{"id":5309,"date":"2020-12-15T10:43:36","date_gmt":"2020-12-15T10:43:36","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5309"},"modified":"2021-07-28T18:33:02","modified_gmt":"2021-07-28T18:33:02","slug":"ambisome-liposomal","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ambisome-liposomal\/","title":{"rendered":"AmBisome liposomal &#8211; Amphotericin B uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg&nbsp;powder for&nbsp;infusion&nbsp;,&nbsp;dispersion<br>Amphotericin B<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What AmBisome liposomal is and what it is used for<\/h2>\n\n\n\n<p>The active substance in AmBisome liposomal is amphotericin B which is encapsulated in small fat particles (&nbsp;liposomes&nbsp;).&nbsp;AmBisome liposomal is an&nbsp;antibiotic&nbsp;used to treat serious&nbsp;infections&nbsp;caused by fungi.&nbsp;You will receive the medicine as an&nbsp;infusion&nbsp;into a blood vessel.<\/p>\n\n\n\n<p>AmBisome liposomal is also used to treat visceral leishmaniasis, a disease caused by a parasite<\/p>\n\n\n\n<p>AmBisome liposomal can also be used to treat patients who are suspected of having fungal infections and fever and are deficient in a type of&nbsp;white blood cell&nbsp;called&nbsp;neutrophils.&nbsp;Neutrophils&nbsp;are a type of white blood cell that helps fight&nbsp;infection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using AmBisome liposomal<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use AmBisome liposomal:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic (hypersensitive)<\/strong>&nbsp;to amphotericin B or any of the other ingredients of AmBisome liposomal.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you get a severe&nbsp;anaphylactic reaction: the doctor will discontinue the&nbsp;infusion. <\/strong>An&nbsp;anaphylactic reaction&nbsp;is an&nbsp;acute, life-threatening&nbsp;allergic reaction&nbsp;with such symptoms as&nbsp;redness,&nbsp;itching, nausea, swelling of the face, mouth, tongue, and airways, often so severe that it becomes difficult to breathe.<\/li><li><strong>if you get other reactions that are thought to be due to the infusion: <\/strong>your doctor may slow down the&nbsp;infusion rate&nbsp;so that you get AmBisome liposomal for a longer period of time (about 2 hours).&nbsp;Your doctor may also give you medicines that prevent reactions to&nbsp;infusion&nbsp;one.&nbsp;See section 4 Possible&nbsp;Side Effects&nbsp;below.<\/li><li><strong>if you are taking other medicines that may cause kidney damage<\/strong>.AmBisome liposomal can damage the kidneys.&nbsp;Your doctor or nurse will take regular blood tests to test for&nbsp;creatinine&nbsp;(a chemical substance in the blood that shows kidney function) and electrolyte levels (especially&nbsp;potassium&nbsp;and&nbsp;magnesium&nbsp;) which may be abnormal due to impaired kidney function.&nbsp;This is especially important if you are taking other medicines that could damage your kidneys.&nbsp;The blood samples will also be tested for changes in your liver function and the body&#8217;s ability to produce new blood cells.<\/li><li><strong>if the results of the blood tests show that you have a low level of&nbsp;potassium in your blood: <\/strong>your doctor may prescribe a potassium supplement to take while you are receiving AmBisome liposomal.<\/li><li><strong>if the results of your blood tests show a change in kidney function or other important changes: <\/strong>your doctor may give you a lower&nbsp;dose of&nbsp;AmBisome liposomal or discontinue treatment.<\/li><li><strong>if you are receiving or have just had a&nbsp;transfusion&nbsp;of white blood cells (&nbsp;leukocytes&nbsp;). <\/strong>Acute and severe lung problems can occur if you receive an AmBisome liposomal&nbsp;infusion&nbsp;during or shortly after a&nbsp;white blood cell&nbsp;transfusion, and therefore your doctor will recommend that the&nbsp;infusions&nbsp;be given as long as possible to reduce the risk of lung problems.