{"id":5228,"date":"2020-12-14T06:17:06","date_gmt":"2020-12-14T06:17:06","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5228"},"modified":"2021-08-02T07:04:44","modified_gmt":"2021-08-02T07:04:44","slug":"allopurinol-orion","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/allopurinol-orion\/","title":{"rendered":"Allopurinol Orion &#8211; Allopurinol uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n100 and 300 mg&nbsp;tablets&nbsp;<br>allopurinol<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Allopurinol Orion is and what it is used for<\/h2>\n\n\n\n<p>Allopurinol Orion belongs to a group of medicines called enzyme inhibitors, which work by controlling the speed of various chemical processes in the body.<\/p>\n\n\n\n<p>Allopurinol Orion tablets are used for the long-term prevention of&nbsp;gout&nbsp;and can also be used for other conditions associated with an excess of&nbsp;uric acid&nbsp;in the body, including&nbsp;kidney stones&nbsp;and other types of kidney disease.<br><\/p>\n\n\n\n<p><em>Children under 15 years of age:<\/em>&nbsp;Only Allopurinol Orion 100 mg tablets can be used in children under 15 years of age.<\/p>\n\n\n\n<p>300 mg tablets contain a para-orange dye (E110) which is not recommended for use in children and adolescents.<br><\/p>\n\n\n\n<p>Allopurinol contained in Allopurinol Orion may also be approved for the treatment of other conditions not mentioned in this leaflet.&nbsp;Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Allopurinol Orion<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Allopurinol Orion<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to allopurinol or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have an ongoing gout attack or have just had a gout attack.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Allopurinol Orion tablets if you<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have liver or kidney problems.&nbsp;Your doctor may give you a lower&nbsp;dose&nbsp;or ask you to take the medicine less often than once a day.&nbsp;You will also be more closely monitored.<\/li><li>have heart problems or high&nbsp;blood pressure.<\/li><li>have thyroid problems.<\/li><li>have an ongoing gout attack.<\/li><\/ul>\n\n\n\n<p>Severe skin reactions (hypersensitivity&nbsp;syndrome,&nbsp;Stevens-Johnson syndrome,&nbsp;and&nbsp;toxic epidermal necrolysis&nbsp;) have been reported with the use of allopurinol.&nbsp;The rash can usually include sores in the mouth, throat, nose, genitals, or eye inflammation (red and swollen eyes).&nbsp;These severe skin reactions are often preceded by&nbsp;flu-like symptoms such&nbsp;as fever, headache, body aches.&nbsp;The rash can develop into blisters over large areas of skin detachment.&nbsp;These severe skin reactions may be more common in people of Han Chinese, Thai or Korean descent.&nbsp;chronic kidney disease may further increase the risk in these patients.&nbsp;If you get a rash or signs of these skin reactions, stop taking allopurinol immediately, and contact a doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Allopurinol Orion<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Talk to your doctor before taking this medicine if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>6-mercaptopurine (used to treat blood cancer)<\/li><li>azathioprine, cyclosporine (used to suppress the immune system).&nbsp;Note that cyclosporine can more often cause&nbsp;side effects.<\/li><li>vidarabine (used to treat&nbsp;herpes&nbsp;).&nbsp;Note that vidarabine can more often cause&nbsp;side effects.&nbsp;Be extra careful if these occur.<\/li><li>salicylates (used to reduce pain, fever, or&nbsp;inflammation, eg&nbsp;acetylsalicylic acid&nbsp;)<\/li><li>probenecid (used to treat&nbsp;gout&nbsp;)<\/li><li>chlorpropamide (used to treat&nbsp;diabetes&nbsp;).&nbsp;A reduced&nbsp;dose&nbsp;of chloropropamide may be necessary, especially in patients with renal impairment.<\/li><li>warfarin, phenprocoumon, acenocoumarol (used to make the blood thinner).&nbsp;Your doctor may check your blood clotting more often and if necessary, lower the&nbsp;dose of&nbsp;one of these medicines.<\/li><li>furosemide,&nbsp;thiazides,&nbsp;or other&nbsp;diuretics&nbsp;(used to treat high&nbsp;blood pressure&nbsp;)<\/li><li>phenytoin&nbsp;(used to treat&nbsp;epilepsy&nbsp;)<\/li><li>theophylline (used to treat&nbsp;asthma&nbsp;and other respiratory diseases).