{"id":4846,"date":"2020-12-02T10:01:17","date_gmt":"2020-12-02T10:01:17","guid":{"rendered":"https:\/\/zeepedia.com\/?p=4846"},"modified":"2021-08-16T07:51:35","modified_gmt":"2021-08-16T07:51:35","slug":"adrenaline-martindale-pharma","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/adrenaline-martindale-pharma\/","title":{"rendered":"Adrenaline Martindale Pharma &#8211; Adrenaline uses, dose and side effects"},"content":{"rendered":"\n<p>0.1 mg \/ ml&nbsp;injection&nbsp;solution&nbsp;<br>adrenaline<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Adrenaline Martindale Pharma is and what it is used for<\/h2>\n\n\n\n<p>Adrenaline&nbsp;Martindale Pharma is used in cardiopulmonary resuscitation and in the treatment of sudden life-threatening allergic reactions (&nbsp;acute&nbsp;anaphylaxis&nbsp;).<\/p>\n\n\n\n<p>Adrenaline contained&nbsp;in&nbsp;Adrenaline&nbsp;Martindale Pharma may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Adrenalin Martindale Pharma<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Adrenaline Martindale Pharma<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;adrenaline, sodium metabisulphite (a&nbsp;preservative&nbsp;), or any of the other ingredients of this medicine (listed in section 6<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before giving&nbsp;Adrenalin&nbsp;Martindale Pharma.<\/p>\n\n\n\n<p>Due to the increased risk of&nbsp;adverse reactions&nbsp;following the use of&nbsp;adrenaline, special care should be taken in patients with<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cardiovascular diseases (such as&nbsp;angina pectoris, heart muscle disease, arrhythmias, lung heart disease, atherosclerosis, and high&nbsp;blood pressure&nbsp;)<\/li><li>overactive thyroid function<\/li><li>adrenal tumor<\/li><li>narrow-angle glaucoma&nbsp;(&nbsp;glaucoma&nbsp;&#8211; increased eye pressure)<\/li><li>severe renal impairment<\/li><li>enlarged&nbsp;prostate&nbsp;that causes urine to remain in the bladder<\/li><li>the increased amount of calcium in the blood<\/li><li>decreased amount of potassium in the blood<\/li><li>diabetes.<\/li><\/ul>\n\n\n\n<p>Special care should also be taken in elderly and pregnant patients.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Adrenaline Martindale Pharma<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking or have recently taken any other medicines.<\/p>\n\n\n\n<p>This is especially important if you use any of the following:<br><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>beta-blockers&nbsp;(eg pindolol and propranolol) may cause a rise in blood pressure and a decrease in heart rate<\/li><li>medicines for general anesthesia as concomitant use of certain medicines for general anesthesia may increase the risk of arrhythmias<\/li><li>medicines that may increase the risk of heart rhythm disorders (eg&nbsp;digitalis&nbsp;and&nbsp;quinidine&nbsp;)<\/li><li>certain antidepressants (eg protriptyline, maprotiline), as the effect of adrenaline, maybe enhanced<\/li><li>insulin&nbsp;or diabetes medications are taken by mouth, as&nbsp;adrenaline&nbsp;increases blood sugar levels.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor, pharmacist, or nurse for advice before taking this medicine.<\/p>\n\n\n\n<p>Experience from use in pregnant women is limited.<\/p>\n\n\n\n<p>Adrenaline&nbsp;passes into the breast milk.&nbsp;Breast-feeding should be avoided in women receiving&nbsp;adrenaline.<\/p>\n\n\n\n<p>Animal studies are lacking in terms of effects on&nbsp;fertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p><strong>Adrenaline&nbsp;Martindale Pharma contains sodium metabisulfite and&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>Sodium metabisulphite can in rare cases cause severe&nbsp;hypersensitivity reactions&nbsp;and&nbsp;bronchospasm.