mg \/ ml injection solution
adrenaline<\/p>\n\n\n\n
Adrenaline belongs to a group of drugs called adrenergic and dopaminergic drugs. Adrenaline Bradex is used in life-threatening acute cases such as severe allergic reactions or cardiac arrest.<\/p>\n\n\n\n
Adrenaline contained in Adrenaline Bradex may also be approved for the treatment of other conditions not mentioned in this leaflet. Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n
\u2022 if you are allergic to adrenaline or any of the other ingredients of this medicine (listed in section 6).
<\/p>\n\n\n\n
Talk to your doctor, pharmacist, or nurse before receiving Adrenaline Bradex if:<\/p>\n\n\n\n
\u2022 you are older<\/p>\n\n\n\n
\u2022 you have a heart problem. especially if it affects your heart rate or if you have chest pain<\/p>\n\n\n\n
\u2022 you have problems with the brain e.g. stroke, brain damage, or vascular disease<\/p>\n\n\n\n
\u2022 you have an overactive thyroid gland, diabetes, or glaucoma (high pressure in the eye)<\/p>\n\n\n\n
\u2022 you have pheochromocytoma (a tumor on the adrenal gland)<\/p>\n\n\n\n
\u2022 you have low potassium levels or high calcium levels in your blood<\/p>\n\n\n\n
\u2022 you have a tumor in the prostate gland or a kidney disease<\/p>\n\n\n\n
\u2022 you are in shock or have lost large amounts of blood<\/p>\n\n\n\n
\u2022 you will undergo surgery under anesthesia<\/p>\n\n\n\n
\u2022 you have high blood pressure<\/p>\n\n\n\n
\u2022 you have atherosclerosis, which means narrowing and hardening of the body’s blood vessels (your doctor can consult with you about this).<\/p>\n\n\n\n
Talk to your doctor before receiving this medicine if any of these apply to you.
<\/p>\n\n\n\n
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n
A large number of drugs can affect the effect of Adrenaline Bradex. These medicines include:<\/p>\n\n\n\n
\u2022 medicines for the treatment of depression, e.g. monoamine oxidase inhibitors ( MAOIs, eg moclobemide) or tricyclic antidepressants (eg imipramine, amitriptyline)<\/p>\n\n\n\n
Cardiac glycosides, e.g. digoxin, which is used for heart failure<\/p>\n\n\n\n
Guanethidine, used for rapid blood pressure control<\/p>\n\n\n\n
\u2022 diuretics ( diuretics ), e.g. hydrochlorothiazide , furosemide<\/p>\n\n\n\n
\u2022 anesthetics e.g. halothane<\/p>\n\n\n\n
\u2022 medicines to raise or lower blood pressure, e.g. beta-blockers such as propranolol, atenolol, bisoprolol, phentolamine<\/p>\n\n\n\n
\u2022 medicines for diabetes such as insulin or oral hypoglycaemic agents (eg glipizide)<\/p>\n\n\n\n
\u2022 aminophylline and theophylline (medicines used to treat asthma )<\/p>\n\n\n\n
\u2022 corticosteroids (medicines used to treat inflammatory conditions in the body such as asthma or rheumatoid arthritis )<\/p>\n\n\n\n
\u2022 antihistamine s (e.g. diphenhydramine) for the treatment of allergy s<\/p>\n\n\n\n
\u2022 medicines for the treatment of mental illness, e.g. chlorpromazine, penicillin, or fluphenazine<\/p>\n\n\n\n
\u2022 drugs for the treatment of underactive thyroid gland<\/p>\n\n\n\n
\u2022 oxytocin (used to initiate labor in full-term pregnancy and to control postpartum hemorrhage)<\/p>\n\n\n\n
\u2022 medicines for coughs and colds ( sympathomimetics ).
<\/p>\n\n\n\n
If you are already taking any of these medicines, talk to your doctor before taking Adrenaline Bradex.<\/p>\n\n\n\n
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Adrenaline Bradex should not be used during pregnancy or childbirth.<\/p>\n\n\n\n
Adrenaline is excreted in breast milk. If you are breast-feeding, talk to your doctor before taking Adrenaline Bradex. Adrenaline should only be used during pregnancy and breastfeeding when doctors consider it absolutely necessary.<\/p>\n\n\n\n
This probably does not apply to you because you will not feel good enough to be able to drive or use machines. Talk to your doctor before considering driving or using machines.