&nbsp;Your doctor will measure the theophylline levels in your blood, especially when starting treatment with Allopurinol Orion, or after changing&nbsp;dose&nbsp;one.<\/li><li>ampicillin or amoxicillin (used to treat bacterial infections).&nbsp;Patients should be given other&nbsp;antibiotics&nbsp;if possible, as allergic reactions can be expected.<br><\/li><\/ul>\n\n\n\n<p>If aluminum hydroxide is taken at the same time, the effect of allopurinol may be reduced.&nbsp;There should be an interval of at least 3 hours between taking these two drugs.<br><\/p>\n\n\n\n<p>When allopurinol and&nbsp;cytostatics&nbsp;are used concomitantly (eg cyclophosphamide, doxorubicin, bleomycin, procarbazine, alkyl halides),&nbsp;blood dyscrasias&nbsp;occur&nbsp;more frequently than when these active substances are used separately.<br><\/p>\n\n\n\n<p>Blood levels should therefore be checked regularly.<br><\/p>\n\n\n\n<p>Your doctor will check your blood levels frequently if you take:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>didanosine (used to treat&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;s)<\/li><li>captopril&nbsp;(used to treat high&nbsp;blood pressure&nbsp;)<\/li><\/ul>\n\n\n\n<p>The risk of skin reactions can increase, especially if your kidney function is chronically impaired.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<br><\/p>\n\n\n\n<p>Allopurinol is excreted in human milk.&nbsp;Allopurinol is not recommended during breast-feeding.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Allopurinol Orion tablets can cause dizziness, drowsiness, and may affect your coordination.&nbsp;If you are affected,&nbsp;<strong>do not drive<\/strong>, use machines, or participate in risky activities.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Allopurinol Orion 100 mg and 300 mg tablets contain lactose and Allopurinol Orion 300 mg tablets contain the dye para-orange (E110)<\/h2>\n\n\n\n<p>Allopurinol Orion 100 mg and 300 mg tablets contain&nbsp;lactose.&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<p>Allopurinol Orion 300 mg tablets contain the dye para-orange (E110) which may cause allergic reactions.&nbsp;300 mg tablets are not recommended for children under 15 years of age.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Allopurinol Orion<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Check with your doctor or pharmacist if you are not sure.<br><\/p>\n\n\n\n<p>The tablet can be divided into equal&nbsp;doses.&nbsp;The tablets should be swallowed with a glass of water.&nbsp;You should take the tablets after a meal.&nbsp;You should drink plenty of fluids (2-3 liters per day) while taking this medicine.<br><\/p>\n\n\n\n<p>The recommended&nbsp;doses&nbsp;are:<\/p>\n\n\n\n<p><em>Adults, young people (15\u201118 years), older<\/em><\/p>\n\n\n\n<p>Starting dose: 100\u2011300 mg \/ day.<\/p>\n\n\n\n<p>When you start treatment, your doctor may also prescribe an anti-inflammatory drug or colchicine for a month or more, to prevent attacks of gouty arthritis.<\/p>\n\n\n\n<p>Your&nbsp;dose&nbsp;of allopurinol can be adjusted depending on the severity of the condition.&nbsp;The maintenance dose is:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>mild conditions: 100\u2011200 mg \/ day<\/li><li>moderately severe conditions: 300\u2011600 mg \/ day<\/li><li>severe conditions: 700\u2011900 mg \/ day.Your&nbsp;dose&nbsp;may also be changed by your doctor if you have impaired kidney and liver function, especially if you are older. If your daily&nbsp;dose&nbsp;exceeds 300 mg\/day and you suffer from gastrointestinal&nbsp;side effects&nbsp;such as nausea or vomiting (see section 4), your doctor may prescribe allopurinol in divided&nbsp;doses&nbsp;to reduce these effects.<br><em>If you have severe kidney disease<\/em><\/li><li>you may be asked to take less than 100 mg per day or so<\/li><li>you may be asked to take 100 mg at longer intervals than one day.If you receive&nbsp;dialysis&nbsp;two or three times a week, your doctor may&nbsp;prescribe&nbsp;a&nbsp;dose&nbsp;of 300 or 400 mg to be taken immediately after&nbsp;dialysis.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Allopurinol 100 mg tablets only:<\/p>\n\n\n\n<p><em>Children under 15 years<\/em><\/p>\n\n\n\n<p>100 to 400 mg \/ day.