{"id":5250,"date":"2020-12-14T06:53:42","date_gmt":"2020-12-14T06:53:42","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5250"},"modified":"2021-08-02T07:03:37","modified_gmt":"2021-08-02T07:03:37","slug":"alpoxen","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/alpoxen\/","title":{"rendered":"Alpoxen &#8211; Naproxen uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n250 mg, 500 mg&nbsp;tablet&nbsp;<br>naproxen<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Alpoxen is and what it is used for<\/h2>\n\n\n\n<p>Alpoxen is&nbsp;anti-inflammatory, analgesic, and antipyretic.&nbsp;Alpoxen belongs to a group of medicines called&nbsp;NSAIDs&nbsp;(non-steroidal anti-inflammatory \/ anti-rheumatic medicines).<br><\/p>\n\n\n\n<p>Alpoxen is used for&nbsp;rheumatoid arthritis, degenerative joint changes, spinal stiffness (Bechterew&#8217;s disease), acute migraine attacks, acute mild to moderate&nbsp;intensity&nbsp;pain, and menstrual cramps.<\/p>\n\n\n\n<p>Naproxen&nbsp;contained in Alpoxen may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you take Alpoxen<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Alpoxen<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;naproxen&nbsp;or any of the other ingredients of this medicine (listed in section 6.)<\/li><li>if you have previously had allergic reactions such as&nbsp;asthma, runny nose, or rash when you have taken painkillers containing&nbsp;acetylsalicylic acid&nbsp;or other medicines for pain\/inflammation within the group&nbsp;NSAID<\/li><li>if you have an increased tendency to bleed<\/li><li>if you have or have had recurrent&nbsp;stomach ulcers&nbsp;or duodenal&nbsp;ulcers<\/li><li>if you have had&nbsp;stomach ulcers&nbsp;or duodenal&nbsp;ulcers&nbsp;during treatment with&nbsp;naproxen&nbsp;or similar preparations<\/li><li>if you have severe liver disease<\/li><li>if you have severe&nbsp;heart failure<\/li><li>if you have severe kidney disease<\/li><li>during the last three months of pregnancy<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>The lowest&nbsp;possible&nbsp;dose&nbsp;and the shortest possible treatment time should always be sought to reduce the risk of&nbsp;side effects.&nbsp;In general, higher&nbsp;doses&nbsp;than recommended can lead to risks.&nbsp;This also means that the combination of several&nbsp;NSAIDs&nbsp;at the same dose should be avoided.<br><\/p>\n\n\n\n<p>If you have or have had any of the following conditions, you should consult a doctor before starting treatment with Alpoxen:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>gastric ulcer&nbsp;or duodenal&nbsp;ulcer<\/li><li>inflammatory bowel disease (&nbsp;ulcerative colitis,&nbsp;Crohn&#8217;s disease&nbsp;)<\/li><li>the skin disease&nbsp;SLE&nbsp;(connective tissue disease)<\/li><li>diseases with an increased tendency to bleed<\/li><li>impaired cardiac, hepatic or renal function<\/li><li>high&nbsp;blood pressure<\/li><li>asthma&nbsp;or&nbsp;allergies&nbsp;are<\/li><\/ul>\n\n\n\n<p>Elderly people should be aware of the increased risk of&nbsp;side effects&nbsp;that occur with older age.<br><\/p>\n\n\n\n<p>Bleeding, ulcers, or rupture of the gastrointestinal tract, which can be fatal, have been reported with all&nbsp;NSAIDs&nbsp;and have occurred regardless of the duration of treatment, with or without warning symptoms or previous severe gastrointestinal side effects.&nbsp;Stop taking Alpoxen and contact a doctor immediately if you experience severe abdominal pain, or discover blood in your vomit or your stools.<br><\/p>\n\n\n\n<p>Especially at the beginning of treatment, patients who have previously had problems with the gastrointestinal tract, especially elderly patients, should contact a doctor in case of symptoms from the abdomen.<\/p>\n\n\n\n<p>Some patients with a high risk of&nbsp;side effects&nbsp;may be prescribed another medicine while taking Alpoxen to reduce the risk of gastrointestinal side effects.<\/p>\n\n\n\n<p>Severe skin reactions when using&nbsp;NSAIDs&nbsp;have been reported in very rare cases.