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per ml&nbsp;solution for injection, ie essentially &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Adrenaline Martindale Pharma<\/h2>\n\n\n\n<p>Adrenaline&nbsp;Martindale Pharma is given by a doctor or nurse.<br><\/p>\n\n\n\n<p><strong>Dosage&nbsp;and&nbsp;route of&nbsp;administration<\/strong><\/p>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor who adjusts it individually for you.<br><\/p>\n\n\n\n<p><em>Cardiac arrest (cardiopulmonary resuscitation)<\/em><\/p>\n\n\n\n<p>For adults and children over 12 years of age, 1 mg is given as an&nbsp;intravenous&nbsp;bolus dose&nbsp;every 3-5 minutes.<br><\/p>\n\n\n\n<p>For children under 12 years of age, 0.01 mg\/kg is given as an&nbsp;intravenous&nbsp;bolus dose.&nbsp;The maximum single&nbsp;dose&nbsp;is 1 mg.<\/p>\n\n\n\n<p>For neonates, 0.01-0.03 mg\/kg is given as an intravenous&nbsp;bolus dose.<\/p>\n\n\n\n<p><em>Life-threatening allergic reactions<\/em><\/p>\n\n\n\n<p>Intramuscular&nbsp;administration&nbsp;(ie&nbsp;injection&nbsp;into a muscle) of 1 mg\/ml adrenaline solution is preferred for the treatment of anaphylactic&nbsp;shock.<\/p>\n\n\n\n<p>It is unlikely that you will receive too much of this medicine as it is only given by a doctor or pharmacist or nurse.<\/p>\n\n\n\n<p>Overdose of&nbsp;adrenaline&nbsp;can cause anxiety, anxiety, tremors, headaches, increased heart rate, palpitations, pallor, cold sweats, nausea, vomiting.&nbsp;At high&nbsp;doses,&nbsp;you can see dilation of the&nbsp;pupils, high&nbsp;blood pressure,&nbsp;pulmonary edema, irregular heartbeat,&nbsp;heart failure.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The most common&nbsp;side effects&nbsp;of&nbsp;adrenaline&nbsp;are effects on the circulation and&nbsp;side effects&nbsp;on the&nbsp;central nervous system.&nbsp;About 1\/3 of patients suffer from&nbsp;side effects.<\/p>\n\n\n\n<p>Common&nbsp;side effects&nbsp;(may affect more than 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache, dizziness.<\/li><li>Fast heart rate, high&nbsp;blood pressure&nbsp;(in high&nbsp;doses&nbsp;), heart rhythm disturbances.<\/li><li>Anxiety, trembling.<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This includes any possible side effects not listed in this leaflet.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;www.lakemedelsverket.se.&nbsp;By reporting side effects, you can help increase drug safety information.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Adrenalin Martindale Pharma<\/h2>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;Keep the&nbsp;vial&nbsp;are in the outer carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>For single use only.<\/p>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;adrenaline.&nbsp;1 ml solution contains adrenaline tartrate corresponding to 0.1 mg&nbsp;adrenaline<\/li><li>The other ingredients are sodium chloride, citric acid monohydrate, sodium citrate, sodium metabisulfite (E223),&nbsp;hydrochloric acid&nbsp;(for&nbsp;pH&nbsp;adjustment&nbsp;), and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Adrenaline&nbsp;Martindale Pharma is a clear and colorless solution.<\/p>\n\n\n\n<p>Pack size: 10 x 10 ml&nbsp;glass&nbsp;ampoules (type I).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Ethypharm<\/p>\n\n\n\n<p>194 Bureaux de la Colline<\/p>\n\n\n\n<p>Building D<\/p>\n\n\n\n<p>92213 Saint-Cloud Cedex<\/p>\n\n\n\n<p>France<br><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Martindale Pharmaceuticals Limited, Bampton Road,<\/p>\n\n\n\n<p>Harold Hill, Essex, RM3 8UG, UK and Northern Ireland.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>This leaflet was last modified on 07\/03\/2020<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The following information is intended for healthcare professionals only:<\/h2>\n\n\n\n<p><strong>Cardiac arrest (cardiopulmonary resuscitation):<\/strong><\/p>\n\n\n\n<p>Adrenaline&nbsp;should be dosed and administered according to current treatment recommendations.