{"id":5083,"date":"2020-12-08T12:27:55","date_gmt":"2020-12-08T12:27:55","guid":{"rendered":"https:\/\/zeepedia.com\/?p=5083"},"modified":"2021-08-07T06:43:54","modified_gmt":"2021-08-07T06:43:54","slug":"aldactone","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/aldactone\/","title":{"rendered":"Aldactone &#8211; Spironolactone uses, dose and side effects"},"content":{"rendered":"\n<p>\n\n25 mg, 50 mg, 100 mg&nbsp;film-coated tablets&nbsp;<br>spironolactone<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Aldactone is and what it is used for<\/h2>\n\n\n\n<p>Aldactone contains the active substance&nbsp;spironolactone.&nbsp;Spironolactone&nbsp;is a potassium-sparing,&nbsp;diuretic&nbsp;(diuretic) that affects the kidneys in such a way that more fluid (urine) is excreted through the body.&nbsp;In addition to the&nbsp;diuretic&nbsp;effect,&nbsp;spironolactone has&nbsp;a blood pressure-lowering effect.<br><\/p>\n\n\n\n<p>Aldactone is used for various forms of morbid fluid retention (&nbsp;edema&nbsp;) and high&nbsp;blood pressure&nbsp;when other treatments have no effect or are insufficient.&nbsp;It is also used in increased production of the adrenal cortex hormone&nbsp;aldosterone&nbsp;(primary aldosteronism) where other&nbsp;therapies&nbsp;are insufficient or inappropriate.<br><\/p>\n\n\n\n<p>Children should only be treated by a pediatrician.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Aldactone<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Aldactone<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;spironolactone&nbsp;or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have&nbsp;acute&nbsp;renal failure, severe renal impairment, or if you have no urine production<\/li><li>if you have&nbsp;Addison&#8217;s disease&nbsp;(decreased production of&nbsp;hormones&nbsp;are&nbsp;cortisol&nbsp;and&nbsp;aldosterone&nbsp;)<\/li><li>if you have high levels of potassium in your blood<\/li><\/ul>\n\n\n\n<p>Children with moderate to severe kidney disease should not use Aldactone.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Aldactone:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you suffer from severe&nbsp;heart failure<\/li><li>if you are elderly and\/or suffer from impaired kidney or liver function<\/li><li>if you suffer from kidney disease, especially children with high&nbsp;blood pressure, or liver disease.&nbsp;Your doctor will routinely evaluate your condition.<\/li><\/ul>\n\n\n\n<p>In the above conditions, your doctor may perform regular blood tests to check the level of&nbsp;potassium,&nbsp;sodium,&nbsp;and\/or&nbsp;urea&nbsp;in your blood.<\/p>\n\n\n\n<p>Concomitant use of Aldactone with certain medicines, potassium supplements, and foods high in&nbsp;potassium&nbsp;can lead to severe&nbsp;hyperkalemia&nbsp;(high blood potassium).&nbsp;Symptoms of severe&nbsp;hyperkalemia&nbsp;may include muscle cramps, irregular heartbeat, diarrhea, nausea, dizziness, or headache.<\/p>\n\n\n\n<p>Aldactone can in rare cases affect the white&nbsp;blood cells&nbsp;so that the defense of infection deteriorates.&nbsp;If you get an&nbsp;infection&nbsp;with symptoms such as fever with severe general deterioration or fever with local infection symptoms such as sore throat\/pharynx\/mouth or urination problems, you should see a doctor as soon as possible so that blood tests can rule out a lack of&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis&nbsp;).&nbsp;It is important that you then information about your medication.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Aldactone<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.&nbsp;The effect of the treatment can be affected if Aldactone is taken at the same time as certain other medicines, such as<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs containing&nbsp;potassium&nbsp;or drugs that can cause high levels of&nbsp;potassium&nbsp;in the blood, a diet rich in&nbsp;potassium,&nbsp;or salt substitutes containing&nbsp;potassium<\/li><li>non-steroidal anti-inflammatory drugs called NSAIDs (used for pain and&nbsp;inflammation&nbsp;)<\/li><li>ACE inhibitors,&nbsp;angiotensin&nbsp;II&nbsp;antagonists, aldosterone&nbsp;inhibitors,&nbsp;digoxin&nbsp;(used to treat high&nbsp;blood pressure&nbsp;and&nbsp;heart failure&nbsp;)<\/li><li>potassium-sparing&nbsp;diuretic&nbsp;drugs<\/li><li>norepinephrine&nbsp;(used under anesthesia)<\/li><li>ammonium chloride (used in conditions with too high a&nbsp;pH&nbsp;in the body)<\/li><li>cholestyramine (used eg for elevated blood fats)<\/li><li>carbenoxolone (used eg for diseases of the esophagus)<\/li><li>heparin, low molecular weight&nbsp;heparin&nbsp;(blood thinner)<\/li><li>tacrolimus (used after transplantation)<\/li><li>trimethoprim and trimethoprim-sulfamethoxazole<\/li><\/ul>\n\n\n\n<p>Aldactone may affect certain laboratory samples.