<\/p>\n\n\n\n<p>Treatment can be started with an anti-inflammatory drug or colchicine, and the&nbsp;dose is&nbsp;adjusted if you have impaired kidney and liver function, or divided to reduce the gastrointestinal&nbsp;side effects, as for adults above.<\/p>\n\n\n\n<p>An overdose can cause symptoms such as nausea, vomiting, diarrhea, or dizziness.<\/p>\n\n\n\n<p>Take this leaflet, any remaining tablets, and the package with you to the hospital or doctor so that they know which tablets have been taken.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Allopurinol Orion<\/h2>\n\n\n\n<p>If you forget to take one tablet, take one as soon as you remember unless it&#8217;s time to take the next one.&nbsp;<strong>Do not take<\/strong>&nbsp;a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.&nbsp;Take the remaining&nbsp;dose&nbsp;at the right time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Allopurinol Orion<\/h2>\n\n\n\n<p>You should continue to take the tablets for as long as your doctor tells you to.&nbsp;<strong>Do not stop<\/strong>&nbsp;taking your medicine without talking to your doctor first.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Stop taking Allopurinol Orion and contact a doctor immediately if you experience:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>an unexpected skin reaction (possibly accompanied by fever, swollen&nbsp;glands, joint pain, unusual blisters or bleeding, kidney problems, or sudden outbursts of cramps).<br><em>Common&nbsp;side effects&nbsp;are<\/em>&nbsp;(may affect up to 1 in 10)<br><ul><li>Rash<\/li><li>Elevated levels of thyroid-stimulating hormone&nbsp;in the blood. <em>Rare&nbsp;side effects&nbsp;are<\/em>&nbsp;(may affect up to 1 in 1000 users)<\/li><\/ul><ul><li>fever and chills, headache, muscle aches (&nbsp;flu-like symptoms&nbsp;), and general malaise<\/li><li>skin changes e.g.&nbsp;sores in mouth, throat, nose, and genitals, eye inflammation (red and swollen eyes), diffuse blistering or skin detachment<\/li><li>severe&nbsp;hypersensitivity reactions&nbsp;such as fever, rash, joint pain, changes in the blood picture, or altered liver values \u200b\u200b(these may be signs of a&nbsp;hypersensitivity reaction&nbsp;involving several organs). <em>Allergic reactions<\/em>&nbsp;(may affect up to 1 in 10,000 users)If you get an&nbsp;allergic reaction, stop taking Allopurinol Orion and contact your doctor immediately.&nbsp;Signs may include:<\/li><\/ul><ul><li>skin rash, flaky skin, boils or sore lips and mouth<\/li><li>swelling of the face, hands, lips, tongue, or throat<\/li><li>difficulty swallowing or breathing<\/li><li>Very unusual symptoms include sudden tingling, tremors, chest tightness, and collapsed not take more tablets unless your doctor tells you to. <strong>If you experience any of the following while taking Allopurinol Orion, stop taking the tablets, and contact your doctor as soon as possible:<\/strong><br><em>Less common&nbsp;side effects&nbsp;are<\/em>&nbsp;(may affect up to 1 in 100):<\/li><\/ul><ul><li>nausea, vomiting (in rare cases containing blood), and diarrhea<\/li><li>symptoms of allergic reactions including itchy rash<\/li><li>higher results in liver function tests are<em>&nbsp;side effects&nbsp;are<\/em>&nbsp;(may affect up to 1 in 1000 people):<\/li><\/ul><ul><li>joint pain or painful swelling in the groin, armpits, or neck<\/li><li>jaundice (yellowing of the skin and whites of the eyes)<\/li><li>affected liver or kidney function<\/li><li>formation of stones in the urinary tract, symptoms that include blood in the urine and pain in the abdomen, sides, or groin<em>Very rare&nbsp;side effects&nbsp;are<\/em>&nbsp;(may affect up to 1 in 10 000 users):<\/li><\/ul><ul><li>fever<\/li><li>blood in the urine<\/li><li>altered bowel habits, or unusual foul-smelling stools<\/li><li>high levels of fat in the blood<\/li><li>a general feeling of feeling unwell<\/li><li>weakness, numbness, instability, inability to move the muscles (paralysis) or unconsciousness, tingling<\/li><li>muscle twitching, seizures, or depression<\/li><li>headache, dizziness, drowsiness, or visual disturbances<\/li><li>chest pain, high&nbsp;blood pressure,&nbsp;or low&nbsp;heart rate<\/li><li>retained fluid leading to swelling (&nbsp;edema&nbsp;) especially in the ankles<\/li><li>male&nbsp;infertility&nbsp;or inability to get or maintain&nbsp;an erection, or