{"id":5194,"date":"2020-12-13T05:54:11","date_gmt":"2020-12-13T05:54:11","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5194"},"modified":"2021-08-03T07:54:58","modified_gmt":"2021-08-03T07:54:58","slug":"alkindi","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/alkindi\/","title":{"rendered":"Alkindi &#8211; Hydrocortisone uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n0.5 mg, 1 mg, 2 mg, 5 mg&nbsp;Granules&nbsp;in capsules designed to be opened&nbsp;<br>Hydrocortisone<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Alkindi is and what it is used for<\/h2>\n\n\n\n<p>Alkindi contains a medicine called&nbsp;hydrocortisone.&nbsp;Hydrocortisone&nbsp;belongs to a group of medicines called&nbsp;corticosteroids.<\/p>\n\n\n\n<p>Hydrocortisone&nbsp;is a&nbsp;synthetic&nbsp;variant of the&nbsp;hormone&nbsp;et&nbsp;cortisol.&nbsp;Cortisol is&nbsp;produced naturally in the body by the adrenal glands.&nbsp;Alkindi is used when the body does not produce enough&nbsp;cortisol&nbsp;due to the adrenal glands not functioning properly (adrenal insufficiency, often caused by a hereditary condition called&nbsp;congenital&nbsp;adrenal hyperplasia).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Alkindi<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Alkindi<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if your child is allergic to&nbsp;hydrocortisone&nbsp;or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if your baby has difficulty swallowing food or is a premature baby who is not yet able to ingest food by mouth.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Warning<\/strong>&nbsp;Alkindi&nbsp;granules&nbsp;are available in capsules that must be opened before use.&nbsp;Discard the empty capsule after use, out of reach of children.&nbsp;The capsule must NOT be swallowed &#8211; small children may suffocate.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Talk to your endocrinologist or pharmacist before giving Alkindi to your child about the baby:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>is ill or has an&nbsp;infection.&nbsp;The endocrinologist may need to increase the&nbsp;dose ofAlkindi temporarily.&nbsp;Talk to your endocrinologist if your child is sick.&nbsp;If the child vomits or is very ill, he or she may need an&nbsp;injection&nbsp;of&nbsp;hydrocortisone.&nbsp;The endocrinologist will show you how to give such injection&nbsp;in an emergency.&nbsp;<\/li><li>to be vaccinated.&nbsp;Alkindi treatment should not be an obstacle to the child being vaccinated.&nbsp;Inform the endocrinologist about when the child should be vaccinated.&nbsp;<\/li><li>to be operated on.&nbsp;Tell your anesthesiologist that your child is receiving Alkindi before the child has surgery.<\/li><li>sonatas.&nbsp;Alkindi&nbsp;granules&nbsp;are not suitable to give via probe because the&nbsp;granules&nbsp;can clog the probe.<\/li><\/ul>\n\n\n\n<p>Do not stop giving Alkindi without the advice of the endocrinologist.&nbsp;It can make your child seriously ill very quickly.<br><\/p>\n\n\n\n<p>Because Alkindi replaces&nbsp;hormones&nbsp;that your child lacks,&nbsp;side effects&nbsp;are uncommon, but:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Too high a&nbsp;dose&nbsp;of Alkindi can&nbsp;inhibit&nbsp;the child&#8217;s growth.&nbsp;The endocrinologist adjusts the&nbsp;dose&nbsp;according to your child&#8217;s body size and closely monitors the child&#8217;s growth.&nbsp;Talk to your endocrinologist if you are concerned about your baby&#8217;s growth (see section 4).<\/li><li>Too high a&nbsp;dose of&nbsp;Alkindi can affect the skeleton.&nbsp;The endocrinologist adjusts the&nbsp;dose&nbsp;according to your child&#8217;s body size.<\/li><li>Some adult patients taking&nbsp;hydrocortisone&nbsp;(the same as Alkindi) suffered from anxiety, depression, or confusion.