&nbsp;The risk of this reaction is higher at the beginning of treatment, most of the cases occur during the first month of treatment.&nbsp;Stop taking Alpoxen and consult a doctor if you get a rash or damage to the mucous membranes.&nbsp;See also section 4.<\/p>\n\n\n\n<p>Medicines such as Alpoxen may have a small increased risk of heart attack or&nbsp;stroke.&nbsp;Such an increase in risk is more likely with the use of high&nbsp;doses&nbsp;and with long-term treatment.&nbsp;Do not exceed the recommended&nbsp;dose&nbsp;or treatment time (see section 3).<br><\/p>\n\n\n\n<p>Consult your doctor or pharmacist about your treatment if you have heart problems, if you have had a&nbsp;stroke&nbsp;before,&nbsp;or if you think you are at risk for these conditions (eg if you have high&nbsp;blood pressure,&nbsp;diabetes, high cholesterol, or if you smoke).<\/p>\n\n\n\n<p>After long-term use (more than 3 months) of Alpoxen every other day or more, headaches may develop or worsen.&nbsp;This headache should not be treated with a higher&nbsp;dose, but treatment with Alpoxen should then be stopped in consultation with a doctor.<br><\/p>\n\n\n\n<p>The results of some urine tests may be affected if you take Alpoxen.&nbsp;Tell your doctor that you are taking Alpoxen if you are going to take a urine sample.<\/p>\n\n\n\n<p>This medicine should not be used for chickenpox (see section 4).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Children under 5 years of age should not be treated with Alpoxen.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Alpoxen<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.&nbsp;Never use several different painkillers at the same time without consulting a doctor or pharmacist.<br><\/p>\n\n\n\n<p>Alpoxen can affect or be affected by certain other medicines, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>certain anticoagulants (eg&nbsp;warfarin,&nbsp;acetylsalicylic acid, ticlopidine)<\/li><li>certain anti-tumor&nbsp;drugs&nbsp;and disorders of the immune system (eg methotrexate)<\/li><li>certain&nbsp;antihypertensive&nbsp;agents&nbsp;(eg&nbsp;ACE inhibitors,&nbsp;angiotensin&nbsp;II inhibitors)<\/li><li>diuretic&nbsp;drugs<\/li><li>certain antidepressants (&nbsp;SSRIs&nbsp;)<\/li><li>certain medicines for&nbsp;inflammation&nbsp;(&nbsp;corticosteroids&nbsp;)<\/li><li>drugs containing lithium (for manic depression)<\/li><li>medicines containing tacrolimus, ciclosporin, probenecid, clopidogrel, or cholestyramine.<\/li><li>medicines for acid stomach (antacids).<\/li><\/ul>\n\n\n\n<p>Concomitant use of other&nbsp;NSAIDs&nbsp;should be avoided as the risk of&nbsp;side effects increases.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The alpoxen with food<\/h2>\n\n\n\n<p>The effect of Alpoxen can be delayed if taken with food at the same time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>Pregnant women should not use Alpoxen during the last three months of pregnancy.&nbsp;Alpoxen should be avoided by women who are planning to become pregnant or are pregnant.&nbsp;Treatment during any part of the pregnancy should only be done after a doctor&#8217;s&nbsp;prescription.<br><\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Alpoxen passes into breast milk but is unlikely to affect breastfed infants.&nbsp;However, consult a physician if you use Alpoxen more than temporarily during breastfeeding.<br><\/p>\n\n\n\n<p><em>Fertility<\/em><\/p>\n\n\n\n<p>The use of Alpoxen may, as with any medicinal product that inhibits cyclooxygenase\/prostaglandin synthesis, make it difficult to conceive.&nbsp;Tell your doctor if you are planning to have a baby or if you have problems getting pregnant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Alpoxen can impair the reactivity of some people, which should be borne in mind at times when sharper attention is required, such as driving and precision work.<br><\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Alpoxen contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Alpoxen<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<p><em>In rheumatic diseases and mild to moderate&nbsp;acute&nbsp;pain: the<\/em>&nbsp;recommended&nbsp;dose&nbsp;for adults is 250-500 mg morning and evening, no more than 1,000 mg\/day.