to ejaculate in sleep (&#8220;nocturnal ejaculation&#8221;)<\/li><li>enlarged breasts in both men and women<\/li><li>taste changes,&nbsp;inflammation&nbsp;of the mouth<\/li><li>cataracts&nbsp;(cloudy contact lenses) and other vision problems<\/li><li>abscesses (small sore, red bumps on the skin)<\/li><li>hair loss or discoloration of the hair<\/li><li>thirst, fatigue, and weight loss (these may be symptoms of&nbsp;diabetes&nbsp;);&nbsp;Your doctor may want to measure your blood sugar level if this happens<\/li><li>muscle pain<\/li><li>swollen&nbsp;glands, usually disappear when allopurinol treatment is stopped you may sometimes feel nauseous, but this can usually be avoided by taking allopurinol after a meal.&nbsp;Tell your doctor if the problem persists. Sometimes allopurinol can affect the blood, which can show up in that you get bruises more easily than usual or that you get a sore throat or other signs of&nbsp;infection.&nbsp;These effects usually occur in people with liver or kidney problems.&nbsp;Tell your doctor as soon as possible.<br><strong>Reporting of&nbsp;side effects&nbsp;if<\/strong> you get&nbsp;any side effects, talk to your doctor or pharmacist.&nbsp;This also applies to side effects that are not mentioned in this information.&nbsp;You can also report&nbsp;side effects&nbsp;directly via The Medical Products AgencyBox 26751 03 Uppsalawww.lakemedelsverket.se<br>By reporting&nbsp;side effects, you can help increase drug safety information.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Allopurinol Orion<\/h2>\n\n\n\n<p>Keep out of sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is allopurinol.&nbsp;Each 100 mg tablet contains 100 mg of allopurinol.&nbsp;Each 300 mg tablet contains 300 mg of allopurinol.<\/li><li>The other ingredients are&nbsp;lactose monohydrate, corn starch, povidone, sodium starch glycolate, and stearic acid.&nbsp;Allopurinol Orion 300 mg also contains the dye para-orange (E 110)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p><em>Allopurinol Orion 100 mg<\/em>&nbsp;tablets are white to off-white, round, biconvex uncoated tablets with \u201cAL\u201d and \u201c100\u201d separated by a score line on one side and smooth on the other.<\/p>\n\n\n\n<p><br><em>Allopurinol Orion 300 mg<\/em>&nbsp;tablets are peach-colored, round, biconvex uncoated tablets with \u201cAL\u201d and \u201c300\u201d separated by a score line on one side and smooth on the other.&nbsp;<br><br>Allopurinol Orion 100 mg tablets are available in packs of 50 and 100.&nbsp;<br>Allopurinol Orion 300 mg tablets are available in packs of 30 and 100.&nbsp;<br><br>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Orion Corporation<\/p>\n\n\n\n<p>Orionintie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Orion Corporation Orion Pharma<\/p>\n\n\n\n<p>Orionintie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<br><\/p>\n\n\n\n<p>Orion Corporation Orion Pharma<\/p>\n\n\n\n<p>Joensuunkatu 7<\/p>\n\n\n\n<p>FI-24100 Salo<\/p>\n\n\n\n<p>Finland<br><\/p>\n\n\n\n<p>For any information about this medicine, please contact the local representative of the Marketing Authorization Holder:<\/p>\n\n\n\n<p>Orion Pharma AB, Danderyd<\/p>\n\n\n\n<p>medinfo@orionpharma.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Allopurinol Orion belongs to a group of medicines called enzyme inhibitors, which work by controlling the speed of various chemical processes in the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10882,10906,10909,10885,10905,10886,10910,10884,10908,10883,10907],"class_list":["post-5228","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-allopurinol","tag-allopurinol-orion","tag-allopurinol-orion-tablet","tag-allopurinol-tablet","tag-benefitofallopurinol","tag-side-effects-of-allopurinol","tag-side-effects-of-allopurinol-orion","tag-what-allopurinol-is-used-for","tag-what-allopurinol-orion-is-used-for","tag-what-is-allopurinol","tag-what-is-allopurinol-orion"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5228"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5228\/revisions"}],"predecessor-version":[{"id":12844,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5228\/revisions\/12844"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5228"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5228"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}