<br><\/p>\n\n\n\n<p>Therefore, consult a physician before using other medicines at the same time, including dietary supplements.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Aldactone with food, drink, and alcohol<\/h2>\n\n\n\n<p>The tablets should be taken with a meal<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>There are no or limited amount of data from the use of&nbsp;spironolactone&nbsp;in pregnant women.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Spironolactone&nbsp;passes into breast milk.<br><\/p>\n\n\n\n<p><em>Fertility<\/em><\/p>\n\n\n\n<p>There are no clinical data available on the effect of spironolactone on&nbsp;fertility.&nbsp;Animal studies have shown reduced&nbsp;fertility&nbsp;in females but there are no animal data on male&nbsp;fertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Side effects&nbsp;in the form of dizziness and fatigue may occur in some patients, especially at the beginning of treatment.&nbsp;This should be taken into account when sharper attention is required, e.g.&nbsp;while driving.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.<\/p>\n\n\n\n<p>One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Aldactone<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor, who adjusts it individually for you.&nbsp;The tablets should be taken with a meal.<\/p>\n\n\n\n<p><em>The usual&nbsp;dose&nbsp;for adults<\/em>&nbsp;is 50-100 mg daily, but higher or lower&nbsp;doses&nbsp;may be used in some cases.&nbsp;It may take some time before the treatment takes effect, so it is important not to stop treatment or change&nbsp;dose&nbsp;one without consulting a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Aldactone is used in some cases for the treatment of children and the&nbsp;dose&nbsp;is then adjusted according to the child&#8217;s weight.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Aldactone<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<br><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p><strong>Contact<\/strong>&nbsp;your&nbsp;<strong>doctor immediately<\/strong>&nbsp;if you experience any of the following symptoms or&nbsp;side effects&nbsp;after taking this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em>Stevens-Johnson syndrome:<br><\/em>An extremely severe&nbsp;allergic reaction&nbsp;with skin rash usually in the form of blisters or sores in the oral cavity and eyes as well as other mucous membranes such as genitals.&nbsp;Occurs in an unknown number of users.<\/li><li><em>Lyell&#8217;s syndrome (&nbsp;toxic epidermal necrolysis&nbsp;):<\/em>&nbsp;<br>Severe widespread skin damage (dermal detachment of the epidermis and superficial mucous membranes).&nbsp;Occurs in an unknown number of users.<\/li><li>Drug reaction that causes skin rash, fever,&nbsp;inflammation&nbsp;of internal organs, altered blood&nbsp;count&nbsp;(&nbsp;eosinophilia&nbsp;), and systemic disease (DRESS).&nbsp;Occurs in an unknown number of users.<\/li><li><em>Agranulocytosis:<br><\/em>In rare cases, Aldactone can affect the white&nbsp;blood cells&nbsp;so that the defense of the infection deteriorates.&nbsp;If you get an&nbsp;infection&nbsp;with symptoms such as fever with severe deterioration in general condition or fever with local infection symptoms such as sore throat\/throat\/mouth or difficulty urinating, you should see a doctor as soon as possible so that blood tests can rule out a lack of&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis&nbsp;).&nbsp;It is important that you then information about your medication.&nbsp;Occurs in an unknown number of users.<\/li><li>Severe fatigue, nausea, and&nbsp;itching&nbsp;or if you urinate less than usual.&nbsp;It may be a sign of kidney damage.&nbsp;May affect up to 1 in 10 users.<\/li><\/ul>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10):<\/em>&nbsp;<br>High levels of potassium in the blood can cause abnormal heart rhythm.