&nbsp;In case of pronounced night and morning symptoms, a&nbsp;dose of&nbsp;500 mg can be taken with the advantage in the evening.<\/p>\n\n\n\n<p>Some patients may benefit from taking 750-1,000 mg once daily.&nbsp;When&nbsp;dosing&nbsp;with 1000 mg as a single dose, intake in the evening is recommended.<br><\/p>\n\n\n\n<p><em>For menstrual pain: the<\/em>&nbsp;recommended&nbsp;dose&nbsp;for adults is 250-500 mg if needed, but not more than 1,250 mg\/day.&nbsp;Treatment is started at the first sign of menstrual bleeding.<br><\/p>\n\n\n\n<p><em>In acute migraine attacks: the<\/em>&nbsp;recommended&nbsp;dose&nbsp;for adults is 750 mg at the first sensation, then 250 mg if necessary, but not more than 1,250 mg\/day.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p><em>Children over 5 years of age: the<\/em>&nbsp;recommended&nbsp;dose&nbsp;is 125 mg (1\/2 tablet of 250 mg) morning and evening.&nbsp;Children weighing more than 50 kg should use the same&nbsp;dose as adults.<\/p>\n\n\n\n<p>Alpoxen is not recommended for children with acute pain.<br><\/p>\n\n\n\n<p>The tablet can be divided into two equal&nbsp;doses.<br><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Alpoxen<\/h2>\n\n\n\n<p>If you forget to take a&nbsp;dose, take it as soon as you remember.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten dose.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>An adverse reaction&nbsp;is from the gastrointestinal tract such as digestive disorders, abdominal pain and nausea are the most common&nbsp;side effects&nbsp;are.<br><\/p>\n\n\n\n<p>Ulcers, rupture, and\/or bleeding in the gastrointestinal tract (sometimes fatal, especially in the elderly) may occur during treatment with Alpoxen.<br><\/p>\n\n\n\n<p><strong>Stop taking Alpoxen and contact a doctor immediately<\/strong>&nbsp;if you experience any of the following rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A severe&nbsp;allergic reaction&nbsp;that causes difficulty breathing or dizziness<\/li><li>Swelling of the face, tongue, or throat;&nbsp;difficulty swallowing;&nbsp;hives&nbsp;and difficulty breathing (&nbsp;angioedema&nbsp;).<\/li><li>Serious skin reactions such as:<ul><li>an extremely severe&nbsp;allergic reaction&nbsp;with skin rash usually in the form of blisters or sores in the oral cavity and eyes, as well as other mucous membranes such as genitals<\/li><li>severe widespread skin damage (skin peeling of the epidermis and superficial mucous membranes)<\/li><li>severe skin rash<\/li><\/ul><\/li><li>Alex can in rare cases affect the white&nbsp;blood cells&nbsp;so that the&nbsp;defense against&nbsp;infection deteriorates.&nbsp;If you get an&nbsp;infection&nbsp;with symptoms such as fever with severe general deterioration or fever with local infection symptoms such as sore throat\/throat\/mouth or difficulty urinating, you should see a doctor as soon as possible so that blood tests can rule out a lack of&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis).&nbsp;It is important that you then information about your medication.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;include:<\/strong><\/p>\n\n\n\n<p><em>Common (may affect up to 1 to 10 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drowsiness, dizziness, headache<\/li><li>Visual disturbances<\/li><li>Tinnitus<\/li><li>Palpitation<\/li><li>Acid reflux, heartburn, abdominal pain, nausea, vomiting, diarrhea, constipation,&nbsp;inflammation&nbsp;of the mouth, flatulence<\/li><li>Rash or superficial skin ulcers<\/li><li>Swelling in the body due to fluid retention (&nbsp;edema&nbsp;), thirst, sweating<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 to 100 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Difficulty sleeping, difficulty concentrating<\/li><li>Hearing loss<\/li><li>Asthma, shortness of breath<\/li><li>Intestinal bleeding,&nbsp;stomach ulcers,&nbsp;inflammation&nbsp;and sores in the mouth, bloody stools<\/li><li>Liver effects<\/li><li>Hives, photosensitivity that causes&nbsp;inflammation&nbsp;and blisters on the skin.