&nbsp;The following&nbsp;dosage&nbsp;of&nbsp;adrenaline&nbsp;is based on the recommendations of the ERC (European Resuscitation Council) 2015.<br><\/p>\n\n\n\n<p><em>Adults and children over 12 years<\/em><\/p>\n\n\n\n<p>1 mg as an&nbsp;intravenous&nbsp;bolus dose&nbsp;every 3-5 minutes.<\/p>\n\n\n\n<p>If the drug is injected through a&nbsp;peripheral&nbsp;venous catheter, the drug must be flushed with at least 20 ml of 0.9% sodium chloride before&nbsp;injection&nbsp;(to facilitate entry into the central circulation).<\/p>\n\n\n\n<p>If venous access is not available, the intraosseous&nbsp;administration is&nbsp;recommended.<\/p>\n\n\n\n<p><em>Children under 12 years<\/em><\/p>\n\n\n\n<p>0.01 mg\/kg as an&nbsp;intravenous&nbsp;bolus dose.&nbsp;The maximum single&nbsp;dose&nbsp;is 1 mg.<br><\/p>\n\n\n\n<p><em>Newborns<\/em><\/p>\n\n\n\n<p>0.01-0.03 mg\/kg as an intravenous&nbsp;bolus dose.&nbsp;Administration&nbsp;via an umbilical venous catheter is recommended.<\/p>\n\n\n\n<p><strong>Acute&nbsp;anaphylaxis<\/strong><\/p>\n\n\n\n<p>Always check that the correct strength of adrenaline solution is used in the treatment of&nbsp;anaphylaxis.<\/p>\n\n\n\n<p>On equipment for the treatment of anaphylactic&nbsp;shock, 0.1 mg\/ml, and 1 mg\/ml adrenaline&nbsp;solution&nbsp;must be very clearly distinguished.<br><\/p>\n\n\n\n<p>Intramuscular&nbsp;administration&nbsp;of 1 mg\/ml adrenaline solution is preferred for the treatment of anaphylactic&nbsp;shock.&nbsp;It is also important not to waste time trying to find an&nbsp;intravenous&nbsp;infarction if&nbsp;intramuscular&nbsp;injection&nbsp;can still be successful.<\/p>\n\n\n\n<p>In the treatment of&nbsp;anaphylaxis,&nbsp;adrenaline&nbsp;for&nbsp;intravenous&nbsp;administration&nbsp;should only be used by experienced personnel under the observation of&nbsp;heart rate&nbsp;and&nbsp;blood pressure.&nbsp;In adults, 0.1 mg\/ml adrenaline&nbsp;solution is given&nbsp;as a 0.05 mg iv&nbsp;bolus dose&nbsp;and titrated by increasing with a&nbsp;bolus dose&nbsp;of 0.05 mg according to the response<em>.<\/em><\/p>\n\n\n\n<p><strong>Incompatibilities<\/strong><\/p>\n\n\n\n<p>Adrenaline is&nbsp;rapidly denatured by oxidizing agents and alkalis including sodium bicarbonate, halogens, nitrates, nitrites, and salts of iron, copper, and zinc.<\/p>\n\n\n\n<p>Adrenaline&nbsp;can be mixed with 0.9% sodium chloride for&nbsp;injection&nbsp;but is incompatible with 5% sodium chloride for&nbsp;injection.&nbsp;The stability of&nbsp;adrenaline&nbsp;in 5% dextrose injection decreases when the&nbsp;pH&nbsp;exceeds 5.5.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Adrenaline Martindale Pharma is used in cardiopulmonary resuscitation and in the treatment of sudden life-threatening allergic reactions ( acute anaphylaxis ).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[4044,4471,11539,11542,11525,11543,11526,11544,11524,11541,4045,11540],"class_list":["post-4846","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-adrenaline","tag-adrenaline-injection","tag-adrenaline-martindale-pharma","tag-adrenaline-martindale-pharma-injection","tag-benefits-of-adrenaline","tag-benefits-of-adrenaline-martindale-pharma","tag-side-effects-of-adrenaline","tag-side-effects-of-adrenaline-martindale-pharma","tag-what-adrenaline-is-used-for","tag-what-adrenaline-martindale-pharma-is-used-for","tag-what-is-adrenaline","tag-what-is-adrenaline-martindale-pharma"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4846","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=4846"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4846\/revisions"}],"predecessor-version":[{"id":13086,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4846\/revisions\/13086"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=4846"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=4846"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=4846"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}