&nbsp;In addition, your lung function will be monitored.<\/li><li><strong>if you have&nbsp;diabetes.&nbsp;<\/strong>Each&nbsp;vial&nbsp;of AmBisome liposomal contains approximately 900 milligrams of sucrose (sugar).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and AmBisome liposomal<\/h2>\n\n\n\n<p>Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription<\/p>\n\n\n\n<p>It is known that the following medicines may affect or be affected by the concomitant use of AmBisome liposomal.<\/p>\n\n\n\n<p>\u2022&nbsp;<strong>Medicines that can cause kidney damage, including:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Immunosuppressive drugs (drugs that reduce the activity of the body&#8217;s natural defenses) e.g.&nbsp;<strong>cyclosporine<\/strong>.<\/li><li>Drugs in the antibiotic group called&nbsp;<strong>aminoglycosides.<\/strong><\/li><li><strong>Pentamidine<\/strong>, a drug used to treat&nbsp;pneumonia&nbsp;in patients with&nbsp;AIDS&nbsp;and leishmaniasis.<\/li><\/ul>\n\n\n\n<p>These medicines can cause kidney damage and AmBisome liposomal can aggravate kidney damage.&nbsp;If you are taking medicines that can cause kidney damage, your doctor or nurse will take regular blood tests to see if there have been any changes in your kidney function.<br><\/p>\n\n\n\n<p>\u2022&nbsp;<strong>Medicines that can lower potassium levels,<\/strong>&nbsp;including:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Corticosteroid&nbsp;s<\/strong>&nbsp;(cortisone: an anti-inflammatory drug that acts by reducing the immune system&#8217;s reaction) and<strong>&nbsp;corticotropin&nbsp;<\/strong>(ACTH), used to control the speed of the natural production of&nbsp;corticosteroid&nbsp;s.<\/li><li><strong>Diuretics<\/strong>&nbsp;(&nbsp;diuretics&nbsp;), e.g.&nbsp;<strong>furosemide<\/strong>&nbsp;.<\/li><li><strong>Digitalis glycosides<\/strong>&nbsp;used to treat&nbsp;heart failure.&nbsp;AmBisome liposomal can lower the level of potassium in the blood which can aggravate the&nbsp;side effects&nbsp;of&nbsp;digitalis(changes in heart rhythm).<\/li><li><strong>Muscle relaxants<\/strong>&nbsp;(eg&nbsp;<strong>tubocurarine<\/strong>&nbsp;).&nbsp;AmBisome liposomal can increase the muscle relaxing effect.<\/li><\/ul>\n\n\n\n<p>\u2022&nbsp;<strong>Other medicines<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Medicines against fungi<\/strong>, e.g.&nbsp;<strong>flucytosine.&nbsp;<\/strong>AmBisome liposomal can aggravate the&nbsp;side effects&nbsp;of flucytosine (changes in the body&#8217;s ability to produce new blood cells as seen in blood tests).<\/li><li><strong>Cancer drugs<\/strong>&nbsp;(antineoplastic drugs) such as&nbsp;<strong>methotrexate, doxorubicin, carmustine, and cyclophosphamide<\/strong>.&nbsp;Taking this type of medicine at the same time as you receive AmBisome liposomal&nbsp;infusion&nbsp;may cause kidney damage, wheezing or difficulty breathing, and low&nbsp;blood pressure.<\/li><li><strong>The transfusion&nbsp;is of white blood cells (&nbsp;leukocytes&nbsp;)<\/strong>.&nbsp;Acute and severe lung problems have occurred in patients receiving amphotericin B during or shortly after&nbsp;transfusion&nbsp;of white blood cells.&nbsp;The infusions&nbsp;should be given at as long intervals as possible and lung function should be monitored.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>The safety of AmBisome liposomal in pregnant women is unknown.&nbsp;If you are pregnant, your doctor will prescribe AmBisome liposomal only if he\/she considers the benefits of the treatment to outweigh the potential risks to you and your unborn baby.<\/p>\n\n\n\n<p>It is not known if AmBisome liposomal passes into breast milk.