<\/p>\n\n\n\n
You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention. One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or side effects. Descriptions of these effects and side effects can be found in other sections. Read all the information in this leaflet for guidance. If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n
Sodium metabisulfite (a preservative ) can in rare cases cause severe allergic reactions ( hypersensitivity reactions ) and rashes.
<\/p>\n\n\n\n
This medicine contains less than 1 mmol sodium (23 mg) per ml, ie essentially ‘sodium-free’.
<\/p>\n\n\n\n
Adrenaline Bradex can be diluted with sodium chloride 9 mg \/ ml (0.9%). This should be considered by patients on a low-salt diet.
<\/p>\n\n\n\n
Adrenaline can be injected into a muscle ( intramuscularly ) or into the skeleton (intraosseous). It must be diluted before injection into a vein. Adrenaline should not be injected in areas such as fingers, toes, ears, nose, or penis as blood flow in these areas may be insufficient.
<\/p>\n\n\n\n
The drug is given by trained healthcare professionals. The doctor decides what does and in what way the medicine should be given depending on what is most appropriate in your particular case based on your age and your general condition.<\/p>\n\n\n\n
This is unlikely because the injection is given by a doctor or nurse. Possible signs of overdose may include restlessness, confusion, pallor, abnormally high heart rate at rest ( tachycardia ), low heart rate ( bradycardia ), irregular heartbeat ( cardiac arrhythmia ), and cardiac arrest.<\/p>\n\n\n\n
Talk to your doctor if you get any side effects so that he\/she can give you appropriate treatment. If you have already left the hospital premises, contact your nearest hospital, doctor, or pharmacist.<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n
Like all medicines, this medicine can cause side effects, although not everybody gets them.
<\/p>\n\n\n\n
The following side effects have also been reported (affects an unknown number of users):
<\/p>\n\n\n\n
\u2022 headache, dizziness<\/p>\n\n\n\n
\u2022 feeling of anxiety, fear, or restlessness<\/p>\n\n\n\n
\u2022 tremors<\/p>\n\n\n\n
\u2022 insomnia, confusion, irritability<\/p>\n\n\n\n
\u2022 deviant mood or behavior<\/p>\n\n\n\n
\u2022 dry mouth or excessive salivation<\/p>\n\n\n\n
\u2022 weakness or sweating<\/p>\n\n\n\n
\u2022 change in heart rate or heart rate<\/p>\n\n\n\n
\u2022 palpitations (rapid or irregular heartbeat), tachycardia (abnormally high heart rate at rest), angina (chest pain of varying intensity )<\/p>\n\n\n\n
\u2022 high blood pressure<\/p>\n\n\n\n
Cold arms or legs<\/p>\n\n\n\n
\u2022 shortness of breath<\/p>\n\n\n\n
\u2022 decreased appetite, nausea or vomiting<\/p>\n\n\n\n
\u2022 repeated injections can damage tissue at the injection site, injuries can also occur in the arms, legs, kidneys, and liver<\/p>\n\n\n\n
\u2022 difficulty or inability to empty the bladder<\/p>\n\n\n\n
\u2022 metabolic acidosis (an imbalance of certain components in the blood) may occur<\/p>\n\n\n\n
\u2022 worsening tremors and worsening stiffness in patients with parkinsonism<\/p>\n\n\n\n
\u2022 bleeding in the head<\/p>\n\n\n\n
\u2022 paralysis in one half of the body<\/p>\n\n\n\n
\u2022 elevated blood sugar levels<\/p>\n\n\n\n
\u2022 decreased potassium levels in the blood<\/p>\n\n\n\n
\u2022 accumulation of fluid in the lungs
<\/p>\n\n\n\n
Reporting of side effects<\/em><\/p>\n\n\n\n If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly to the Medical Products Agency, www.lakemedelsverket.se. By reporting side effects, you can help increase drug safety information. <\/p>\n\n\n\n Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton and ampoule after EXP. The expiration date is the last day of the specified month. Do not store above 25 \u00b0 C. Keep the vial are in the outer carton. Sensitive to light.<\/p>\n\n\n\n For single use only. If only part of the contents of the ampoule is used, discard any remaining solution. Do not remove an ampoule from the carton before use.<\/strong> After dilution, the reconstituted solution should be administered as soon as possible but under no circumstances should it be stored for more than 24 hours at 2\u20138 \u00b0 C, 3 hours at 23\u201127 \u00b0 C when exposed to light, or 6 hours at 23-27 \u00b0 C protected from light. Only clear colorless or pale yellow solution free from particles or precipitates should be used. