{"id":5244,"date":"2020-12-14T06:47:00","date_gmt":"2020-12-14T06:47:00","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5244"},"modified":"2021-08-02T07:04:03","modified_gmt":"2021-08-02T07:04:03","slug":"aloxi","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/aloxi\/","title":{"rendered":"Aloxi &#8211; Palonosetron uses, dose and side effects"},"content":{"rendered":"\n<p> 250 micrograms&nbsp;solution for injection.&nbsp;<br>palonosetron<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Aloxi is and what it is used for<\/h2>\n\n\n\n<p>Aloxi contains the active substance palonosetron.&nbsp;It belongs to a group of medicines called &#8216;serotonin (&nbsp;5HT&nbsp;<sub>3<\/sub>&nbsp;) antagonists&#8217;.<\/p>\n\n\n\n<p>Aloxi is used in adults, adolescents and children over one month of age to prevent nausea and vomiting during so-called chemotherapy treatment (&#8220;cytotoxic drugs&#8221;) for cancer.<\/p>\n\n\n\n<p>It works by blocking the activity of the chemical&nbsp;serotonin, which can make you feel sick or vomit.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you get Aloxi<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Aloxi if:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>you are allergic to palonosetron or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>You will not receive Aloxi if any of the above apply to you.&nbsp;If you are not sure, talk to your doctor or nurse before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before receiving Aloxi if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have any obstruction in the intestine or have had constipation repeatedly in the past<\/li><li>you have had heart problems or if there are heart problems in the family, such as a change in heart rate (&#8220;extended&nbsp;QT&nbsp;interval&#8221;)<\/li><li>you have an imbalance in certain minerals in the blood that has not been treated &#8211; e.g.&nbsp;potassium&nbsp;and&nbsp;magnesium.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or you are not sure), talk to your doctor or nurse before getting Aloxi.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Aloxi<\/h2>\n\n\n\n<p>Tell your doctor or nurse if you are taking, have recently taken, or might take any other medicines.&nbsp;It is especially important that you tell them if you are taking the following medicines:<br><\/p>\n\n\n\n<p><strong>Medicines for depression or anxiety<\/strong><\/p>\n\n\n\n<p>Tell your doctor or nurse if you are taking any medicines for depression or anxiety, for example:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>so-called&nbsp;SSRIs&nbsp;(&#8220;selective serotonin reuptake inhibitors&#8221;) such as&nbsp;fluoxetine,&nbsp;paroxetine,&nbsp;sertraline, fluvoxamine,&nbsp;citalopram,&nbsp;and escitalopram<\/li><li>so-called&nbsp;SNRIs&nbsp;(&#8220;serotonin and norepinephrine reuptake inhibitors&#8221;) such as&nbsp;venlafaxine&nbsp;and duloxetine (may lead to the development of serotonin syndrome and should be used with caution).<\/li><\/ul>\n\n\n\n<p><strong>Drugs that can affect the heartbeat<\/strong><\/p>\n\n\n\n<p>Tell your doctor or nurse if you are taking any other medicines that may affect your heart rate &#8211; you may have heart problems if you take them with Aloxi.&nbsp;These are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs for heart problems, e.g.&nbsp;amiodarone, nicardipine, and&nbsp;quinidine<\/li><li>medicines for&nbsp;infection, e.g.&nbsp;moxifloxacin and erythromycin<\/li><li>medicines for severe mental problems, e.g.&nbsp;haloperidol, chlorpromazine, quetiapine, and thioridazine<\/li><li>medicine for nausea and vomiting called domperidone.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or you are not sure), talk to your doctor or nurse before taking Aloxi &#8211; you may have heart problems if you take these medicines with Aloxi.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy<\/h2>\n\n\n\n<p>If you are pregnant or think you may be pregnant, your doctor will not give you Aloxi unless absolutely necessary.&nbsp;The reason is that it is not known whether Aloxi can harm the child.<\/p>\n\n\n\n<p>Consult your doctor or nurse before receiving this medicine if you are pregnant or think you may be.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>It is not known if Aloxi passes into breast milk.<br><\/p>\n\n\n\n<p>Ask your doctor or nurse for advice before taking Aloxi if you are breast-feeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You may feel dizzy or tired after taking this medicine.&nbsp;If this happens, do not drive or use any tools or machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Aloxy contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per&nbsp;vial, ie essentially &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to get Aloxi<\/h2>\n\n\n\n<p>Aloxi is usually given by a doctor or nurse.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You will receive the medicine about 30 minutes before the start of chemotherapy.<\/li><\/ul>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended&nbsp;dose of&nbsp;Aloxi is 250 micrograms.<\/li><li>It is given as an&nbsp;injection&nbsp;to a friend.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and adolescents (aged 1 month to 17 years)<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The doctor calculates the correct&nbsp;dose&nbsp;based on body weight.<\/li><li>The highest&nbsp;dose&nbsp;is 1,500 micrograms.<\/li><li>Aloxi is given as a drip (a slow&nbsp;infusion&nbsp;into a vein).