&nbsp;It is not known if this applies to children, but tell your endocrinologist if your child&#8217;s behavior changes after starting treatment with Alkindi (see section 4).<\/li><li>Some patients who are allergic to other drugs have also developed&nbsp;allergies&nbsp;to&nbsp;hydrocortisone.&nbsp;Tell your endocrinologist immediately if your child develops a reaction such as swelling or shortness of breath after receiving Alkindi (see section 4).<\/li><li>Contact the endocrinologist if your child sees worse (blurred vision) or has other visual disturbances.<\/li><\/ul>\n\n\n\n<p>It happens that you discover Alkindi&nbsp;granules&nbsp;in the baby&#8217;s diaper or stool when it has received Alkindi.&nbsp;This is because the core of the&nbsp;granules is&nbsp;not absorbed by the intestine when the drug itself has been released.&nbsp;This does not mean that the medicine does not work and you do not need to give the child an extra&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Alkindi<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if your child is taking, has recently taken, or might take any other medicines.&nbsp;This also applies to over-the-counter medicines.<\/p>\n\n\n\n<p>Some medicines may affect the way Alkindi works.&nbsp;The endocrinologist may therefore need to change the child&#8217;s&nbsp;dose&nbsp;of Alkindi.<\/p>\n\n\n\n<p>Drugs that can cause the doctor to increase the child&#8217;s&nbsp;dose&nbsp;of Alkindi include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs for the treatment of epilepsy:&nbsp;phenytoin, carbamazepine, and oxcarbazepine&nbsp;<\/li><li>drugs for the treatment of&nbsp;infections&nbsp;(&nbsp;antibiotics&nbsp;): rifampicin and rifabutin&nbsp;<\/li><li>so-called&nbsp;barbiturates, which can be used to treat seizures (such as phenobarbital and primidone)&nbsp;<\/li><li>drugs for the treatment of AIDS: efavirenz and nevirapine.&nbsp;<\/li><\/ul>\n\n\n\n<p>Drugs that can help a doctor reduce a child&#8217;s&nbsp;dose&nbsp;of Alkindi include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs for the treatment of fungal infections: itraconazole, posaconazole, and voriconazole<\/li><li>drugs for the treatment of&nbsp;infections&nbsp;(&nbsp;antibiotics&nbsp;): erythromycin and clarithromycin<\/li><li>drugs for the treatment of&nbsp;HIV&nbsp;(human immunodeficiency virus) and AIDS: ritonavir.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Alkindi with food, drink, and alcohol<\/h2>\n\n\n\n<p>Some foods and beverages may affect the way Alkindi works.&nbsp;The endocrinologist may therefore need to reduce the child&#8217;s&nbsp;dose&nbsp;of Alkindi.&nbsp;This applies:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>grapefruit juice<\/li><li>licorice<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Hydrocortisone&nbsp;can be used during pregnancy and lactation if the body does not produce enough&nbsp;cortisol.<\/p>\n\n\n\n<p>There are no data on the possible effects of Alkindi on&nbsp;fertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Alkindi does not affect the child&#8217;s ability to perform actions that require some skill (eg cycling) or using machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Alkindi<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Always use this medicine exactly as your endocrinologist, nurse or pharmacist has told you.&nbsp;If you are not sure, consult an endocrinologist, nurse, or pharmacist.<\/p>\n\n\n\n<p>The endocrinologist determines an appropriate&nbsp;dose of&nbsp;Alkindi based on the child&#8217;s weight or size (body surface area) and then adjusts&nbsp;dose&nbsp;one as the child grows.&nbsp;In case of illness, if the child is to undergo surgery or is under severe stress, the endocrinologist may recommend that more&nbsp;doses of&nbsp;Alkindi be given.&nbsp;Your child may also be given other types of&nbsp;hydrocortisone&nbsp;instead of, or in addition to, Alkindi.<\/p>\n\n\n\n<p><strong>How to give the medicine<\/strong><\/p>\n\n\n\n<p>Granules&nbsp;must be given orally and should not be chewed.