&nbsp;Contact a doctor if you develop blisters on the skin.<\/li><li>Kidney impact<\/li><li>Hair loss, fever<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Meningitis<\/li><li>Impact on the blood picture<\/li><li>Elevated potassium levels in the blood<\/li><li>Mental disorders that can affect learning, memory, perception, and problem solving<\/li><li>Depression, nightmares, and mild anxiety<\/li><li>Seizures<\/li><li>Heart failure<\/li><li>Inflammation&nbsp;of the walls of blood vessels, high&nbsp;blood pressure<\/li><li>Pneumonia, fluid accumulation in the lungs<\/li><li>Inflammation&nbsp;of the colon, worsening of certain inflammatory bowel diseases (&nbsp;Crohn&#8217;s disease,&nbsp;ulcerative colitis&nbsp;), rupture of the stomach \/ intestinal wall,&nbsp;inflammation&nbsp;of the esophagus,&nbsp;inflammation&nbsp;of the pancreas, vomiting of blood,&nbsp;inflammation&nbsp;of the stomach<\/li><li>Hepatitis (&nbsp;hepatitis, isolated cases have been fatal)<\/li><li>Muscle weakness, muscle pain<\/li><li>Bloody urine<\/li><\/ul>\n\n\n\n<p>Medicines such as Alpoxen may cause a slight increase in the risk of heart attack or&nbsp;stroke&nbsp;(see section 2 Warnings and precautions).<br><\/p>\n\n\n\n<p>Drugs such as Alpoxen may affect the results of certain liver tests.<br><\/p>\n\n\n\n<p>In rare cases, severe skin infections are associated with chickenpox.<br><\/p>\n\n\n\n<p>Alpoxen may increase your risk of bleeding.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Alpoxen<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>No special storage instructions.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;naproxen.&nbsp;Each tablet contains 250 mg and 500 mg&nbsp;naproxen,&nbsp;respectively.<\/li><li>The other ingredients are&nbsp;lactose monohydrate&nbsp;15 mg and 30 mg respectively, carmellose sodium, hypromellose, magnesium stearate, silica (&nbsp;colloidal, anhydrous).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p><em>Tablets 250 mg<\/em>&nbsp;<br>White, capsule-shaped tablets with a scoreline, marked \u201cAL\u201d on one side and marked \u201cN\u201d and \u201c250\u201d on the other side.&nbsp;12 x 7 mm.<\/p>\n\n\n\n<p>Printing packaging: 10, 20, 25, 28, 50&#215;1 (single dose), 98 and 100 pcs.&nbsp;<br>Plastic jar: 25, 30, 100, and 250 pcs (rheumatism packaging).<br><\/p>\n\n\n\n<p><em>Tablets 500 mg<\/em>&nbsp;<br>White, capsule-shaped tablets with a scoreline, marked \u201cAL\u201d on one side and marked \u201cN\u201d and \u201c500\u201d on the other side.&nbsp;18 x 8 mm.<\/p>\n\n\n\n<p>Printing packaging: 10, 25, 28, 98, 98&#215;1 (single dose) and 100 pcs.<\/p>\n\n\n\n<p>Plastic jar: 25, 30, 100, and 250 pcs (rheumatism packaging).<br><\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Actavis Group hf<\/p>\n\n\n\n<p>Reykjavikurvegur 76-78<\/p>\n\n\n\n<p>IS-220 Hafnarfjordur<\/p>\n\n\n\n<p>Iceland<br><\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Allphamed PHARBIL Arzneimittel GmBH<\/p>\n\n\n\n<p>Hildebrandstr.&nbsp;12<\/p>\n\n\n\n<p>37081 G\u00f6ttingen<\/p>\n\n\n\n<p>Germany<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alpoxen is anti-inflammatory, analgesic, and antipyretic. Alpoxen belongs to a group of medicines called NSAIDs (non-steroidal anti-inflammatory \/ anti-rheumatic medicines).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10823,10826,10818,10821,10827,10822,10825,10824,10819,10820],"class_list":["post-5250","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-alpoxen","tag-alpoxen-tablet","tag-naproxen","tag-naproxen-tablet","tag-side-effects-of-alpoxen","tag-side-effects-of-naproxen","tag-what-alpoxen-is-used-for","tag-what-is-alpoxen","tag-what-is-naproxen","tag-what-naproxen-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5250"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5250\/revisions"}],"predecessor-version":[{"id":12837,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5250\/revisions\/12837"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}