<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<br><\/em>Confusion, headache, dizziness,&nbsp;itching, rash, muscle cramps, difficulty getting and maintaining an&nbsp;erection, breast augmentation in men, chest pain in men, general malaise, drowsiness, fatigue, diarrhea, nausea, and vomiting.<\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em>&nbsp;<br>Benign breast lumps in men missed \/ absent periods, postmenopausal menstrual bleeding and irregular menstruation, breast pain in women,&nbsp;hives, redness of the skin which is often a sign of&nbsp;infection&nbsp;or&nbsp;inflammation&nbsp;(irritation), abnormal levels of certain salts (eg&nbsp;calcium,&nbsp;potassium,&nbsp;and&nbsp;magnesium&nbsp;) necessary for the normal functioning of the body, decreased sodium levels in the blood, tingling, and irritation of the skin, abnormal blood test results (increased&nbsp;creatinine&nbsp;), abnormal liver function.<br><\/p>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users):<\/em>&nbsp;<br>Severe decrease in&nbsp;white blood cell count&nbsp;(&nbsp;leukopenia&nbsp;) which increases the risk of&nbsp;infection, a decrease in&nbsp;platelet count<\/p>\n\n\n\n<p>, changed<\/p>\n\n\n\n<p>sexual desire, gastrointestinal upset, hair loss, abnormal hair growth, and&nbsp;pemphigus(a condition that causes fluid-filled blisters on the skin).<br><\/p>\n\n\n\n<p>Dry mouth, thirst, headache, fatigue, and drowsiness may occur due to sodium deficiency, during concomitant treatment with other&nbsp;diuretics.&nbsp;In that case, contact a doctor who may be able to change the&nbsp;dosage.<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Aldactone<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br><\/p>\n\n\n\n<p>Store below 30 \u00b0 C.<br><\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;date.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;spironolactone&nbsp;25 mg, 50 mg, and 100 mg per tablet respectively.<\/li><li>The other ingredients are titanium dioxide (dye E 171), magnesium stearate, povidone, calcium sulfate dihydrate, corn starch, macrogol, hypromellose, peppermint flavor.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>The 25 mg tablets are white, round, marked Searle 39.<\/p>\n\n\n\n<p>The 50 mg tablets are white, round, marked Searle 916.<\/p>\n\n\n\n<p>The 100 mg tablets are white, round, marked Searle 134.<br><\/p>\n\n\n\n<p>Printing package containing 100 tablets.<\/p>\n\n\n\n<p>Not all pack sizes and strengths may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Pfizer AB<\/p>\n\n\n\n<p>191 90 Sollentuna<\/p>\n\n\n\n<p>Tel: 08-550 520 00<\/p>\n\n\n\n<p>Email: eumedinfo@pfizer.com<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Piramal Healthcare UK Limited<\/p>\n\n\n\n<p>Whalton Road<\/p>\n\n\n\n<p>Morpeth<\/p>\n\n\n\n<p>Northumberland<\/p>\n\n\n\n<p>NE61 3YA<\/p>\n\n\n\n<p>UK<br><\/p>\n\n\n\n<p>or<br><\/p>\n\n\n\n<p>Piramal Pharma Solutions (Dutch) BV<\/p>\n\n\n\n<p>Level, 7th floor<\/p>\n\n\n\n<p>Bargelaan 200<\/p>\n\n\n\n<p>2333 CW<\/p>\n\n\n\n<p>Leiden<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aldactone contains the active substance spironolactone. Spironolactone is a potassium-sparing, diuretic (diuretic) that affects the kidneys in such a way that more fluid (urine) is excreted through the body. In addition to the diuretic effect, spironolactone has a blood pressure-lowering effect.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[11202,11205,11206,11201,11197,11200,11204,11203,11198,11199],"class_list":["post-5083","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-aldactone","tag-aldactone-tablet","tag-side-effects-of-aldactone","tag-side-effects-of-spironolactone","tag-spironolactone","tag-spironolactone-tablet","tag-what-aldactone-is-used-for","tag-what-is-aldactone","tag-what-is-spironolactone","tag-what-spironolactone-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5083","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=5083"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5083\/revisions"}],"predecessor-version":[{"id":12954,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/5083\/revisions\/12954"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=5083"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=5083"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=5083"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}