<\/li><\/ul>\n\n\n\n<p>You should not receive Aloxi in the next few days after chemotherapy unless you are given another round of&nbsp;chemotherapy.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;may be caused by this medicine:<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Tell your doctor immediately if you get any of the following serious side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reaction&nbsp;&#8211; signs of this may be swelling of the lips, face, tongue, or throat, difficulty breathing or collapse, itchy raised rash (&nbsp;hives&nbsp;).&nbsp;This is very rare: may affect up to 1 in 10,000 people.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you get any of the&nbsp;side effects&nbsp;listed above.<br><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you get any of the following side effects:<br><\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p><strong>Common<\/strong>: may affect up to 1 in 10 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache, dizziness<\/li><li>constipation, diarrhea.<br><\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>: may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>color changes and enlargement of the veins<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>you feel happier than usual or more anxious<\/li><li>drowsiness or insomnia<\/li><li>loss of appetite or loss of appetite<\/li><li>weakness, fatigue, fever, or&nbsp;flu-like symptoms<\/li><li>numbness, burning, tingling, or ant crawling in the skin<\/li><li>skin rash with&nbsp;itching<\/li><li>impaired vision or eye irritation<\/li><li>motion sickness<\/li><li>tinnitus<\/li><li>hiccups,&nbsp;flatulence,&nbsp;dry mouth,&nbsp;or indigestion<\/li><li>abdominal pain<\/li><li>urination difficulties<\/li><li>joint pain.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you get any of the&nbsp;side effects&nbsp;listed above.<br><\/p>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;were seen on specimens<\/strong>: may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high or low&nbsp;blood pressure<\/li><li>abnormal heart rate or poor blood flow to the heart<\/li><li>abnormally high or low levels of&nbsp;potassium&nbsp;in the blood<\/li><li>high levels of sugar in the blood or sugar in the urine<\/li><li>low level of&nbsp;calcium&nbsp;in the blood<\/li><li>high level of the pigment&nbsp;bilirubin&nbsp;in the blood<\/li><li>high levels of certain liver enzymes<\/li><li>abnormal&nbsp;ECG&nbsp;(&nbsp;electrocardiogram&nbsp;) (&nbsp;QT&nbsp;prolongation).<br><\/li><\/ul>\n\n\n\n<p><strong>Very rare<\/strong>: may affect up to 1 in 10,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Burning, pain, or&nbsp;redness&nbsp;at the injection site.<br><\/li><\/ul>\n\n\n\n<p><strong>Children and young people<\/strong><br><\/p>\n\n\n\n<p><strong>Common<\/strong>: may affect up to 1 in 10 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>: may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>jerky body movements<\/li><li>abnormal heart rate<\/li><li>cough or shortness of breath<\/li><li>nosebleeds<\/li><li>itchy rash or hives<\/li><li>fever<\/li><li>pain at the infusion site.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you get any of the&nbsp;side effects&nbsp;listed above.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Aloxi<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the vial and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/li><li>No special storage instructions.<\/li><li>For single use only, any remaining solution should be discarded.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is palonosetron (as hydrochloride).&nbsp;Each ml of solution contains 50 micrograms of palonosetron.&nbsp;One&nbsp;vial&nbsp;of 5 ml solution contains 250 micrograms palonosetron.<\/li><li>The other ingredients are mannitol, disodium edetate, sodium citrate, citric acid monohydrate, water for injections, sodium hydroxide, and&nbsp;hydrochloric acid.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Aloxi&nbsp;injection&nbsp;solution is a clear, colorless solution and is supplied in a pack with one&nbsp;vial&nbsp;of type I glass with chlorobutyl siliconized rubber stopper and aluminum.&nbsp;The vial contains 5 ml of solution, which is a&nbsp;dose.<br><\/p>\n\n\n\n<p>Available in packs of 1&nbsp;vial&nbsp;containing 5 ml solution.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Helsinn Birex Pharmaceuticals Ltd.&nbsp;<br>Damastown&nbsp;<br>Mulhuddart&nbsp;<br>Dublin 15&nbsp;<br>Ireland<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aloxi contains the active substance palonosetron. It belongs to a group of medicines called &#8216;serotonin ( 5HT 3 ) antagonists&#8217;.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10849,10852,10844,10847,10853,10848,10851,10850,10845,10846],"class_list":["post-5244","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-aloxi","tag-aloxi-injection","tag-palonosetron","tag-palonosetron-injection","tag-side-effects-of-aloxi","tag-side-effects-of-palonosetron","tag-what-aloxi-is-used-for","tag-what-is-aloxi","tag-what-is-palonosetron","tag-what-palonosetron-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5244"}],"version-history":[{"count":7,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5244\/revisions"}],"predecessor-version":[{"id":12840,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5244\/revisions\/12840"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5244"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5244"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}