/li><li>dizziness and fainting<\/li><li>worsening&nbsp;heart failure<\/li><li>hepatic impairment (eg cholestatic liver disease).<\/li><\/ul>\n\n\n\n<p>Rare: may affect up to 1 in 1,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased appetite<\/li><li>delirium, which is a condition with e.g.&nbsp;decreased consciousness, confusion or loss of reality (in elderly patients), or hallucinations<\/li><li>abnormal heart rhythm or irregular heartbeat<\/li><li>swollen salivary glands<\/li><li>hair loss<\/li><li>increased sensitivity to sunlight<\/li><li>mammary gland enlargement in men<\/li><li>fever<\/li><li>weight loss<\/li><li>abnormal liver function values.<\/li><\/ul>\n\n\n\n<p>Very rare: may affect up to 1 in 10,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart muscle disease<\/li><li>the feeling of inner restlessness and a strong need to be in constant motion<\/li><li>a condition called&nbsp;peripheral&nbsp;nerve disease, which involves e.g.&nbsp;numbness and tingling in the legs and feet, sensitivity to touch or deterioration of sensation<\/li><li>acute&nbsp;elevated pressure in the eye<\/li><li>special forms of abnormal heart rhythm (so-called&nbsp;torsades de pointes&nbsp;)<\/li><li>allergic&nbsp;inflammation&nbsp;in the alveoli and in the lung tissue<\/li><\/ul>\n\n\n\n<p>Has been reported: occurs in an unknown number of users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>loss of appetite<\/li><li>increase or decrease in blood sugar<\/li><li>paranoia&nbsp;(delusions)<\/li><li>motion sickness (involuntary movements or reduced movements)<\/li><li>myocarditis due to&nbsp;hypersensitivity reaction<\/li><li>inflammation&nbsp;of the liver<\/li><li>hot flashes<\/li><li>dry eyes<\/li><\/ul>\n\n\n\n<p>An increased risk of bone fractures has been observed in patients taking this type of medicine.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Amitriptyline Abcur<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;and on the blister card or jar after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Blister packs should not be stored above 30 \u00b0 C.&nbsp;Store blisters in the outer carton.&nbsp;Sensitive to light.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is amitriptyline.&nbsp;Each tablet contains 10, 25, and 50 mg amitriptyline respectively (as amitriptyline hydrochloride).<\/li><li>The other ingredients are&nbsp;lactose monohydrate,&nbsp;maize&nbsp;starch, povidone, magnesium stearate, talc, polyvinyl alcohol, macrogol, titanium dioxide (E171), and iron oxide (E172).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Amitriptyline Abcur 10 mg is a light pink, round, biconvex film-coated tablet without embossing, tablet size 7 x 3.4 mm.<\/p>\n\n\n\n<p>Amitriptyline Abcur 25 mg is a pink, round, biconvex film-coated tablet without embossing, tablet size 7 x 3.4 mm.<\/p>\n\n\n\n<p>Amitriptyline Abcur 50 mg is a brown-pink, round, biconvex film-coated tablet without embossing, tablet size 9 x 4.4 mm.<br><\/p>\n\n\n\n<p>Amitriptyline Abcur is available in:<\/p>\n\n\n\n<p>Jar: 20 and 100 tablets.<\/p>\n\n\n\n<p>Blister: 20 and 100 tablets.<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Abcur AB<\/p>\n\n\n\n<p>Box 1452<\/p>\n\n\n\n<p>251 14 Helsingborg<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Extractum Pharma Co.&nbsp;Ltd.<\/p>\n\n\n\n<p>6413 Kunfeh\u00e9rt\u00f3.&nbsp;IV.&nbsp;K\u00f6rzet 6<\/p>\n\n\n\n<p>Hungary<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amitriptyline Abcur belongs to the group of tricyclic antidepressants.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10613,10623,10626,10616,10617,10627,10625,10615,10614,10624],"class_list":["post-5351","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-amitriptyline","tag-amitriptyline-abcur","tag-amitriptyline-abcur-tablet","tag-amitriptyline-tablet","tag-side-effects-of-amitriptyline","tag-side-effects-of-amitriptyline-abcur","tag-what-amitriptyline-abcur-is-used-for","tag-what-amitriptyline-is-used-for","tag-what-is-amitriptyline","tag-what-is-amitriptyline-abcur"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5351"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5351\/revisions"}],"predecessor-version":[{"id":12722,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5351\/revisions\/12722"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}