&nbsp;The capsule cover should not be swallowed but should be carefully opened as follows:<br><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product;jsessionid=_BxahSgbzT-SOXyhTmbyclV1RvCqsRXB2edp2yDhG2aye0PuCOjr!1898129783?userType=2&amp;nplId=20161129000044#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/f745f0d3-f54c-4f54-8b54-57f19687aa27\" alt=\"picture 1\"\/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Alkindi than you should&nbsp;<\/h2>\n\n\n\n<p>If you have given too much Alkindi to your child, contact your endocrinologist or pharmacist for advice as soon as possible.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Alkindi<\/h2>\n\n\n\n<p>If you forget to give your child a&nbsp;dose, give it as soon as you remember.&nbsp;The next&nbsp;dose&nbsp;should be given at the usual time, even if it means that your child receives two&nbsp;doses&nbsp;at the same time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Alkindi<\/h2>\n\n\n\n<p>Do not stop giving your child Alkindi without first asking the endocrinologist.&nbsp;If you stop treatment suddenly, the child can quickly become very ill.<\/p>\n\n\n\n<p><strong>If your child becomes ill<\/strong><\/p>\n\n\n\n<p>Tell your endocrinologist or pharmacist if your child becomes ill, is under severe stress, is injured, or needs surgery.&nbsp;The endocrinologist may need to increase the&nbsp;dose&nbsp;of Alkindi in such cases (see section 2).<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If your child develops a reaction with swelling or shortness of breath after receiving Alkindi,&nbsp;<strong>seek medical attention immediately, and inform the endocrinologist as soon as possible<\/strong>.&nbsp;This may be a sign of an&nbsp;allergic reaction(see section 2).<\/li><\/ul>\n\n\n\n<p>No&nbsp;side effects&nbsp;of Alkindi have been observed, but the following&nbsp;side effects&nbsp;have occurred with other hydrocortisone medicines used to replace cortisol:<\/p>\n\n\n\n<p>Has been reported (occurs in an unknown number of users):<br><\/p>\n\n\n\n<p>Behavioral changes such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lost contact with reality (&nbsp;psychosis&nbsp;) with hallucinations and mental confusion (&nbsp;delirium&nbsp;)<\/li><li>strong arousal and overactivity (mania)<\/li><li>strong feelings of happiness and excitement (&nbsp;euphoria&nbsp;)<\/li><\/ul>\n\n\n\n<p>Contact the endocrinologist if the child&#8217;s behavior changes dramatically (see section 2).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stomach pain (&nbsp;gastritis&nbsp;) or nausea.<\/li><\/ul>\n\n\n\n<p>Contact the endocrinologist if the child complains of this.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Altered potassium levels in the blood, which leads to body tissues and fluids becoming alkaline (hypokalemic&nbsp;alkalosis&nbsp;).<\/li><\/ul>\n\n\n\n<p>The endocrinologist will monitor the baby&#8217;s potassium levels to see if they change.<br><\/p>\n\n\n\n<p>Long-term treatment with&nbsp;hydrocortisone&nbsp;may be associated with changes in skeletal development and stunted growth.&nbsp;The endocrinologist will monitor the baby&#8217;s growth and skeleton (see section 2).<br><\/p>\n\n\n\n<p><strong>Reporting of side effects:<\/strong><br><\/p>\n\n\n\n<p>If your child has&nbsp;any side effects, talk to&nbsp;your&nbsp;doctor or pharmacist.&nbsp;This also applies to any&nbsp;side effects&nbsp;not mentioned in this information.&nbsp;You can also report&nbsp;side effects directly via the national reporting system listed in&nbsp;Appendix V..&nbsp;By reporting&nbsp;side effects, you can help increase drug safety information.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Alkindi<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the can and carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<br><\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.