&nbsp;A decision to breastfeed or not while receiving AmBisome liposomal should be based on the potential risk to the baby, the benefit of breast-feeding to the baby, and the benefit of AmBisome liposomal therapy to the mother.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Some of the&nbsp;side effects&nbsp;of AmBisome liposomal may affect your ability to drive or use machines safely (see section 4 on Possible&nbsp;side effects&nbsp;).<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use AmBisome liposomal<\/h2>\n\n\n\n<p>You will always receive AmBisome liposomal from a doctor or nurse.<\/p>\n\n\n\n<p><strong>Adults<\/strong><br><\/p>\n\n\n\n<p>The&nbsp;dose of an AmBisome liposomal depends on body weight and is adjusted according to the needs of each individual patient.<\/p>\n\n\n\n<p>For the treatment of systemic fungal infections, the treatment can usually last up to 21 days.<br><\/p>\n\n\n\n<p>You will receive the appropriate&nbsp;dose of&nbsp;an AmBisome liposomal as an&nbsp;infusion&nbsp;into a vein.<br><\/p>\n\n\n\n<p>Normally it takes&nbsp;infusion,&nbsp;30 to 60 minutes, but the larger&nbsp;the dose&nbsp;you can&nbsp;infusion&nbsp;takes up to 2 hours.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, AmBisome liposomal can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p>Fever, chills, and chills are the most common reactions associated with&nbsp;infusion&nbsp;one.<\/p>\n\n\n\n<p>Uncommon reactions to&nbsp;infusion&nbsp;may include tightness in the chest, chest pain, shortness of breath, difficulty breathing (possibly with wheezing),&nbsp;redness, a faster-than-normal heart rate, low&nbsp;blood pressure,&nbsp;and pain in the joints, back, or skeleton (musculoskeletal pain).&nbsp;These pass quickly when the&nbsp;infusion&nbsp;is stopped.&nbsp;These reactions do not need to occur during future&nbsp;infusions&nbsp;of AmBisome liposomal or when a slower infusion rate (2 hours) is used.<br><\/p>\n\n\n\n<p>Your doctor may give you other medicines to prevent&nbsp;infusion&nbsp;reactions&nbsp;or to treat the symptoms should they occur.&nbsp;For example, you can get medicines for pain, hypersensitivity, or medicines that work by reducing the reaction of the immune system.<br><\/p>\n\n\n\n<p>If you get a severe reaction to&nbsp;infusion&nbsp;one, your doctor will discontinue AmBisome liposomal&nbsp;infusion&nbsp;one and you should not receive this treatment in the future.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have occurred during treatment with AmBisome liposomal:<br><\/p>\n\n\n\n<p><strong>Very common<\/strong><\/p>\n\n\n\n<p><em>(may affect more than 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Feeling tired or confused or muscle weakness or cramps caused by low potassium levels in the blood<\/li><li>Nausea, vomiting<\/li><li>Fever, chills, or chills<\/li><\/ul>\n\n\n\n<p><strong>Usual<\/strong><\/p>\n\n\n\n<p><em>(may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fatigue or confusion or muscle weakness or cramps caused by low levels of&nbsp;magnesium,&nbsp;calcium,&nbsp;or&nbsp;sodium&nbsp;in the blood<\/li><li>High blood sugar levels<\/li><li>Headache<\/li><li>Faster heart rate than usual<\/li><li>Dilation of blood vessels, low&nbsp;blood pressure,&nbsp;and&nbsp;redness<\/li><li>Shortness of breath<\/li><li>Diarrhea, abdominal pain<\/li><li>Abnormal results regarding liver or kidney function seen in blood or urine tests<\/li><li>Rash<\/li><li>Chest or back pain<\/li><\/ul>\n\n\n\n<p><strong>Less common<\/strong><\/p>\n\n\n\n<p><em>(may affect up to 1 in 100 people)&nbsp;<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bleeding in the skin, bruising for no apparent reason, and bleeding for a long time after an injury<\/li><li>Allergy-like (anaphylactoid) reaction [(see section 2 of this leaflet for information on severe&nbsp;hypersensitivity reactions&nbsp;(anaphylactic reactions)].