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment. \u2022 The active substance is adrenaline as adrenaline tartrate. One ml solution for injection contains 1 mg of adrenaline as adrenaline tartrate. The other ingredients are sodium metabisulfite (E223), sodium chloride, water for injections, hydrochloric acid, and sodium hydroxide.<\/p>\n\n\n\n Adrenaline Bradex is a clear, colorless, or pale yellow, sterile solution for injection in an amber glass ampoule of glass I.<\/p>\n\n\n\n Adrenaline Bradex is available in packs of 10, 25, and 50 ampoules.<\/p>\n\n\n\n Holder of approval<\/strong><\/p>\n\n\n\n BRADEX SA, 27 Asklipiou street, 14568 Kryoneri Greece.<\/p>\n\n\n\n Manufacturer<\/strong><\/p>\n\n\n\n DEMO SA PHARMACEUTICAL INDUSTRY, 21st km National Road Athens-Lamia, 145 68 Krioneri, Attiki, Greece. Information is provided by<\/strong><\/p>\n\n\n\n FrostPharma AB<\/p>\n\n\n\n Berga Backe 2<\/p>\n\n\n\n 182 53 Danderyd This leaflet was last modified on 18\/09\/2020<\/p>\n\n\n\n Only clear colorless or pale yellow solution free from particles or precipitates should be used.<\/p>\n\n\n\n <\/p>\n\n\n\n Repeated topical administration may cause necrosis at the injection site. The best site for intramuscular injection is anterolateral in the middle third of the thigh. The needle used for injection must be long enough to ensure that the adrenaline reaches the muscle. Intramuscular injection of adrenaline into the gluteal muscle should be avoided due to the risk of tissue necrosis. Prolonged administration may cause metabolic acidosis, renal necrosis, and decreased sensitivity to adrenaline or tachyphylaxis.<\/p>\n\n\n\n The use of adrenaline should be avoided or avoided with extreme caution in patients under anesthesia with halothane or other halogenated anesthetics, due to the risk of causing ventricular fibrillation.<\/p>\n\n\n\n Adrenaline should not be used together with local anesthesia of peripheral structures e.g. fingers, toes, and earlobes.<\/p>\n\n\n\n Do not mix with other drugs unless compatibility has been confirmed. Adrenaline should not be used during the expulsion phase of labor. Accidental intravascular injection may result in cerebral hemorrhage due to the sudden rise in blood pressure.<\/p>\n\n\n\n Start monitoring the patient as soon as possible (heart rate, blood pressure, ECG, pulse oximetry) to assess the response to adrenaline.<\/p>\n\n\n\n Incompatibilities<\/strong><\/p>\n\n\n\n Dilution<\/em><\/p>\n\n\n\n For intravenous administration , Adrenaline Bradex should be diluted to a 0.1 mg \/ ml solution (a 1:10 dilution of the ampoule contents) with sodium chloride 9 mg \/ ml (0.9%).<\/p>\n\n\n\n Dosage and route of administration<\/strong><\/p>\n\n\n\n Adrenaline Bradex is intended for intramuscular and intraosseous use. For intravenous administration only after dilution.<\/p>\n\n\n\n Acute anaphylaxis<\/em> The intramuscular route of administration<\/strong> is preferred for most individuals requiring treatment with adrenaline for acute anaphylaxis, in doses listed in Table 1.<\/p>\n\n\n\n The recommended dose of adrenaline is generally 0.01 mg per kg of body weight.<\/p>\n\n\n\n For adults, the usual recommended dose of adrenaline is 0.5 mg. For children whose weight is not known, the following table, which shows the recommended dose by age, can be used: Table 1. <\/em><\/strong>Dose adrenaline 1 mg\/ml as an intramuscular injection for a severe anaphylactic reaction<\/em><\/p>\n\n\n\n If the patient is seriously ill and there is reason to suspect inadequate circulation and absorption from the intramuscular injection site, adrenaline may be given as an intravenous injection.<\/p>\n\n\n\n Intravenous adrenaline should only be given by staff experienced in the use and titration of vasopressors from their normal clinical practice (see section 4.4 of the Summary of Product Characteristics). Upon administration of intravenous epinephrine will dose a given after dilution to 0.1 mg\/ml solution (i.e. ml of a 1:10 dilution). Dose one should be titrated with bolus doses of 0.05 mg according to the response. Do not give the undiluted 1 mg\/ml adrenaline solution intravenously.