&nbsp;Store in the original jar.&nbsp;Sensitive to light.<br><\/p>\n\n\n\n<p>Once the jar has been opened, the capsules should be used within 60 days.<br><\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.&nbsp;<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;hydrocortisone.<\/li><li>Alkindi 0.5 mg&nbsp;granules&nbsp;in capsules to be opened contain 0.5 mg&nbsp;hydrocortisone.<\/li><li>Alkindi 1 mg&nbsp;granules&nbsp;in capsules to be opened contains 1 mg&nbsp;hydrocortisone.<\/li><li>Alkindi 2 mg&nbsp;granules&nbsp;in capsules to be opened contain 2 mg&nbsp;hydrocortisone.<\/li><li>Alkindi 5 mg&nbsp;granules&nbsp;in capsules to be opened contain 5 mg&nbsp;hydrocortisone.<\/li><li>The other ingredients are microcrystalline cellulose, hypromellose, magnesium stearate, and ethylcellulose.<\/li><li>The capsule is made of hypromellose.<\/li><li>The printing ink on the capsules contains shellac, propylene glycol, and ammonia concentrated.&nbsp;The ink on the 0.5 mg capsules also contains potassium hydroxide and red iron oxide (E172).&nbsp;The ink on the 1 mg capsules also contains indigo carmine (E132).&nbsp;The ink on the 2 mg capsules also contains indigo carmine (E132), yellow iron oxide (E172), and titanium dioxide (E171).&nbsp;The ink on the 5 mg capsules also contains potassium hydroxide, titanium dioxide (E171), and black iron oxide (E172).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>White to off-white&nbsp;granules&nbsp;in a transparent colorless hard capsule intended to be opened.&nbsp;The strength is pressed on the capsule.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Alkindi 0.5 mg&nbsp;granules&nbsp;in capsules to be opened: the capsule is marked with \u201cINF-0.5\u201d in red ink.<\/li><li>Alkindi 1 mg&nbsp;granules&nbsp;in capsules to be opened: the capsule is marked with \u201cINF-1.0\u201d in blue ink.<\/li><li>Alkindi 2 mg&nbsp;granules&nbsp;in capsules to be opened: the capsule is marked with \u201cINF-2.0\u201d in green ink.<\/li><li>Alkindi 5 mg&nbsp;granules&nbsp;in capsules to be opened: the capsule is marked with \u201cINF-5.0\u201d in gray ink.<\/li><\/ul>\n\n\n\n<p>Alkindi is packaged in plastic cans of high-density polyethylene containing 50 capsules.&nbsp;Each carton contains a jar.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Diurnal Europe BV<\/p>\n\n\n\n<p>Van Heuven Goedhartlaan 935 A<\/p>\n\n\n\n<p>1181LD Amstelveen<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Tel: +31 (0) 20 6615 072<\/p>\n\n\n\n<p>info@diurnal.co.uk<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Delpharm Lille SAS<\/p>\n\n\n\n<p>Roubaix-Est Activity Park<\/p>\n\n\n\n<p>22 rue de Toufflers CS 50070<\/p>\n\n\n\n<p>Lys&nbsp;Lez Lannoy, 59 452<\/p>\n\n\n\n<p>France<br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alkindi contains a medicine called hydrocortisone. Hydrocortisone belongs to a group of medicines called corticosteroids.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[10950,10953,10949,2406,10947,10954,10948,10952,10946,10951,10945],"class_list":["post-5194","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-alkindi","tag-alkindi-capsule","tag-benefit-of-hydrocortisone","tag-hydrocortisone","tag-hydrocortisone-capsule","tag-side-effects-of-alkindi","tag-side-effects-of-hydrocortisone","tag-what-alkindi-is-used-for","tag-what-hydrocortisone-is-used-for","tag-what-is-alkindi","tag-what-is-hydrocortisone"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5194","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5194"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5194\/revisions"}],"predecessor-version":[{"id":12870,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5194\/revisions\/12870"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5194"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5194"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}