<\/li><li>Seizures (attacks or seizures)<\/li><li>Breathing difficulties, possibly with wheezing<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong><\/p>\n\n\n\n<p><em>(occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anemia&nbsp;(&nbsp;anemia&nbsp;&#8211; a decrease in the number of&nbsp;red blood cells&nbsp;in the blood, with symptoms in the form of pronounced fatigue, shortness of breath after light activity, and pallor)<\/li><li>Anaphylactic reactions and&nbsp;hypersensitivity reactions&nbsp;(see section 2 of this leaflet for information on anaphylactic reactions)<\/li><li>Heart attacks and a change in the normal heart rhythm<\/li><li>Renal failure&nbsp;and renal impairment<\/li><li>Severe swelling of the skin around the lips and eyes or of the tongue<\/li><li>Muscle breakdown<\/li><li>Skeletal pain and joint pain<\/li><\/ul>\n\n\n\n<p><strong>Impact on phosphorus blood test results.&nbsp;<\/strong>False results that show increased levels of&nbsp;phosphates&nbsp;in your blood can occur during analysis with a special analysis method called the PHOSm method.<br><\/p>\n\n\n\n<p>If your test shows high levels of&nbsp;phosphates, another test with another method may be necessary to confirm the results.<br><\/p>\n\n\n\n<p>If any of the&nbsp;side effects&nbsp;gets serious, or if you notice any&nbsp;side effects&nbsp;not listed in this leaflet, please tell your doctor.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store AmBisome liposomal<\/h2>\n\n\n\n<p>Keep out of sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label after {EXP}.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance in each&nbsp;vial&nbsp;is amphotericin B 50 mg, encapsulated in&nbsp;liposomes&nbsp;(small fat particles).<br><\/li><li>The other ingredients are hydrogenated soy phosphatidylcholine,&nbsp;cholesterol, di-stearoyl phosphatidylglycerol, sucrose (sugar), disodium succinate hexahydrate, alpha-tocopherol, sodium hydroxide, and&nbsp;hydrochloric acid.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>AmBisome liposomal is a lyophilized powder for&nbsp;infusion,&nbsp;dispersion.&nbsp;It is a sterile, light yellow powder that is supplied in a 15, 20,112 or 30-milliliter glass vial.&nbsp;Each&nbsp;vial contains 50 milligrams of the active substance, amphotericin B. The closure consists of a rubber stopper and a sealing aluminum ring with a removable plastic cap.&nbsp;Ten vials are packed in a carton along with 10 filters.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>Carrigtohill,<\/p>\n\n\n\n<p>County Cork, T45 DP77<\/p>\n\n\n\n<p>Ireland<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>IDA Business &amp; Technology Park<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active substance in AmBisome liposomal is amphotericin B which is encapsulated in small fat particles ( liposomes ). AmBisome liposomal is an antibiotic used to treat serious infections caused by fungi. You will receive the medicine as an infusion into a blood vessel.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10705,10708,10700,10703,10709,10704,10707,10702,10706,10701],"class_list":["post-5309","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-ambisome-liposomal","tag-ambisome-liposomal-powder","tag-amphotericin-b","tag-amphotericin-b-powder","tag-side-effects-of-ambisome-liposomal","tag-side-effects-of-amphotericin-b","tag-what-ambisome-liposomal-is-used-for","tag-what-amphotericin-b-is-used-for","tag-what-is-ambisome-liposomal","tag-what-is-amphotericin-b"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5309","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5309"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5309\/revisions"}],"predecessor-version":[{"id":12761,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5309\/revisions\/12761"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5309"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5309"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}