<\/p>\n\n\n\n If necessary, repeated dosing with adrenaline recommended intravenous infusion, with the rate titrated according to response followed by continued hemodynamic monitoring.<\/p>\n\n\n\n Cardiopulmonary rescue<\/strong> Adults<\/em><\/p>\n\n\n\n 1 mg adrenaline administered intravenously or intraosseously, repeated at 3-5 minute intervals until spontaneous circulation returns. If the injection is made through a peripheral inlet, this must be followed by flushing with at least 20 ml of fluid and raising the extremity one for 10\u201320 seconds to promote the drug’s distribution to the central circulation.<\/p>\n\n\n\n Pediatric population<\/em><\/p>\n\n\n\n The recommended intravenous or intraosseous dose of adrenaline in children is 0.01 mg\/kg. Depending on the weight, this dose may need to be given as a 0.1 mg\/ml solution (ie a 1:10 dilution of the ampoule contents). Subsequent dose s adrenaline is given 3-5 minutes. The maximum single dose is 1 mg.<\/p>\n\n\n\n Disposal<\/strong> Any unused product or waste material should be disposed of in accordance with local requirements.<\/p>\n\n\n\n Overdose<\/strong> Sign<\/em><\/p>\n\n\n\n Overdose with Adrenaline Bradex leads to restlessness, confusion, pallor, tachycardia, bradycardia, cardiac arrhythmias, and cardiac arrest. Treatment<\/em><\/p>\n\n\n\n Treatment is mainly symptomatic and supportive. Attempts have been made to counteract the astringent and arrhythmogenic effects of adrenaline with an immediate injection of fast-acting alpha-receptor blockers, e.g. phentolamine, followed by a beta-blocker, e.g. propranolol. A fast-acting vasodilator, e.g. glyceryl trinitrate has also been used.<\/p>\n","protected":false},"excerpt":{"rendered":" Adrenaline belongs to a group of drugs called adrenergic and dopaminergic drugs. Adrenaline Bradex is used in life-threatening acute cases such as severe allergic reactions or cardiac arrest.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2201,2200],"tags":[4044,11551,11555,4471,4046,11525,11556,11557,11554,11524,4045,11553],"class_list":["post-4842","post","type-post","status-publish","format-standard","hentry","category-a","category-medicines","tag-adrenaline","tag-adrenaline-bradex","tag-adrenaline-bradex-injection","tag-adrenaline-injection","tag-adrenaline-side-effects","tag-benefits-of-adrenaline","tag-benefits-of-adrenaline-bradex","tag-side-effects-of-adrenaline-bradex","tag-what-adrenaline-bradex-is-used-for","tag-what-adrenaline-is-used-for","tag-what-is-adrenaline","tag-what-is-adrenaline-bradex"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=4842"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4842\/revisions"}],"predecessor-version":[{"id":13088,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/4842\/revisions\/13088"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=4842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=4842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=4842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}5. How to store Adrenaline Bradex<\/h2>\n\n\n\n
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<\/p>\n\n\n\n6. Contents of the packaging and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
<\/p>\n\n\n\nWhat the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
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<\/p>\n\n\n\nThe following information is intended for healthcare professionals only:<\/h2>\n\n\n\n
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<\/p>\n\n\n\nAge<\/td> Dose<\/td> Volume of adrenaline 1 mg \/ ml<\/td><\/tr> Adults<\/td> 0.5mg<\/td> 0.5 ml<\/td><\/tr> Children> 12 years<\/td> 0.5 mg<\/td> 0.5 ml<\/td><\/tr> Children 6 – 12 years<\/td> 0.3 mg<\/td> 0.3 ml<\/td><\/tr> Children 6 months \u2013 6 years<\/td> 0.15 mg<\/td> 0.15 ml<\/td><\/tr> For 6 months<\/td> 0.01 mg \/ kg<\/td> 0.01 ml \/ kg<\/td><\/tr> If necessary, these doses can be repeated several times at intervals of 5\u201115 minutes depending on blood pressure , heart rate and respiratory function.
A small volume syringe should be used.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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